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The map label for this gene is udg [H]

Identifier: 34499584

GI number: 34499584

Start: 4468744

End: 4470036

Strand: Reverse

Name: udg [H]

Synonym: CV_4129

Alternate gene names: 34499584

Gene position: 4470036-4468744 (Counterclockwise)

Preceding gene: 34499585

Following gene: 34499583

Centisome position: 94.08

GC content: 64.27

Gene sequence:

>1293_bases
CTGCTCAATCGTATCGCGGACAAATCCGCTGTGATCGGCATCGTGGGTCTGGGCTATGTTGGCCTGCCGCTGATGCTGCG
TTTCGCCGAAGTCGGCTACAAGGTGCTGGGTTTCGACATCGACCAGAGCAAGGTCGACGCCCTGATGGCCGGCAACAGCT
ACATCGAGCATATCTCCGCCGACAGCATCGCCACCGCGCTGACCCGCGGCTTCGAGGCCACCACCGACTTCTCCCGCGCC
GGCGAGGCCGACACGCTGATCCTGTGCGTGCCGACGCCGCTCAACAAGTACCGCGAGCCGGACCTCAGCTTCGTGCTGAA
CACCATAGACAGCCTGGTGCCCTATCTGCGCAAGGGCCACCTGGTGTCGCTGGAGTCCACCACCTACCCCGGCACCACCG
ACGAAGAACTGCTGCCGCGGATGGAGTCGCGCGGTCTGAAGGTCGGCGACGACGCCTTCCTGGTGTTCTCGCCGGAGCGC
GAAGATCCGGGCAATCCCGACTTCACCACCCGGACCATTCCCAAAGTGTGCGGCGGCGTGACCGAAGCCTGCCAGGAAAT
CGGCGTCGCGCTGTACGGCGCGGTGATCGACAAGGTGGTGCCGGTGTCGTCCACCCGCGCCGCCGAGATGACCAAGCTGC
TGGAAAACATCCACCGCGCGGTCAACATCGGCCTGGTCAACGAGATGAAGATCGTCGCCGACAAGATGGGCATCGACATC
CACGAGGTGATCCGCGCCGCGGCCACCAAGCCCTTCGGCTTCGTGCCCTACTACCCGGGTCCGGGCCTGGGCGGCCACTG
CATCCCGATCGACCCGTTCTACCTGACCTGGAAGGCGCGCGAGTACGGCGTCAACACCCGTTTCATCGAGCTGGCCGGCG
AGGTGAACAGCAATATGCCGGACTACGTGGTGTCCAAGGTGGCCTCCGCGCTGAACCTGCGCAAGAAGTCCATCAACGGC
AGCCGCGTGCTGGTGCTGGGCATCGCCTACAAGAAGAACGTCGACGACATGCGCGAGAGCCCGTCGGTGTTCCTGATGGA
AAAGCTGCGCGACCTGGGCGCCGAAGTGGCGTACAGCGATCCGCACGTGCCGGTGTTCCCGAAGATGCGCGAGCACAAGT
TCGACCTGAAGAGCGTGCCGTTGACCGCCGAATCCATCGCCGGCTACGACTGCGTGCTGCTGGCCACCGACCACGACAAG
TTCGACTACGAGCTGATCAAGGCCAAGGCCCAACTGGTGGTGGACAGCCGCGGCAAGTACCTGGAGCCCGCCGAGCACAT
CGTCAAGGCCTAA

Upstream 100 bases:

>100_bases
AGTACCTTATACCTGAGTACCGAATGACCGGGCGGCAGACGGGCGTCTGCCGCTCAAGCTTTTACATCCTGTTGGGACAT
TCATCGTGATCAAGCAGCAA

Downstream 100 bases:

>100_bases
GGCGTGTGCGGACGCTTGCCCCCGCCGGGGGCGTGGCTGGCGGCGCTGGGCGCGCTCGCGCTGCTGGCCGTGCTGGCGCT
GGTGCCGCTGATCCGCTATT

Product: udpglucose 6-dehydrogenase

Products: UDP-glucuronate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLNRIADKSAVIGIVGLGYVGLPLMLRFAEVGYKVLGFDIDQSKVDALMAGNSYIEHISADSIATALTRGFEATTDFSRA
GEADTLILCVPTPLNKYREPDLSFVLNTIDSLVPYLRKGHLVSLESTTYPGTTDEELLPRMESRGLKVGDDAFLVFSPER
EDPGNPDFTTRTIPKVCGGVTEACQEIGVALYGAVIDKVVPVSSTRAAEMTKLLENIHRAVNIGLVNEMKIVADKMGIDI
HEVIRAAATKPFGFVPYYPGPGLGGHCIPIDPFYLTWKAREYGVNTRFIELAGEVNSNMPDYVVSKVASALNLRKKSING
SRVLVLGIAYKKNVDDMRESPSVFLMEKLRDLGAEVAYSDPHVPVFPKMREHKFDLKSVPLTAESIAGYDCVLLATDHDK
FDYELIKAKAQLVVDSRGKYLEPAEHIVKA

Sequences:

>Translated_430_residues
MLNRIADKSAVIGIVGLGYVGLPLMLRFAEVGYKVLGFDIDQSKVDALMAGNSYIEHISADSIATALTRGFEATTDFSRA
GEADTLILCVPTPLNKYREPDLSFVLNTIDSLVPYLRKGHLVSLESTTYPGTTDEELLPRMESRGLKVGDDAFLVFSPER
EDPGNPDFTTRTIPKVCGGVTEACQEIGVALYGAVIDKVVPVSSTRAAEMTKLLENIHRAVNIGLVNEMKIVADKMGIDI
HEVIRAAATKPFGFVPYYPGPGLGGHCIPIDPFYLTWKAREYGVNTRFIELAGEVNSNMPDYVVSKVASALNLRKKSING
SRVLVLGIAYKKNVDDMRESPSVFLMEKLRDLGAEVAYSDPHVPVFPKMREHKFDLKSVPLTAESIAGYDCVLLATDHDK
FDYELIKAKAQLVVDSRGKYLEPAEHIVKA
>Mature_430_residues
MLNRIADKSAVIGIVGLGYVGLPLMLRFAEVGYKVLGFDIDQSKVDALMAGNSYIEHISADSIATALTRGFEATTDFSRA
GEADTLILCVPTPLNKYREPDLSFVLNTIDSLVPYLRKGHLVSLESTTYPGTTDEELLPRMESRGLKVGDDAFLVFSPER
EDPGNPDFTTRTIPKVCGGVTEACQEIGVALYGAVIDKVVPVSSTRAAEMTKLLENIHRAVNIGLVNEMKIVADKMGIDI
HEVIRAAATKPFGFVPYYPGPGLGGHCIPIDPFYLTWKAREYGVNTRFIELAGEVNSNMPDYVVSKVASALNLRKKSING
SRVLVLGIAYKKNVDDMRESPSVFLMEKLRDLGAEVAYSDPHVPVFPKMREHKFDLKSVPLTAESIAGYDCVLLATDHDK
FDYELIKAKAQLVVDSRGKYLEPAEHIVKA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=435, Percent_Identity=24.367816091954, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI48994968, Length=429, Percent_Identity=33.3333333333333, Blast_Score=208, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17560350, Length=392, Percent_Identity=23.2142857142857, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.22

Molecular weight: Translated: 47175; Mature: 47175

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRIADKSAVIGIVGLGYVGLPLMLRFAEVGYKVLGFDIDQSKVDALMAGNSYIEHISA
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHHHHCH
DSIATALTRGFEATTDFSRAGEADTLILCVPTPLNKYREPDLSFVLNTIDSLVPYLRKGH
HHHHHHHHCCCCCCCCHHHCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHCCC
LVSLESTTYPGTTDEELLPRMESRGLKVGDDAFLVFSPEREDPGNPDFTTRTIPKVCGGV
EEEEECCCCCCCCHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCCCCCCHHHHHHCHH
TEACQEIGVALYGAVIDKVVPVSSTRAAEMTKLLENIHRAVNIGLVNEMKIVADKMGIDI
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCH
HEVIRAAATKPFGFVPYYPGPGLGGHCIPIDPFYLTWKAREYGVNTRFIELAGEVNSNMP
HHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEHHHHCCCEEEEEEECCCCCCCH
DYVVSKVASALNLRKKSINGSRVLVLGIAYKKNVDDMRESPSVFLMEKLRDLGAEVAYSD
HHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHCCCCHHHHHHHHHCCCEEECCC
PHVPVFPKMREHKFDLKSVPLTAESIAGYDCVLLATDHDKFDYELIKAKAQLVVDSRGKY
CCCCCCCCHHHCCCCCCCCCCCHHHHCCCEEEEEEECCCCHHHHHHHHHHHEEECCCCCC
LEPAEHIVKA
CCHHHHHHCC
>Mature Secondary Structure
MLNRIADKSAVIGIVGLGYVGLPLMLRFAEVGYKVLGFDIDQSKVDALMAGNSYIEHISA
CCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHHHHCH
DSIATALTRGFEATTDFSRAGEADTLILCVPTPLNKYREPDLSFVLNTIDSLVPYLRKGH
HHHHHHHHCCCCCCCCHHHCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHCCC
LVSLESTTYPGTTDEELLPRMESRGLKVGDDAFLVFSPEREDPGNPDFTTRTIPKVCGGV
EEEEECCCCCCCCHHHHHHHHHHCCCEECCCEEEEEECCCCCCCCCCCCCCHHHHHHCHH
TEACQEIGVALYGAVIDKVVPVSSTRAAEMTKLLENIHRAVNIGLVNEMKIVADKMGIDI
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCH
HEVIRAAATKPFGFVPYYPGPGLGGHCIPIDPFYLTWKAREYGVNTRFIELAGEVNSNMP
HHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEEHHHHCCCEEEEEEECCCCCCCH
DYVVSKVASALNLRKKSINGSRVLVLGIAYKKNVDDMRESPSVFLMEKLRDLGAEVAYSD
HHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHCCCCHHHHHHHHHCCCEEECCC
PHVPVFPKMREHKFDLKSVPLTAESIAGYDCVLLATDHDKFDYELIKAKAQLVVDSRGKY
CCCCCCCCHHHCCCCCCCCCCCHHHHCCCEEEEEEECCCCHHHHHHHHHHHEEECCCCCC
LEPAEHIVKA
CCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucose; NAD+; H2O

Specific reaction: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + 2 H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]