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The map label for this gene is efp

Identifier: 34496833

GI number: 34496833

Start: 1454130

End: 1454693

Strand: Reverse

Name: efp

Synonym: CV_1378

Alternate gene names: 34496833

Gene position: 1454693-1454130 (Counterclockwise)

Preceding gene: 34496834

Following gene: 34496831

Centisome position: 30.62

GC content: 58.51

Gene sequence:

>564_bases
ATGAAAACCGCACAAGAACTGCGCGCAGGCAACGTATTCATGGTCGGCAGCGACCCGATGGTTGTTCAAAAGGCTGAATT
CAGCAAGTCCGGCCGCAACGCCTCCGTCGTCAAGATGAAGATGAAGAACCTGCTGACCGGCGCCGGCAGCGAAGCCGTAT
ACCGCGCGGACGACAAGTTCGACGTAGTGGTGCTGGATCGCAAGGACTGCACCTACTCCTACTTCGCCGACCCGATGTAC
GTGTTCATGGACACCGAATTCAACCAGTACGAAGTGGAAGCCGACAACCTGGGCGACACCATCAACTACATCGTCGACGG
CATGGAAGACGTGTGCCAGGTAACCTTCTACGACGGCAAGGCCATCTCCGTGGAACTGCCGACCACCGTGATCCGCGAAG
TGGAATACACCGAGCCGGCCGTGCGCGGCGACACCTCGGGCAAAGTGCTGAAGCCGGCCCGCCTGGTAGGCACCACCTTC
GAAGTTCAGGTTCCGGCCTTCGTCAACACCGGCGAAAAGATCGAAATCGACACCCGCACCAACGAATTCAAGAAGCGCGC
CTAA

Upstream 100 bases:

>100_bases
GGCCAGACTGCTGCACTTCATCGCCGAAATCAGCTAGAATACCGCGTTTTGTCGGGAATCTTTCCCGGCTTCAATTCAAG
AGTTTGGGAATTAGACAAGC

Downstream 100 bases:

>100_bases
GCCTTCTTACTCGTTGTGCAGAAAAAAAGCGCCCCACGGGGCGCTTTTTTGTTGCCGGACGCGGCCGGACTGGCAGCGCC
GCGACGCCACTCCAGCCGTC

Product: elongation factor P

Products: NA

Alternate protein names: EF-P

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MKTAQELRAGNVFMVGSDPMVVQKAEFSKSGRNASVVKMKMKNLLTGAGSEAVYRADDKFDVVVLDRKDCTYSYFADPMY
VFMDTEFNQYEVEADNLGDTINYIVDGMEDVCQVTFYDGKAISVELPTTVIREVEYTEPAVRGDTSGKVLKPARLVGTTF
EVQVPAFVNTGEKIEIDTRTNEFKKRA

Sequences:

>Translated_187_residues
MKTAQELRAGNVFMVGSDPMVVQKAEFSKSGRNASVVKMKMKNLLTGAGSEAVYRADDKFDVVVLDRKDCTYSYFADPMY
VFMDTEFNQYEVEADNLGDTINYIVDGMEDVCQVTFYDGKAISVELPTTVIREVEYTEPAVRGDTSGKVLKPARLVGTTF
EVQVPAFVNTGEKIEIDTRTNEFKKRA
>Mature_187_residues
MKTAQELRAGNVFMVGSDPMVVQKAEFSKSGRNASVVKMKMKNLLTGAGSEAVYRADDKFDVVVLDRKDCTYSYFADPMY
VFMDTEFNQYEVEADNLGDTINYIVDGMEDVCQVTFYDGKAISVELPTTVIREVEYTEPAVRGDTSGKVLKPARLVGTTF
EVQVPAFVNTGEKIEIDTRTNEFKKRA

Specific function: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing t

COG id: COG0231

COG function: function code J; Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the elongation factor P family

Homologues:

Organism=Escherichia coli, GI1790590, Length=184, Percent_Identity=34.7826086956522, Blast_Score=109, Evalue=9e-26,
Organism=Escherichia coli, GI87082061, Length=190, Percent_Identity=31.0526315789474, Blast_Score=90, Evalue=8e-20,

Paralogues:

None

Copy number: 1600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): EFP_CHRVO (Q7NY96)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901048.1
- ProteinModelPortal:   Q7NY96
- SMR:   Q7NY96
- GeneID:   2550957
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1378
- NMPDR:   fig|243365.1.peg.1378
- HOGENOM:   HBG303311
- OMA:   MISSNDF
- PhylomeDB:   Q7NY96
- ProtClustDB:   PRK00529
- BioCyc:   CVIO243365:CV_1378-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00141
- InterPro:   IPR015365
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR020599
- InterPro:   IPR013185
- InterPro:   IPR001059
- InterPro:   IPR011768
- InterPro:   IPR014722
- InterPro:   IPR008991
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:2.30.30.30
- PIRSF:   PIRSF005901
- SMART:   SM00841
- TIGRFAMs:   TIGR00038

Pfam domain/function: PF01132 EFP; PF08207 EFP_N; PF09285 Elong-fact-P_C; SSF50249 Nucleic_acid_OB; SSF50104 Transl_SH3_like

EC number: NA

Molecular weight: Translated: 20907; Mature: 20907

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS01275 EFP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAQELRAGNVFMVGSDPMVVQKAEFSKSGRNASVVKMKMKNLLTGAGSEAVYRADDKF
CCCHHHHCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCEEEECCCCE
DVVVLDRKDCTYSYFADPMYVFMDTEFNQYEVEADNLGDTINYIVDGMEDVCQVTFYDGK
EEEEECCCCCCEEECCCEEEEEEECCCCEEEEECCCCCCHHHHHHCCCHHHEEEEEECCE
AISVELPTTVIREVEYTEPAVRGDTSGKVLKPARLVGTTFEVQVPAFVNTGEKIEIDTRT
EEEEECCHHHHHHCCCCCCCCCCCCCCCEECCHHHCCCEEEEEECCEECCCCEEEEECCC
NEFKKRA
CHHHCCC
>Mature Secondary Structure
MKTAQELRAGNVFMVGSDPMVVQKAEFSKSGRNASVVKMKMKNLLTGAGSEAVYRADDKF
CCCHHHHCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCEEEECCCCE
DVVVLDRKDCTYSYFADPMYVFMDTEFNQYEVEADNLGDTINYIVDGMEDVCQVTFYDGK
EEEEECCCCCCEEECCCEEEEEEECCCCEEEEECCCCCCHHHHHHCCCHHHEEEEEECCE
AISVELPTTVIREVEYTEPAVRGDTSGKVLKPARLVGTTFEVQVPAFVNTGEKIEIDTRT
EEEEECCHHHHHHCCCCCCCCCCCCCCCEECCHHHCCCEEEEEECCEECCCCEEEEECCC
NEFKKRA
CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782