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The map label for this gene is lldP [H]

Identifier: 34498481

GI number: 34498481

Start: 3302865

End: 3304499

Strand: Reverse

Name: lldP [H]

Synonym: CV_3026

Alternate gene names: 34498481

Gene position: 3304499-3302865 (Counterclockwise)

Preceding gene: 34498482

Following gene: 34498480

Centisome position: 69.55

GC content: 66.06

Gene sequence:

>1635_bases
ATGCAAGGAATCTGGACCCAACAGTACTTTCCCGCCGGCGGCTCCGCGCTGTCGGCGCTGATGGCCGCGCTGCCCATCGC
CTTCTTCTTTGTCGCGCTGGCGCTGCTGCGGCTCAAAGGCCATGTCGCCGGCACGCTGACGGTGCTGATCGCGCTGGCGG
TGGCCATGCTGTTCTACGGCATGCCGGCGCAGATGGCGCTGGCGGCGGCGGCCTTCGGTTTCGGCTACGGCCTGTGGCCG
ATCGCCTGGATCATCGTCGCGGCGGTGTTCCTGTACAAGATCACGGTCAAGACCGGGCAGTTCGACATCATCCGCGCCTC
GGTGCTGTCGGTGACCGAGGACCAGCGGCTGCAGATGCTGCTGGTGGGCTTCTCCTTCGGCGCCTTTCTGGAGGGCGCGG
CCGGTTTCGGCGCGCCGGTGGCCATCACCGCCGCGCTGCTGGTGGGGCTGGGCTTCAATCCGCTGTACGCGGCCGGGCTG
TGCCTGATCGCCAACACCGCGCCGGTGGCTTTCGGCGCGATGGGGATACCCATCATCGTCGCCGGGCAGGTGACCGGGCT
GGATGCTTTCGCCATCGGCGCCAAGGCCGGCCATCAGCTGCCCATCCTGTCGGTGATCGTGCCGTTCTGGCTGGTGATGA
TGATGGACGGGCTCAAGGGCGTGCGCCAGACCTGGCCGGCCATCCTGGTGGCCGGCCTGTCCTTCGCCGTCACCCAGTTT
TTCACTTCCAACTACATCGGGCCCGAGCTGCCGGACATCACGTCGGCGCTGGTCAGCCTGGTATGCCTGACGCTGTTTCT
GAAGGTATGGCAGCCCGGTGAAATCTTCACGTTCAACGGCCGCCGCGCGCCGTCCGCTCGTCAGGCCAGCGGCTTTGGCC
TGGGCCGGATCGTCCGCGCCTGGAGTCCATTTTTGATCCTGACCGCGCTGGTGACGGTGTGGAGCGTCAAGCCGTTCAAG
GCCTTGTTCGTCAAGGGCGGCGCGCTGGAGGGCTGGATCTGGAAGCTGCATGTGCCGGGGCTGGACAAGCTGGTGCTGAA
GACCGCGCCCATCGTCGCCCATGACGCGCCGTACGAGGCGCTGTACAAGTTCGACATCGTCTCCGCCGTCGGCAGCGCCA
TCTTTCTATCCGCATTGCTGTCCATGATCTTGCTGAAGTTCCGCCCGGCCGACGGCGCGCGCGCTTTCGCCGAGACGCTG
GTCGAATTGCGCCGGCCGATATTGTCGATAGGCATGGTGCTGGCCTTCGCCTTCGTCGCCAATTATTCCGGCATGTCCAG
CACGCTGGCGCTGTGCCTGGCGGGCACCGGCAAGGCCTTCCCGTTCTTCTCGCCCTTTCTGGGCTGGCTGGGCGTGTTCC
TGACCGGTTCCGATACCTCGTCCAACGCCTTGTTCTCCGCCTTGCAGGCGGCCACCGCGCACCAATTGGGCGTGTCGGAC
GTGCTGCTGGTGGCGGCCAATACCACCGGCGGGGTCACCGGCAAGATGATCTCGCCACAGTCCATCGCCGTCGCCTGCGC
GGCGGTGGGGCTGATCGGCAAGGAGGCGGACCTGTTCCGCTTTACGCTGAAGCACAGCCTGATCTTCTGCAGCTTCGTCG
GCGCGCTGACCTGGCTGATGGCCTACATGGGGTGA

Upstream 100 bases:

>100_bases
ACCCAAGAAACGCAAGCCAGCCCCGCCATGCCGAAACGATCCCGTTCATCGGCAGGGGAGCGGCTGCGCCTGCGAAACCA
GGAATGAGGAGAAGCTTCAC

Downstream 100 bases:

>100_bases
TGCCGCCTCCCCGCGCCCGCGGCGGGCGGTCGCCGCCGCGGGCGCGGACTGTCCGGTTACCGATGGTTATTAGATTAGAA
ATAACGATTTCGCATCTGCT

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MQGIWTQQYFPAGGSALSALMAALPIAFFFVALALLRLKGHVAGTLTVLIALAVAMLFYGMPAQMALAAAAFGFGYGLWP
IAWIIVAAVFLYKITVKTGQFDIIRASVLSVTEDQRLQMLLVGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGL
CLIANTAPVAFGAMGIPIIVAGQVTGLDAFAIGAKAGHQLPILSVIVPFWLVMMMDGLKGVRQTWPAILVAGLSFAVTQF
FTSNYIGPELPDITSALVSLVCLTLFLKVWQPGEIFTFNGRRAPSARQASGFGLGRIVRAWSPFLILTALVTVWSVKPFK
ALFVKGGALEGWIWKLHVPGLDKLVLKTAPIVAHDAPYEALYKFDIVSAVGSAIFLSALLSMILLKFRPADGARAFAETL
VELRRPILSIGMVLAFAFVANYSGMSSTLALCLAGTGKAFPFFSPFLGWLGVFLTGSDTSSNALFSALQAATAHQLGVSD
VLLVAANTTGGVTGKMISPQSIAVACAAVGLIGKEADLFRFTLKHSLIFCSFVGALTWLMAYMG

Sequences:

>Translated_544_residues
MQGIWTQQYFPAGGSALSALMAALPIAFFFVALALLRLKGHVAGTLTVLIALAVAMLFYGMPAQMALAAAAFGFGYGLWP
IAWIIVAAVFLYKITVKTGQFDIIRASVLSVTEDQRLQMLLVGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGL
CLIANTAPVAFGAMGIPIIVAGQVTGLDAFAIGAKAGHQLPILSVIVPFWLVMMMDGLKGVRQTWPAILVAGLSFAVTQF
FTSNYIGPELPDITSALVSLVCLTLFLKVWQPGEIFTFNGRRAPSARQASGFGLGRIVRAWSPFLILTALVTVWSVKPFK
ALFVKGGALEGWIWKLHVPGLDKLVLKTAPIVAHDAPYEALYKFDIVSAVGSAIFLSALLSMILLKFRPADGARAFAETL
VELRRPILSIGMVLAFAFVANYSGMSSTLALCLAGTGKAFPFFSPFLGWLGVFLTGSDTSSNALFSALQAATAHQLGVSD
VLLVAANTTGGVTGKMISPQSIAVACAAVGLIGKEADLFRFTLKHSLIFCSFVGALTWLMAYMG
>Mature_544_residues
MQGIWTQQYFPAGGSALSALMAALPIAFFFVALALLRLKGHVAGTLTVLIALAVAMLFYGMPAQMALAAAAFGFGYGLWP
IAWIIVAAVFLYKITVKTGQFDIIRASVLSVTEDQRLQMLLVGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGL
CLIANTAPVAFGAMGIPIIVAGQVTGLDAFAIGAKAGHQLPILSVIVPFWLVMMMDGLKGVRQTWPAILVAGLSFAVTQF
FTSNYIGPELPDITSALVSLVCLTLFLKVWQPGEIFTFNGRRAPSARQASGFGLGRIVRAWSPFLILTALVTVWSVKPFK
ALFVKGGALEGWIWKLHVPGLDKLVLKTAPIVAHDAPYEALYKFDIVSAVGSAIFLSALLSMILLKFRPADGARAFAETL
VELRRPILSIGMVLAFAFVANYSGMSSTLALCLAGTGKAFPFFSPFLGWLGVFLTGSDTSSNALFSALQAATAHQLGVSD
VLLVAANTTGGVTGKMISPQSIAVACAAVGLIGKEADLFRFTLKHSLIFCSFVGALTWLMAYMG

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=555, Percent_Identity=67.9279279279279, Blast_Score=719, Evalue=0.0,
Organism=Escherichia coli, GI1790031, Length=544, Percent_Identity=67.2794117647059, Blast_Score=705, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 57388; Mature: 57388

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCC
>Mature Secondary Structure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HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]