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The map label for this gene is trpC

Identifier: 34498167

GI number: 34498167

Start: 2935829

End: 2936626

Strand: Direct

Name: trpC

Synonym: CV_2712

Alternate gene names: 34498167

Gene position: 2935829-2936626 (Clockwise)

Preceding gene: 34498163

Following gene: 34498171

Centisome position: 61.79

GC content: 68.17

Gene sequence:

>798_bases
ATGTCCGACATTCTCAACACCATCATCGCCACCAAGCATCAGGAAATCGCCGCCGCGCTGGCCAGCCGGCCGCTGGCCGC
GGTTCGCGCCGACGCCGAGGCGCGCGGCGACCGCCGCGACTTCGTCGCCGCCCTGCGCGCCAAACACGCGCTGGGCAAGG
CCGCCGTCATCGCCGAAGTCAAGAAGGCCAGCCCGAGCAAGGGCGTGATCCGCGAGGATTTCCAGCCCGCCGCCATCGCC
GAGAGCTACGCGGCCCACGGCGCCGCCTGCCTGTCGGTGCTGACCGACCGCCAGTATTTCCAGGGCGATGCCCGCTACCT
GGAAGACGCCCGCGCCGCCTGCCATCTGCCGGCGCTGCGCAAGGACTTCATCGTCGACGAATACCAGGTGTACGAAGCCC
GCGCGATGGGGGCCGACTGCATCCTGCTGATCGCCGCCGCGCTCGAGCTGCCCAAGATGAAAGCGCTGGAAGCGCTGGCG
AACGAGCTGGGCATGGCGGTGCTGGTGGAAGTCCACAACGAAGAAGAACTGGACGCCGCGCTGCAATTGAAGACCGAGCT
GGTCGGCGTCAACAACCGCAACCTGCGCACGTTCGAAGTCAGCCTGGCCACCACGCTGAAGCTGCTGCCGCGCATCACCG
ACGGCCGCATCGCCGTCACCGAGAGCGGCATCGCCACGGTGGAGGATGTGCGGCTGATGCAGGCCAGCGGCGTGCATACC
TTCCTGGTCGGCGAGGCCTTCATGCGCGAGGCCGAACCGGGCGAGGCGCTGAGCCGCCTGTTCTTCGCCCAATCCTGA

Upstream 100 bases:

>100_bases
GAGAATGATTTGAATCAAGCATCCGGAAAGCGCCTGCGCTTGCCATCCCGCCGGATGTTCTGCATGATGGCCCATTCGTT
GTGTCAACATAGAAGCCAGC

Downstream 100 bases:

>100_bases
CGCGAAGCCGCCCCATGAAAAACAGGCGCCGCAATGGCGCCTGTTTCATTTCGGCATGGCTCAGTTGGACAGATAAGCCG
GCAGCCGCAGCGACTCCTGT

Product: indole-3-glycerol phosphate synthase protein

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSDILNTIIATKHQEIAAALASRPLAAVRADAEARGDRRDFVAALRAKHALGKAAVIAEVKKASPSKGVIREDFQPAAIA
ESYAAHGAACLSVLTDRQYFQGDARYLEDARAACHLPALRKDFIVDEYQVYEARAMGADCILLIAAALELPKMKALEALA
NELGMAVLVEVHNEEELDAALQLKTELVGVNNRNLRTFEVSLATTLKLLPRITDGRIAVTESGIATVEDVRLMQASGVHT
FLVGEAFMREAEPGEALSRLFFAQS

Sequences:

>Translated_265_residues
MSDILNTIIATKHQEIAAALASRPLAAVRADAEARGDRRDFVAALRAKHALGKAAVIAEVKKASPSKGVIREDFQPAAIA
ESYAAHGAACLSVLTDRQYFQGDARYLEDARAACHLPALRKDFIVDEYQVYEARAMGADCILLIAAALELPKMKALEALA
NELGMAVLVEVHNEEELDAALQLKTELVGVNNRNLRTFEVSLATTLKLLPRITDGRIAVTESGIATVEDVRLMQASGVHT
FLVGEAFMREAEPGEALSRLFFAQS
>Mature_264_residues
SDILNTIIATKHQEIAAALASRPLAAVRADAEARGDRRDFVAALRAKHALGKAAVIAEVKKASPSKGVIREDFQPAAIAE
SYAAHGAACLSVLTDRQYFQGDARYLEDARAACHLPALRKDFIVDEYQVYEARAMGADCILLIAAALELPKMKALEALAN
ELGMAVLVEVHNEEELDAALQLKTELVGVNNRNLRTFEVSLATTLKLLPRITDGRIAVTESGIATVEDVRLMQASGVHTF
LVGEAFMREAEPGEALSRLFFAQS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=265, Percent_Identity=39.2452830188679, Blast_Score=167, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=222, Percent_Identity=41.4414414414414, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_CHRVO (Q7NUI6)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_902382.1
- HSSP:   P00909
- ProteinModelPortal:   Q7NUI6
- SMR:   Q7NUI6
- GeneID:   2549125
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2712
- NMPDR:   fig|243365.1.peg.2712
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- PhylomeDB:   Q7NUI6
- BioCyc:   CVIO243365:CV_2712-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28654; Mature: 28523

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00614 IGPS; PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILNTIIATKHQEIAAALASRPLAAVRADAEARGDRRDFVAALRAKHALGKAAVIAEV
CHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KKASPSKGVIREDFQPAAIAESYAAHGAACLSVLTDRQYFQGDARYLEDARAACHLPALR
HHCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
KDFIVDEYQVYEARAMGADCILLIAAALELPKMKALEALANELGMAVLVEVHNEEELDAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCHHHHHH
LQLKTELVGVNNRNLRTFEVSLATTLKLLPRITDGRIAVTESGIATVEDVRLMQASGVHT
HHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCHH
FLVGEAFMREAEPGEALSRLFFAQS
HHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SDILNTIIATKHQEIAAALASRPLAAVRADAEARGDRRDFVAALRAKHALGKAAVIAEV
HHHHHHHHHCCHHHHHHHHHHCCHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
KKASPSKGVIREDFQPAAIAESYAAHGAACLSVLTDRQYFQGDARYLEDARAACHLPALR
HHCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
KDFIVDEYQVYEARAMGADCILLIAAALELPKMKALEALANELGMAVLVEVHNEEELDAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCHHHHHH
LQLKTELVGVNNRNLRTFEVSLATTLKLLPRITDGRIAVTESGIATVEDVRLMQASGVHT
HHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCHH
FLVGEAFMREAEPGEALSRLFFAQS
HHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782