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The map label for this gene is rho

Identifier: 34497040

GI number: 34497040

Start: 1708629

End: 1709885

Strand: Direct

Name: rho

Synonym: CV_1585

Alternate gene names: 34497040

Gene position: 1708629-1709885 (Clockwise)

Preceding gene: 34497039

Following gene: 34497041

Centisome position: 35.96

GC content: 62.37

Gene sequence:

>1257_bases
ATGCACTTATCTGATCTCAAACATCTCCACGTATCCGAACTCGTTGAAATGGCCATTTCCAACGAGATCGACGGCGCCAA
CCGGTTGCGCAAGCAGGACCTGATCTTTGCGCTTTTGAAGAACCAGGCCAAGAAAGGCGAGAGCATTTTCGGCGAGGGTA
CGCTGGAAGTGTTGCCGGACGGCTTCGGTTTCCTGCGCAGTCCGGATACCTCCTATCTGGCCGGTCCCGACGACATCTAC
GTCAGCCCGTCGCAGATCCGCCGCTTCAACCTGCATACCGGCGATTCGATCGAGGGCGAGATCCGCACGCCGAAGGACGG
CGAGCGCTACTTCGCGCTGGTGAAGGTGGACAAGGTCAACGGCGAGGCGCCGGAAAACTCCAAGCACAAGATCCTGTTCG
AGAACCTGACGCCGCTGTTCCCGACCGAGCAGTTCAAGCTGGAGCGCGAGATCCGCGCCGAGGAAAACATCACCGGCCGC
ATCATCGATCTGATCTCGCCGATCGGCAAGGGCCAGCGCGCGCTGCTGGTCGCTCCGCCGAAGTCCGGCAAGACCGTGAT
GCTGCAGCACATCGCCCACGCGATCACCGCCAACCACCCGGAGGCGGTGCTGATCGTGCTGCTGATCGACGAGCGTCCGG
AAGAAGTGACGGAAATGCAACGCTCGGTGCGCGGCGAAGTGGTGTCCTCCACCTTCGACGAGCCGGCCACCCGCCACGTG
CAAGTGGCCGAGATGGTGATCGAGAAGGCCAAGCGTCTGGTCGAGCACAAGAAGGACGTGGTGATCCTGCTGGATTCCAT
CACTCGCCTGGCCCGCGCCTACAACACCGTGGTGCCGGCGTCCGGCAAGGTGCTGACCGGCGGCGTGGACGCCAACGCGC
TGCAGCGTCCGAAGCGTTTCTTCGGCGCCGCGCGCAATGTGGAAGAGGGCGGCAGCCTGACTATCGTCGCCACCGCGCTG
ATCGACACCGGCAGCCGCATGGACGATGTGATCTATGAAGAATTCAAGGGCACCGGCAACAGCGAAATCCACCTGGACCG
CCGCATGGCCGAGAAGCGCATCTTCCCGGCGCTGAACATCAACCGTTCCGGCACCCGCCGCGAGGAGCTGCTGGTTCCCC
AGGACCAGTTGCAGCGCATCTGGGTGCTGCGCAAGCTGCTGTACCCGATGGACGACCTGGAGGCGATGGAATTCCTGCAG
GACAAGATCAAGGCCACCAAGTCGAACCAGGCTTTCTTCGACTCGATGCGCCGCTGA

Upstream 100 bases:

>100_bases
TTCATGACGGGTGGCATATAGCAAGCCGCCCGTTTTCTTACGCTTCCACACCCTCGACGGCGTTCCGCCCGAATACTACC
GAGTCGACCTCACGACCGCT

Downstream 100 bases:

>100_bases
GCGGCAACCGCCCGCCAAGATGCCAGACCATGCCGGTCTGGCATTTTTTTTGGTACATTGGAGGGAGGTCCGCCGGGAAG
AGCGGATGCCGGGAGGCAAA

Product: transcription termination factor Rho

Products: NA

Alternate protein names: ATP-dependent helicase Rho

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MHLSDLKHLHVSELVEMAISNEIDGANRLRKQDLIFALLKNQAKKGESIFGEGTLEVLPDGFGFLRSPDTSYLAGPDDIY
VSPSQIRRFNLHTGDSIEGEIRTPKDGERYFALVKVDKVNGEAPENSKHKILFENLTPLFPTEQFKLEREIRAEENITGR
IIDLISPIGKGQRALLVAPPKSGKTVMLQHIAHAITANHPEAVLIVLLIDERPEEVTEMQRSVRGEVVSSTFDEPATRHV
QVAEMVIEKAKRLVEHKKDVVILLDSITRLARAYNTVVPASGKVLTGGVDANALQRPKRFFGAARNVEEGGSLTIVATAL
IDTGSRMDDVIYEEFKGTGNSEIHLDRRMAEKRIFPALNINRSGTRREELLVPQDQLQRIWVLRKLLYPMDDLEAMEFLQ
DKIKATKSNQAFFDSMRR

Sequences:

>Translated_418_residues
MHLSDLKHLHVSELVEMAISNEIDGANRLRKQDLIFALLKNQAKKGESIFGEGTLEVLPDGFGFLRSPDTSYLAGPDDIY
VSPSQIRRFNLHTGDSIEGEIRTPKDGERYFALVKVDKVNGEAPENSKHKILFENLTPLFPTEQFKLEREIRAEENITGR
IIDLISPIGKGQRALLVAPPKSGKTVMLQHIAHAITANHPEAVLIVLLIDERPEEVTEMQRSVRGEVVSSTFDEPATRHV
QVAEMVIEKAKRLVEHKKDVVILLDSITRLARAYNTVVPASGKVLTGGVDANALQRPKRFFGAARNVEEGGSLTIVATAL
IDTGSRMDDVIYEEFKGTGNSEIHLDRRMAEKRIFPALNINRSGTRREELLVPQDQLQRIWVLRKLLYPMDDLEAMEFLQ
DKIKATKSNQAFFDSMRR
>Mature_418_residues
MHLSDLKHLHVSELVEMAISNEIDGANRLRKQDLIFALLKNQAKKGESIFGEGTLEVLPDGFGFLRSPDTSYLAGPDDIY
VSPSQIRRFNLHTGDSIEGEIRTPKDGERYFALVKVDKVNGEAPENSKHKILFENLTPLFPTEQFKLEREIRAEENITGR
IIDLISPIGKGQRALLVAPPKSGKTVMLQHIAHAITANHPEAVLIVLLIDERPEEVTEMQRSVRGEVVSSTFDEPATRHV
QVAEMVIEKAKRLVEHKKDVVILLDSITRLARAYNTVVPASGKVLTGGVDANALQRPKRFFGAARNVEEGGSLTIVATAL
IDTGSRMDDVIYEEFKGTGNSEIHLDRRMAEKRIFPALNINRSGTRREELLVPQDQLQRIWVLRKLLYPMDDLEAMEFLQ
DKIKATKSNQAFFDSMRR

Specific function: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template

COG id: COG1158

COG function: function code K; Transcription termination factor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Rho family

Homologues:

Organism=Escherichia coli, GI1790217, Length=418, Percent_Identity=70.3349282296651, Blast_Score=627, Evalue=0.0,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RHO_CHRVO (Q7NXP1)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901255.1
- HSSP:   P03002
- ProteinModelPortal:   Q7NXP1
- SMR:   Q7NXP1
- GeneID:   2547726
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1585
- NMPDR:   fig|243365.1.peg.1585
- HOGENOM:   HBG335262
- OMA:   YNYLPGP
- PhylomeDB:   Q7NXP1
- ProtClustDB:   PRK09376
- BioCyc:   CVIO243365:CV_1585-MONOMER
- HAMAP:   MF_01884
- InterPro:   IPR000194
- InterPro:   IPR003593
- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR011112
- InterPro:   IPR011113
- InterPro:   IPR004665
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00382
- SMART:   SM00357
- SMART:   SM00959
- TIGRFAMs:   TIGR00767

Pfam domain/function: PF00006 ATP-synt_ab; PF07498 Rho_N; PF07497 Rho_RNA_bind; SSF50249 Nucleic_acid_OB; SSF68912 Rho_N

EC number: NA

Molecular weight: Translated: 47004; Mature: 47004

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: BINDING 212-212

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLSDLKHLHVSELVEMAISNEIDGANRLRKQDLIFALLKNQAKKGESIFGEGTLEVLPD
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCC
GFGFLRSPDTSYLAGPDDIYVSPSQIRRFNLHTGDSIEGEIRTPKDGERYFALVKVDKVN
CCCCCCCCCCCEECCCCCEEECHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECC
GEAPENSKHKILFENLTPLFPTEQFKLEREIRAEENITGRIIDLISPIGKGQRALLVAPP
CCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECC
KSGKTVMLQHIAHAITANHPEAVLIVLLIDERPEEVTEMQRSVRGEVVSSTFDEPATRHV
CCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
QVAEMVIEKAKRLVEHKKDVVILLDSITRLARAYNTVVPASGKVLTGGVDANALQRPKRF
HHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHH
FGAARNVEEGGSLTIVATALIDTGSRMDDVIYEEFKGTGNSEIHLDRRMAEKRIFPALNI
HHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCC
NRSGTRREELLVPQDQLQRIWVLRKLLYPMDDLEAMEFLQDKIKATKSNQAFFDSMRR
CCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MHLSDLKHLHVSELVEMAISNEIDGANRLRKQDLIFALLKNQAKKGESIFGEGTLEVLPD
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCC
GFGFLRSPDTSYLAGPDDIYVSPSQIRRFNLHTGDSIEGEIRTPKDGERYFALVKVDKVN
CCCCCCCCCCCEECCCCCEEECHHHHEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECC
GEAPENSKHKILFENLTPLFPTEQFKLEREIRAEENITGRIIDLISPIGKGQRALLVAPP
CCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECC
KSGKTVMLQHIAHAITANHPEAVLIVLLIDERPEEVTEMQRSVRGEVVSSTFDEPATRHV
CCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
QVAEMVIEKAKRLVEHKKDVVILLDSITRLARAYNTVVPASGKVLTGGVDANALQRPKRF
HHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHH
FGAARNVEEGGSLTIVATALIDTGSRMDDVIYEEFKGTGNSEIHLDRRMAEKRIFPALNI
HHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCC
NRSGTRREELLVPQDQLQRIWVLRKLLYPMDDLEAMEFLQDKIKATKSNQAFFDSMRR
CCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782