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The map label for this gene is gyrA [H]

Identifier: 34497753

GI number: 34497753

Start: 2485398

End: 2487998

Strand: Direct

Name: gyrA [H]

Synonym: CV_2298

Alternate gene names: 34497753

Gene position: 2485398-2487998 (Clockwise)

Preceding gene: 34497752

Following gene: 34497754

Centisome position: 52.31

GC content: 65.51

Gene sequence:

>2601_bases
ATGACCGATAACCTGTTCGCCAAGGAAACGCTTCCCATCAGCCTCGAAGAGGAGATGCGCCGTTCTTACCTGGATTACGC
GATGAGCGTGATCGTGGGCCGGGCGCTGCCGGACGTGCGCGACGGCCTGAAGCCGGTGCACCGCCGCGTGCTGTACGCGA
TGCACGAGCTGTCCAACGACTGGAACCGCGCGTACAAGAAGTCGGCGCGTATCGTTGGCGACGTGATCGGTAAATACCAC
CCGCACGGCGATACCGCCGTGTACGACACCATCGTGCGCCTGGCGCAGGACTTTTCGCTGCGCTACCCGCTGGTGGACGG
CCAGGGCAACTTCGGCTCGGTGGACGGCGACAACGCCGCCGCGATGCGTTACACCGAAATCCGCATGGCGCGCATCGCGC
ACGAGCTGTTGGCCGACATCGAAAAAGAAACCGTGGATTTCGGCCCCAACTACGACGGCTCCGAGCATGAGCCGCTGATC
CTGCCGGCCAAGATCCCGAACCTGCTGGTCAACGGCTCCTCCGGCATCGCCGTGGGCATGGCCACCAACATCCCGCCGCA
CAACCTGAACGAGGTGGTGGACGCCTGCCTGGCCTTGCTGGCCAACAGCGACCTGACCATCGACGAGCTGATCGACATCA
TCCCGGCGCCGGACTTCCCGACCGCCGGCATCATCTACGGCACCGCCGGCGTCAAGGAAGGCTACCGCACCGGCCGCGGC
CGCGTGATCATGCGCGCGCGCACCCATACCGAACCCATCGGCAAGGGCGACCGCGAAGCGATCATCGTCGACGAGATTCC
GTACCAGGTAAACAAGGCCCGCCTGCTGGAGCGCATCAGCGAACTGGTGCGCGACAAGCAGATCGAGGGCATTTCCGACC
TGCGCGACGAGTCGGACAAGTCCGGCATGCGCGTGGTGATCGAGCTCAAGCGCGGCGAAATGCCGGAAGTGGTGCTCAAC
CACCTGTTCAAGATGACCCAGCTGCAGGACAGCTTCGGCATGAACATGGTGGCGCTGGTCGACGGCCAGCCGCGCCTGTT
GAACCTGAAGCAGATCCTGGAAGAATTCCTGCGCCATCGCCGCGAGGTGGTGACCCGCCGCACCATCTTCGAACTGAAGA
AGGCCCGCGAGCGCGGCCACATCCTGGAAGGCCTGGCCGTCGCGCTGTCCAATGTCGACGAGATCATCGCGCTGATCAAG
GCGTCCGAGGCGCCGCCGCAGGCCAAGGCCGCGCTGATGGCGCGCGCCTGGCGCTCGTCGCTGGTGGAGGACATGCTGTC
CCGCGTCGAGGGCGACAAGGCGCGTCCGGAAAACATCGATCCGGCCTTCGGCATGAAGGAAGACGGCTACCATCTGTCCG
ACACCCAGGCTCAGGCCATCCTCGACATGCGCCTGCAGCGCCTGACCGGCCTGGAACAGGACAAGATCGTCGGCGAATAC
CGCGAGATCATGGACGTGATCCTGGACCTGCTGGACATCCTGGCCAAGCCCGAGCGCATCAGCCAGATCATCGGCGAGGA
ACTGACCGCCATCCGCGCGCAGTTCGGCGATCCGCGCCGCTCGGAAATCGAGCCGTACGGCGGCGACATCAATATCGAAG
ACCTGATCACCCCGCAGGACATGGTGGTGACCATCTCGCATACCGGCTACATCAAGGCGCAGCCGATCGACGACTACAGC
TCGCAGCGCCGCGGCGGCCGCGGCAAGCAGGCGGCGGCCACCAAGGACGACGACTTCATCGAAACGCTGTTCGTCGCCAA
CACCCACGACTACGTGCTGTGCTTCTCCAGCCGCGGCCGCTGCTACTGGCGCAAGGTGTACGACCTGCCGCAGGGCGGCC
GCCAGAGCCGCGGCAAGCCGATGGTCAACGTGCTGCCGCTGGAAGAGGGCGAGAAGATCAACGCGCTGCTGCCGGTCAAG
GAATTCCGCGACGACCAGTTCGTGTTCATGTGCACCGCCAACGGCACGGTGAAGAAGACCCCGCTGGTGGACTTCTCCCG
TCCGCGCACCGCCGGCATCATCGCGGTGAACCTGGATGACGGCGACAACCTGATCGGCGTGGCGCTGACCCACGGCGACG
ACCAGATCATGCTGTTCTCCGACGCCGGCAAGGCCGTGCGCTTCAGCGAAACCGACGTGCGCCCGATGGGCCGCAACGCC
ACCGGCGTGCGCGGCATGATGCTGGGGGACGATCACCAGGTGATCTCGCTCTTGGTCAGCAATTCCGAGCAGCAGATGGT
GTTGACCGCCAGCGACGGCGGCTACGGCAAGCGCACCTGCGTCGGCGATTTCCGCCGCACCAGCCGCGGCACCCAGGGCG
TGATCGCGATGGACCTGACCGACAAGACCGGCCTGAAGCTGGTGGCGGCCAGCCTGGTGGAGGAAACCGACGACATCATG
CTGATCACCACCGGCGGCGTGCTGATCCGCACCAAGGTGGCGGAAGTGCGCGAAACCGGCCGTTCGGCCCAGGGCGTGCG
CTTGATCAATCTGGACGAGGGCGAGAAGCTGATCGGTCTGGAGATCGTGGCCGAGTCCGAGGCCGAGTGCGCCGAAGGCG
AAACCGAGGGCGGCGACGCGCCGGAGCAGGGCGAAGCGTGA

Upstream 100 bases:

>100_bases
TGTCACATCCGTCGGCAGGCGGCTGGGCGGGCGCGAAAACGCAAATGCGGAGCGCGCGGCCCAGGCGGCTGCCGGATCAT
CCTTACGAATCAAGATACTT

Downstream 100 bases:

>100_bases
TGATCCCGACGCCGGCCAATCCCCGGATACTGGAGACGATGAGCCAGCTCTTCGTCTCCTTTCCCCACTGCGCGACGCTG
GGCTTCGAATACGTCGGCAC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 866; Mature: 865

Protein sequence:

>866_residues
MTDNLFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSNDWNRAYKKSARIVGDVIGKYH
PHGDTAVYDTIVRLAQDFSLRYPLVDGQGNFGSVDGDNAAAMRYTEIRMARIAHELLADIEKETVDFGPNYDGSEHEPLI
LPAKIPNLLVNGSSGIAVGMATNIPPHNLNEVVDACLALLANSDLTIDELIDIIPAPDFPTAGIIYGTAGVKEGYRTGRG
RVIMRARTHTEPIGKGDREAIIVDEIPYQVNKARLLERISELVRDKQIEGISDLRDESDKSGMRVVIELKRGEMPEVVLN
HLFKMTQLQDSFGMNMVALVDGQPRLLNLKQILEEFLRHRREVVTRRTIFELKKARERGHILEGLAVALSNVDEIIALIK
ASEAPPQAKAALMARAWRSSLVEDMLSRVEGDKARPENIDPAFGMKEDGYHLSDTQAQAILDMRLQRLTGLEQDKIVGEY
REIMDVILDLLDILAKPERISQIIGEELTAIRAQFGDPRRSEIEPYGGDINIEDLITPQDMVVTISHTGYIKAQPIDDYS
SQRRGGRGKQAAATKDDDFIETLFVANTHDYVLCFSSRGRCYWRKVYDLPQGGRQSRGKPMVNVLPLEEGEKINALLPVK
EFRDDQFVFMCTANGTVKKTPLVDFSRPRTAGIIAVNLDDGDNLIGVALTHGDDQIMLFSDAGKAVRFSETDVRPMGRNA
TGVRGMMLGDDHQVISLLVSNSEQQMVLTASDGGYGKRTCVGDFRRTSRGTQGVIAMDLTDKTGLKLVAASLVEETDDIM
LITTGGVLIRTKVAEVRETGRSAQGVRLINLDEGEKLIGLEIVAESEAECAEGETEGGDAPEQGEA

Sequences:

>Translated_866_residues
MTDNLFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSNDWNRAYKKSARIVGDVIGKYH
PHGDTAVYDTIVRLAQDFSLRYPLVDGQGNFGSVDGDNAAAMRYTEIRMARIAHELLADIEKETVDFGPNYDGSEHEPLI
LPAKIPNLLVNGSSGIAVGMATNIPPHNLNEVVDACLALLANSDLTIDELIDIIPAPDFPTAGIIYGTAGVKEGYRTGRG
RVIMRARTHTEPIGKGDREAIIVDEIPYQVNKARLLERISELVRDKQIEGISDLRDESDKSGMRVVIELKRGEMPEVVLN
HLFKMTQLQDSFGMNMVALVDGQPRLLNLKQILEEFLRHRREVVTRRTIFELKKARERGHILEGLAVALSNVDEIIALIK
ASEAPPQAKAALMARAWRSSLVEDMLSRVEGDKARPENIDPAFGMKEDGYHLSDTQAQAILDMRLQRLTGLEQDKIVGEY
REIMDVILDLLDILAKPERISQIIGEELTAIRAQFGDPRRSEIEPYGGDINIEDLITPQDMVVTISHTGYIKAQPIDDYS
SQRRGGRGKQAAATKDDDFIETLFVANTHDYVLCFSSRGRCYWRKVYDLPQGGRQSRGKPMVNVLPLEEGEKINALLPVK
EFRDDQFVFMCTANGTVKKTPLVDFSRPRTAGIIAVNLDDGDNLIGVALTHGDDQIMLFSDAGKAVRFSETDVRPMGRNA
TGVRGMMLGDDHQVISLLVSNSEQQMVLTASDGGYGKRTCVGDFRRTSRGTQGVIAMDLTDKTGLKLVAASLVEETDDIM
LITTGGVLIRTKVAEVRETGRSAQGVRLINLDEGEKLIGLEIVAESEAECAEGETEGGDAPEQGEA
>Mature_865_residues
TDNLFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSNDWNRAYKKSARIVGDVIGKYHP
HGDTAVYDTIVRLAQDFSLRYPLVDGQGNFGSVDGDNAAAMRYTEIRMARIAHELLADIEKETVDFGPNYDGSEHEPLIL
PAKIPNLLVNGSSGIAVGMATNIPPHNLNEVVDACLALLANSDLTIDELIDIIPAPDFPTAGIIYGTAGVKEGYRTGRGR
VIMRARTHTEPIGKGDREAIIVDEIPYQVNKARLLERISELVRDKQIEGISDLRDESDKSGMRVVIELKRGEMPEVVLNH
LFKMTQLQDSFGMNMVALVDGQPRLLNLKQILEEFLRHRREVVTRRTIFELKKARERGHILEGLAVALSNVDEIIALIKA
SEAPPQAKAALMARAWRSSLVEDMLSRVEGDKARPENIDPAFGMKEDGYHLSDTQAQAILDMRLQRLTGLEQDKIVGEYR
EIMDVILDLLDILAKPERISQIIGEELTAIRAQFGDPRRSEIEPYGGDINIEDLITPQDMVVTISHTGYIKAQPIDDYSS
QRRGGRGKQAAATKDDDFIETLFVANTHDYVLCFSSRGRCYWRKVYDLPQGGRQSRGKPMVNVLPLEEGEKINALLPVKE
FRDDQFVFMCTANGTVKKTPLVDFSRPRTAGIIAVNLDDGDNLIGVALTHGDDQIMLFSDAGKAVRFSETDVRPMGRNAT
GVRGMMLGDDHQVISLLVSNSEQQMVLTASDGGYGKRTCVGDFRRTSRGTQGVIAMDLTDKTGLKLVAASLVEETDDIML
ITTGGVLIRTKVAEVRETGRSAQGVRLINLDEGEKLIGLEIVAESEAECAEGETEGGDAPEQGEA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=27.0348837209302, Blast_Score=87, Evalue=1e-16,
Organism=Homo sapiens, GI19913406, Length=319, Percent_Identity=26.0188087774295, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=864, Percent_Identity=60.9953703703704, Blast_Score=1072, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=714, Percent_Identity=37.1148459383754, Blast_Score=420, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17535065, Length=387, Percent_Identity=25.0645994832041, Blast_Score=83, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=388, Percent_Identity=25.2577319587629, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=381, Percent_Identity=24.6719160104987, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=345, Percent_Identity=26.3768115942029, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17136538, Length=351, Percent_Identity=26.2108262108262, Blast_Score=84, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 95846; Mature: 95714

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNLFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSND
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCH
WNRAYKKSARIVGDVIGKYHPHGDTAVYDTIVRLAQDFSLRYPLVDGQGNFGSVDGDNAA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEECCCCCCCCCCCCCCC
AMRYTEIRMARIAHELLADIEKETVDFGPNYDGSEHEPLILPAKIPNLLVNGSSGIAVGM
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEECCCCEEEEE
ATNIPPHNLNEVVDACLALLANSDLTIDELIDIIPAPDFPTAGIIYGTAGVKEGYRTGRG
ECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCHHHHHCCCC
RVIMRARTHTEPIGKGDREAIIVDEIPYQVNKARLLERISELVRDKQIEGISDLRDESDK
EEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
SGMRVVIELKRGEMPEVVLNHLFKMTQLQDSFGMNMVALVDGQPRLLNLKQILEEFLRHR
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHH
REVVTRRTIFELKKARERGHILEGLAVALSNVDEIIALIKASEAPPQAKAALMARAWRSS
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LVEDMLSRVEGDKARPENIDPAFGMKEDGYHLSDTQAQAILDMRLQRLTGLEQDKIVGEY
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
REIMDVILDLLDILAKPERISQIIGEELTAIRAQFGDPRRSEIEPYGGDINIEDLITPQD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCC
MVVTISHTGYIKAQPIDDYSSQRRGGRGKQAAATKDDDFIETLFVANTHDYVLCFSSRGR
EEEEEECCCEEEECCCCCHHHHHCCCCCCCCCCCCCCHHHHHHEEECCCCEEEEECCCCC
CYWRKVYDLPQGGRQSRGKPMVNVLPLEEGEKINALLPVKEFRDDQFVFMCTANGTVKKT
EEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCEEEECHHHCCCCCEEEEEECCCCEEEC
PLVDFSRPRTAGIIAVNLDDGDNLIGVALTHGDDQIMLFSDAGKAVRFSETDVRPMGRNA
CCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEECCCCCCCCCCCC
TGVRGMMLGDDHQVISLLVSNSEQQMVLTASDGGYGKRTCVGDFRRTSRGTQGVIAMDLT
CCCEEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEEECC
DKTGLKLVAASLVEETDDIMLITTGGVLIRTKVAEVRETGRSAQGVRLINLDEGEKLIGL
CCCCHHHHHHHHHHCCCCEEEEEECCEEEEHHHHHHHHCCCCCCCEEEEECCCCCEEEEE
EIVAESEAECAEGETEGGDAPEQGEA
EEEECCCCHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDNLFAKETLPISLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELSND
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCH
WNRAYKKSARIVGDVIGKYHPHGDTAVYDTIVRLAQDFSLRYPLVDGQGNFGSVDGDNAA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEECCCCCCCCCCCCCCC
AMRYTEIRMARIAHELLADIEKETVDFGPNYDGSEHEPLILPAKIPNLLVNGSSGIAVGM
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCEEEECCCCEEEEE
ATNIPPHNLNEVVDACLALLANSDLTIDELIDIIPAPDFPTAGIIYGTAGVKEGYRTGRG
ECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCHHHHHCCCC
RVIMRARTHTEPIGKGDREAIIVDEIPYQVNKARLLERISELVRDKQIEGISDLRDESDK
EEEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
SGMRVVIELKRGEMPEVVLNHLFKMTQLQDSFGMNMVALVDGQPRLLNLKQILEEFLRHR
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHH
REVVTRRTIFELKKARERGHILEGLAVALSNVDEIIALIKASEAPPQAKAALMARAWRSS
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LVEDMLSRVEGDKARPENIDPAFGMKEDGYHLSDTQAQAILDMRLQRLTGLEQDKIVGEY
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
REIMDVILDLLDILAKPERISQIIGEELTAIRAQFGDPRRSEIEPYGGDINIEDLITPQD
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCC
MVVTISHTGYIKAQPIDDYSSQRRGGRGKQAAATKDDDFIETLFVANTHDYVLCFSSRGR
EEEEEECCCEEEECCCCCHHHHHCCCCCCCCCCCCCCHHHHHHEEECCCCEEEEECCCCC
CYWRKVYDLPQGGRQSRGKPMVNVLPLEEGEKINALLPVKEFRDDQFVFMCTANGTVKKT
EEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCEEEECHHHCCCCCEEEEEECCCCEEEC
PLVDFSRPRTAGIIAVNLDDGDNLIGVALTHGDDQIMLFSDAGKAVRFSETDVRPMGRNA
CCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEEECCCCEEEECCCCCCCCCCCC
TGVRGMMLGDDHQVISLLVSNSEQQMVLTASDGGYGKRTCVGDFRRTSRGTQGVIAMDLT
CCCEEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEEECC
DKTGLKLVAASLVEETDDIMLITTGGVLIRTKVAEVRETGRSAQGVRLINLDEGEKLIGL
CCCCHHHHHHHHHHCCCCEEEEEECCEEEEHHHHHHHHCCCCCCCEEEEECCCCCEEEEE
EIVAESEAECAEGETEGGDAPEQGEA
EEEECCCCHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]