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The map label for this gene is nadC [H]

Identifier: 33864337

GI number: 33864337

Start: 2180658

End: 2181548

Strand: Reverse

Name: nadC [H]

Synonym: PMT2073

Alternate gene names: 33864337

Gene position: 2181548-2180658 (Counterclockwise)

Preceding gene: 33864338

Following gene: 33864335

Centisome position: 90.49

GC content: 57.35

Gene sequence:

>891_bases
ATGTTTTCCATGTCAGTCTCTTCACCTTCGCTGACCCTGACTCCAGAACTGCGCAGCAGGCTTGAGAGCTGGTTGGCAGA
AGATCTCGGTCGCGGTGATCTCACCGCTCCTGCTTTGCGTGGTTGTCATGGTCGTGCGTGTTGGCGAGCGAAAGCCGATG
GTCTGTTTTGTGGAGGAGTGTTCGTTGAGCCATTGCTGCATGCGCTTGATCCAAAGGCCAGGGTGCAGCTTCTCGTCAGT
GAAGGGGCTTCAGTTTCAGTTGGCCAAGATTTACTGCGGCTTGAGGGGCAGGCCTCAGCGTTGGCGGCTGTTGAGCGAAC
AGCACTGAATTTGGCGATGCGATTGTCTGGCGTGGCAACCGCAACTGCCGCACTCGTGGATCAGTTGCGTGGGTCGTCTG
TGCGCTTGGCTGACACCCGTAAGACCACTCCTGGGCTACGTGTGTTGGAGAAGTACGCCGTTCGCTGTGGGGGGGGAGTG
AATCACCGTTGTGGTTTGGATGATGCCGCCATGCTGAAGGAGAACCATTTGGCTTGGGCTGGCAGCATGGCTGCAGCTGT
CGCCGCTGTTCGCACAAGCGCACCATGGCCAGCTCAAGTGATCGTTGAAGCTGAAACTGCCGACCAGGCTGCTGAGGCGA
TTCGGGCTGGAGCGAATGGTGTGCTGTTGGATGAATTTTCCCCTACTCAGTTGCAAGACTTGGTGCCGCGCTTGCGTCTA
TTGGCAGAGCAGAGAGCTGAAGGGCCTGTGGTTCTGGAGGCGTCTGGTGTGGACCCTGGCCAGTTGCATGCCTACGCGGC
AACAGGGATTGATTTGATCTCGACGAGTGCTCCAGTGACGCGCAGCCCCTGGCTTGATATCAGCATGCGATTTGAATCAA
CAGCGGTTTGA

Upstream 100 bases:

>100_bases
TAAGTGAAAATAGAAACGCACTAGTGTGAATCAATAGTGGCAAAACGCTTTTTTCTGCCTAGCCAATCACGCTTGGAAAG
ATTGTATTTTTGTTTGCAAG

Downstream 100 bases:

>100_bases
ATCAACGACGCCTGCCTAAGTGGTATCGAGGTTGTTCTATTTTAAGCCAATCTTGCTTGCTAACACAGCGACTGACTCAA
GCTCAGCCATTAAACCCATT

Product: nicotinate-nucleotide pyrophosphorylase:quinolinate phosphoriobsyl transferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MFSMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGVFVEPLLHALDPKARVQLLVS
EGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVATATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGV
NHRCGLDDAAMLKENHLAWAGSMAAAVAAVRTSAPWPAQVIVEAETADQAAEAIRAGANGVLLDEFSPTQLQDLVPRLRL
LAEQRAEGPVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTAV

Sequences:

>Translated_296_residues
MFSMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGVFVEPLLHALDPKARVQLLVS
EGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVATATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGV
NHRCGLDDAAMLKENHLAWAGSMAAAVAAVRTSAPWPAQVIVEAETADQAAEAIRAGANGVLLDEFSPTQLQDLVPRLRL
LAEQRAEGPVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTAV
>Mature_296_residues
MFSMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGVFVEPLLHALDPKARVQLLVS
EGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVATATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGV
NHRCGLDDAAMLKENHLAWAGSMAAAVAAVRTSAPWPAQVIVEAETADQAAEAIRAGANGVLLDEFSPTQLQDLVPRLRL
LAEQRAEGPVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTAV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=297, Percent_Identity=33.6700336700337, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1786299, Length=275, Percent_Identity=39.6363636363636, Blast_Score=156, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321162, Length=297, Percent_Identity=31.3131313131313, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31153; Mature: 31153

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGV
CCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHEEECCCCEEECHH
FVEPLLHALDPKARVQLLVSEGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVAT
HHHHHHHHHCCHHHEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGVNHRCGLDDAAMLKENHLAWA
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHH
GSMAAAVAAVRTSAPWPAQVIVEAETADQAAEAIRAGANGVLLDEFSPTQLQDLVPRLRL
HHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHH
LAEQRAEGPVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTAV
HHHHCCCCCEEEEECCCCCHHEEEEHHCCHHHCCCCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MFSMSVSSPSLTLTPELRSRLESWLAEDLGRGDLTAPALRGCHGRACWRAKADGLFCGGV
CCCCCCCCCCEEECHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHEEECCCCEEECHH
FVEPLLHALDPKARVQLLVSEGASVSVGQDLLRLEGQASALAAVERTALNLAMRLSGVAT
HHHHHHHHHCCHHHEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATAALVDQLRGSSVRLADTRKTTPGLRVLEKYAVRCGGGVNHRCGLDDAAMLKENHLAWA
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHH
GSMAAAVAAVRTSAPWPAQVIVEAETADQAAEAIRAGANGVLLDEFSPTQLQDLVPRLRL
HHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHH
LAEQRAEGPVVLEASGVDPGQLHAYAATGIDLISTSAPVTRSPWLDISMRFESTAV
HHHHCCCCCEEEEECCCCCHHEEEEHHCCHHHCCCCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]