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The map label for this gene is pncB

Identifier: 34498877

GI number: 34498877

Start: 3713641

End: 3714849

Strand: Direct

Name: pncB

Synonym: CV_3422

Alternate gene names: 34498877

Gene position: 3713641-3714849 (Clockwise)

Preceding gene: 34498876

Following gene: 34498879

Centisome position: 78.16

GC content: 63.44

Gene sequence:

>1209_bases
ATGCCCAAGAACACGCCCATCATCCGGTCGCTGCTGGATACCGATCTGTACAAGTTCACCATGCTGCAGGTGGTGTTGCA
CCAATTCCCCGCAGCCCATGGCGAATACGAATTCCGCTGCCGCAACCATCCGGACACGCCGCTGACCCAGCTGAAGCAGC
AACTGGAAACGCAGCTGGACCTGCTGTGCGAGCTGCGCTTCAGCCAGGACGAGCTGGATTATCTGCGCGGCCTGCGCTTC
ATCAAGAGCGACTACGTCGACTACCTGGAGCTGTTCCACCTGCAGCGCCGCTTCATCAGCGTCAGCGAGGAAGGCGAACA
GCTGGCCATCCGGATCAAGGGCCCGATGGTGCAGGCGATGTTCTTCGAGATTTTCGTGCTGGCCATCGTCAACGAGCTGT
ATTTCCGCCCTCTGGACAGCAAGGCCGTGCGCGAGGAAGGCCGCCGCCGGCTGGAAGCCAAGCTGGCGGAGTTGGAGCGC
TTCCAGCGCGAAGAGGCCCCCGGCCAGCGCTTTCCGCTGCTGATCGCCGACTTCGGCACCCGCCGCCGCTTCAGCCGCGA
CTGGCAGGCCCACGTGGTGGAGAGGCTGAACCACGCGCTGCCGCAGGTGTTCCGCGGCACCAGCAACGTCTACCTAGCCC
GCAAGCTGGGCATCACGCCTATCGGCACCATGGCCCACGAATTCTTCCAGGCCTTCCAGGCGCTGGGCGTGCGGCTGCGG
GATTTCCAGAAAGCGGCGCTGGAATCGTGGGTGCAGGAATACCGCGGCGACCTGGGCATCGCGCTGACCGACGTGGTCGG
CATGGATGCCTTTCTGGCCGATTTCGATCTCTATTTCGCCAAGCTGTTCGACGGCCTGCGCCACGACAGCGGCGATCCCT
ACATCTGGGGCGAGAAGGCGATCGCCCATTATCGCAAGCTGCGGATAGACCCCGCGACCAAGATGCTGACCTTCAGCGAC
GGCCTCAGCGTGGACAGCGCGCTGCAACTGCAGCGCCATTTCAGCCCGCACATCCAGGTCAGCTTCGGCATCGGCACCCA
CTTCACCAACGACATGGGGCTGGAGCCGCTGCAGATCGTGCTCAAGCTGGTCAGCTGCAACGGCCAGCCGGTAGCCAAAC
TGTCCGACAGCCCCGGCAAAACCATGTGCAGCGACGAAACTTTCCTGGCCTACCTGCGCCAGGTATTCAAGGTCCCCGCC
CTCGCCTGA

Upstream 100 bases:

>100_bases
CCATCGTCAGCCACCGCGTGCAGGATTGGCCGCAGAACCCGCCCGACCTGCACAAGCGGCCGGCCATCTTCGTGATCCAC
GCCGCTTGAGACGCGCCGCC

Downstream 100 bases:

>100_bases
GCGCCGCGAACCCGCCCCCCCCGATCCTGCACCCTATCGCCAAGACCCGCGTCGGCCTTGTCTGCAGGCTATCAAGCGGA
TCAGTACAGCAGCGCCAGCA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MPKNTPIIRSLLDTDLYKFTMLQVVLHQFPAAHGEYEFRCRNHPDTPLTQLKQQLETQLDLLCELRFSQDELDYLRGLRF
IKSDYVDYLELFHLQRRFISVSEEGEQLAIRIKGPMVQAMFFEIFVLAIVNELYFRPLDSKAVREEGRRRLEAKLAELER
FQREEAPGQRFPLLIADFGTRRRFSRDWQAHVVERLNHALPQVFRGTSNVYLARKLGITPIGTMAHEFFQAFQALGVRLR
DFQKAALESWVQEYRGDLGIALTDVVGMDAFLADFDLYFAKLFDGLRHDSGDPYIWGEKAIAHYRKLRIDPATKMLTFSD
GLSVDSALQLQRHFSPHIQVSFGIGTHFTNDMGLEPLQIVLKLVSCNGQPVAKLSDSPGKTMCSDETFLAYLRQVFKVPA
LA

Sequences:

>Translated_402_residues
MPKNTPIIRSLLDTDLYKFTMLQVVLHQFPAAHGEYEFRCRNHPDTPLTQLKQQLETQLDLLCELRFSQDELDYLRGLRF
IKSDYVDYLELFHLQRRFISVSEEGEQLAIRIKGPMVQAMFFEIFVLAIVNELYFRPLDSKAVREEGRRRLEAKLAELER
FQREEAPGQRFPLLIADFGTRRRFSRDWQAHVVERLNHALPQVFRGTSNVYLARKLGITPIGTMAHEFFQAFQALGVRLR
DFQKAALESWVQEYRGDLGIALTDVVGMDAFLADFDLYFAKLFDGLRHDSGDPYIWGEKAIAHYRKLRIDPATKMLTFSD
GLSVDSALQLQRHFSPHIQVSFGIGTHFTNDMGLEPLQIVLKLVSCNGQPVAKLSDSPGKTMCSDETFLAYLRQVFKVPA
LA
>Mature_401_residues
PKNTPIIRSLLDTDLYKFTMLQVVLHQFPAAHGEYEFRCRNHPDTPLTQLKQQLETQLDLLCELRFSQDELDYLRGLRFI
KSDYVDYLELFHLQRRFISVSEEGEQLAIRIKGPMVQAMFFEIFVLAIVNELYFRPLDSKAVREEGRRRLEAKLAELERF
QREEAPGQRFPLLIADFGTRRRFSRDWQAHVVERLNHALPQVFRGTSNVYLARKLGITPIGTMAHEFFQAFQALGVRLRD
FQKAALESWVQEYRGDLGIALTDVVGMDAFLADFDLYFAKLFDGLRHDSGDPYIWGEKAIAHYRKLRIDPATKMLTFSDG
LSVDSALQLQRHFSPHIQVSFGIGTHFTNDMGLEPLQIVLKLVSCNGQPVAKLSDSPGKTMCSDETFLAYLRQVFKVPAL
A

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=398, Percent_Identity=46.4824120603015, Blast_Score=345, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6324783, Length=406, Percent_Identity=32.0197044334975, Blast_Score=192, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_CHRVO (Q7NSK2)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903092.1
- ProteinModelPortal:   Q7NSK2
- SMR:   Q7NSK2
- GeneID:   2548424
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3422
- NMPDR:   fig|243365.1.peg.3422
- HOGENOM:   HBG325503
- OMA:   LYKFTML
- PhylomeDB:   Q7NSK2
- ProtClustDB:   PRK05321
- BioCyc:   CVIO243365:CV_3422-MONOMER
- BRENDA:   2.4.2.11
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 46341; Mature: 46210

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKNTPIIRSLLDTDLYKFTMLQVVLHQFPAAHGEYEFRCRNHPDTPLTQLKQQLETQLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
LLCELRFSQDELDYLRGLRFIKSDYVDYLELFHLQRRFISVSEEGEQLAIRIKGPMVQAM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
FFEIFVLAIVNELYFRPLDSKAVREEGRRRLEAKLAELERFQREEAPGQRFPLLIADFGT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCH
RRRFSRDWQAHVVERLNHALPQVFRGTSNVYLARKLGITPIGTMAHEFFQAFQALGVRLR
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHH
DFQKAALESWVQEYRGDLGIALTDVVGMDAFLADFDLYFAKLFDGLRHDSGDPYIWGEKA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHH
IAHYRKLRIDPATKMLTFSDGLSVDSALQLQRHFSPHIQVSFGIGTHFTNDMGLEPLQIV
HHHHHHHCCCCHHHEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHH
LKLVSCNGQPVAKLSDSPGKTMCSDETFLAYLRQVFKVPALA
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PKNTPIIRSLLDTDLYKFTMLQVVLHQFPAAHGEYEFRCRNHPDTPLTQLKQQLETQLD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
LLCELRFSQDELDYLRGLRFIKSDYVDYLELFHLQRRFISVSEEGEQLAIRIKGPMVQAM
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
FFEIFVLAIVNELYFRPLDSKAVREEGRRRLEAKLAELERFQREEAPGQRFPLLIADFGT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCH
RRRFSRDWQAHVVERLNHALPQVFRGTSNVYLARKLGITPIGTMAHEFFQAFQALGVRLR
HHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHH
DFQKAALESWVQEYRGDLGIALTDVVGMDAFLADFDLYFAKLFDGLRHDSGDPYIWGEKA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHH
IAHYRKLRIDPATKMLTFSDGLSVDSALQLQRHFSPHIQVSFGIGTHFTNDMGLEPLQIV
HHHHHHHCCCCHHHEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHH
LKLVSCNGQPVAKLSDSPGKTMCSDETFLAYLRQVFKVPALA
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782