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The map label for this gene is wecB [H]

Identifier: 34499475

GI number: 34499475

Start: 4345871

End: 4347016

Strand: Reverse

Name: wecB [H]

Synonym: CV_4020

Alternate gene names: 34499475

Gene position: 4347016-4345871 (Counterclockwise)

Preceding gene: 34499476

Following gene: 34499474

Centisome position: 91.5

GC content: 43.8

Gene sequence:

>1146_bases
ATGAGTACGCGTAAGAAAATTATGCTAGCTTTTGGCACGAGGCCAGAGGCGATTAAAATGGCTCCTCTTTATCATGCTTT
GAAAAGCTGCGAAGAAAATTTCGAAACAGTCGTATGCCTTACCGCGCAACATCGGCAAATGCTAGATCAGGTTTTGTCAG
TATTCAATATTGATGCGGATATTGACTTGAATTTGATGAAGCCAGGGCAAGATCTGTTTGATGTGACCTCATCTGTGCTT
TTGCATATGCGCAGTGTTTTGAAGGAGCACAAGCCTGATATGCTGCTTGTGCATGGGGATACGACAACTTCTCTTGCTGC
CGGTATGGCTGCGTTTTATCTTGGGATTCCTTTGGGACATGTCGAAGCGGGTTTGAGAACCTTTGATGTGCACGCTCCAT
TTCCTGAGGAGTTTAACCGGCAGGTAGTTTCAAAGATATCTCAACTTCACTTCGCGCCTACTGAGCAAAGCAAGGATAAC
TTGCTTAATGAGAATGTGCTGGAAAAGGATATTCTAGTTACAGGCAATACGGTAATCGATGCTCTTTTCTGGGTGCTCCA
TAGAATTGATAGCGATCCAGTAAAATATAAAGCGTTATGTGATGTATTATCTGTTCACCTTCCCTTTAACTGGAAGGAGC
AATGTTATATTCTCATCACAGGGCATAGGCGAGAAAACTTTGGCTCGGGCTTCCTGCAGATTTGTGAAGCTCTTAAAGAT
TTGGCTAATAAATATCCAGATGTGAATTTCGTTTATCCTGTGCATTTGAACCCACAAGTTCAAGAGCCAGTGAATGCGAT
TCTTAATAATCTGAATAATGTTCACCTGATTCCGCCGCTCGATTACGAGCCCTTTGTCATGCTTCTTAAGCACAGCTACA
TTGTATTGACTGATAGTGGCGGCATTCAAGAGGAGGCTCCAAGCTTAGGGAAGCCAGTTCTCGTTATGCGAGATGTTACC
GAAAGACCTGAAGCGGTCGCGGCTGGAACGGTGAAGTTGGTGGGGGCTGATCGGGCCAAGATCATTGAGCATGTTTCAAT
TTTGCTGGATGATTCCAATCATTATGAAATGATGTCCAAAGCGCATAATCCTTATGGTGATGGCAGCGCATGTGAACGGA
TTATTTCTGCTTTAAAGAGGGTGTAA

Upstream 100 bases:

>100_bases
CAAGGATTTCGTAGTAGGTGTTTAGAAGGTGCGCTGAAATATAATAGACGTAATCTGGCATTGAAAATGCTTGATATTTT
AAAGAAGGTGAATGTCTAAG

Downstream 100 bases:

>100_bases
GTGATGATGAATAAAACGGTTTGCGTAGTCGGCTTGGGATATATTGGCTTGCCTACTGCAGCATTATTGGCGAGCAATGG
TTATAAAGTTGTTGGTGTTG

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSTRKKIMLAFGTRPEAIKMAPLYHALKSCEENFETVVCLTAQHRQMLDQVLSVFNIDADIDLNLMKPGQDLFDVTSSVL
LHMRSVLKEHKPDMLLVHGDTTTSLAAGMAAFYLGIPLGHVEAGLRTFDVHAPFPEEFNRQVVSKISQLHFAPTEQSKDN
LLNENVLEKDILVTGNTVIDALFWVLHRIDSDPVKYKALCDVLSVHLPFNWKEQCYILITGHRRENFGSGFLQICEALKD
LANKYPDVNFVYPVHLNPQVQEPVNAILNNLNNVHLIPPLDYEPFVMLLKHSYIVLTDSGGIQEEAPSLGKPVLVMRDVT
ERPEAVAAGTVKLVGADRAKIIEHVSILLDDSNHYEMMSKAHNPYGDGSACERIISALKRV

Sequences:

>Translated_381_residues
MSTRKKIMLAFGTRPEAIKMAPLYHALKSCEENFETVVCLTAQHRQMLDQVLSVFNIDADIDLNLMKPGQDLFDVTSSVL
LHMRSVLKEHKPDMLLVHGDTTTSLAAGMAAFYLGIPLGHVEAGLRTFDVHAPFPEEFNRQVVSKISQLHFAPTEQSKDN
LLNENVLEKDILVTGNTVIDALFWVLHRIDSDPVKYKALCDVLSVHLPFNWKEQCYILITGHRRENFGSGFLQICEALKD
LANKYPDVNFVYPVHLNPQVQEPVNAILNNLNNVHLIPPLDYEPFVMLLKHSYIVLTDSGGIQEEAPSLGKPVLVMRDVT
ERPEAVAAGTVKLVGADRAKIIEHVSILLDDSNHYEMMSKAHNPYGDGSACERIISALKRV
>Mature_380_residues
STRKKIMLAFGTRPEAIKMAPLYHALKSCEENFETVVCLTAQHRQMLDQVLSVFNIDADIDLNLMKPGQDLFDVTSSVLL
HMRSVLKEHKPDMLLVHGDTTTSLAAGMAAFYLGIPLGHVEAGLRTFDVHAPFPEEFNRQVVSKISQLHFAPTEQSKDNL
LNENVLEKDILVTGNTVIDALFWVLHRIDSDPVKYKALCDVLSVHLPFNWKEQCYILITGHRRENFGSGFLQICEALKDL
ANKYPDVNFVYPVHLNPQVQEPVNAILNNLNNVHLIPPLDYEPFVMLLKHSYIVLTDSGGIQEEAPSLGKPVLVMRDVTE
RPEAVAAGTVKLVGADRAKIIEHVSILLDDSNHYEMMSKAHNPYGDGSACERIISALKRV

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=375, Percent_Identity=58.4, Blast_Score=437, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42668; Mature: 42537

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRKKIMLAFGTRPEAIKMAPLYHALKSCEENFETVVCLTAQHRQMLDQVLSVFNIDAD
CCCCCEEEEEECCCCCCEEHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCC
IDLNLMKPGQDLFDVTSSVLLHMRSVLKEHKPDMLLVHGDTTTSLAAGMAAFYLGIPLGH
CEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCHHH
VEAGLRTFDVHAPFPEEFNRQVVSKISQLHFAPTEQSKDNLLNENVLEKDILVTGNTVID
HHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEECHHHHH
ALFWVLHRIDSDPVKYKALCDVLSVHLPFNWKEQCYILITGHRRENFGSGFLQICEALKD
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
LANKYPDVNFVYPVHLNPQVQEPVNAILNNLNNVHLIPPLDYEPFVMLLKHSYIVLTDSG
HHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCCEEEEECCC
GIQEEAPSLGKPVLVMRDVTERPEAVAAGTVKLVGADRAKIIEHVSILLDDSNHYEMMSK
CCCCCCCCCCCCEEEEECCCCCCCHHHCCCEEEECCCHHHHHHHHHHEECCCCHHHHHHH
AHNPYGDGSACERIISALKRV
CCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
STRKKIMLAFGTRPEAIKMAPLYHALKSCEENFETVVCLTAQHRQMLDQVLSVFNIDAD
CCCCEEEEEECCCCCCEEHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCC
IDLNLMKPGQDLFDVTSSVLLHMRSVLKEHKPDMLLVHGDTTTSLAAGMAAFYLGIPLGH
CEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCHHH
VEAGLRTFDVHAPFPEEFNRQVVSKISQLHFAPTEQSKDNLLNENVLEKDILVTGNTVID
HHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEECHHHHH
ALFWVLHRIDSDPVKYKALCDVLSVHLPFNWKEQCYILITGHRRENFGSGFLQICEALKD
HHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
LANKYPDVNFVYPVHLNPQVQEPVNAILNNLNNVHLIPPLDYEPFVMLLKHSYIVLTDSG
HHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCCEEEEECCC
GIQEEAPSLGKPVLVMRDVTERPEAVAAGTVKLVGADRAKIIEHVSILLDDSNHYEMMSK
CCCCCCCCCCCCEEEEECCCCCCCHHHCCCEEEECCCHHHHHHHHHHEECCCCHHHHHHH
AHNPYGDGSACERIISALKRV
CCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]