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The map label for this gene is ndk [H]

Identifier: 33864412

GI number: 33864412

Start: 2264293

End: 2264751

Strand: Reverse

Name: ndk [H]

Synonym: PMT2148

Alternate gene names: 33864412

Gene position: 2264751-2264293 (Counterclockwise)

Preceding gene: 33864415

Following gene: 33864411

Centisome position: 93.94

GC content: 54.9

Gene sequence:

>459_bases
ATGGCCATGGAACGCACCTTTGTTGCCATCAAGCCCGATGGCGTCCAGCGTGGTCTGGTGGGAGAAATTCTGGGTCGATT
TGAGCGCAAGGGCTTCAAGCTCGTGGGACTTAAACAGGTCACCCCCAGTCGTGATTTGGCTGGTGAGCATTACGGTGTGC
ACCGTGAGCGCCCTTTCTTTGCTGGGCTTGTTGATTTCATTACCTCCGGCCCGGTGATTGCAATGGTCTGGGAAGGTGAT
GGTGTGATTGCGAGTGCCCGCAAGTTGATCGGCGCCACCAAGCCTCTTGATGCTGAGCCGGGCACCATCCGCGGTGATTT
AGCTGTGAACATCGGTCGTAATGTGATCCACGGCTCAGATGGTCCAGACACCGCTCAGTTTGAGATCAACCTCTGGTTCT
CTGCTGAAGAGCTCAACGCATGGACTCCTTCAGATCAAAGCTGGCGTATTGAAAGCTGA

Upstream 100 bases:

>100_bases
TAGGGCATTGCTGCTTGTCTGATTCAGATCTAGGGCCATTGGTTGGCTTGCCAAGCGGTAACTCCAACACGGACGATGGC
CGCAACAACGACTGATCAGC

Downstream 100 bases:

>100_bases
GGTTGAAAGATTTCGCGTGCCTGATTGGGGCAAAATGATTGCGCTGTTGATCAGGCTTTTGTGATGATTGGGACTGACAT
CACGACCCTGAAGCCAGTGG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MAMERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQVTPSRDLAGEHYGVHRERPFFAGLVDFITSGPVIAMVWEGD
GVIASARKLIGATKPLDAEPGTIRGDLAVNIGRNVIHGSDGPDTAQFEINLWFSAEELNAWTPSDQSWRIES

Sequences:

>Translated_152_residues
MAMERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQVTPSRDLAGEHYGVHRERPFFAGLVDFITSGPVIAMVWEGD
GVIASARKLIGATKPLDAEPGTIRGDLAVNIGRNVIHGSDGPDTAQFEINLWFSAEELNAWTPSDQSWRIES
>Mature_151_residues
AMERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQVTPSRDLAGEHYGVHRERPFFAGLVDFITSGPVIAMVWEGDG
VIASARKLIGATKPLDAEPGTIRGDLAVNIGRNVIHGSDGPDTAQFEINLWFSAEELNAWTPSDQSWRIES

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI4557797, Length=149, Percent_Identity=59.0604026845638, Blast_Score=189, Evalue=7e-49,
Organism=Homo sapiens, GI38045913, Length=149, Percent_Identity=59.0604026845638, Blast_Score=189, Evalue=8e-49,
Organism=Homo sapiens, GI37693993, Length=150, Percent_Identity=59.3333333333333, Blast_Score=185, Evalue=1e-47,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=53.6912751677852, Blast_Score=176, Evalue=8e-45,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=53.6912751677852, Blast_Score=176, Evalue=8e-45,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=53.6912751677852, Blast_Score=176, Evalue=8e-45,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=53.6912751677852, Blast_Score=176, Evalue=8e-45,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=53.6912751677852, Blast_Score=176, Evalue=9e-45,
Organism=Homo sapiens, GI4826862, Length=143, Percent_Identity=52.4475524475524, Blast_Score=162, Evalue=1e-40,
Organism=Homo sapiens, GI37574614, Length=138, Percent_Identity=34.7826086956522, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI7019465, Length=138, Percent_Identity=34.7826086956522, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788866, Length=142, Percent_Identity=42.9577464788732, Blast_Score=120, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=52.3489932885906, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=54.0540540540541, Blast_Score=175, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=55.4054054054054, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI18860097, Length=153, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 16632; Mature: 16501

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQVTPSRDLAGEHYGVHRERPFF
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
AGLVDFITSGPVIAMVWEGDGVIASARKLIGATKPLDAEPGTIRGDLAVNIGRNVIHGSD
HHHHHHHCCCCEEEEEECCCCEEHHHHHHHCCCCCCCCCCCEEECEEEEECCCEEEECCC
GPDTAQFEINLWFSAEELNAWTPSDQSWRIES
CCCCEEEEEEEEEEHHHCCCCCCCCCCEEECC
>Mature Secondary Structure 
AMERTFVAIKPDGVQRGLVGEILGRFERKGFKLVGLKQVTPSRDLAGEHYGVHRERPFF
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCCCCHH
AGLVDFITSGPVIAMVWEGDGVIASARKLIGATKPLDAEPGTIRGDLAVNIGRNVIHGSD
HHHHHHHCCCCEEEEEECCCCEEHHHHHHHCCCCCCCCCCCEEECEEEEECCCEEEECCC
GPDTAQFEINLWFSAEELNAWTPSDQSWRIES
CCCCEEEEEEEEEEHHHCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA