Click here to switch to the map view.

The map label for this gene is cysM [H]

Identifier: 34498480

GI number: 34498480

Start: 3301831

End: 3302721

Strand: Reverse

Name: cysM [H]

Synonym: CV_3025

Alternate gene names: 34498480

Gene position: 3302721-3301831 (Counterclockwise)

Preceding gene: 34498481

Following gene: 34498479

Centisome position: 69.52

GC content: 67.12

Gene sequence:

>891_bases
GTGTACAAACATCTGGAAGATTTCGTCGGCGGCACGCCGCTGGTGCGGCTCAAACGCCTGCCGGGCGACAACGGCAACGT
GGTGCTGCTGAAGCTGGAGGGCAACAATCCGGCAGGATCGGTGAAGGACCGGCCGGCGCTGTCGATGATCCGCCGCGCCG
AGGCGCGCGGCGACATCCGGCCCGGCGACACGCTGATCGAGCCGACCAGCGGCAACACCGGCATCGCGCTGGCGATGGCG
GCGGCGATGATGGGCTACCGCATGGTGCTGATCATGCCGGAGAATTCCAGCGCCGAGCGGGTGCAGGCGATGCGCGCCTA
CGGCGCCGAGGTGATCCTGACGCCGGCGGCCGGTTCGATGCCGGCGGCGATAGACCTGGCGCGCAGCATGGAGGCGGCAG
GCGAGGGCCGCATCCTGGATCAATTCTCCAATCCGGACAATCCCCAGGCGCATTACGAGGGCACCGGCCCGGAAATCTGG
GCGGAGACCGAAGGCAGGATCACCCATTTCGTGTCCAGCATGGGCACCACTGGCACCATCATGGGCACCGGCCGCTTCCT
GAAGGAGAAGAATCCGGCCATCCGCATCGTCGGCGTCCACCCGGAGCCGGGCAGCCAGATCGCCGGCATCCGCAAGTGGG
AAGACCCGTACGTGCCCAAGATCTGCGATTTTTCCCGCATCGACGAGATCCTGCACGTCGGACAGAAGGAGGCGGAAGAC
ACTGCCCGGCTGCTGGCGAGGCGCGAGGGCATCCTGGCCGGGCCGTCGTCTGGCGGCGCGTTGGCGGTGGCTCTTAGGCT
GGACGCGCAACTGAGGGACGCGGTGATCGTGTCCGTGGTGTGCGACCGCGGCGACCGCTACCTGTCCACTGGATTGTTCG
ATCCTGCTTGA

Upstream 100 bases:

>100_bases
GCGGACTGTCCGGTTACCGATGGTTATTAGATTAGAAATAACGATTTCGCATCTGCTGATAGCCAATCGATATAATGTGG
CCAGTTCTGGGAGAGTCTCT

Downstream 100 bases:

>100_bases
CGCCCGGTGCTCCGCCGCCGGCTTGGCAGCGGACGCTTCGGCGATTAGCATGGCGTTTTCCCATCAAGATGCCGCCATGC
TGAAACTCTATGTCGATCAC

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MYKHLEDFVGGTPLVRLKRLPGDNGNVVLLKLEGNNPAGSVKDRPALSMIRRAEARGDIRPGDTLIEPTSGNTGIALAMA
AAMMGYRMVLIMPENSSAERVQAMRAYGAEVILTPAAGSMPAAIDLARSMEAAGEGRILDQFSNPDNPQAHYEGTGPEIW
AETEGRITHFVSSMGTTGTIMGTGRFLKEKNPAIRIVGVHPEPGSQIAGIRKWEDPYVPKICDFSRIDEILHVGQKEAED
TARLLARREGILAGPSSGGALAVALRLDAQLRDAVIVSVVCDRGDRYLSTGLFDPA

Sequences:

>Translated_296_residues
MYKHLEDFVGGTPLVRLKRLPGDNGNVVLLKLEGNNPAGSVKDRPALSMIRRAEARGDIRPGDTLIEPTSGNTGIALAMA
AAMMGYRMVLIMPENSSAERVQAMRAYGAEVILTPAAGSMPAAIDLARSMEAAGEGRILDQFSNPDNPQAHYEGTGPEIW
AETEGRITHFVSSMGTTGTIMGTGRFLKEKNPAIRIVGVHPEPGSQIAGIRKWEDPYVPKICDFSRIDEILHVGQKEAED
TARLLARREGILAGPSSGGALAVALRLDAQLRDAVIVSVVCDRGDRYLSTGLFDPA
>Mature_296_residues
MYKHLEDFVGGTPLVRLKRLPGDNGNVVLLKLEGNNPAGSVKDRPALSMIRRAEARGDIRPGDTLIEPTSGNTGIALAMA
AAMMGYRMVLIMPENSSAERVQAMRAYGAEVILTPAAGSMPAAIDLARSMEAAGEGRILDQFSNPDNPQAHYEGTGPEIW
AETEGRITHFVSSMGTTGTIMGTGRFLKEKNPAIRIVGVHPEPGSQIAGIRKWEDPYVPKICDFSRIDEILHVGQKEAED
TARLLARREGILAGPSSGGALAVALRLDAQLRDAVIVSVVCDRGDRYLSTGLFDPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=306, Percent_Identity=39.2156862745098, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI295821200, Length=306, Percent_Identity=39.2156862745098, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI4557415, Length=306, Percent_Identity=39.2156862745098, Blast_Score=195, Evalue=3e-50,
Organism=Escherichia coli, GI2367138, Length=289, Percent_Identity=62.9757785467128, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1788754, Length=315, Percent_Identity=41.5873015873016, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=42.6174496644295, Blast_Score=220, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI115535073, Length=297, Percent_Identity=41.4141414141414, Blast_Score=201, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=40.9395973154362, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=40.8026755852843, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=38.5906040268456, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17534315, Length=314, Percent_Identity=38.2165605095541, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25147552, Length=311, Percent_Identity=37.9421221864952, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=38.6792452830189, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321594, Length=319, Percent_Identity=39.4984326018809, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=31.1728395061728, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=38.3116883116883, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=38.3116883116883, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31729; Mature: 31729

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKHLEDFVGGTPLVRLKRLPGDNGNVVLLKLEGNNPAGSVKDRPALSMIRRAEARGDIR
CCCCHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCC
PGDTLIEPTSGNTGIALAMAAAMMGYRMVLIMPENSSAERVQAMRAYGAEVILTPAAGSM
CCCCEEECCCCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCC
PAAIDLARSMEAAGEGRILDQFSNPDNPQAHYEGTGPEIWAETEGRITHFVSSMGTTGTI
CHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCEEE
MGTGRFLKEKNPAIRIVGVHPEPGSQIAGIRKWEDPYVPKICDFSRIDEILHVGQKEAED
EECCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHH
TARLLARREGILAGPSSGGALAVALRLDAQLRDAVIVSVVCDRGDRYLSTGLFDPA
HHHHHHHHCCCEECCCCCCEEEEEEEECCHHHHHEEEEEEECCCCCEECCCCCCCC
>Mature Secondary Structure
MYKHLEDFVGGTPLVRLKRLPGDNGNVVLLKLEGNNPAGSVKDRPALSMIRRAEARGDIR
CCCCHHHHHCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCC
PGDTLIEPTSGNTGIALAMAAAMMGYRMVLIMPENSSAERVQAMRAYGAEVILTPAAGSM
CCCCEEECCCCCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCC
PAAIDLARSMEAAGEGRILDQFSNPDNPQAHYEGTGPEIWAETEGRITHFVSSMGTTGTI
CHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHCCCCEEE
MGTGRFLKEKNPAIRIVGVHPEPGSQIAGIRKWEDPYVPKICDFSRIDEILHVGQKEAED
EECCHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHH
TARLLARREGILAGPSSGGALAVALRLDAQLRDAVIVSVVCDRGDRYLSTGLFDPA
HHHHHHHHCCCEECCCCCCEEEEEEEECCHHHHHEEEEEEECCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]