Click here to switch to the map view.

The map label for this gene is deoA

Identifier: 34499155

GI number: 34499155

Start: 3998773

End: 4000098

Strand: Reverse

Name: deoA

Synonym: CV_3700

Alternate gene names: 34499155

Gene position: 4000098-3998773 (Counterclockwise)

Preceding gene: 34499156

Following gene: 34499154

Centisome position: 84.19

GC content: 68.25

Gene sequence:

>1326_bases
ATGTTTTTGCCGCAGGAAATCATCCGCAAGAAACGCGACAACTTGACGCTGTCGCAACAGGAGATTCAGCAGTTCGTCGC
CGGCATCACCGACAACAGCGTCGCCGACAGCCAGATCGCCGCGCTGGCGATGGCCATCTACTTCAACGGCATGGAGCTGG
AAGAGAACGTGCACCTGGCGCTGGCCATGCGCGACTCCGGCCGCCGCATGCACTGGAAGGACCTGAACCTGCCGGGCCCC
ATCGTCGACAAGCACTCCACCGGCGGCGTCGGCGACGTGGTGTCGCTGATGCTCGGGCCCATGGTCGCCGCCTGCGGCGG
CTTCGTGCCGATGATTTCCGGCCGCGGCCTGGGCCATACCGGCGGCACGCTGGACAAGCTGTCCGCGGTGCCCGGCTACA
ACCCGTTCCCGGAGCCGGAACTGTTCCGCAAGGTGGTGAAGGATGTGGGCGTGGCCATCATCGGCCAGACCTCCGACCTG
GCGCCGGCCGACCGCCGCTTCTACGCCACCCGCGACGTCACCGCCACCGTGGAGTCGATCGCGCTGATCACCGCGTCCAT
CCTGTCCAAGAAGCTGGCTGCCGGCCTGGACGTGCTGGTGATGGACGTGAAGGCCGGCAGCGGCGCCTTCATGCCGACCA
TGCAGAAGTCCATCGAACTGGCCGAGCGCATCGTCAAGGTGGGCAACGGCGCCGGCGTGGCCACCACCGCGCTGATCACC
GAGATGAGCCAGCCGCTGGCCTCCACCGCCGGCAACAGCATCGAAACCCGCGAAGCGGTGCGCTACCTGAAGGGCGACCA
GCGCAACCCGCGCCTGCACGAGGTGACCATGGCGCTGTGTGCGCAGATGCTGATCGGCGGCAAGCTGGCCGCCGACGAGG
CCGATGCCCGCGCCAAGCTGCAGGCCGCGCTGGATTCCGGCCGCGCCGCCGAGATCTTCGGCCGCATGGTGACCGCGCTG
GGCGGTCCGGCCGACTTCATGGAACATTACGACCGCCACCTGGCGCCGGCGCCCATCATGCGCCCGGTGTACGCCGACCG
CGCCGGCTATGTCGGCGCGATGGACACCCGCGGCATCGGCATGGCGGTGTGCGCGCTGGGCGGCGGACGCCGCCTGGCCA
CCGACGTGCTGGACTTCCGCGTAGGACTGTCGCAGTTCGTGGAACTGGGCCAGAATATCGGCAAGGACACCCCGCTGATG
ATGATCCACGCCGCCGACGAGGCGAGCTTCGAAGACGCGGCGCGCCGCGTCAAGGCCGCCATCCGCATCGACGAAGCCGC
GCCGTCCGAGCTGCCGCTGGTCTACCAGATCATCCGCGGAGAATAA

Upstream 100 bases:

>100_bases
TTCGCGGGGTTACCGCAACTCTGGCCGGGCGATTTCCCGGCCGCACCGCCCATTGCCGTTTCATTCTGCAGCGCGATGGG
TATCAGGCAGGGAGAATGCC

Downstream 100 bases:

>100_bases
GGCCGGGGAGGCATCATGAAACGCGCAATCATTCTGATACTGGACTCGCTGGGCATAGGCGCGGCGGCTGACGCGCCGAA
GTTCGGCGACGCCGGCAGCA

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MFLPQEIIRKKRDNLTLSQQEIQQFVAGITDNSVADSQIAALAMAIYFNGMELEENVHLALAMRDSGRRMHWKDLNLPGP
IVDKHSTGGVGDVVSLMLGPMVAACGGFVPMISGRGLGHTGGTLDKLSAVPGYNPFPEPELFRKVVKDVGVAIIGQTSDL
APADRRFYATRDVTATVESIALITASILSKKLAAGLDVLVMDVKAGSGAFMPTMQKSIELAERIVKVGNGAGVATTALIT
EMSQPLASTAGNSIETREAVRYLKGDQRNPRLHEVTMALCAQMLIGGKLAADEADARAKLQAALDSGRAAEIFGRMVTAL
GGPADFMEHYDRHLAPAPIMRPVYADRAGYVGAMDTRGIGMAVCALGGGRRLATDVLDFRVGLSQFVELGQNIGKDTPLM
MIHAADEASFEDAARRVKAAIRIDEAAPSELPLVYQIIRGE

Sequences:

>Translated_441_residues
MFLPQEIIRKKRDNLTLSQQEIQQFVAGITDNSVADSQIAALAMAIYFNGMELEENVHLALAMRDSGRRMHWKDLNLPGP
IVDKHSTGGVGDVVSLMLGPMVAACGGFVPMISGRGLGHTGGTLDKLSAVPGYNPFPEPELFRKVVKDVGVAIIGQTSDL
APADRRFYATRDVTATVESIALITASILSKKLAAGLDVLVMDVKAGSGAFMPTMQKSIELAERIVKVGNGAGVATTALIT
EMSQPLASTAGNSIETREAVRYLKGDQRNPRLHEVTMALCAQMLIGGKLAADEADARAKLQAALDSGRAAEIFGRMVTAL
GGPADFMEHYDRHLAPAPIMRPVYADRAGYVGAMDTRGIGMAVCALGGGRRLATDVLDFRVGLSQFVELGQNIGKDTPLM
MIHAADEASFEDAARRVKAAIRIDEAAPSELPLVYQIIRGE
>Mature_441_residues
MFLPQEIIRKKRDNLTLSQQEIQQFVAGITDNSVADSQIAALAMAIYFNGMELEENVHLALAMRDSGRRMHWKDLNLPGP
IVDKHSTGGVGDVVSLMLGPMVAACGGFVPMISGRGLGHTGGTLDKLSAVPGYNPFPEPELFRKVVKDVGVAIIGQTSDL
APADRRFYATRDVTATVESIALITASILSKKLAAGLDVLVMDVKAGSGAFMPTMQKSIELAERIVKVGNGAGVATTALIT
EMSQPLASTAGNSIETREAVRYLKGDQRNPRLHEVTMALCAQMLIGGKLAADEADARAKLQAALDSGRAAEIFGRMVTAL
GGPADFMEHYDRHLAPAPIMRPVYADRAGYVGAMDTRGIGMAVCALGGGRRLATDVLDFRVGLSQFVELGQNIGKDTPLM
MIHAADEASFEDAARRVKAAIRIDEAAPSELPLVYQIIRGE

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Homologues:

Organism=Homo sapiens, GI166158925, Length=439, Percent_Identity=39.8633257403189, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI4503445, Length=439, Percent_Identity=39.8633257403189, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI166158922, Length=439, Percent_Identity=39.8633257403189, Blast_Score=268, Evalue=8e-72,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=63.9269406392694, Blast_Score=562, Evalue=1e-161,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_CHRVO (Q7NRT0)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903370.1
- ProteinModelPortal:   Q7NRT0
- SMR:   Q7NRT0
- GeneID:   2548212
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3700
- NMPDR:   fig|243365.1.peg.3700
- HOGENOM:   HBG288505
- OMA:   AEIFGRM
- PhylomeDB:   Q7NRT0
- ProtClustDB:   PRK05820
- BioCyc:   CVIO243365:CV_3700-MONOMER
- BRENDA:   2.4.2.4
- HAMAP:   MF_01628
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR02643
- TIGRFAMs:   TIGR02644

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 47056; Mature: 47056

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLPQEIIRKKRDNLTLSQQEIQQFVAGITDNSVADSQIAALAMAIYFNGMELEENVHLA
CCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEE
LAMRDSGRRMHWKDLNLPGPIVDKHSTGGVGDVVSLMLGPMVAACGGFVPMISGRGLGHT
EEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
GGTLDKLSAVPGYNPFPEPELFRKVVKDVGVAIIGQTSDLAPADRRFYATRDVTATVESI
CCCHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEECCCHHHHHHHH
ALITASILSKKLAAGLDVLVMDVKAGSGAFMPTMQKSIELAERIVKVGNGAGVATTALIT
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EMSQPLASTAGNSIETREAVRYLKGDQRNPRLHEVTMALCAQMLIGGKLAADEADARAKL
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QAALDSGRAAEIFGRMVTALGGPADFMEHYDRHLAPAPIMRPVYADRAGYVGAMDTRGIG
HHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHCHHHHCCCCCCCCCCCCCCC
MAVCALGGGRRLATDVLDFRVGLSQFVELGQNIGKDTPLMMIHAADEASFEDAARRVKAA
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHH
IRIDEAAPSELPLVYQIIRGE
HEECCCCCCCCCHHHHEECCC
>Mature Secondary Structure
MFLPQEIIRKKRDNLTLSQQEIQQFVAGITDNSVADSQIAALAMAIYFNGMELEENVHLA
CCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEE
LAMRDSGRRMHWKDLNLPGPIVDKHSTGGVGDVVSLMLGPMVAACGGFVPMISGRGLGHT
EEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCC
GGTLDKLSAVPGYNPFPEPELFRKVVKDVGVAIIGQTSDLAPADRRFYATRDVTATVESI
CCCHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEECCCHHHHHHHH
ALITASILSKKLAAGLDVLVMDVKAGSGAFMPTMQKSIELAERIVKVGNGAGVATTALIT
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EMSQPLASTAGNSIETREAVRYLKGDQRNPRLHEVTMALCAQMLIGGKLAADEADARAKL
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
QAALDSGRAAEIFGRMVTALGGPADFMEHYDRHLAPAPIMRPVYADRAGYVGAMDTRGIG
HHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHCHHHHCCCCCCCCCCCCCCC
MAVCALGGGRRLATDVLDFRVGLSQFVELGQNIGKDTPLMMIHAADEASFEDAARRVKAA
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHH
IRIDEAAPSELPLVYQIIRGE
HEECCCCCCCCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782