Click here to switch to the map view.

The map label for this gene is mltA [H]

Identifier: 34499214

GI number: 34499214

Start: 4057188

End: 4058447

Strand: Direct

Name: mltA [H]

Synonym: CV_3759

Alternate gene names: 34499214

Gene position: 4057188-4058447 (Clockwise)

Preceding gene: 34499212

Following gene: 34499226

Centisome position: 85.4

GC content: 70.4

Gene sequence:

>1260_bases
ATGAAGCAGACACTGTTGAAGAAAAGCTGGCCGCTGTGGCTGGCCTTGCTGGCGCTTGCCGGCTGCACCACCACGCCCTC
CGTCACGCCCGGCGGCCCCTCCACGGGCATCCCCGCCGGCGCCGACAGCGCCAGCCCCGCCGCGCTGCCGTCCTGGAACG
ACCAAGCCGTCGGCGATTCGCTGCAGGGCCTGCGCCAAAGCTGCCGCACGCTGCAGAAGAAACCGGCCTGGAGCGGCGTC
TGCCGCGAAGCCGGCGCGCTGGCGGACAACGACGCCGACGCCGCGCGCCGCTTCTTCGAAAACCGCTTCACCGCCTGGAA
ACTGCGCGACGGCGGCCGCGACAGCGGCCTGATCACCGGCTACTACGAGCCGCTGCTCAACGGCAGCCTCAACCGCTCCG
AGCGCACGCCATGGCCGGTCTACGGCGCGCCGCGCGACATGCTCAGCGTCGACGTGCCGATGAGCCAGCGCAATCGAGGC
ACGCTGCGCGCCAAGCAGGCCGGCCCGGGCCGGCTGGTGCTGGCGGCGGGCGGCAATATCGAGATCAATCCGGCCGACTT
CCCCGCGGATCCGCGCGGCATCCGGCTGAAGGGCCGCCTGTCCGGCTCGCGGCTGCTGCCCTACTTCACCCGCGGCCAGA
TCAACCAGGGCAGCATCGCCGGCAGCGCGCCGGTGATCGCCTGGGTGGAGGACCCGGTGGAGCTGTTCTTCCTGCAGGTG
CAGGGCTCCGGCCGCATCCAGCTCGACGACGGCAGCTTCCTGCACGTCGGTTTCGCCGACCAAAACGGCTATCCCTACCA
GTCGATCGGCAAATGGCTGGTGGACAAGGGCGAGATGACGCTGGGACAAGCGTCGATGCAGGGGATCAAGGACTGGCTGG
CGAAAAACCCGCAGCGCCGCGACGAGCTGCTGGCCGTCAATCAGAGCTACATCTTCTTCAAGCCGCTGCCCGGCGACAAC
GGCGGGCCGATCGGCGCGCTGGGGGTGCCGCTGACCGGCGGCTACAGCATCGCGGTGGACCCGCGCTACATCCCGCTGGG
CGCGCCGGTCTACCTGTCCACGACCTGGCCTCACTCCAGCGAGCCGCTGGTGCGGCTGGTGCACGCACAGGACACCGGCA
GCGCGATCAAGGGCGCGCTGCGCGCCGACCTGTTCTGGGGCTACGGCACCGAGGCCGGCATGTACGCGGGCCGGATGAAG
CAACAGGGCAGCCTGTGGCTGCTGCTGCCCAAGGGCGTGTCGCCCGGCGCCTCGCTGTAG

Upstream 100 bases:

>100_bases
GTTTCAGCTCAATGACTTCACATCTGCCCGGCATCACGCCGGGCCGCGCATCGGGTTACAATCCAGACCATCTATCACGG
AAAGGCCTTCCGGCCCAAGC

Downstream 100 bases:

>100_bases
CGCGAAGCAAGACAAACGGGGCCTAGCGGCCCCGCTCCGCTTTCCCTCGCGGCTCAGACCGCCAGCGCGCGCTGGCGGCA
GCGGCCGGCCACCATGACCG

Product: peptidoglycan N-acetylmuramoylhydrolase

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKQTLLKKSWPLWLALLALAGCTTTPSVTPGGPSTGIPAGADSASPAALPSWNDQAVGDSLQGLRQSCRTLQKKPAWSGV
CREAGALADNDADAARRFFENRFTAWKLRDGGRDSGLITGYYEPLLNGSLNRSERTPWPVYGAPRDMLSVDVPMSQRNRG
TLRAKQAGPGRLVLAAGGNIEINPADFPADPRGIRLKGRLSGSRLLPYFTRGQINQGSIAGSAPVIAWVEDPVELFFLQV
QGSGRIQLDDGSFLHVGFADQNGYPYQSIGKWLVDKGEMTLGQASMQGIKDWLAKNPQRRDELLAVNQSYIFFKPLPGDN
GGPIGALGVPLTGGYSIAVDPRYIPLGAPVYLSTTWPHSSEPLVRLVHAQDTGSAIKGALRADLFWGYGTEAGMYAGRMK
QQGSLWLLLPKGVSPGASL

Sequences:

>Translated_419_residues
MKQTLLKKSWPLWLALLALAGCTTTPSVTPGGPSTGIPAGADSASPAALPSWNDQAVGDSLQGLRQSCRTLQKKPAWSGV
CREAGALADNDADAARRFFENRFTAWKLRDGGRDSGLITGYYEPLLNGSLNRSERTPWPVYGAPRDMLSVDVPMSQRNRG
TLRAKQAGPGRLVLAAGGNIEINPADFPADPRGIRLKGRLSGSRLLPYFTRGQINQGSIAGSAPVIAWVEDPVELFFLQV
QGSGRIQLDDGSFLHVGFADQNGYPYQSIGKWLVDKGEMTLGQASMQGIKDWLAKNPQRRDELLAVNQSYIFFKPLPGDN
GGPIGALGVPLTGGYSIAVDPRYIPLGAPVYLSTTWPHSSEPLVRLVHAQDTGSAIKGALRADLFWGYGTEAGMYAGRMK
QQGSLWLLLPKGVSPGASL
>Mature_419_residues
MKQTLLKKSWPLWLALLALAGCTTTPSVTPGGPSTGIPAGADSASPAALPSWNDQAVGDSLQGLRQSCRTLQKKPAWSGV
CREAGALADNDADAARRFFENRFTAWKLRDGGRDSGLITGYYEPLLNGSLNRSERTPWPVYGAPRDMLSVDVPMSQRNRG
TLRAKQAGPGRLVLAAGGNIEINPADFPADPRGIRLKGRLSGSRLLPYFTRGQINQGSIAGSAPVIAWVEDPVELFFLQV
QGSGRIQLDDGSFLHVGFADQNGYPYQSIGKWLVDKGEMTLGQASMQGIKDWLAKNPQRRDELLAVNQSYIFFKPLPGDN
GGPIGALGVPLTGGYSIAVDPRYIPLGAPVYLSTTWPHSSEPLVRLVHAQDTGSAIKGALRADLFWGYGTEAGMYAGRMK
QQGSLWLLLPKGVSPGASL

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=216, Percent_Identity=36.1111111111111, Blast_Score=105, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 44956; Mature: 44956

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTLLKKSWPLWLALLALAGCTTTPSVTPGGPSTGIPAGADSASPAALPSWNDQAVGDS
CCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LQGLRQSCRTLQKKPAWSGVCREAGALADNDADAARRFFENRFTAWKLRDGGRDSGLITG
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEEE
YYEPLLNGSLNRSERTPWPVYGAPRDMLSVDVPMSQRNRGTLRAKQAGPGRLVLAAGGNI
EHHHHHCCCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCEEEECCCCCEEEEEECCCE
EINPADFPADPRGIRLKGRLSGSRLLPYFTRGQINQGSIAGSAPVIAWVEDPVELFFLQV
EECCCCCCCCCCCEEEEEECCCCEECCCHHCCCCCCCCCCCCCCEEEEECCCEEEEEEEE
QGSGRIQLDDGSFLHVGFADQNGYPYQSIGKWLVDKGEMTLGQASMQGIKDWLAKNPQRR
CCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHCCCCCC
DELLAVNQSYIFFKPLPGDNGGPIGALGVPLTGGYSIAVDPRYIPLGAPVYLSTTWPHSS
CCEEEECCCEEEEEECCCCCCCCEEEECCCCCCCEEEEECCEEEECCCCEEEEECCCCCC
EPLVRLVHAQDTGSAIKGALRADLFWGYGTEAGMYAGRMKQQGSLWLLLPKGVSPGASL
CCEEEEEECCCCCHHHHHHHHHEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MKQTLLKKSWPLWLALLALAGCTTTPSVTPGGPSTGIPAGADSASPAALPSWNDQAVGDS
CCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LQGLRQSCRTLQKKPAWSGVCREAGALADNDADAARRFFENRFTAWKLRDGGRDSGLITG
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCEEEE
YYEPLLNGSLNRSERTPWPVYGAPRDMLSVDVPMSQRNRGTLRAKQAGPGRLVLAAGGNI
EHHHHHCCCCCCCCCCCCCCCCCCHHHEEEECCCCCCCCCCEEEECCCCCEEEEEECCCE
EINPADFPADPRGIRLKGRLSGSRLLPYFTRGQINQGSIAGSAPVIAWVEDPVELFFLQV
EECCCCCCCCCCCEEEEEECCCCEECCCHHCCCCCCCCCCCCCCEEEEECCCEEEEEEEE
QGSGRIQLDDGSFLHVGFADQNGYPYQSIGKWLVDKGEMTLGQASMQGIKDWLAKNPQRR
CCCCEEEECCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEECHHHHHHHHHHHHCCCCCC
DELLAVNQSYIFFKPLPGDNGGPIGALGVPLTGGYSIAVDPRYIPLGAPVYLSTTWPHSS
CCEEEECCCEEEEEECCCCCCCCEEEECCCCCCCEEEEECCEEEECCCCEEEEECCCCCC
EPLVRLVHAQDTGSAIKGALRADLFWGYGTEAGMYAGRMKQQGSLWLLLPKGVSPGASL
CCEEEEEECCCCCHHHHHHHHHEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]