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The map label for this gene is pyrH

Identifier: 34497653

GI number: 34497653

Start: 2369197

End: 2369916

Strand: Direct

Name: pyrH

Synonym: CV_2198

Alternate gene names: 34497653

Gene position: 2369197-2369916 (Clockwise)

Preceding gene: 34497652

Following gene: 34497654

Centisome position: 49.87

GC content: 61.81

Gene sequence:

>720_bases
ATGAGCCAAGTTCCCGCCTATAAACGCATCCTGTTGAAACTTTCCGGCGAAGCCCTGATGGGGGATGACAGCTATGGCAT
CAACCGCACGACCATCGAACAGATCGTCGGCCAGATCAAGGAGGTGGTGGAGCTGGGCGTTGAAGTGGGTGTCGTGATCG
GCGGCGGCAACATCTTCCGCGGCGTGGCGCCGGCGGCGGCGGGCATGGATCGCGCCACGGCCGATTACATGGGCATGATG
GCCACCGTGATGAACGCGCTGGCGCTGAAGGACGCGATGACCAAGGCGGGCCTGATCGCCCGCGTGCAGTCCGCGCTGAC
CATGCAGCAGATCGCCGAGCCCTATGTCCGCGGCAAGGCGATGCAGTACCTGGAAGAGGGCAAGGTGGTGATCTTCGCCG
CAGGTACCGGCAACCCCTTCTTCACCACCGATACCGCCGCGGCGCTGCGCGGCATGGAAATGAACGTCGACATCATGCTG
AAGGCCACCAAGGTGGATGGCGTGTATACCGACGATCCGAAAAAGAATCCCGACGCGGTTCGTTACCAGAGCGTCACTTT
CGACGAGGCGATCTCGCGCAATCTGAAAGTGATGGATGCCACCGCCTTCGCGCTGTGCCGCGACCAGCACCTGAACATCA
AGGTGTTCAGCATCTTCAAGAACGGCGCGCTGCGCCGCGTCGTGCTTGGCGAAGACGAAGGCACGCTGGTACACTGCTGA

Upstream 100 bases:

>100_bases
AAGCTGTAAGCTCAGGCTTACCGCTTTATTGACGGCACCCTGCTTGCAGGGTGCCGTTTTGCAAACTGAACACACCACAA
ACCGCCAATCCGAGGACATC

Downstream 100 bases:

>100_bases
GTTTGAAAATTGCTGAGGGCGAAAACGGCAATGGCCGTTTTCGCCTTGTCATTTTAAGTGTTCCGGGAGTGCGACATGAT
TAACGAGATCAAAAAATCGG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSQVPAYKRILLKLSGEALMGDDSYGINRTTIEQIVGQIKEVVELGVEVGVVIGGGNIFRGVAPAAAGMDRATADYMGMM
ATVMNALALKDAMTKAGLIARVQSALTMQQIAEPYVRGKAMQYLEEGKVVIFAAGTGNPFFTTDTAAALRGMEMNVDIML
KATKVDGVYTDDPKKNPDAVRYQSVTFDEAISRNLKVMDATAFALCRDQHLNIKVFSIFKNGALRRVVLGEDEGTLVHC

Sequences:

>Translated_239_residues
MSQVPAYKRILLKLSGEALMGDDSYGINRTTIEQIVGQIKEVVELGVEVGVVIGGGNIFRGVAPAAAGMDRATADYMGMM
ATVMNALALKDAMTKAGLIARVQSALTMQQIAEPYVRGKAMQYLEEGKVVIFAAGTGNPFFTTDTAAALRGMEMNVDIML
KATKVDGVYTDDPKKNPDAVRYQSVTFDEAISRNLKVMDATAFALCRDQHLNIKVFSIFKNGALRRVVLGEDEGTLVHC
>Mature_238_residues
SQVPAYKRILLKLSGEALMGDDSYGINRTTIEQIVGQIKEVVELGVEVGVVIGGGNIFRGVAPAAAGMDRATADYMGMMA
TVMNALALKDAMTKAGLIARVQSALTMQQIAEPYVRGKAMQYLEEGKVVIFAAGTGNPFFTTDTAAALRGMEMNVDIMLK
ATKVDGVYTDDPKKNPDAVRYQSVTFDEAISRNLKVMDATAFALCRDQHLNIKVFSIFKNGALRRVVLGEDEGTLVHC

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=55.3648068669528, Blast_Score=274, Evalue=5e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CHRVO (Q7NVZ2)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901868.1
- HSSP:   P65932
- ProteinModelPortal:   Q7NVZ2
- SMR:   Q7NVZ2
- GeneID:   2549277
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2198
- NMPDR:   fig|243365.1.peg.2198
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q7NVZ2
- ProtClustDB:   PRK00358
- BioCyc:   CVIO243365:CV_2198-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25805; Mature: 25674

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: BINDING 55-55 BINDING 56-56 BINDING 60-60 BINDING 75-75 BINDING 163-163 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVPAYKRILLKLSGEALMGDDSYGINRTTIEQIVGQIKEVVELGVEVGVVIGGGNIFR
CCCCCHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHH
GVAPAAAGMDRATADYMGMMATVMNALALKDAMTKAGLIARVQSALTMQQIAEPYVRGKA
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQYLEEGKVVIFAAGTGNPFFTTDTAAALRGMEMNVDIMLKATKVDGVYTDDPKKNPDAV
HHHHHCCCEEEEEECCCCCCEECCHHHHHCCCCCCEEEEEEEEEECCEECCCCCCCCCCE
RYQSVTFDEAISRNLKVMDATAFALCRDQHLNIKVFSIFKNGALRRVVLGEDEGTLVHC
EEEECCHHHHHHCCCEEEHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCEEEC
>Mature Secondary Structure 
SQVPAYKRILLKLSGEALMGDDSYGINRTTIEQIVGQIKEVVELGVEVGVVIGGGNIFR
CCCCHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHH
GVAPAAAGMDRATADYMGMMATVMNALALKDAMTKAGLIARVQSALTMQQIAEPYVRGKA
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQYLEEGKVVIFAAGTGNPFFTTDTAAALRGMEMNVDIMLKATKVDGVYTDDPKKNPDAV
HHHHHCCCEEEEEECCCCCCEECCHHHHHCCCCCCEEEEEEEEEECCEECCCCCCCCCCE
RYQSVTFDEAISRNLKVMDATAFALCRDQHLNIKVFSIFKNGALRRVVLGEDEGTLVHC
EEEECCHHHHHHCCCEEEHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782