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The map label for this gene is argS

Identifier: 33864335

GI number: 33864335

Start: 2176837

End: 2178675

Strand: Reverse

Name: argS

Synonym: PMT2070

Alternate gene names: 33864335

Gene position: 2178675-2176837 (Counterclockwise)

Preceding gene: 33864337

Following gene: 33864334

Centisome position: 90.37

GC content: 55.19

Gene sequence:

>1839_bases
TTGCAGGCCCATTTCGCCTCGGAGTTCATGCTCAGCCTTGCTCACGCTCTGGAGAGTCAACTGCGGGCGGCGATCGACCG
TGCCTTCCCTGAAGCCGCAGCCTCCGCACGTGAGAGTGGCACTGGCTTGGATCCACAATTGGCCCCAGCCAGCAAGCCTG
AATTTGGTGATTTTCAGGCCAATGCTGCCTTACCCCTCGCTAAGCCGCTCAAGCAGCCTCCGCGTCAAATTGCTGCAGCG
ATTGTCGACCAGCTGATGGTCGATACGGCATTCACGGCCATTTGCTTGACGCCAGAAATTGCTGGGCCTGGTTTCATTAA
TCTCACCGTCCGGCCCGAATGCCTGGCTGCTGAAGTGCAGGCAAGGCTGGCTGATGCTCGTTTGGGCGTGCCGCTGGTGG
AGGGCGATAACGATGGGCAACAGCCCACTCCAGTGGTGGTGGATTTCTCCAGCCCCAACATCGCCAAGGAGATGCATGTG
GGGCACTTGCGTTCCACGATCATTGGCGATTCCCTCGCTCGGGTGTTGGAGTTTCGTGGACACCCCGTGCTGCGTCTTAA
CCATGTAGGCGATTGGGGTACGCAGTTTGGGATGTTGATTACCCACTTGAAGCAAGTGGCACCAGAGGCTCTTGAAACAG
CTGATGCTGTTGATCTTGGCGATCTTGTGGTGTTTTATCGCCAGGCGAAGCAACGCTTTGATGATGACGAGGCTTTTCAG
ACCACCTCCCGTGAGGAGGTGGTGAAATTGCAAGGGGGTGATCCTATTTCCTTGAAGGCTTGGAGTTTGCTATGTGATCA
GTCGCGCCGTGAATTTCAAAAGATCTACGATCGGCTTGATGTTCGTCTCAACGAGCGCGGCGAATCGTTTTACAATGCCT
ATCTAGAGAGCGTCGTTGAGGATCTCAATGTCTCCGGTTTGCTCGTTAGCGATGACGGCGCTCAGTGTGTTTTTCTTGAG
GGTGTTACGGGTAAGGACGGCAAACCTCTGCCTGTGATTGTTCAGAAGAGTGATGGTGGCTTCAATTACGCCACCACCGA
TCTGGCAGCCATGCGCTATCGCTTTGCTGCTCCTCCCCAAGGTGATGGCGCTCGGCGTGTGATTTACGTGACCGATGCTG
GCCAGGCCAATCATTTCGCTGGCGTCTTTCAGGTTGCTCAGCGCGCAGGTTGGATCCCTGATGCTGGTCGTCTCCAGCAC
GTGCCTTTTGGCCTGGTTCAGGGGGAAGATGGCAAGAAGCTCAAAACGCGTGCTGGTGACACTGTTCGTCTGCGCGAGTT
ACTCGATGAGGCTGTTGAGCGCGCTGAGTCTGATCTGCGCCGTCGGCTGCAGGAGGAGGGCCGGGATGAAGATGAATCTT
TTATTGAGCAGGTGGCCACCACGGTGGGGCTGGCAGCAGTGAAGTATGCCGATCTCAGCCAGAACCGAATCACCAACTAC
CAGTTCAGTTTTGATCGCATGCTTGCTCTGCAGGGCAATACAGCTCCCTATCTGCTTTATGCCGTTGTTCGTATCGCCGG
TATTGCGCGCAAGGGGGGCGATCTTGATGTCACTACGGCTGAGCTTCAGTTCAGTGAAACGCAGGAATGGGCTTTAGTGC
GTGAGTTACTTAAGTTTGATGCAGTGATCGCCGAAGTTGAGGAGGAGTTGTTACCCAATCGTCTCTGCACCTATCTGTTT
GAGCTCAGCCAGGTGTTTAATCGCTTTTACGATCAGGTGCCGGTGTTGAAGGCTGAGCAACCTTCTCGTAGCTGTCGCCT
TGCACTCTGCCGGCTCACGGCAGATACCCTAAAACTAGGGCTGTCGTTGTTGGGTATTCCCACGCTGGAGCGGATGTGA

Upstream 100 bases:

>100_bases
TTTAAAAGATCAGCCCTCATTGTTAATGGTGATCGCTTGAGAAGAGTGCTGAAGCAGGCTTGCTGGTTGCCGGCATCGTG
GTCAGTGATGATCAGGGTGA

Downstream 100 bases:

>100_bases
TGGGGTCTTCACCTGCACGAATGAGTTCTGGTGCCCCCGCTCCTCGGGTGGAAGTGGAGTGTCTGAAGGCCTATAGCGCT
CCGCTTGAGGGACGCCGTGG

Product: arginyl-tRNA synthetase

Products: NA

Alternate protein names: Arginine--tRNA ligase; ArgRS

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MQAHFASEFMLSLAHALESQLRAAIDRAFPEAAASARESGTGLDPQLAPASKPEFGDFQANAALPLAKPLKQPPRQIAAA
IVDQLMVDTAFTAICLTPEIAGPGFINLTVRPECLAAEVQARLADARLGVPLVEGDNDGQQPTPVVVDFSSPNIAKEMHV
GHLRSTIIGDSLARVLEFRGHPVLRLNHVGDWGTQFGMLITHLKQVAPEALETADAVDLGDLVVFYRQAKQRFDDDEAFQ
TTSREEVVKLQGGDPISLKAWSLLCDQSRREFQKIYDRLDVRLNERGESFYNAYLESVVEDLNVSGLLVSDDGAQCVFLE
GVTGKDGKPLPVIVQKSDGGFNYATTDLAAMRYRFAAPPQGDGARRVIYVTDAGQANHFAGVFQVAQRAGWIPDAGRLQH
VPFGLVQGEDGKKLKTRAGDTVRLRELLDEAVERAESDLRRRLQEEGRDEDESFIEQVATTVGLAAVKYADLSQNRITNY
QFSFDRMLALQGNTAPYLLYAVVRIAGIARKGGDLDVTTAELQFSETQEWALVRELLKFDAVIAEVEEELLPNRLCTYLF
ELSQVFNRFYDQVPVLKAEQPSRSCRLALCRLTADTLKLGLSLLGIPTLERM

Sequences:

>Translated_612_residues
MQAHFASEFMLSLAHALESQLRAAIDRAFPEAAASARESGTGLDPQLAPASKPEFGDFQANAALPLAKPLKQPPRQIAAA
IVDQLMVDTAFTAICLTPEIAGPGFINLTVRPECLAAEVQARLADARLGVPLVEGDNDGQQPTPVVVDFSSPNIAKEMHV
GHLRSTIIGDSLARVLEFRGHPVLRLNHVGDWGTQFGMLITHLKQVAPEALETADAVDLGDLVVFYRQAKQRFDDDEAFQ
TTSREEVVKLQGGDPISLKAWSLLCDQSRREFQKIYDRLDVRLNERGESFYNAYLESVVEDLNVSGLLVSDDGAQCVFLE
GVTGKDGKPLPVIVQKSDGGFNYATTDLAAMRYRFAAPPQGDGARRVIYVTDAGQANHFAGVFQVAQRAGWIPDAGRLQH
VPFGLVQGEDGKKLKTRAGDTVRLRELLDEAVERAESDLRRRLQEEGRDEDESFIEQVATTVGLAAVKYADLSQNRITNY
QFSFDRMLALQGNTAPYLLYAVVRIAGIARKGGDLDVTTAELQFSETQEWALVRELLKFDAVIAEVEEELLPNRLCTYLF
ELSQVFNRFYDQVPVLKAEQPSRSCRLALCRLTADTLKLGLSLLGIPTLERM
>Mature_612_residues
MQAHFASEFMLSLAHALESQLRAAIDRAFPEAAASARESGTGLDPQLAPASKPEFGDFQANAALPLAKPLKQPPRQIAAA
IVDQLMVDTAFTAICLTPEIAGPGFINLTVRPECLAAEVQARLADARLGVPLVEGDNDGQQPTPVVVDFSSPNIAKEMHV
GHLRSTIIGDSLARVLEFRGHPVLRLNHVGDWGTQFGMLITHLKQVAPEALETADAVDLGDLVVFYRQAKQRFDDDEAFQ
TTSREEVVKLQGGDPISLKAWSLLCDQSRREFQKIYDRLDVRLNERGESFYNAYLESVVEDLNVSGLLVSDDGAQCVFLE
GVTGKDGKPLPVIVQKSDGGFNYATTDLAAMRYRFAAPPQGDGARRVIYVTDAGQANHFAGVFQVAQRAGWIPDAGRLQH
VPFGLVQGEDGKKLKTRAGDTVRLRELLDEAVERAESDLRRRLQEEGRDEDESFIEQVATTVGLAAVKYADLSQNRITNY
QFSFDRMLALQGNTAPYLLYAVVRIAGIARKGGDLDVTTAELQFSETQEWALVRELLKFDAVIAEVEEELLPNRLCTYLF
ELSQVFNRFYDQVPVLKAEQPSRSCRLALCRLTADTLKLGLSLLGIPTLERM

Specific function: Unknown

COG id: COG0018

COG function: function code J; Arginyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15149476, Length=625, Percent_Identity=40.32, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI197100773, Length=578, Percent_Identity=32.6989619377163, Blast_Score=238, Evalue=1e-62,
Organism=Escherichia coli, GI1788184, Length=576, Percent_Identity=45.4861111111111, Blast_Score=480, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71985061, Length=622, Percent_Identity=38.9067524115756, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71985068, Length=588, Percent_Identity=39.6258503401361, Blast_Score=380, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17532153, Length=486, Percent_Identity=27.3662551440329, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320548, Length=535, Percent_Identity=32.1495327102804, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6321883, Length=495, Percent_Identity=30.9090909090909, Blast_Score=197, Evalue=5e-51,
Organism=Drosophila melanogaster, GI18859963, Length=626, Percent_Identity=41.0543130990415, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI28571570, Length=521, Percent_Identity=29.3666026871401, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: 789 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYR_PROMM (Q7V493)

Other databases:

- EMBL:   BX548175
- RefSeq:   NP_895895.1
- ProteinModelPortal:   Q7V493
- STRING:   Q7V493
- GeneID:   1728247
- GenomeReviews:   BX548175_GR
- KEGG:   pmt:PMT2070
- NMPDR:   fig|74547.1.peg.2062
- eggNOG:   COG0018
- HOGENOM:   HBG695395
- OMA:   HMGFGTM
- ProtClustDB:   PRK01611
- BioCyc:   PMAR74547:PMT2070-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00123
- InterPro:   IPR001412
- InterPro:   IPR001278
- InterPro:   IPR015945
- InterPro:   IPR005148
- InterPro:   IPR008909
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.30.1360.70
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11956
- PRINTS:   PR01038
- SMART:   SM00836
- TIGRFAMs:   TIGR00456

Pfam domain/function: PF03485 Arg_tRNA_synt_N; PF05746 DALR_1; PF00750 tRNA-synt_1d; SSF55190 Arg-tRNA-synth_Ic_N; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.19

Molecular weight: Translated: 67430; Mature: 67430

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAHFASEFMLSLAHALESQLRAAIDRAFPEAAASARESGTGLDPQLAPASKPEFGDFQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NAALPLAKPLKQPPRQIAAAIVDQLMVDTAFTAICLTPEIAGPGFINLTVRPECLAAEVQ
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEECCHHHHHHHH
ARLADARLGVPLVEGDNDGQQPTPVVVDFSSPNIAKEMHVGHLRSTIIGDSLARVLEFRG
HHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
HPVLRLNHVGDWGTQFGMLITHLKQVAPEALETADAVDLGDLVVFYRQAKQRFDDDEAFQ
CCEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHH
TTSREEVVKLQGGDPISLKAWSLLCDQSRREFQKIYDRLDVRLNERGESFYNAYLESVVE
CCCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHH
DLNVSGLLVSDDGAQCVFLEGVTGKDGKPLPVIVQKSDGGFNYATTDLAAMRYRFAAPPQ
HCCCCEEEEECCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
GDGARRVIYVTDAGQANHFAGVFQVAQRAGWIPDAGRLQHVPFGLVQGEDGKKLKTRAGD
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEECCCEEEEECCCCCCHHHCCCC
TVRLRELLDEAVERAESDLRRRLQEEGRDEDESFIEQVATTVGLAAVKYADLSQNRITNY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
QFSFDRMLALQGNTAPYLLYAVVRIAGIARKGGDLDVTTAELQFSETQEWALVRELLKFD
EECCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
AVIAEVEEELLPNRLCTYLFELSQVFNRFYDQVPVLKAEQPSRSCRLALCRLTADTLKLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHH
LSLLGIPTLERM
HHHHCCCHHCCC
>Mature Secondary Structure
MQAHFASEFMLSLAHALESQLRAAIDRAFPEAAASARESGTGLDPQLAPASKPEFGDFQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NAALPLAKPLKQPPRQIAAAIVDQLMVDTAFTAICLTPEIAGPGFINLTVRPECLAAEVQ
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEEEECCHHHHHHHH
ARLADARLGVPLVEGDNDGQQPTPVVVDFSSPNIAKEMHVGHLRSTIIGDSLARVLEFRG
HHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
HPVLRLNHVGDWGTQFGMLITHLKQVAPEALETADAVDLGDLVVFYRQAKQRFDDDEAFQ
CCEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHH
TTSREEVVKLQGGDPISLKAWSLLCDQSRREFQKIYDRLDVRLNERGESFYNAYLESVVE
CCCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHH
DLNVSGLLVSDDGAQCVFLEGVTGKDGKPLPVIVQKSDGGFNYATTDLAAMRYRFAAPPQ
HCCCCEEEEECCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
GDGARRVIYVTDAGQANHFAGVFQVAQRAGWIPDAGRLQHVPFGLVQGEDGKKLKTRAGD
CCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEECCCEEEEECCCCCCHHHCCCC
TVRLRELLDEAVERAESDLRRRLQEEGRDEDESFIEQVATTVGLAAVKYADLSQNRITNY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
QFSFDRMLALQGNTAPYLLYAVVRIAGIARKGGDLDVTTAELQFSETQEWALVRELLKFD
EECCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
AVIAEVEEELLPNRLCTYLFELSQVFNRFYDQVPVLKAEQPSRSCRLALCRLTADTLKLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHH
LSLLGIPTLERM
HHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642