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The map label for this gene is yegE [H]

Identifier: 34497037

GI number: 34497037

Start: 1705849

End: 1707132

Strand: Direct

Name: yegE [H]

Synonym: CV_1582

Alternate gene names: 34497037

Gene position: 1705849-1707132 (Clockwise)

Preceding gene: 34497036

Following gene: 34497039

Centisome position: 35.9

GC content: 69.16

Gene sequence:

>1284_bases
CTGGCGGAGAAGCTGCTCCATACCGCCGAGAGCGATGCCGGCATCGGTTCCTGGGTGCTGCACATGGAGAGCGGCAGACT
GGAGTGGAGCCAGGCGGTCCATGATATTTTCGGCACCGATTCCGCCACCTTCGACGCCACCGAAGACGCGTATTTCCAGC
GCGTGCATCCGGACGACCGCGCCAGGGTGAGGCGGGAGCTGGATCGGCATGTCCTGGGCGATCGACCGTTCGACGTCGAG
TACCGCATCGTCAGGCCGGACGGACAGGTCAGGGAGTTGCTGGAGCGCAACCACATCCAGCGGCAGGCTTCCGGGCAGGT
CGACCATCTATGGGGCACGGTGATAGACATGACCGAGCACAAGCAACTGAAGCGGCAACTGCAGCTGTCCCAGTTGGCCG
TCGAGCATTGCTCGGAAGGCATCGCCATCGCTGACGAAGGATTGGACTGGCTGTACGTCAATCCGGCGCTGGCGAGGATG
GGCGGACTGACCATGGCGGACCCGTCCCAATTGAGCGGCCTGTTCATGGCCCCGGGGGTGGAAGCGCGGCTGGAGCGGGA
AGCCTTGCGCGAGTTGCTGGACGCGTCCGGCGCCTGGCAGGGCGAACTGTTGCTCGCGCGGCGCGGCGCGGCGCCGCTGC
CGGTGCTGGCTTCCGCGACCAGGCTGCGGGACGAGGACGGCAGGCTGTTGTCCGTGTGGGTGGTCAGCGATATCAGCGGC
ATGAAGGAGTCCGAGCGCAGACTGCACGCGCTGGCCTTTTTCGATGGCCTGACCGGTCTCGCCAACCGCGCCCTGTTCGG
CGAGCGGCTGCGCTGGCATCTGCAGAACGAGCCGGCCGGCGGGCGGTTGGCGATCCTCTTCCTGGACCTGAACGGCTTCA
AGCAGGTGAACGATCTGCTGGGCCACGAGGCGGGAGACCAAGTGCTGCGGGAAGTGGCGCGGCGGCTGCAGGCGGGCTGC
CGTCCCGGCGAACTGGCCGCGCGCTGGGGCGGCGACGAGTTCGCGGTATTGCTGCCCGGCGTCGCCGACGATGCGGTCCT
GGCCGCGCGTTTGCGGGAGCTGCGGGAGGCTGCGCGCGCCGAGCGCTGGGGCGGCGGACGCTGGCTGCGGGTGTCGGCGA
GCCTGGGGGCGGCGGTCTATCCGGAGTCGGCAGAAGACGCCGAACGGCTGATCCAGCTGGCGGACCGGGCGATGTACCGG
GCCAAGTCGGAGGGCGGCGGCCAGGTGTGGCTGCACGACGGCGGCGGTTTGCGGACGCTGGCCGGCGCCGATTGCGGCGC
GTGA

Upstream 100 bases:

>100_bases
CGAATGGCTGATCACCGCCCGGGCATTGTCCGAGGATAGGGCGGTGCTGCTGTCTTTGAGGCGGCCCCAGGAATTGTATC
CGGACCAGCCGAAATACTAT

Downstream 100 bases:

>100_bases
ATGAAAAACGGCGCGGGAAAACCGCGCCGTCTGCCTTGGGTCGCGCGAAAGCGCTTATTCTTCCGGCACGTTCAGCGCGT
TGACGCTGTAGCCGGCGTCG

Product: GGDEF family protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MAEKLLHTAESDAGIGSWVLHMESGRLEWSQAVHDIFGTDSATFDATEDAYFQRVHPDDRARVRRELDRHVLGDRPFDVE
YRIVRPDGQVRELLERNHIQRQASGQVDHLWGTVIDMTEHKQLKRQLQLSQLAVEHCSEGIAIADEGLDWLYVNPALARM
GGLTMADPSQLSGLFMAPGVEARLEREALRELLDASGAWQGELLLARRGAAPLPVLASATRLRDEDGRLLSVWVVSDISG
MKESERRLHALAFFDGLTGLANRALFGERLRWHLQNEPAGGRLAILFLDLNGFKQVNDLLGHEAGDQVLREVARRLQAGC
RPGELAARWGGDEFAVLLPGVADDAVLAARLRELREAARAERWGGGRWLRVSASLGAAVYPESAEDAERLIQLADRAMYR
AKSEGGGQVWLHDGGGLRTLAGADCGA

Sequences:

>Translated_427_residues
MAEKLLHTAESDAGIGSWVLHMESGRLEWSQAVHDIFGTDSATFDATEDAYFQRVHPDDRARVRRELDRHVLGDRPFDVE
YRIVRPDGQVRELLERNHIQRQASGQVDHLWGTVIDMTEHKQLKRQLQLSQLAVEHCSEGIAIADEGLDWLYVNPALARM
GGLTMADPSQLSGLFMAPGVEARLEREALRELLDASGAWQGELLLARRGAAPLPVLASATRLRDEDGRLLSVWVVSDISG
MKESERRLHALAFFDGLTGLANRALFGERLRWHLQNEPAGGRLAILFLDLNGFKQVNDLLGHEAGDQVLREVARRLQAGC
RPGELAARWGGDEFAVLLPGVADDAVLAARLRELREAARAERWGGGRWLRVSASLGAAVYPESAEDAERLIQLADRAMYR
AKSEGGGQVWLHDGGGLRTLAGADCGA
>Mature_426_residues
AEKLLHTAESDAGIGSWVLHMESGRLEWSQAVHDIFGTDSATFDATEDAYFQRVHPDDRARVRRELDRHVLGDRPFDVEY
RIVRPDGQVRELLERNHIQRQASGQVDHLWGTVIDMTEHKQLKRQLQLSQLAVEHCSEGIAIADEGLDWLYVNPALARMG
GLTMADPSQLSGLFMAPGVEARLEREALRELLDASGAWQGELLLARRGAAPLPVLASATRLRDEDGRLLSVWVVSDISGM
KESERRLHALAFFDGLTGLANRALFGERLRWHLQNEPAGGRLAILFLDLNGFKQVNDLLGHEAGDQVLREVARRLQAGCR
PGELAARWGGDEFAVLLPGVADDAVLAARLRELREAARAERWGGGRWLRVSASLGAAVYPESAEDAERLIQLADRAMYRA
KSEGGGQVWLHDGGGLRTLAGADCGA

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=419, Percent_Identity=29.5942720763723, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87081881, Length=189, Percent_Identity=36.5079365079365, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787541, Length=173, Percent_Identity=36.4161849710983, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI145693134, Length=160, Percent_Identity=34.375, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787262, Length=162, Percent_Identity=35.1851851851852, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082007, Length=196, Percent_Identity=33.6734693877551, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786584, Length=179, Percent_Identity=31.8435754189944, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788956, Length=154, Percent_Identity=38.3116883116883, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787802, Length=197, Percent_Identity=30.4568527918782, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081977, Length=174, Percent_Identity=35.0574712643678, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787816, Length=163, Percent_Identity=34.3558282208589, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788085, Length=186, Percent_Identity=28.494623655914, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787056, Length=169, Percent_Identity=33.1360946745562, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081974, Length=136, Percent_Identity=30.1470588235294, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 47113; Mature: 46982

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKLLHTAESDAGIGSWVLHMESGRLEWSQAVHDIFGTDSATFDATEDAYFQRVHPDDR
CCHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHH
ARVRRELDRHVLGDRPFDVEYRIVRPDGQVRELLERNHIQRQASGQVDHLWGTVIDMTEH
HHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KQLKRQLQLSQLAVEHCSEGIAIADEGLDWLYVNPALARMGGLTMADPSQLSGLFMAPGV
HHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECHHHHHHCCCCCCCHHHCCCEEECCCH
EARLEREALRELLDASGAWQGELLLARRGAAPLPVLASATRLRDEDGRLLSVWVVSDISG
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEECCHHC
MKESERRLHALAFFDGLTGLANRALFGERLRWHLQNEPAGGRLAILFLDLNGFKQVNDLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEEECCCHHHHHHHH
GHEAGDQVLREVARRLQAGCRPGELAARWGGDEFAVLLPGVADDAVLAARLRELREAARA
CCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
ERWGGGRWLRVSASLGAAVYPESAEDAERLIQLADRAMYRAKSEGGGQVWLHDGGGLRTL
HHCCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEE
AGADCGA
CCCCCCC
>Mature Secondary Structure 
AEKLLHTAESDAGIGSWVLHMESGRLEWSQAVHDIFGTDSATFDATEDAYFQRVHPDDR
CHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHH
ARVRRELDRHVLGDRPFDVEYRIVRPDGQVRELLERNHIQRQASGQVDHLWGTVIDMTEH
HHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KQLKRQLQLSQLAVEHCSEGIAIADEGLDWLYVNPALARMGGLTMADPSQLSGLFMAPGV
HHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECHHHHHHCCCCCCCHHHCCCEEECCCH
EARLEREALRELLDASGAWQGELLLARRGAAPLPVLASATRLRDEDGRLLSVWVVSDISG
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEECCHHC
MKESERRLHALAFFDGLTGLANRALFGERLRWHLQNEPAGGRLAILFLDLNGFKQVNDLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEEECCCHHHHHHHH
GHEAGDQVLREVARRLQAGCRPGELAARWGGDEFAVLLPGVADDAVLAARLRELREAARA
CCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
ERWGGGRWLRVSASLGAAVYPESAEDAERLIQLADRAMYRAKSEGGGQVWLHDGGGLRTL
HHCCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEE
AGADCGA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]