Click here to switch to the map view.

The map label for this gene is arnA [H]

Identifier: 34496202

GI number: 34496202

Start: 767208

End: 768251

Strand: Reverse

Name: arnA [H]

Synonym: CV_0747

Alternate gene names: 34496202

Gene position: 768251-767208 (Counterclockwise)

Preceding gene: 34496203

Following gene: 34496200

Centisome position: 16.17

GC content: 60.54

Gene sequence:

>1044_bases
ATGAAAAAAGTACTGATCCTGGGCGTGAACGGCTTCATCGGCCACCACCTGACCAAACGCATCATCGAGACCACCGACTG
GGAAATCTACGGCATGGACATGCATGCCGACCGCGTGGCCGAATGGAAGGATCATCCGCGCTTCCACTTCTTCGAGGGCG
ACATCACCATCAACAAGGAGTGGATCGAATACCACGTCAAGAAGTGCGACGTGGTGCTGCCGCTGGTGGCCATCGCTACA
CCGTCCACCTACGTCAACAACCCGCTGCGCGTGTTCGAGCTGGACTTCGAGGCCAATCTGCCCATCGTCCGCCAGTGCGT
GAAGTACAAGAAGCACCTGGTGTTCCCGTCCACCTCTGAAGTGTACGGCATGAGCCAGGACGCCGAGTTCGACCCGGAAA
ACTCCCAGCTGATCTACGGCCCGATCAACAAGCCGCGCTGGATCTACGCCTGCTCCAAGCAGCTGATGGACCGCGTGATC
CACGCCTACGCGATGGAAGAGGGCCTGAATTACACGCTGTTCCGCCCGTTCAACTGGATCGGTGGCGGCCTGGACAACAT
CAACACGCCGAAGGAAGGCTCCAGCCGCGTGATCACCCAGTTCCTGGGCCACATCGTCCGCGGCGAGACCATCAAGCTGG
TCGACGGCGGCCACCAGAAGCGCGCCTTCACCTATGTCGACGACGGCATCAGCGCGCTGATGAAGATCATCGAGAACAAG
GACGGCAAGGCTTCCGGCCAGATCTACAACATCGGCAACCCGGCCAACAACTACTCGATCCGCGAACTGGCGCAGATGAT
GCTGGACCTGGCGCGCGTCTATCCGGAATACCAGCTGAACGCCGACAAGGTGCAGGTGGTGGAAACCACCTCCGGCCAGT
ACTACGGCAAGGGCTACCAGGACGTGCAGAACCGCGTGCCCAAGATCGCCAACACCATGGCCGATCTGGACTGGAAGCCG
GGCGTGACCATGGCCGACGCGCTGCGCGGCATCTACGACTACTACCGCGACCAAGTCGCCGCCAGCCGCGATCTGTCTGT
GTAA

Upstream 100 bases:

>100_bases
GCCGCCGACAACTTCGCCGCCCGCGTCGGAAGCGACGCGCTGGCGCTGTGAACCGATTACCGAATTCGATTTTCCGCCTG
CGGGCGAGTGAGGACTTGGA

Downstream 100 bases:

>100_bases
TCCCCAAGCCGTAGGGCGGAAGCCCGGCTCTGCCGGGCGTTCCGCCACATACCGTACCCCCATAGTACGGGTTGGCTGCA
GGCCATACCCAAGAACCACT

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKKVLILGVNGFIGHHLTKRIIETTDWEIYGMDMHADRVAEWKDHPRFHFFEGDITINKEWIEYHVKKCDVVLPLVAIAT
PSTYVNNPLRVFELDFEANLPIVRQCVKYKKHLVFPSTSEVYGMSQDAEFDPENSQLIYGPINKPRWIYACSKQLMDRVI
HAYAMEEGLNYTLFRPFNWIGGGLDNINTPKEGSSRVITQFLGHIVRGETIKLVDGGHQKRAFTYVDDGISALMKIIENK
DGKASGQIYNIGNPANNYSIRELAQMMLDLARVYPEYQLNADKVQVVETTSGQYYGKGYQDVQNRVPKIANTMADLDWKP
GVTMADALRGIYDYYRDQVAASRDLSV

Sequences:

>Translated_347_residues
MKKVLILGVNGFIGHHLTKRIIETTDWEIYGMDMHADRVAEWKDHPRFHFFEGDITINKEWIEYHVKKCDVVLPLVAIAT
PSTYVNNPLRVFELDFEANLPIVRQCVKYKKHLVFPSTSEVYGMSQDAEFDPENSQLIYGPINKPRWIYACSKQLMDRVI
HAYAMEEGLNYTLFRPFNWIGGGLDNINTPKEGSSRVITQFLGHIVRGETIKLVDGGHQKRAFTYVDDGISALMKIIENK
DGKASGQIYNIGNPANNYSIRELAQMMLDLARVYPEYQLNADKVQVVETTSGQYYGKGYQDVQNRVPKIANTMADLDWKP
GVTMADALRGIYDYYRDQVAASRDLSV
>Mature_347_residues
MKKVLILGVNGFIGHHLTKRIIETTDWEIYGMDMHADRVAEWKDHPRFHFFEGDITINKEWIEYHVKKCDVVLPLVAIAT
PSTYVNNPLRVFELDFEANLPIVRQCVKYKKHLVFPSTSEVYGMSQDAEFDPENSQLIYGPINKPRWIYACSKQLMDRVI
HAYAMEEGLNYTLFRPFNWIGGGLDNINTPKEGSSRVITQFLGHIVRGETIKLVDGGHQKRAFTYVDDGISALMKIIENK
DGKASGQIYNIGNPANNYSIRELAQMMLDLARVYPEYQLNADKVQVVETTSGQYYGKGYQDVQNRVPKIANTMADLDWKP
GVTMADALRGIYDYYRDQVAASRDLSV

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=344, Percent_Identity=26.7441860465116, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI7657641, Length=357, Percent_Identity=22.96918767507, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1788589, Length=339, Percent_Identity=56.6371681415929, Blast_Score=400, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17539532, Length=344, Percent_Identity=25.8720930232558, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21356223, Length=346, Percent_Identity=25.7225433526012, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 39673; Mature: 39673

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLILGVNGFIGHHLTKRIIETTDWEIYGMDMHADRVAEWKDHPRFHFFEGDITINKE
CCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEECCEEECHH
WIEYHVKKCDVVLPLVAIATPSTYVNNPLRVFELDFEANLPIVRQCVKYKKHLVFPSTSE
HHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHH
VYGMSQDAEFDPENSQLIYGPINKPRWIYACSKQLMDRVIHAYAMEEGLNYTLFRPFNWI
HCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHH
GGGLDNINTPKEGSSRVITQFLGHIVRGETIKLVDGGHQKRAFTYVDDGISALMKIIENK
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEHHHHHHHHHHHHHCC
DGKASGQIYNIGNPANNYSIRELAQMMLDLARVYPEYQLNADKVQVVETTSGQYYGKGYQ
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCHH
DVQNRVPKIANTMADLDWKPGVTMADALRGIYDYYRDQVAASRDLSV
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKVLILGVNGFIGHHLTKRIIETTDWEIYGMDMHADRVAEWKDHPRFHFFEGDITINKE
CCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEEECCEEECHH
WIEYHVKKCDVVLPLVAIATPSTYVNNPLRVFELDFEANLPIVRQCVKYKKHLVFPSTSE
HHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHH
VYGMSQDAEFDPENSQLIYGPINKPRWIYACSKQLMDRVIHAYAMEEGLNYTLFRPFNWI
HCCCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHH
GGGLDNINTPKEGSSRVITQFLGHIVRGETIKLVDGGHQKRAFTYVDDGISALMKIIENK
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEHHHHHHHHHHHHHCC
DGKASGQIYNIGNPANNYSIRELAQMMLDLARVYPEYQLNADKVQVVETTSGQYYGKGYQ
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCHH
DVQNRVPKIANTMADLDWKPGVTMADALRGIYDYYRDQVAASRDLSV
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA