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The map label for this gene is cobC [H]

Identifier: 34497029

GI number: 34497029

Start: 1690745

End: 1691731

Strand: Reverse

Name: cobC [H]

Synonym: CV_1574

Alternate gene names: 34497029

Gene position: 1691731-1690745 (Counterclockwise)

Preceding gene: 34497030

Following gene: 34497028

Centisome position: 35.61

GC content: 70.82

Gene sequence:

>987_bases
ATGCTTGAACACGGAGGCGGCCTGCTGCGCGCGGCCGCGGAATACGGCATACCCGTCGGCGACTGGCTGGACCTGTCCAC
CGGCGTCAATCCCAACGGCTGGCCGGTGCCGCCGCTGCCGGCGGACAGCTGGCTGCGGCTGCCGCAAAACCATGACGGGC
TGGAAGCGGCGGCGGCGGAGTATTACGGCAGCGACAAACTGCTGGCCGTGGCCGGCTCGCAGCCGGCGATCCAGTTGCTG
CCGCGGCTGCGCGCGCCCTGCCGCGTCGGCATGCTGGCGCTGTGCTACGCCGAGCACCCGCACCACTGGCAGAAGCGCGG
GCACCAGCTGTTCAGGCTGTCGCCGGAAGAACTGGCCGCCGGCATAGACCAGCTGGACGTGGTGTTGCTGTGCAACCCCA
ACAACCCCACCGGCGACCGCTTCGACCCGGCGTTGCTGGAAAACTGGCGGCAGAGGCTGGCCGCGCGCGGCGGCTGGCTG
GTGGTGGATGAGGCGTTTCTGGACGCCGCGCCGCAAGACAGCATGCTGCCGCACGCCGGCAAGCCGGGATTGATCGTGTT
GCGCTCGGTCGGCAAGTTCTTCGGCCTGGCCGGCGCGCGCGCCGGCTTCGTGTTCGGTTGGCCGGAACTGCTGCGGGCGC
TGGCCGAGGAGCTGGGGCCGTGGACGGTGGCCGGCCCGGCGCGCGAGGCGGTGAAGCTGGCGCTGCGCGATGCCCCATGG
CAACAGGCGATGAAAACCAAGCTGCAGCGCGATAGCTCCAGGCTGCAACGCTGCCTGGAGCGGCACGGCCTGCCGCCCGC
CGGCGGCTGCGAGCTGTTTCAGTGGGTGCCGGACGAAAACAGCCTGGCCGCGCACCGCTACCTGGCCGGCCGCGGCATCC
TGACCCGCCATTTCGAAGCCATCCCCAGCCTGCGCTTCGGCCTGCCCAGGACCGACGCCGACTGGGTTCGGCTGGAGCAG
GCGCTGACCGATTGGCGTCGCTTGTAA

Upstream 100 bases:

>100_bases
ACGCATGAAGACATCGGCCGCGCGGTGCGGCTGGTCAACCGCGGCATGTGGCTGTGGGCGGCGTTGTCGCTGGCGGCCGC
CATCTTGATCGGAGCGATCC

Downstream 100 bases:

>100_bases
TCGGAACCATTTCGGTTCACAGCCCCAAGCTTGTCGCGTATCATTCTTGCCATTCTTGACGGTGCCCCAAAAGGGTGAAA
CGGGAACGCGGTGGAATGCC

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MLEHGGGLLRAAAEYGIPVGDWLDLSTGVNPNGWPVPPLPADSWLRLPQNHDGLEAAAAEYYGSDKLLAVAGSQPAIQLL
PRLRAPCRVGMLALCYAEHPHHWQKRGHQLFRLSPEELAAGIDQLDVVLLCNPNNPTGDRFDPALLENWRQRLAARGGWL
VVDEAFLDAAPQDSMLPHAGKPGLIVLRSVGKFFGLAGARAGFVFGWPELLRALAEELGPWTVAGPAREAVKLALRDAPW
QQAMKTKLQRDSSRLQRCLERHGLPPAGGCELFQWVPDENSLAAHRYLAGRGILTRHFEAIPSLRFGLPRTDADWVRLEQ
ALTDWRRL

Sequences:

>Translated_328_residues
MLEHGGGLLRAAAEYGIPVGDWLDLSTGVNPNGWPVPPLPADSWLRLPQNHDGLEAAAAEYYGSDKLLAVAGSQPAIQLL
PRLRAPCRVGMLALCYAEHPHHWQKRGHQLFRLSPEELAAGIDQLDVVLLCNPNNPTGDRFDPALLENWRQRLAARGGWL
VVDEAFLDAAPQDSMLPHAGKPGLIVLRSVGKFFGLAGARAGFVFGWPELLRALAEELGPWTVAGPAREAVKLALRDAPW
QQAMKTKLQRDSSRLQRCLERHGLPPAGGCELFQWVPDENSLAAHRYLAGRGILTRHFEAIPSLRFGLPRTDADWVRLEQ
ALTDWRRL
>Mature_328_residues
MLEHGGGLLRAAAEYGIPVGDWLDLSTGVNPNGWPVPPLPADSWLRLPQNHDGLEAAAAEYYGSDKLLAVAGSQPAIQLL
PRLRAPCRVGMLALCYAEHPHHWQKRGHQLFRLSPEELAAGIDQLDVVLLCNPNNPTGDRFDPALLENWRQRLAARGGWL
VVDEAFLDAAPQDSMLPHAGKPGLIVLRSVGKFFGLAGARAGFVFGWPELLRALAEELGPWTVAGPAREAVKLALRDAPW
QQAMKTKLQRDSSRLQRCLERHGLPPAGGCELFQWVPDENSLAAHRYLAGRGILTRHFEAIPSLRFGLPRTDADWVRLEQ
ALTDWRRL

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=195, Percent_Identity=29.2307692307692, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 36219; Mature: 36219

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHGGGLLRAAAEYGIPVGDWLDLSTGVNPNGWPVPPLPADSWLRLPQNHDGLEAAAAE
CCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHH
YYGSDKLLAVAGSQPAIQLLPRLRAPCRVGMLALCYAEHPHHWQKRGHQLFRLSPEELAA
HCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCCCEECCCHHHHHC
GIDQLDVVLLCNPNNPTGDRFDPALLENWRQRLAARGGWLVVDEAFLDAAPQDSMLPHAG
CCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCCC
KPGLIVLRSVGKFFGLAGARAGFVFGWPELLRALAEELGPWTVAGPAREAVKLALRDAPW
CCCEEHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCH
QQAMKTKLQRDSSRLQRCLERHGLPPAGGCELFQWVPDENSLAAHRYLAGRGILTRHFEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHCCCHHHHHHHH
IPSLRFGLPRTDADWVRLEQALTDWRRL
HHHHHCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLEHGGGLLRAAAEYGIPVGDWLDLSTGVNPNGWPVPPLPADSWLRLPQNHDGLEAAAAE
CCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHH
YYGSDKLLAVAGSQPAIQLLPRLRAPCRVGMLALCYAEHPHHWQKRGHQLFRLSPEELAA
HCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCCCEECCCHHHHHC
GIDQLDVVLLCNPNNPTGDRFDPALLENWRQRLAARGGWLVVDEAFLDAAPQDSMLPHAG
CCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCCC
KPGLIVLRSVGKFFGLAGARAGFVFGWPELLRALAEELGPWTVAGPAREAVKLALRDAPW
CCCEEHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCH
QQAMKTKLQRDSSRLQRCLERHGLPPAGGCELFQWVPDENSLAAHRYLAGRGILTRHFEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHHCCCHHHHHHHH
IPSLRFGLPRTDADWVRLEQALTDWRRL
HHHHHCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]