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The map label for this gene is ilvA [H]

Identifier: 34498548

GI number: 34498548

Start: 3377774

End: 3379303

Strand: Reverse

Name: ilvA [H]

Synonym: CV_3093

Alternate gene names: 34498548

Gene position: 3379303-3377774 (Counterclockwise)

Preceding gene: 34498558

Following gene: 34498547

Centisome position: 71.13

GC content: 64.31

Gene sequence:

>1530_bases
ATGAGCAACAAGCAAGACTATCTGGAACGCATCCTCACCTCGCGGGTGTACGACGTGGCGGTGGAAACGCCGCTGGAGCT
GGCGCCCAATCTGTCGCGCCGTTACCGCAACCACATCCTGCTCAAGCGCGAGGATCTGCAGCCAGTGTTCTCGTTCAAGC
TGCGCGGCGCTTACAACAAGATGGCCAAGCTGACGCCGGAGCAGCGCGCGCGCGGCGTGATCACCGCCAGCGCCGGCAAC
CACGCCCAGGGCGTGGCGCTGTCGGCCAGCAAGCTCGGCTGCGAGGCGGTGATCGTGATGCCGGTCACCACGCCGCAGAT
CAAGATAGACGCGGTGAAGCAGCGCGGCGGCCAGGTGGTGCTGTCGGGAGACTCCTTCAACGAAGCCTACCTGCATGCGG
TGAAGCTGGCCGAGGAGAGCGGCCGCACCTACATCCCGCCTTTCGACGACCCGGACGTGATCGCCGGCCAGGGGACGGTG
GGCATGGAAATCCTGCGCCAGCATCCGGATGATCTGGATGCCGTATTCGTCGCCATCGGCGGCGGCGGCCTGGCGGCCGG
CGTGGCCAGCTTCATCAAACGGCTGAAGCCCGAGATCAAGATCATCGGCGTGCAGCCTGTCGACTCGGACGCGATGCGCC
AGTCCATAGAGAAGGGCGAGCGGGTCGAGCTGAAGGATGTGGGTTTGTTCGCCGACGGCGTGGCGGTGAAGCTGGTGGGC
GAAGAGACCTTCCGCATCTGCCGCGAGCTGCTGGACGAGATCATCCTGGTGGATTCCGACGCCATCTGCGCGGCGATCAA
GGATATTTTTGAAGATACCCGCTCCATCGTCGAGCCGGCCGGCGCGCTGGCGGTGGCGGGCGCCAAGGCCTACATCGAGC
GCGAGGGCTGCGAGGGCCAGTCGCTGGTGGCGATCTCCTGCGGCGCCAACATGAATTTCGACCGCCTGCGCCATGTCTCG
GAGCGATCCGAGCTCGGCGAGCGGCGCGAGGCCATCATTGCCGTCACCATTCCGGAGAAGCCGGGCAGCTTTAAGCGCTT
CTGTTCGGTGATAGGCGGCCGCAACATCACCGAGTTCAACTACCGTTTCGCCGACCCCAGCGTCGCCCATGTGTTCGTCG
GCGTGCAGATCGCCGGCAAGGAGGATGTGGAAAAGCTGTTGCGCGACTTGCGCGCGGCGGAGCTGGATGGCATCGACCTG
ACCGACAACGAGCTGGCCAAGCTGCACATCCGCCACTTGGTCGGCGGCCACGCGCCGCAACTGAAGGACGAACGCGTGCT
GCGCTTCGAGTTTCCCGACCGTCCCGGCGCGCTGATGCGCTTTTTGGAGGCGATGCGCACCGACTGGAACATCAGCCTGT
TCCACTACCGCAACCATGGCGCGGACTATGGCCGGGTGCTGGTCGGCATCCAGGTGCCGTCCGGCGACGCCCAGGCCTTT
CAGCAATTCCTCGACACGCTCGGATATCCTTATATAGAGGAAACCGAAAATCCGGCCTATCGATTGTTCCTTGGCAAGAC
CATCCGTTGA

Upstream 100 bases:

>100_bases
GCATTGCAGCAAAATCTGTCCGGCAGGCCTCCCGCTAGTTTGGAGTTCCTGTTAGTCTGACAGTTCAAACACAAGAAACT
ACAGGGACGAAAGCAGCGCC

Downstream 100 bases:

>100_bases
TGGTGCAATGTCGGCCTCATTCCCAATCCGCTGAAGCAGGAATCATGATCAAGGCAGTATTGTTCGATTTGGACGGCACG
TTGGCCGACACCGCCCGCGA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MSNKQDYLERILTSRVYDVAVETPLELAPNLSRRYRNHILLKREDLQPVFSFKLRGAYNKMAKLTPEQRARGVITASAGN
HAQGVALSASKLGCEAVIVMPVTTPQIKIDAVKQRGGQVVLSGDSFNEAYLHAVKLAEESGRTYIPPFDDPDVIAGQGTV
GMEILRQHPDDLDAVFVAIGGGGLAAGVASFIKRLKPEIKIIGVQPVDSDAMRQSIEKGERVELKDVGLFADGVAVKLVG
EETFRICRELLDEIILVDSDAICAAIKDIFEDTRSIVEPAGALAVAGAKAYIEREGCEGQSLVAISCGANMNFDRLRHVS
ERSELGERREAIIAVTIPEKPGSFKRFCSVIGGRNITEFNYRFADPSVAHVFVGVQIAGKEDVEKLLRDLRAAELDGIDL
TDNELAKLHIRHLVGGHAPQLKDERVLRFEFPDRPGALMRFLEAMRTDWNISLFHYRNHGADYGRVLVGIQVPSGDAQAF
QQFLDTLGYPYIEETENPAYRLFLGKTIR

Sequences:

>Translated_509_residues
MSNKQDYLERILTSRVYDVAVETPLELAPNLSRRYRNHILLKREDLQPVFSFKLRGAYNKMAKLTPEQRARGVITASAGN
HAQGVALSASKLGCEAVIVMPVTTPQIKIDAVKQRGGQVVLSGDSFNEAYLHAVKLAEESGRTYIPPFDDPDVIAGQGTV
GMEILRQHPDDLDAVFVAIGGGGLAAGVASFIKRLKPEIKIIGVQPVDSDAMRQSIEKGERVELKDVGLFADGVAVKLVG
EETFRICRELLDEIILVDSDAICAAIKDIFEDTRSIVEPAGALAVAGAKAYIEREGCEGQSLVAISCGANMNFDRLRHVS
ERSELGERREAIIAVTIPEKPGSFKRFCSVIGGRNITEFNYRFADPSVAHVFVGVQIAGKEDVEKLLRDLRAAELDGIDL
TDNELAKLHIRHLVGGHAPQLKDERVLRFEFPDRPGALMRFLEAMRTDWNISLFHYRNHGADYGRVLVGIQVPSGDAQAF
QQFLDTLGYPYIEETENPAYRLFLGKTIR
>Mature_508_residues
SNKQDYLERILTSRVYDVAVETPLELAPNLSRRYRNHILLKREDLQPVFSFKLRGAYNKMAKLTPEQRARGVITASAGNH
AQGVALSASKLGCEAVIVMPVTTPQIKIDAVKQRGGQVVLSGDSFNEAYLHAVKLAEESGRTYIPPFDDPDVIAGQGTVG
MEILRQHPDDLDAVFVAIGGGGLAAGVASFIKRLKPEIKIIGVQPVDSDAMRQSIEKGERVELKDVGLFADGVAVKLVGE
ETFRICRELLDEIILVDSDAICAAIKDIFEDTRSIVEPAGALAVAGAKAYIEREGCEGQSLVAISCGANMNFDRLRHVSE
RSELGERREAIIAVTIPEKPGSFKRFCSVIGGRNITEFNYRFADPSVAHVFVGVQIAGKEDVEKLLRDLRAAELDGIDLT
DNELAKLHIRHLVGGHAPQLKDERVLRFEFPDRPGALMRFLEAMRTDWNISLFHYRNHGADYGRVLVGIQVPSGDAQAFQ
QFLDTLGYPYIEETENPAYRLFLGKTIR

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=296, Percent_Identity=32.7702702702703, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI33469958, Length=320, Percent_Identity=30.625, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI19923959, Length=323, Percent_Identity=28.7925696594427, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1790207, Length=501, Percent_Identity=55.688622754491, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI1789505, Length=309, Percent_Identity=39.4822006472492, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71991565, Length=377, Percent_Identity=33.42175066313, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17508781, Length=287, Percent_Identity=32.404181184669, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17537387, Length=344, Percent_Identity=32.5581395348837, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17535051, Length=272, Percent_Identity=26.1029411764706, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320930, Length=517, Percent_Identity=51.6441005802708, Blast_Score=514, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=36.963696369637, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=301, Percent_Identity=25.9136212624585, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21355833, Length=414, Percent_Identity=30.6763285024155, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24645328, Length=342, Percent_Identity=28.3625730994152, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56154; Mature: 56023

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKQDYLERILTSRVYDVAVETPLELAPNLSRRYRNHILLKREDLQPVFSFKLRGAYNK
CCCHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCEEEEECCCCHHHHHHHCCHHHH
MAKLTPEQRARGVITASAGNHAQGVALSASKLGCEAVIVMPVTTPQIKIDAVKQRGGQVV
HHHCCHHHHHCEEEEECCCCCCCCEEEEHHHCCCEEEEEEECCCCCEEEEEHHCCCCEEE
LSGDSFNEAYLHAVKLAEESGRTYIPPFDDPDVIAGQGTVGMEILRQHPDDLDAVFVAIG
EECCCCCHHHHHHHHHHHHCCCEECCCCCCCCEEECCCCHHHHHHHCCCCCCCEEEEEEC
GGGLAAGVASFIKRLKPEIKIIGVQPVDSDAMRQSIEKGERVELKDVGLFADGVAVKLVG
CCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEECCEEECCEEEEEEC
EETFRICRELLDEIILVDSDAICAAIKDIFEDTRSIVEPAGALAVAGAKAYIEREGCEGQ
HHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHCCCCCCCC
SLVAISCGANMNFDRLRHVSERSELGERREAIIAVTIPEKPGSFKRFCSVIGGRNITEFN
EEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEE
YRFADPSVAHVFVGVQIAGKEDVEKLLRDLRAAELDGIDLTDNELAKLHIRHLVGGHAPQ
EEECCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
LKDERVLRFEFPDRPGALMRFLEAMRTDWNISLFHYRNHGADYGRVLVGIQVPSGDAQAF
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCCCHHHH
QQFLDTLGYPYIEETENPAYRLFLGKTIR
HHHHHHHCCCCEECCCCCEEEEEECCCCC
>Mature Secondary Structure 
SNKQDYLERILTSRVYDVAVETPLELAPNLSRRYRNHILLKREDLQPVFSFKLRGAYNK
CCHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHCEEEEECCCCHHHHHHHCCHHHH
MAKLTPEQRARGVITASAGNHAQGVALSASKLGCEAVIVMPVTTPQIKIDAVKQRGGQVV
HHHCCHHHHHCEEEEECCCCCCCCEEEEHHHCCCEEEEEEECCCCCEEEEEHHCCCCEEE
LSGDSFNEAYLHAVKLAEESGRTYIPPFDDPDVIAGQGTVGMEILRQHPDDLDAVFVAIG
EECCCCCHHHHHHHHHHHHCCCEECCCCCCCCEEECCCCHHHHHHHCCCCCCCEEEEEEC
GGGLAAGVASFIKRLKPEIKIIGVQPVDSDAMRQSIEKGERVELKDVGLFADGVAVKLVG
CCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCEEEEEECCEEECCEEEEEEC
EETFRICRELLDEIILVDSDAICAAIKDIFEDTRSIVEPAGALAVAGAKAYIEREGCEGQ
HHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHCCCCCCCC
SLVAISCGANMNFDRLRHVSERSELGERREAIIAVTIPEKPGSFKRFCSVIGGRNITEFN
EEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEE
YRFADPSVAHVFVGVQIAGKEDVEKLLRDLRAAELDGIDLTDNELAKLHIRHLVGGHAPQ
EEECCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
LKDERVLRFEFPDRPGALMRFLEAMRTDWNISLFHYRNHGADYGRVLVGIQVPSGDAQAF
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCCCHHHH
QQFLDTLGYPYIEETENPAYRLFLGKTIR
HHHHHHHCCCCEECCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA