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The map label for this gene is glmU [C]

Identifier: 34498558

GI number: 34498558

Start: 3391237

End: 3391851

Strand: Reverse

Name: glmU [C]

Synonym: CV_3103

Alternate gene names: 34498558

Gene position: 3391851-3391237 (Counterclockwise)

Preceding gene: 34498559

Following gene: 34498548

Centisome position: 71.39

GC content: 67.8

Gene sequence:

>615_bases
ATGCCGGAATTGCACCGCCTGCTGCACTCGGTGGCCCAGGTCTTGCCCTGGCTGGATAAGACGATGGCGCCGTGGCAATG
GCTGGCAGACTTGTCCGCCCTGCTGGCTGCGCAAAGGCGCGGCGCTTTTCCGGATGACTGGATGGTCGATGGCGAGTCCA
TGATCCACCGCAGCGCGGTGCTGGAGGAGGGCGCGATCCTGAAGGGGCCGATCTGGATCGGCCCAGGCTGCCGGGTGGCC
GCCCATGCCTACTTGCGCGGCGGCGTAGTGCTGTGTCCCGGCGCGACAGTGGGGCCGGGGTGCGAAATCAAGACTTCCAT
CGTCGGGCCGGGCAGCCGTCTTGCCCATTTCAATTTCGTCGGCGACTCTGTGCTGGGCGCCGACGTCAATCTGGAGGCCG
GCGCCATCCTCGCCAATCATTGGAACGAGCGCGCCGACAAGGCTATCCGGCTGCATGTGGCCGGCGAAGTGCTGCTGCCG
GGGCTGGATAAGCTGGGCGCGCTGCTGGGCGACGGCGTGAGAGTGGGCGCCAACGCGGTGTTGTCGCCGGGCACGGTGCT
GGCGGCCGGAACCGTGGTGCCGCGGTTGGGGCTGGTGGAGCAGGATAGGCCATGA

Upstream 100 bases:

>100_bases
AGACTGCCGTTCCCGCGAGGGAGCGGCAGTTTTGTTTTGGGCGGCTTGCCAGCCCGCGCCTGCGGGCGTTAAATCGGACT
TTTGCCTACAGGAGAGTTCG

Downstream 100 bases:

>100_bases
AAACGGACCGCCGCGGCCTAGCCGGGCGGTCCGTGTCGGGGGCGCGAGGGCAAGCTAGCGCGGGAAGGCGGAAACGCCCA
GTTTGCCCAGCAGGTAGCCG

Product: bifuncional: UDP-N-acetylglucosamineglucose-1-phosphate thymidylyltransferase; glucosamine-1-phosphate

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MPELHRLLHSVAQVLPWLDKTMAPWQWLADLSALLAAQRRGAFPDDWMVDGESMIHRSAVLEEGAILKGPIWIGPGCRVA
AHAYLRGGVVLCPGATVGPGCEIKTSIVGPGSRLAHFNFVGDSVLGADVNLEAGAILANHWNERADKAIRLHVAGEVLLP
GLDKLGALLGDGVRVGANAVLSPGTVLAAGTVVPRLGLVEQDRP

Sequences:

>Translated_204_residues
MPELHRLLHSVAQVLPWLDKTMAPWQWLADLSALLAAQRRGAFPDDWMVDGESMIHRSAVLEEGAILKGPIWIGPGCRVA
AHAYLRGGVVLCPGATVGPGCEIKTSIVGPGSRLAHFNFVGDSVLGADVNLEAGAILANHWNERADKAIRLHVAGEVLLP
GLDKLGALLGDGVRVGANAVLSPGTVLAAGTVVPRLGLVEQDRP
>Mature_203_residues
PELHRLLHSVAQVLPWLDKTMAPWQWLADLSALLAAQRRGAFPDDWMVDGESMIHRSAVLEEGAILKGPIWIGPGCRVAA
HAYLRGGVVLCPGATVGPGCEIKTSIVGPGSRLAHFNFVGDSVLGADVNLEAGAILANHWNERADKAIRLHVAGEVLLPG
LDKLGALLGDGVRVGANAVLSPGTVLAAGTVVPRLGLVEQDRP

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=125, Percent_Identity=32, Blast_Score=60, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 21455; Mature: 21324

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELHRLLHSVAQVLPWLDKTMAPWQWLADLSALLAAQRRGAFPDDWMVDGESMIHRSAV
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHH
LEEGAILKGPIWIGPGCRVAAHAYLRGGVVLCPGATVGPGCEIKTSIVGPGSRLAHFNFV
HHCCCEEECCEEECCCCHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCCEEEEEEC
GDSVLGADVNLEAGAILANHWNERADKAIRLHVAGEVLLPGLDKLGALLGDGVRVGANAV
CCCEECCCCCCCCCCHHHHHHHHHHCCEEEEEECCCEECCCHHHHHHHHCCCEEECCCEE
LSPGTVLAAGTVVPRLGLVEQDRP
ECCCCEEEHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PELHRLLHSVAQVLPWLDKTMAPWQWLADLSALLAAQRRGAFPDDWMVDGESMIHRSAV
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHH
LEEGAILKGPIWIGPGCRVAAHAYLRGGVVLCPGATVGPGCEIKTSIVGPGSRLAHFNFV
HHCCCEEECCEEECCCCHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCCEEEEEEC
GDSVLGADVNLEAGAILANHWNERADKAIRLHVAGEVLLPGLDKLGALLGDGVRVGANAV
CCCEECCCCCCCCCCHHHHHHHHHHCCEEEEEECCCEECCCHHHHHHHHCCCEEECCCEE
LSPGTVLAAGTVVPRLGLVEQDRP
ECCCCEEEHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA