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The map label for this gene is lysA [H]

Identifier: 34499212

GI number: 34499212

Start: 4055371

End: 4056600

Strand: Direct

Name: lysA [H]

Synonym: CV_3757

Alternate gene names: 34499212

Gene position: 4055371-4056600 (Clockwise)

Preceding gene: 34499209

Following gene: 34499214

Centisome position: 85.36

GC content: 68.54

Gene sequence:

>1230_bases
ATGCACGCTTTCGACAATCGCCAGCTCGCCGACATCGCCCGCCAGTACGGCACGCCGCTATGGGTCTACCGCGCCGATAC
CATCCGCGAGCGCATCGCGGAGCTGAAAGCCTTCGACACCATACGCTACGCGCAGAAGGCCAACTCCAATACCCACATCC
TCAGGCTGATGCGCGCCGAGGGCGTCAAGGTGGACGCGGTGTCGCTGGGAGAGATCGAGCGCGCGCTGGCGGCCGGCTAC
CGCGGCGGCGGCGAACCGTCCGATATCGTGTTCACCGCCGACGTGCTGGATCGGCCGACGCTGGCCAAGGTGATCGCCGA
GAACATTCCGGTCAACGCCGGCTCCATCGACATGCTGCGGCAGCTTGGCGAAGCCGCCCCCGGCCACCCGGTCTGGCTGC
GCATCAACCCCGGCTTCGGCCACGGCCACAGCCAGAAGACCAACACCGGCGGCGAAAACAGCAAGCACGGCATCTGGCAT
GGCGACCTGGACGAGGCGCTGCAGGCGGTGCGCCGCTTCAATCTGCGCCTGATCGGCATTCACATGCACATCGGCTCCGG
CGTCGACTACGGCCATCTGGAGCAGGTATGCGGCGCGATGGTGGAGCTGGTGGCCCGGCTGGAATGCGACATCGAGGCGA
TCTCGGCCGGCGGCGGCCTGTCCATCCCCTACCGCGACGGCGACGCGCGCATCGACACCGCCCACTACTTCCAGCTATGG
GATGCGGCGCGGCGGCGCATCGAAGCGCATCTGGGCCATCCGGTGCAGCTGGAAATCGAGCCCGGCCGCTTCCTGGTGGC
CGAAGCGGGGGCGCTGCTCTCCGAGGTGCGCGCGGTGAAAAACATGGGCAGCCGCCATTTCGTGCTGGTGGACGCCGGCT
TCAACGATCTGATGCGGCCGTCGCTGTACGGCAGCTATCACCGCATCTCGCTGCTGGACGCGGACGGCGCGGAAAAAACC
GGCGCCGTCGACACCGTGGTGGCCGGCCCGCTGTGCGAATCCGGCGACGTGTTCACCCAGCAGGAAGGCGGCACCGTGGA
AACCCGGCCGCTGCCGCCGGCGCAAGTCGGCGACCTGATGGTGTTCCACGACGCCGGCGCCTACGGCGCGACCATGTCGT
CCAACTACAACAGCCGGCCGCTGCTGGCCGAGGCGCTGGTGGATGGCGGAGCCGTCCGGCAGATCCGCCGCCGCCAGACC
ATCGCCGAGCTGCTGGCGCTGGAGGCCTGA

Upstream 100 bases:

>100_bases
CAATCCATATCATAAATGAAAGACTGATCTAAAAATTGCTATTTTATTTTTATGTCCCGCCAGCGGATCATCGTGTGAAA
CCTCAACCGGATTGCCCGCC

Downstream 100 bases:

>100_bases
CGCCGCGCTCGGCGCGCGAAAAAGCCGGGCAGCGCCCGGCTTTTTCGCACATTCCGTCAAACCCGGGCCGGAATCAGCCC
TTCTGTTCCATCTTGTTGAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MHAFDNRQLADIARQYGTPLWVYRADTIRERIAELKAFDTIRYAQKANSNTHILRLMRAEGVKVDAVSLGEIERALAAGY
RGGGEPSDIVFTADVLDRPTLAKVIAENIPVNAGSIDMLRQLGEAAPGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWH
GDLDEALQAVRRFNLRLIGIHMHIGSGVDYGHLEQVCGAMVELVARLECDIEAISAGGGLSIPYRDGDARIDTAHYFQLW
DAARRRIEAHLGHPVQLEIEPGRFLVAEAGALLSEVRAVKNMGSRHFVLVDAGFNDLMRPSLYGSYHRISLLDADGAEKT
GAVDTVVAGPLCESGDVFTQQEGGTVETRPLPPAQVGDLMVFHDAGAYGATMSSNYNSRPLLAEALVDGGAVRQIRRRQT
IAELLALEA

Sequences:

>Translated_409_residues
MHAFDNRQLADIARQYGTPLWVYRADTIRERIAELKAFDTIRYAQKANSNTHILRLMRAEGVKVDAVSLGEIERALAAGY
RGGGEPSDIVFTADVLDRPTLAKVIAENIPVNAGSIDMLRQLGEAAPGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWH
GDLDEALQAVRRFNLRLIGIHMHIGSGVDYGHLEQVCGAMVELVARLECDIEAISAGGGLSIPYRDGDARIDTAHYFQLW
DAARRRIEAHLGHPVQLEIEPGRFLVAEAGALLSEVRAVKNMGSRHFVLVDAGFNDLMRPSLYGSYHRISLLDADGAEKT
GAVDTVVAGPLCESGDVFTQQEGGTVETRPLPPAQVGDLMVFHDAGAYGATMSSNYNSRPLLAEALVDGGAVRQIRRRQT
IAELLALEA
>Mature_409_residues
MHAFDNRQLADIARQYGTPLWVYRADTIRERIAELKAFDTIRYAQKANSNTHILRLMRAEGVKVDAVSLGEIERALAAGY
RGGGEPSDIVFTADVLDRPTLAKVIAENIPVNAGSIDMLRQLGEAAPGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWH
GDLDEALQAVRRFNLRLIGIHMHIGSGVDYGHLEQVCGAMVELVARLECDIEAISAGGGLSIPYRDGDARIDTAHYFQLW
DAARRRIEAHLGHPVQLEIEPGRFLVAEAGALLSEVRAVKNMGSRHFVLVDAGFNDLMRPSLYGSYHRISLLDADGAEKT
GAVDTVVAGPLCESGDVFTQQEGGTVETRPLPPAQVGDLMVFHDAGAYGATMSSNYNSRPLLAEALVDGGAVRQIRRRQT
IAELLALEA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=395, Percent_Identity=68.8607594936709, Blast_Score=567, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44460; Mature: 44460

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAFDNRQLADIARQYGTPLWVYRADTIRERIAELKAFDTIRYAQKANSNTHILRLMRAE
CCCCCCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHC
GVKVDAVSLGEIERALAAGYRGGGEPSDIVFTADVLDRPTLAKVIAENIPVNAGSIDMLR
CCEEEEECHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCHHHHHHHHHHCCCCCCHHHHHH
QLGEAAPGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWHGDLDEALQAVRRFNLRLIGI
HHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEE
HMHIGSGVDYGHLEQVCGAMVELVARLECDIEAISAGGGLSIPYRDGDARIDTAHYFQLW
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEECHHHHHHHH
DAARRRIEAHLGHPVQLEIEPGRFLVAEAGALLSEVRAVKNMGSRHFVLVDAGFNDLMRP
HHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCH
SLYGSYHRISLLDADGAEKTGAVDTVVAGPLCESGDVFTQQEGGTVETRPLPPAQVGDLM
HHCCCCEEEEEEECCCCCCCCCCHHHEECCCCCCCCEEEECCCCEEECCCCCCHHHCCEE
VFHDAGAYGATMSSNYNSRPLLAEALVDGGAVRQIRRRQTIAELLALEA
EEECCCCCCCEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHAFDNRQLADIARQYGTPLWVYRADTIRERIAELKAFDTIRYAQKANSNTHILRLMRAE
CCCCCCCHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHC
GVKVDAVSLGEIERALAAGYRGGGEPSDIVFTADVLDRPTLAKVIAENIPVNAGSIDMLR
CCEEEEECHHHHHHHHHHCCCCCCCCCCEEEEHHHHCCHHHHHHHHHHCCCCCCHHHHHH
QLGEAAPGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWHGDLDEALQAVRRFNLRLIGI
HHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEE
HMHIGSGVDYGHLEQVCGAMVELVARLECDIEAISAGGGLSIPYRDGDARIDTAHYFQLW
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEECHHHHHHHH
DAARRRIEAHLGHPVQLEIEPGRFLVAEAGALLSEVRAVKNMGSRHFVLVDAGFNDLMRP
HHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHCH
SLYGSYHRISLLDADGAEKTGAVDTVVAGPLCESGDVFTQQEGGTVETRPLPPAQVGDLM
HHCCCCEEEEEEECCCCCCCCCCHHHEECCCCCCCCEEEECCCCEEECCCCCCHHHCCEE
VFHDAGAYGATMSSNYNSRPLLAEALVDGGAVRQIRRRQTIAELLALEA
EEECCCCCCCEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]