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The map label for this gene is adiC [H]

Identifier: 34498887

GI number: 34498887

Start: 3728534

End: 3729865

Strand: Reverse

Name: adiC [H]

Synonym: CV_3432

Alternate gene names: 34498887

Gene position: 3729865-3728534 (Counterclockwise)

Preceding gene: 34498888

Following gene: 34498886

Centisome position: 78.51

GC content: 66.29

Gene sequence:

>1332_bases
TTGAACGAAAACAGTTCCACTCAAAAGAAGGGCTCGCTCGGAGTCTGGATGTGCACCGCCCTGGTGGTGGGCAATATGAT
AGGTTCCGGCGTCTTCCTGCTGCCGGCCTCGCTGGCGCCGTTCGGCGGCGTGTCCATGCTGGGCTGGCTGGTGACTTCCT
GCGGCGCCATCTGCCTGGCGCTGGTGTTCGCCCGGCTGTCGTCCATCCTGCCGCGCGAGGGCGGACCCTACGCCTATATC
CACGCCGGCTTCGGCGACTTCGCCGGCTTCTGGATCGCCTGGGGCTACTGGATCGCGCTGTGGGCGGGCAATGCCGCGCT
GGCGGTGGCGGCCACCAGCTATCTGCAGGTGTTCTTCCCGATATTGGGGCATAGCGAGCCGCTGGCCGGCGCCGTCGCCA
TCGGCCTGATCTGGGTCGTCACCTGGATCAACAGCCGCGGCGCGCGCAGCTCGGGCGTGGTGGCTGTGGTGACCACGCTG
CTGAAGCTGCTGCCGCTGGCGGCGGTCACCTTCATCGGCTTCTTCCATTTCCAGCCGGAAAACCTGGCGTTCAACCCTCA
TGGCAAGCCACTGCTGTCCTCGCTGTCGGCGACGATGGCGCTGACCTTGTGGGCCTTCCTCGGCCTGGAGTCGGCCTCGG
TGCCGGCAGGCGACGTGGTGGAGCCGGAGAAGACCATTCCGCGCGCGACAGTGATAGGCACGCTGCTGGCCACCGTGCTC
TACATCCTGTCCACGGTGTCGCTGATGGGCCTGATGCCGGCGGACACGCTGGCGGCTTCGCAGGCGCCGTTCGCCGATGC
GGCGCGGCTGATGTGGGGCGACTGGGGCTACTGGCTGGTGGGCTTCGGCGCAGTGGTGTCCTGCTTCGGCGCGCTCAACG
GCTGGAGCCTGATGCAGGCCCACGTGCCGGCGGCGGCTGCCAAGGACGGGTTGTTCCCCAGCCGTTTCGACCAGCGCAAC
GCGGCCGGCGTGCCCATCTTCGGCCTGGTGCTGTCCAGCGCGCTGGTCACCATTCTGATGGCGATGAAGTACGCAGGCGG
CGACAGCGGGGTGAAGATCTTCGAGTTCATCATCCTGCTGGCCACCGCCACTACGCTGCTGCCCTACGCTTTCTGCTCGA
TGGCGCTGATCGCCATCATGCTGATGCGCGGCAAGGCGTTCACGGCCAAGGATTACATCGCGCCCGGTTTCTTCGCCGGC
ATCGGCTTCGTCTACTCGCTGTGGGCGCTGTACGGCTCCGGCGCCGACATCGTGATGTGGGGCATGCTGCTGTTGCTGAT
GGGCCTGCCCATTTATGTCTGGCAGTTGAAGGAGCGGTACGCGGCCGATTGA

Upstream 100 bases:

>100_bases
GACAGGCTTGCCGATGCGGTTTTGACCTTTCCCGCATGTCTGGCGCCGGGTGTGTCCATCCCCGGCGCGCGATGCTTTCG
TTCCCCACGGAGAGTCAGGT

Downstream 100 bases:

>100_bases
TCCGCGTGCGGATCAACGAAAAGCGCAGCGCGGCAGCCTGCGCTTTTTTCATTTTCGAATGGTTGTGATGAGGGAAATGG
CGCGTTTTTTTTCCTTCAAA

Product: amino acid permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MNENSSTQKKGSLGVWMCTALVVGNMIGSGVFLLPASLAPFGGVSMLGWLVTSCGAICLALVFARLSSILPREGGPYAYI
HAGFGDFAGFWIAWGYWIALWAGNAALAVAATSYLQVFFPILGHSEPLAGAVAIGLIWVVTWINSRGARSSGVVAVVTTL
LKLLPLAAVTFIGFFHFQPENLAFNPHGKPLLSSLSATMALTLWAFLGLESASVPAGDVVEPEKTIPRATVIGTLLATVL
YILSTVSLMGLMPADTLAASQAPFADAARLMWGDWGYWLVGFGAVVSCFGALNGWSLMQAHVPAAAAKDGLFPSRFDQRN
AAGVPIFGLVLSSALVTILMAMKYAGGDSGVKIFEFIILLATATTLLPYAFCSMALIAIMLMRGKAFTAKDYIAPGFFAG
IGFVYSLWALYGSGADIVMWGMLLLLMGLPIYVWQLKERYAAD

Sequences:

>Translated_443_residues
MNENSSTQKKGSLGVWMCTALVVGNMIGSGVFLLPASLAPFGGVSMLGWLVTSCGAICLALVFARLSSILPREGGPYAYI
HAGFGDFAGFWIAWGYWIALWAGNAALAVAATSYLQVFFPILGHSEPLAGAVAIGLIWVVTWINSRGARSSGVVAVVTTL
LKLLPLAAVTFIGFFHFQPENLAFNPHGKPLLSSLSATMALTLWAFLGLESASVPAGDVVEPEKTIPRATVIGTLLATVL
YILSTVSLMGLMPADTLAASQAPFADAARLMWGDWGYWLVGFGAVVSCFGALNGWSLMQAHVPAAAAKDGLFPSRFDQRN
AAGVPIFGLVLSSALVTILMAMKYAGGDSGVKIFEFIILLATATTLLPYAFCSMALIAIMLMRGKAFTAKDYIAPGFFAG
IGFVYSLWALYGSGADIVMWGMLLLLMGLPIYVWQLKERYAAD
>Mature_443_residues
MNENSSTQKKGSLGVWMCTALVVGNMIGSGVFLLPASLAPFGGVSMLGWLVTSCGAICLALVFARLSSILPREGGPYAYI
HAGFGDFAGFWIAWGYWIALWAGNAALAVAATSYLQVFFPILGHSEPLAGAVAIGLIWVVTWINSRGARSSGVVAVVTTL
LKLLPLAAVTFIGFFHFQPENLAFNPHGKPLLSSLSATMALTLWAFLGLESASVPAGDVVEPEKTIPRATVIGTLLATVL
YILSTVSLMGLMPADTLAASQAPFADAARLMWGDWGYWLVGFGAVVSCFGALNGWSLMQAHVPAAAAKDGLFPSRFDQRN
AAGVPIFGLVLSSALVTILMAMKYAGGDSGVKIFEFIILLATATTLLPYAFCSMALIAIMLMRGKAFTAKDYIAPGFFAG
IGFVYSLWALYGSGADIVMWGMLLLLMGLPIYVWQLKERYAAD

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI33286428, Length=467, Percent_Identity=25.0535331905782, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI71999149, Length=418, Percent_Identity=24.8803827751196, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI186910308, Length=327, Percent_Identity=25.0764525993884, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI186910306, Length=327, Percent_Identity=25.0764525993884, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI186910304, Length=327, Percent_Identity=25.0764525993884, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI115648063, Length=332, Percent_Identity=24.3975903614458, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI115648022, Length=332, Percent_Identity=24.3975903614458, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI9790235, Length=317, Percent_Identity=25.2365930599369, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI187423910, Length=324, Percent_Identity=25.6172839506173, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI7657591, Length=324, Percent_Identity=25.6172839506173, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI110347453, Length=360, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI71979932, Length=353, Percent_Identity=22.9461756373938, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI7657683, Length=281, Percent_Identity=26.6903914590747, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367353, Length=445, Percent_Identity=37.752808988764, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1786908, Length=445, Percent_Identity=33.0337078651685, Blast_Score=207, Evalue=8e-55,
Organism=Escherichia coli, GI1790575, Length=449, Percent_Identity=33.8530066815145, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1787890, Length=450, Percent_Identity=29.7777777777778, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87082250, Length=352, Percent_Identity=29.8295454545455, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790584, Length=382, Percent_Identity=25.130890052356, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786302, Length=392, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786694, Length=304, Percent_Identity=25.3289473684211, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786789, Length=427, Percent_Identity=23.6533957845433, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=370, Percent_Identity=26.2162162162162, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71995388, Length=335, Percent_Identity=26.865671641791, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71995382, Length=337, Percent_Identity=26.1127596439169, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982612, Length=343, Percent_Identity=25.9475218658892, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71982608, Length=343, Percent_Identity=25.9475218658892, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI32566699, Length=424, Percent_Identity=24.0566037735849, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71993915, Length=323, Percent_Identity=24.7678018575851, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17532491, Length=362, Percent_Identity=24.0331491712707, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71982623, Length=286, Percent_Identity=25.5244755244755, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651635, Length=306, Percent_Identity=27.1241830065359, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24651633, Length=306, Percent_Identity=27.1241830065359, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221331183, Length=332, Percent_Identity=25.3012048192771, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17647653, Length=332, Percent_Identity=25.3012048192771, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664379, Length=332, Percent_Identity=25.3012048192771, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45550968, Length=345, Percent_Identity=26.9565217391304, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19921172, Length=345, Percent_Identity=26.9565217391304, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24641993, Length=419, Percent_Identity=25.5369928400955, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24641995, Length=419, Percent_Identity=25.5369928400955, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24667468, Length=339, Percent_Identity=24.4837758112094, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357367, Length=469, Percent_Identity=21.3219616204691, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668806, Length=430, Percent_Identity=20.6976744186046, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356285, Length=430, Percent_Identity=20.6976744186046, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24668802, Length=430, Percent_Identity=20.6976744186046, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46930; Mature: 46930

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNENSSTQKKGSLGVWMCTALVVGNMIGSGVFLLPASLAPFGGVSMLGWLVTSCGAICLA
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
LVFARLSSILPREGGPYAYIHAGFGDFAGFWIAWGYWIALWAGNAALAVAATSYLQVFFP
HHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ILGHSEPLAGAVAIGLIWVVTWINSRGARSSGVVAVVTTLLKLLPLAAVTFIGFFHFQPE
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCC
NLAFNPHGKPLLSSLSATMALTLWAFLGLESASVPAGDVVEPEKTIPRATVIGTLLATVL
CCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHH
YILSTVSLMGLMPADTLAASQAPFADAARLMWGDWGYWLVGFGAVVSCFGALNGWSLMQA
HHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHH
HVPAAAAKDGLFPSRFDQRNAAGVPIFGLVLSSALVTILMAMKYAGGDSGVKIFEFIILL
HCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ATATTLLPYAFCSMALIAIMLMRGKAFTAKDYIAPGFFAGIGFVYSLWALYGSGADIVMW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
GMLLLLMGLPIYVWQLKERYAAD
HHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNENSSTQKKGSLGVWMCTALVVGNMIGSGVFLLPASLAPFGGVSMLGWLVTSCGAICLA
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
LVFARLSSILPREGGPYAYIHAGFGDFAGFWIAWGYWIALWAGNAALAVAATSYLQVFFP
HHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ILGHSEPLAGAVAIGLIWVVTWINSRGARSSGVVAVVTTLLKLLPLAAVTFIGFFHFQPE
HHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCC
NLAFNPHGKPLLSSLSATMALTLWAFLGLESASVPAGDVVEPEKTIPRATVIGTLLATVL
CCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHH
YILSTVSLMGLMPADTLAASQAPFADAARLMWGDWGYWLVGFGAVVSCFGALNGWSLMQA
HHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHH
HVPAAAAKDGLFPSRFDQRNAAGVPIFGLVLSSALVTILMAMKYAGGDSGVKIFEFIILL
HCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
ATATTLLPYAFCSMALIAIMLMRGKAFTAKDYIAPGFFAGIGFVYSLWALYGSGADIVMW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHH
GMLLLLMGLPIYVWQLKERYAAD
HHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]