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The map label for this gene is trxA [H]

Identifier: 34497039

GI number: 34497039

Start: 1708177

End: 1708503

Strand: Direct

Name: trxA [H]

Synonym: CV_1584

Alternate gene names: 34497039

Gene position: 1708177-1708503 (Clockwise)

Preceding gene: 34497037

Following gene: 34497040

Centisome position: 35.95

GC content: 58.41

Gene sequence:

>327_bases
ATGAGCGATCTGATCCTGCACGTAACCGACGATTCTTTCGAAAACGAAGTCCTGAAGGCCGACCGCCCGGTATTGGTCGA
TTACTGGGCCGAATGGTGCGGCCCGTGCAAGATGATCGCCCCGATCCTGGACGAAGTGGCCAAGGAATACGACGGCAAGC
TGAAAATCGCCAAGCTGAACATCGACCAGAACGAGCAGACTCCGCCCAAGTTCGGCATCCGCGGCATTCCAACCCTGATG
CTGTTCAAGGACGGCCAGGTCGCCGCCACCAAGGTGGGCGCGCTGTCCAAGAGCCAGCTGACCGCCTTCATTGACAGCCA
ACTGTAA

Upstream 100 bases:

>100_bases
TTGGGCGGAGGGGGAACGGAACTTCGTGCCGCAGGTTGCCGCCCGCTCCATCGCTTGCTACCATCCCGAATTAAGCACAC
TAAATCTCGACGAGGAAGCC

Downstream 100 bases:

>100_bases
AGCGTCTATCCTCCACGCACAATCTTTCATGACGGGTGGCATATAGCAAGCCGCCCGTTTTCTTACGCTTCCACACCCTC
GACGGCGTTCCGCCCGAATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDLILHVTDDSFENEVLKADRPVLVDYWAEWCGPCKMIAPILDEVAKEYDGKLKIAKLNIDQNEQTPPKFGIRGIPTLM
LFKDGQVAATKVGALSKSQLTAFIDSQL

Sequences:

>Translated_108_residues
MSDLILHVTDDSFENEVLKADRPVLVDYWAEWCGPCKMIAPILDEVAKEYDGKLKIAKLNIDQNEQTPPKFGIRGIPTLM
LFKDGQVAATKVGALSKSQLTAFIDSQL
>Mature_107_residues
SDLILHVTDDSFENEVLKADRPVLVDYWAEWCGPCKMIAPILDEVAKEYDGKLKIAKLNIDQNEQTPPKFGIRGIPTLML
FKDGQVAATKVGALSKSQLTAFIDSQL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=34.7826086956522, Blast_Score=76, Evalue=6e-15,
Organism=Homo sapiens, GI21361657, Length=105, Percent_Identity=32.3809523809524, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI5031973, Length=102, Percent_Identity=31.3725490196078, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI224493972, Length=106, Percent_Identity=31.1320754716981, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI42794771, Length=106, Percent_Identity=31.1320754716981, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=74.0740740740741, Blast_Score=174, Evalue=2e-45,
Organism=Escherichia coli, GI1788936, Length=104, Percent_Identity=39.4230769230769, Blast_Score=98, Evalue=1e-22,
Organism=Escherichia coli, GI87081747, Length=64, Percent_Identity=40.625, Blast_Score=65, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=35.7142857142857, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17556044, Length=107, Percent_Identity=30.8411214953271, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=92, Percent_Identity=34.7826086956522, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=38.6363636363636, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=96, Percent_Identity=35.4166666666667, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=105, Percent_Identity=32.3809523809524, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=105, Percent_Identity=32.3809523809524, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=85, Percent_Identity=36.4705882352941, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=85, Percent_Identity=36.4705882352941, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=85, Percent_Identity=36.4705882352941, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=67, Percent_Identity=37.3134328358209, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=38.3720930232558, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=82, Percent_Identity=35.3658536585366, Blast_Score=67, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324862, Length=89, Percent_Identity=31.4606741573034, Blast_Score=61, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=39.0804597701149, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=35.2272727272727, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664269, Length=65, Percent_Identity=35.3846153846154, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=27.9569892473118, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12008; Mature: 11877

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLILHVTDDSFENEVLKADRPVLVDYWAEWCGPCKMIAPILDEVAKEYDGKLKIAKLN
CCCEEEEEECCCCCCHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEC
IDQNEQTPPKFGIRGIPTLMLFKDGQVAATKVGALSKSQLTAFIDSQL
CCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHEECCCC
>Mature Secondary Structure 
SDLILHVTDDSFENEVLKADRPVLVDYWAEWCGPCKMIAPILDEVAKEYDGKLKIAKLN
CCEEEEEECCCCCCHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEC
IDQNEQTPPKFGIRGIPTLMLFKDGQVAATKVGALSKSQLTAFIDSQL
CCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]