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The map label for this gene is frr

Identifier: 34497654

GI number: 34497654

Start: 2369992

End: 2370549

Strand: Direct

Name: frr

Synonym: CV_2199

Alternate gene names: 34497654

Gene position: 2369992-2370549 (Clockwise)

Preceding gene: 34497653

Following gene: 34497655

Centisome position: 49.88

GC content: 58.96

Gene sequence:

>558_bases
ATGATTAACGAGATCAAAAAATCGGCCGAACAAAAAATGCAGAAAACGCTGGAAGCGTTCAAGAACGACCTGGCCAAGGT
TCGTACCGGACGCGCCCATACCGGCATTCTGGATCATGTCATGGTTGACTATTACGGCAGCGACGTGCCGGTCAATCAAG
TGGCCAACGTCACCCTGATCGACGCCCGCACCATCGGTGTGCAGCCGTGGGAAAAACCGATGCTGGCCAAGATCGAAAAA
GCCATCCGCGATTCCGACCTGGGCCTGAACCCGGCCTCGATGGGCGAGATCATCCGCGTGCCGATGCCGATGCTGACCGA
AGAGCGGCGCAAGGACCTGATCAAGGTGGTGCGCGGCGAGGCCGAAGGCGCCCGCGTGGCCGTGCGCAACATCCGCCGCG
ACTCCAACACCGAGTTCAAGAATCTGCTGAAGGACAAGGCCATCACCGAGGACGACGAGCGCCGCGGCCAGGACGAAATC
CAGAAGCTGACCGACAAGTACACCGCCGAAATCGACAAGATGCTGGCCACCAAAGAAGCCGACCTGTTGGCGGTATAA

Upstream 100 bases:

>100_bases
CGAAGGCACGCTGGTACACTGCTGAGTTTGAAAATTGCTGAGGGCGAAAACGGCAATGGCCGTTTTCGCCTTGTCATTTT
AAGTGTTCCGGGAGTGCGAC

Downstream 100 bases:

>100_bases
GGGGCGATCTTGTTTTCCGGTTCTTCGAATGCAGTGCCGGAGGGGCGCGAGCCGCCCCGGCATATCGCCATCATCATGGA
TGGCAACGGCCGCTGGGCCA

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MINEIKKSAEQKMQKTLEAFKNDLAKVRTGRAHTGILDHVMVDYYGSDVPVNQVANVTLIDARTIGVQPWEKPMLAKIEK
AIRDSDLGLNPASMGEIIRVPMPMLTEERRKDLIKVVRGEAEGARVAVRNIRRDSNTEFKNLLKDKAITEDDERRGQDEI
QKLTDKYTAEIDKMLATKEADLLAV

Sequences:

>Translated_185_residues
MINEIKKSAEQKMQKTLEAFKNDLAKVRTGRAHTGILDHVMVDYYGSDVPVNQVANVTLIDARTIGVQPWEKPMLAKIEK
AIRDSDLGLNPASMGEIIRVPMPMLTEERRKDLIKVVRGEAEGARVAVRNIRRDSNTEFKNLLKDKAITEDDERRGQDEI
QKLTDKYTAEIDKMLATKEADLLAV
>Mature_185_residues
MINEIKKSAEQKMQKTLEAFKNDLAKVRTGRAHTGILDHVMVDYYGSDVPVNQVANVTLIDARTIGVQPWEKPMLAKIEK
AIRDSDLGLNPASMGEIIRVPMPMLTEERRKDLIKVVRGEAEGARVAVRNIRRDSNTEFKNLLKDKAITEDDERRGQDEI
QKLTDKYTAEIDKMLATKEADLLAV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=176, Percent_Identity=31.25, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI291042689, Length=151, Percent_Identity=32.4503311258278, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI1786368, Length=183, Percent_Identity=56.8306010928962, Blast_Score=213, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24661488, Length=174, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_CHRVO (Q7NVZ1)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901869.1
- ProteinModelPortal:   Q7NVZ1
- SMR:   Q7NVZ1
- GeneID:   2549215
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_2199
- NMPDR:   fig|243365.1.peg.2199
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- PhylomeDB:   Q7NVZ1
- ProtClustDB:   PRK00083
- BioCyc:   CVIO243365:CV_2199-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20916; Mature: 20916

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINEIKKSAEQKMQKTLEAFKNDLAKVRTGRAHTGILDHVMVDYYGSDVPVNQVANVTLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHCCEEEE
DARTIGVQPWEKPMLAKIEKAIRDSDLGLNPASMGEIIRVPMPMLTEERRKDLIKVVRGE
ECEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
AEGARVAVRNIRRDSNTEFKNLLKDKAITEDDERRGQDEIQKLTDKYTAEIDKMLATKEA
CCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
DLLAV
HHHCC
>Mature Secondary Structure
MINEIKKSAEQKMQKTLEAFKNDLAKVRTGRAHTGILDHVMVDYYGSDVPVNQVANVTLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHCCEEEE
DARTIGVQPWEKPMLAKIEKAIRDSDLGLNPASMGEIIRVPMPMLTEERRKDLIKVVRGE
ECEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
AEGARVAVRNIRRDSNTEFKNLLKDKAITEDDERRGQDEIQKLTDKYTAEIDKMLATKEA
CCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
DLLAV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782