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The map label for this gene is serS

Identifier: 34496830

GI number: 34496830

Start: 1449771

End: 1451054

Strand: Reverse

Name: serS

Synonym: CV_1375

Alternate gene names: 34496830

Gene position: 1451054-1449771 (Counterclockwise)

Preceding gene: 34496831

Following gene: 34496825

Centisome position: 30.54

GC content: 64.49

Gene sequence:

>1284_bases
ATGCTCGACATCAATCTACTTCGTAATGACATCGAAGCGGTCGCCGCCCGTCTGGCCGGCCGCGGCTACACCCTGGACAC
CGCAGCGTTCAATCAGCTGGAATCCGAGCGCAAGTCCCTGCAATCCCGGATGCAGGAACTGCAAGCCAAGCGCAACGCCA
CTTCCAAGCAGATCGGCATCGCCAAGGGCAAGGGTGAAGATGTCTCCGCCATTCTGGCCGAAGTAGCCACCCTGGGTGAC
GAGCTGAAAGCCGCGGAACAGGCGTTCGACGGCGTGCAGGGCCAGCTGGACGCCTGGCTGATGTCCATCCCCAACCTGCC
GCACGAATCGGTGCCGGTGGGCAAGGATGAAAACGACAACGTGGAAGTGCGCCGCGTCGGCGTGCCGCGCCAGTTCGACT
TCGAAGTGAAAGACCACGTCGACGTCGGCGCCCCGCTGGGCCTGGATTTCGACACCGGCGCCAAGCTGTCCGGCGCGCGC
TTCACCGTGCTGAAGGGCGACATCGCCCGCCTGCACCGCGCCATCGCGCAGTTCATGCTGAACACCCACACCGGCAGCCA
CGGCTACCAGGAGCACTACACCCCGTACATCGTCAACGACACCGCGCTTTTGGGCACCGGCCAACTGCCGAAATTCGCCG
ACGACATGTTCAAGGTGACCCGCGGCGGCGACGAGTCCGCCGTGCCGCAATACCTGATTTCCACCTCGGAAGTGACGCTG
ACCAATACCGTCGCCGACACCATCCTGCAAGAGAGCGAGCTGCCGAAGAAGATGACCGCGCACTCGCCGTGCTTCCGCTC
CGAGGCCGGCAGCTACGGCCGCGACACCCGCGGCATGATCCGCCAGCACCAGTTCGACAAGGTGGAGATGGTGCGCGTGG
AGAAGCCGGAACACTCCTACGCCGCGCTGGAGGAAATGGTGGGCCACGCCGAGAACATCCTGAAGGCGCTGGAACTGCCC
TACCGCGTGATCACGCTGTGCACCGGCGACATGGGTTTCGGCTCCGCCAAAACCTACGACCTGGAAGTGTGGCTGCCGGC
GCAGAACACCTACCGCGAGATCTCCAGCTGCTCCAACTGCGAGGCCTTCCAGGCCCGCCGCATGAAGGCGCGCTACAAGG
ACGAAAACGGCAAGAACCAGCTGGTGCACACGCTGAACGGCTCCGGCCTGGCGGTGGGCCGCACCCTGGTGGCCATCCTG
GAAAACTACCAGAACGCCGACGGCAGCGTCACCGTGCCGACCGTGCTGCGCCCCTTCATGGGCAAGGACAGGATAGGCGG
CTGA

Upstream 100 bases:

>100_bases
CGCGCGGGCTGGAAAGCAAGATTCAGGATAAACTGGCCTTTTTGCGTCAGCTGGATGCAGACGCCCAGCAAGATCCCGAT
AGTGAAAAACAGGAATAATC

Downstream 100 bases:

>100_bases
GCTTGGCCCTGCCGATGAAACCGGCGCCGAAAGGCGCCGGTTTTTTTACGCCTCCGCGCCCACCTCGCTGCGGCTCAGCA
GCGCCTCGTAGGCGTCGCGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDINLLRNDIEAVAARLAGRGYTLDTAAFNQLESERKSLQSRMQELQAKRNATSKQIGIAKGKGEDVSAILAEVATLGD
ELKAAEQAFDGVQGQLDAWLMSIPNLPHESVPVGKDENDNVEVRRVGVPRQFDFEVKDHVDVGAPLGLDFDTGAKLSGAR
FTVLKGDIARLHRAIAQFMLNTHTGSHGYQEHYTPYIVNDTALLGTGQLPKFADDMFKVTRGGDESAVPQYLISTSEVTL
TNTVADTILQESELPKKMTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVRVEKPEHSYAALEEMVGHAENILKALELP
YRVITLCTGDMGFGSAKTYDLEVWLPAQNTYREISSCSNCEAFQARRMKARYKDENGKNQLVHTLNGSGLAVGRTLVAIL
ENYQNADGSVTVPTVLRPFMGKDRIGG

Sequences:

>Translated_427_residues
MLDINLLRNDIEAVAARLAGRGYTLDTAAFNQLESERKSLQSRMQELQAKRNATSKQIGIAKGKGEDVSAILAEVATLGD
ELKAAEQAFDGVQGQLDAWLMSIPNLPHESVPVGKDENDNVEVRRVGVPRQFDFEVKDHVDVGAPLGLDFDTGAKLSGAR
FTVLKGDIARLHRAIAQFMLNTHTGSHGYQEHYTPYIVNDTALLGTGQLPKFADDMFKVTRGGDESAVPQYLISTSEVTL
TNTVADTILQESELPKKMTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVRVEKPEHSYAALEEMVGHAENILKALELP
YRVITLCTGDMGFGSAKTYDLEVWLPAQNTYREISSCSNCEAFQARRMKARYKDENGKNQLVHTLNGSGLAVGRTLVAIL
ENYQNADGSVTVPTVLRPFMGKDRIGG
>Mature_427_residues
MLDINLLRNDIEAVAARLAGRGYTLDTAAFNQLESERKSLQSRMQELQAKRNATSKQIGIAKGKGEDVSAILAEVATLGD
ELKAAEQAFDGVQGQLDAWLMSIPNLPHESVPVGKDENDNVEVRRVGVPRQFDFEVKDHVDVGAPLGLDFDTGAKLSGAR
FTVLKGDIARLHRAIAQFMLNTHTGSHGYQEHYTPYIVNDTALLGTGQLPKFADDMFKVTRGGDESAVPQYLISTSEVTL
TNTVADTILQESELPKKMTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVRVEKPEHSYAALEEMVGHAENILKALELP
YRVITLCTGDMGFGSAKTYDLEVWLPAQNTYREISSCSNCEAFQARRMKARYKDENGKNQLVHTLNGSGLAVGRTLVAIL
ENYQNADGSVTVPTVLRPFMGKDRIGG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=466, Percent_Identity=33.0472103004292, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI225579074, Length=331, Percent_Identity=32.6283987915408, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI8923421, Length=331, Percent_Identity=32.6283987915408, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=61.6279069767442, Blast_Score=538, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17539260, Length=335, Percent_Identity=38.2089552238806, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=29.0419161676647, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=394, Percent_Identity=32.994923857868, Blast_Score=210, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=402, Percent_Identity=30.3482587064677, Blast_Score=182, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24581334, Length=429, Percent_Identity=32.4009324009324, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17737985, Length=331, Percent_Identity=33.2326283987915, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_CHRVO (Q7NY99)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_901045.1
- ProteinModelPortal:   Q7NY99
- SMR:   Q7NY99
- GeneID:   2550920
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_1375
- NMPDR:   fig|243365.1.peg.1375
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q7NY99
- ProtClustDB:   PRK05431
- BioCyc:   CVIO243365:CV_1375-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46993; Mature: 46993

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 289-289 BINDING 388-388

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDINLLRNDIEAVAARLAGRGYTLDTAAFNQLESERKSLQSRMQELQAKRNATSKQIGI
CCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
AKGKGEDVSAILAEVATLGDELKAAEQAFDGVQGQLDAWLMSIPNLPHESVPVGKDENDN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRVGVPRQFDFEVKDHVDVGAPLGLDFDTGAKLSGARFTVLKGDIARLHRAIAQFML
EEEEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
NTHTGSHGYQEHYTPYIVNDTALLGTGQLPKFADDMFKVTRGGDESAVPQYLISTSEVTL
HCCCCCCCCHHCCCCEEECCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEE
TNTVADTILQESELPKKMTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVRVEKPEHSY
HHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHH
AALEEMVGHAENILKALELPYRVITLCTGDMGFGSAKTYDLEVWLPAQNTYREISSCSNC
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHCCCCC
EAFQARRMKARYKDENGKNQLVHTLNGSGLAVGRTLVAILENYQNADGSVTVPTVLRPFM
HHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHC
GKDRIGG
CCCCCCC
>Mature Secondary Structure
MLDINLLRNDIEAVAARLAGRGYTLDTAAFNQLESERKSLQSRMQELQAKRNATSKQIGI
CCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCC
AKGKGEDVSAILAEVATLGDELKAAEQAFDGVQGQLDAWLMSIPNLPHESVPVGKDENDN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRVGVPRQFDFEVKDHVDVGAPLGLDFDTGAKLSGARFTVLKGDIARLHRAIAQFML
EEEEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
NTHTGSHGYQEHYTPYIVNDTALLGTGQLPKFADDMFKVTRGGDESAVPQYLISTSEVTL
HCCCCCCCCHHCCCCEEECCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCEEE
TNTVADTILQESELPKKMTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVRVEKPEHSY
HHHHHHHHHHHHCCCHHHHCCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHH
AALEEMVGHAENILKALELPYRVITLCTGDMGFGSAKTYDLEVWLPAQNTYREISSCSNC
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHCCCCC
EAFQARRMKARYKDENGKNQLVHTLNGSGLAVGRTLVAILENYQNADGSVTVPTVLRPFM
HHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHC
GKDRIGG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782