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The map label for this gene is dfp [H]

Identifier: 34498535

GI number: 34498535

Start: 3355576

End: 3356757

Strand: Direct

Name: dfp [H]

Synonym: CV_3080

Alternate gene names: 34498535

Gene position: 3355576-3356757 (Clockwise)

Preceding gene: 34498527

Following gene: 34498536

Centisome position: 70.63

GC content: 68.78

Gene sequence:

>1182_bases
ATGACTGCCAAACGCATCCTCCTCGGCGTCGGCGGCGGCATCGCCGCCTACAAATCCGCCGAGCTGACCCGCCAGCTGAT
CAAGGCCGGGCACCAAGTGGAAGTGGTGATGACCGAATCGGCCACCCGTTTCGTCGCGCCCGCCACCTTCCAGGCGCTGT
CGGGCCACACCGTCTACACCGACCTGTGGGACCCCCGCCCCAGCAACGCGATGGCCCATATCGAGCTGTCGCGCCGCGCC
GACGCGTTCCTGATCGCGCCGGCCACCGCCAACCTGCTGTTCAAGCTGGCCCACGGCGCCTGCGACGACCTGGTCTCGAC
GCTGGCCGCCGCCCGCGCCTGCCCGCTGATCGTCGCTCCGGCGATGAATCTGCAGATGTGGCAGAACCCGCCCAACCAGC
GCAACATCGCCCAGCTGGAGGCGGACGGCGTGACCGTGTTCGGCCCCGGCAACGGCTTCCAGGCCTGCGGCGAGACCGGC
GACGGCCGCATGCTGGAGCCGCATGAAATCGTCGAGCTGCTGCACGGCTTCTTCGCCGACAAGCGGCTGGCCGGCAAGAA
AGTGCTGCTGACCGCCGGCCCCACTTACGAAGCGATAGACGCGGTGCGCGGCATCACCAACATCAGCTCGGGCAAGATGG
GCTACGCGCTGGCGCGCGCCTGCCGCGACGCCGGCGCCGAAGTGACCCTGGTCTCCGGCCCCACCGGCATGGAGGCGCCG
ATGAATGTGCGCCGCCTGGACGTCCAGAGCGCCGCCGAGATGCAGCAGGCGGTGCTGGCCGAAGTGGGCCGCAGCGACGT
GTTCATCTCGGTGGCGGCGGTGGCCGACTACCGGGTGAAGAACCGCAGCGAGCACAAGATCAAGAAAGGCGCCGCCGCGC
CGACCATCGAGCTGGAGGAGAATCCGGACATCCTGGCCACCGTCGCCAGCCTGCCCGCCGCGCCGTTCTGCGTCGGCTTC
GCCGCCGAAAGCCAGAACCTGCTGGAATTCGCCGAAGCCAAGCGCAAGCGCAAGAAACTGCCGATGCTGGTGGCCAATCT
CGCCCAGCAGGCGATGGGCGCAGACGACAACCAGGTCGTGCTGCTGGACGACGCGGGCCAACATCCCTTGCCGCAAATGC
CCAAGGACGAAGTGGCCTCGGCCATCGTCCGCCACCTGGCCGCCCTGCTGGCCAAACGCTGA

Upstream 100 bases:

>100_bases
CAATGACATTAACATTGGCATGAACTGCGGACGACATGGCCACCCGAAAGGACAAATCCGCTAGAATGGCCAGTTTACGG
CTGCTTTCGAACCCATAGAG

Downstream 100 bases:

>100_bases
AGAATCAACCATGCGGCGGCCAGCCGGCCGCCGCCGCATCACAAGGAAACACCATGCAAGCCGTTATCGACGTCAAGATC
CTGGACGCGCGCCTGCGCGA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTAKRILLGVGGGIAAYKSAELTRQLIKAGHQVEVVMTESATRFVAPATFQALSGHTVYTDLWDPRPSNAMAHIELSRRA
DAFLIAPATANLLFKLAHGACDDLVSTLAAARACPLIVAPAMNLQMWQNPPNQRNIAQLEADGVTVFGPGNGFQACGETG
DGRMLEPHEIVELLHGFFADKRLAGKKVLLTAGPTYEAIDAVRGITNISSGKMGYALARACRDAGAEVTLVSGPTGMEAP
MNVRRLDVQSAAEMQQAVLAEVGRSDVFISVAAVADYRVKNRSEHKIKKGAAAPTIELEENPDILATVASLPAAPFCVGF
AAESQNLLEFAEAKRKRKKLPMLVANLAQQAMGADDNQVVLLDDAGQHPLPQMPKDEVASAIVRHLAALLAKR

Sequences:

>Translated_393_residues
MTAKRILLGVGGGIAAYKSAELTRQLIKAGHQVEVVMTESATRFVAPATFQALSGHTVYTDLWDPRPSNAMAHIELSRRA
DAFLIAPATANLLFKLAHGACDDLVSTLAAARACPLIVAPAMNLQMWQNPPNQRNIAQLEADGVTVFGPGNGFQACGETG
DGRMLEPHEIVELLHGFFADKRLAGKKVLLTAGPTYEAIDAVRGITNISSGKMGYALARACRDAGAEVTLVSGPTGMEAP
MNVRRLDVQSAAEMQQAVLAEVGRSDVFISVAAVADYRVKNRSEHKIKKGAAAPTIELEENPDILATVASLPAAPFCVGF
AAESQNLLEFAEAKRKRKKLPMLVANLAQQAMGADDNQVVLLDDAGQHPLPQMPKDEVASAIVRHLAALLAKR
>Mature_392_residues
TAKRILLGVGGGIAAYKSAELTRQLIKAGHQVEVVMTESATRFVAPATFQALSGHTVYTDLWDPRPSNAMAHIELSRRAD
AFLIAPATANLLFKLAHGACDDLVSTLAAARACPLIVAPAMNLQMWQNPPNQRNIAQLEADGVTVFGPGNGFQACGETGD
GRMLEPHEIVELLHGFFADKRLAGKKVLLTAGPTYEAIDAVRGITNISSGKMGYALARACRDAGAEVTLVSGPTGMEAPM
NVRRLDVQSAAEMQQAVLAEVGRSDVFISVAAVADYRVKNRSEHKIKKGAAAPTIELEENPDILATVASLPAAPFCVGFA
AESQNLLEFAEAKRKRKKLPMLVANLAQQAMGADDNQVVLLDDAGQHPLPQMPKDEVASAIVRHLAALLAKR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=176, Percent_Identity=36.9318181818182, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI87082301, Length=379, Percent_Identity=45.910290237467, Blast_Score=293, Evalue=9e-81,
Organism=Caenorhabditis elegans, GI17560194, Length=190, Percent_Identity=33.6842105263158, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=186, Percent_Identity=30.6451612903226, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24657262, Length=179, Percent_Identity=30.7262569832402, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 41827; Mature: 41695

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKRILLGVGGGIAAYKSAELTRQLIKAGHQVEVVMTESATRFVAPATFQALSGHTVYT
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCHHHHHHCCCEEEE
DLWDPRPSNAMAHIELSRRADAFLIAPATANLLFKLAHGACDDLVSTLAAARACPLIVAP
ECCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEC
AMNLQMWQNPPNQRNIAQLEADGVTVFGPGNGFQACGETGDGRMLEPHEIVELLHGFFAD
CCCHHHHCCCCCCCCCEEEECCCEEEEECCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHH
KRLAGKKVLLTAGPTYEAIDAVRGITNISSGKMGYALARACRDAGAEVTLVSGPTGMEAP
HHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCC
MNVRRLDVQSAAEMQQAVLAEVGRSDVFISVAAVADYRVKNRSEHKIKKGAAAPTIELEE
CCHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCCHHHHHHCCCCCEEEECC
NPDILATVASLPAAPFCVGFAAESQNLLEFAEAKRKRKKLPMLVANLAQQAMGADDNQVV
CCCHHHHHHHCCCCCEEEEEHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEE
LLDDAGQHPLPQMPKDEVASAIVRHLAALLAKR
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAKRILLGVGGGIAAYKSAELTRQLIKAGHQVEVVMTESATRFVAPATFQALSGHTVYT
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEECCHHHHHHCCCEEEE
DLWDPRPSNAMAHIELSRRADAFLIAPATANLLFKLAHGACDDLVSTLAAARACPLIVAP
ECCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEC
AMNLQMWQNPPNQRNIAQLEADGVTVFGPGNGFQACGETGDGRMLEPHEIVELLHGFFAD
CCCHHHHCCCCCCCCCEEEECCCEEEEECCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHH
KRLAGKKVLLTAGPTYEAIDAVRGITNISSGKMGYALARACRDAGAEVTLVSGPTGMEAP
HHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCC
MNVRRLDVQSAAEMQQAVLAEVGRSDVFISVAAVADYRVKNRSEHKIKKGAAAPTIELEE
CCHHHCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCCHHHHHHCCCCCEEEECC
NPDILATVASLPAAPFCVGFAAESQNLLEFAEAKRKRKKLPMLVANLAQQAMGADDNQVV
CCCHHHHHHHCCCCCEEEEEHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCEEE
LLDDAGQHPLPQMPKDEVASAIVRHLAALLAKR
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]