Click here to switch to the map view.

The map label for this gene is ubiE [H]

Identifier: 37519696

GI number: 37519696

Start: 122286

End: 122966

Strand: Reverse

Name: ubiE [H]

Synonym: gvip014

Alternate gene names: 37519696

Gene position: 122966-122286 (Counterclockwise)

Preceding gene: 37519697

Following gene: 37519692

Centisome position: 2.64

GC content: 64.9

Gene sequence:

>681_bases
ATGCAGGGTAGCCAGGAGATCCAGGGCATCTTCAACGCCATTGCGCCGGTCTATGACCAGATCAATGACCGGATGAGCTT
CGGTTTGCACCGGGTCTGGAAGAAGATGGCCATCCGTTGGACCGATTGCAAGCCGGGGGATACGGTGCTCGATCTGTGCT
GCGGCACCGGCGATCTGGCTTTTTTGCTCGCCCGGCGGGTGGGGGTCGCCGGTACGGTCTGGGGGGTCGATTTTGCCGCC
GCCCAGCTGGCCCAGGCCCGCCGCCGCGATCGCGAAGGGCGGGTGCGTTGGCTCGAAGCGGACGCCCTGGATTTGCCTTT
TGCCGACGACAGCTTCGACGCGGTGACTCAGGGTTTCGGACTGCGCAACGTCGTCGATATTCCCGCCTGCTTCGCACAGC
TGCGTCGGGTGCTCAAACCCGGCGGCCGAGCGGTGATTCTCGATTTGCACGCCCCGGCCGACGCCGGGTGGCGGGCTTTT
CAGCGCTGGTATCTTGAAGGCTGGGTCACGGCACTCGGCCGCGCCCAAGGCCTGGAGGCCGAGTACGCCTACATCGCCCC
GAGCCTGGAGCGCTTTCCTACAGGAGACGAGCAGGTGCGGCTGGCCCAGCAAGCCGGATTTAGCCAAGCGAGCCACTATC
CGTTGATCGGTGGAACGGTTGGGGTGCTGGTGGCGCAATAA

Upstream 100 bases:

>100_bases
AGCGCATCGAGATTTTTGCCCTGGCGGCGGACAGGGACATGCTGCGCAATTGCAATACGCCGGAGGATCTGTCCGAAGAA
GGGGAGCGGGCAGTGTTTTG

Downstream 100 bases:

>100_bases
GCCGCTAACGGGGTGAAGGAGTGATGCAGCGCACGGTATAGATTTATGTTCAGCCTATGTGCGGTTGACATGTCCTGGTC
TAATCACTGCTATTTATCCA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MQGSQEIQGIFNAIAPVYDQINDRMSFGLHRVWKKMAIRWTDCKPGDTVLDLCCGTGDLAFLLARRVGVAGTVWGVDFAA
AQLAQARRRDREGRVRWLEADALDLPFADDSFDAVTQGFGLRNVVDIPACFAQLRRVLKPGGRAVILDLHAPADAGWRAF
QRWYLEGWVTALGRAQGLEAEYAYIAPSLERFPTGDEQVRLAQQAGFSQASHYPLIGGTVGVLVAQ

Sequences:

>Translated_226_residues
MQGSQEIQGIFNAIAPVYDQINDRMSFGLHRVWKKMAIRWTDCKPGDTVLDLCCGTGDLAFLLARRVGVAGTVWGVDFAA
AQLAQARRRDREGRVRWLEADALDLPFADDSFDAVTQGFGLRNVVDIPACFAQLRRVLKPGGRAVILDLHAPADAGWRAF
QRWYLEGWVTALGRAQGLEAEYAYIAPSLERFPTGDEQVRLAQQAGFSQASHYPLIGGTVGVLVAQ
>Mature_226_residues
MQGSQEIQGIFNAIAPVYDQINDRMSFGLHRVWKKMAIRWTDCKPGDTVLDLCCGTGDLAFLLARRVGVAGTVWGVDFAA
AQLAQARRRDREGRVRWLEADALDLPFADDSFDAVTQGFGLRNVVDIPACFAQLRRVLKPGGRAVILDLHAPADAGWRAF
QRWYLEGWVTALGRAQGLEAEYAYIAPSLERFPTGDEQVRLAQQAGFSQASHYPLIGGTVGVLVAQ

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=255, Percent_Identity=28.6274509803922, Blast_Score=104, Evalue=7e-23,
Organism=Escherichia coli, GI48994983, Length=229, Percent_Identity=36.2445414847162, Blast_Score=144, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17557039, Length=227, Percent_Identity=29.0748898678414, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17561380, Length=115, Percent_Identity=35.6521739130435, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323526, Length=233, Percent_Identity=30.9012875536481, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24641702, Length=239, Percent_Identity=29.2887029288703, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 24878; Mature: 24878

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS01183 UBIE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGSQEIQGIFNAIAPVYDQINDRMSFGLHRVWKKMAIRWTDCKPGDTVLDLCCGTGDLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHHCCCCHHH
FLLARRVGVAGTVWGVDFAAAQLAQARRRDREGRVRWLEADALDLPFADDSFDAVTQGFG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCC
LRNVVDIPACFAQLRRVLKPGGRAVILDLHAPADAGWRAFQRWYLEGWVTALGRAQGLEA
CCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EYAYIAPSLERFPTGDEQVRLAQQAGFSQASHYPLIGGTVGVLVAQ
CHHHCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MQGSQEIQGIFNAIAPVYDQINDRMSFGLHRVWKKMAIRWTDCKPGDTVLDLCCGTGDLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHHCCCCHHH
FLLARRVGVAGTVWGVDFAAAQLAQARRRDREGRVRWLEADALDLPFADDSFDAVTQGFG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCC
LRNVVDIPACFAQLRRVLKPGGRAVILDLHAPADAGWRAFQRWYLEGWVTALGRAQGLEA
CCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EYAYIAPSLERFPTGDEQVRLAQQAGFSQASHYPLIGGTVGVLVAQ
CHHHCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA