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The map label for this gene is dprE1 [H]

Identifier: 33864300

GI number: 33864300

Start: 2147254

End: 2148684

Strand: Direct

Name: dprE1 [H]

Synonym: PMT2035

Alternate gene names: 33864300

Gene position: 2147254-2148684 (Clockwise)

Preceding gene: 33864299

Following gene: 33864301

Centisome position: 89.07

GC content: 54.23

Gene sequence:

>1431_bases
GTGGTGGGCACAGATCATGTGGTTCATTCGCTTGTTGCCTGCGCCCTTTGCTTCAAGGCTGTGACCTTGCCCCTCTCTTC
GCAAACACAAATCCTCAGCGGTTGGGGCCGCACAATGCCAGTGCAGGCAAAGGTTGTGCAGCCAGCCAGCGTCCAACAAG
TCCAGGAGCTAGTGCGTCAGGCAAGCCCGGCCTCACTGATCGCGAGAGGGCTAGGCCGCTCATACGGTGATGCGGCCCAA
CTGGATGGTGCCTCTGCGGTTGAGATGGGAGCCTTTGATCAAATCAACCTTGATCTTGTCAAAGGCTCTGTGACAGCCGG
CGCAGGGGTAAGTCTGAATCAGTTGCTGCGGGTAATCGTGCCGGCAGGCTTTTTTTTGCCCGTCACCCCTGGCACTCGTA
ACGTCACCATTGGCGGTGCCATTGCAGCAGATGTGCACGGCAAAAACCATCACGTTGATGGCAGCTTTGGCAATCATCTC
CAACGGCTGTTGCTTGTTGATGGCAGAGGCGAGCTGCGTGAGCTCACCCCCAGCGGGAAAAGCAGCGTGGATGAAATCGA
ACAGTTCTGGGCAACGGTGGGTGGGATGGGTCTCACCGGCATCATCGTGGAAGCCACCTTTTCACTCATCCCAATCAGCA
GCTCTTTGATCAGCGTCAATACCGCTCGATATCACAATCTCGATGAGCTGATGGCTGCGATGGTGGCGTCTGATAGCAAT
TACCGTTACAGCGTCGCCTGGATCGACAGCCTCAATGCAAAGGGCCGCGGAGTTCTCAGCTGCGGTGACCATGCCATGGC
CGAACAACTACCCACCAGCCAACAGGCGGATCCACTTGTTTACGACCCAAAGCCCTTGGCCTCAGCACCGACTTTTCTCC
CTGTAGGGCTACTCAACAAGCTCACCGTACGAGCCTTTAACGAAGCCTGGTTTCGCAAGGCACCCAAGCAGCGGCTAGGT
GAATTGCAGACAATCGGAGCCTATTTCCACCCTCTTGATGGTGTGCAGGACTGGAATCGTATCTATGGCCCGGCCGGTTT
TTTGCAGTATCAATTCGTTGTGCCAGACAACGCCTCACACTTAGTGCTCTACACGCTAGAAGCCTTGCGAAAAATTGGCA
CTTCGAGCTTTTTGACTGTGCTCAAGCGTTTTGGTCCTAGTAACCCAGGCCACTTGTCGTTTCCAATGCAGGGATGGACA
CTTGCAGTGGATCTTCCTGCAGCGGTACCGGGATTATTTGAGGTACTTGACCATCTAGATGAACACATAGCTGCTGAGAA
TGGCAGACTTTACCTAGCGAAAGATTCGCGCCAATCAGCCACAATCCTTCGCCGAACTTATCCACGACTGGAGGAGTGGC
AGCAAGCAAGAGAAAAACTTGACCCCAGCAAAGTCTTCTCTTCAGACATGGCTATTAGGACTGGACTTTAG

Upstream 100 bases:

>100_bases
CGATTGGCAAGGCACCAAAAGTTCTGTGCGTCAGTCCACAATCGGTGGCGCGTGATCTACTGAGACGCCCCAACCGTAGA
GGTATCGAATACCTCCCCTG

Downstream 100 bases:

>100_bases
ACCAATCATTCTCATCAATCTAGAGAACACTCCCTGACACTATCTGCATGTATATGACGCAATCATTCTGCGCCAACAAG
TCAATCCTTCTCTAGCGAAC

Product: FAD linked oxidase, N-terminal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MVGTDHVVHSLVACALCFKAVTLPLSSQTQILSGWGRTMPVQAKVVQPASVQQVQELVRQASPASLIARGLGRSYGDAAQ
LDGASAVEMGAFDQINLDLVKGSVTAGAGVSLNQLLRVIVPAGFFLPVTPGTRNVTIGGAIAADVHGKNHHVDGSFGNHL
QRLLLVDGRGELRELTPSGKSSVDEIEQFWATVGGMGLTGIIVEATFSLIPISSSLISVNTARYHNLDELMAAMVASDSN
YRYSVAWIDSLNAKGRGVLSCGDHAMAEQLPTSQQADPLVYDPKPLASAPTFLPVGLLNKLTVRAFNEAWFRKAPKQRLG
ELQTIGAYFHPLDGVQDWNRIYGPAGFLQYQFVVPDNASHLVLYTLEALRKIGTSSFLTVLKRFGPSNPGHLSFPMQGWT
LAVDLPAAVPGLFEVLDHLDEHIAAENGRLYLAKDSRQSATILRRTYPRLEEWQQAREKLDPSKVFSSDMAIRTGL

Sequences:

>Translated_476_residues
MVGTDHVVHSLVACALCFKAVTLPLSSQTQILSGWGRTMPVQAKVVQPASVQQVQELVRQASPASLIARGLGRSYGDAAQ
LDGASAVEMGAFDQINLDLVKGSVTAGAGVSLNQLLRVIVPAGFFLPVTPGTRNVTIGGAIAADVHGKNHHVDGSFGNHL
QRLLLVDGRGELRELTPSGKSSVDEIEQFWATVGGMGLTGIIVEATFSLIPISSSLISVNTARYHNLDELMAAMVASDSN
YRYSVAWIDSLNAKGRGVLSCGDHAMAEQLPTSQQADPLVYDPKPLASAPTFLPVGLLNKLTVRAFNEAWFRKAPKQRLG
ELQTIGAYFHPLDGVQDWNRIYGPAGFLQYQFVVPDNASHLVLYTLEALRKIGTSSFLTVLKRFGPSNPGHLSFPMQGWT
LAVDLPAAVPGLFEVLDHLDEHIAAENGRLYLAKDSRQSATILRRTYPRLEEWQQAREKLDPSKVFSSDMAIRTGL
>Mature_476_residues
MVGTDHVVHSLVACALCFKAVTLPLSSQTQILSGWGRTMPVQAKVVQPASVQQVQELVRQASPASLIARGLGRSYGDAAQ
LDGASAVEMGAFDQINLDLVKGSVTAGAGVSLNQLLRVIVPAGFFLPVTPGTRNVTIGGAIAADVHGKNHHVDGSFGNHL
QRLLLVDGRGELRELTPSGKSSVDEIEQFWATVGGMGLTGIIVEATFSLIPISSSLISVNTARYHNLDELMAAMVASDSN
YRYSVAWIDSLNAKGRGVLSCGDHAMAEQLPTSQQADPLVYDPKPLASAPTFLPVGLLNKLTVRAFNEAWFRKAPKQRLG
ELQTIGAYFHPLDGVQDWNRIYGPAGFLQYQFVVPDNASHLVLYTLEALRKIGTSSFLTVLKRFGPSNPGHLSFPMQGWT
LAVDLPAAVPGLFEVLDHLDEHIAAENGRLYLAKDSRQSATILRRTYPRLEEWQQAREKLDPSKVFSSDMAIRTGL

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 51456; Mature: 51456

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGTDHVVHSLVACALCFKAVTLPLSSQTQILSGWGRTMPVQAKVVQPASVQQVQELVRQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHC
ASPASLIARGLGRSYGDAAQLDGASAVEMGAFDQINLDLVKGSVTAGAGVSLNQLLRVIV
CCCHHHHHHHHCCCCCCHHHCCCCCCEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
PAGFFLPVTPGTRNVTIGGAIAADVHGKNHHVDGSFGNHLQRLLLVDGRGELRELTPSGK
CCCCEEECCCCCCEEEECCEEEEECCCCCCCCCCCHHHHHHHHEEECCCCHHHHCCCCCC
SSVDEIEQFWATVGGMGLTGIIVEATFSLIPISSSLISVNTARYHNLDELMAAMVASDSN
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCEEECHHHHCCHHHHHHHHHHCCCC
YRYSVAWIDSLNAKGRGVLSCGDHAMAEQLPTSQQADPLVYDPKPLASAPTFLPVGLLNK
CEEEEEEEECCCCCCCEEEECCCHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHH
LTVRAFNEAWFRKAPKQRLGELQTIGAYFHPLDGVQDWNRIYGPAGFLQYQFVVPDNASH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCCCCE
LVLYTLEALRKIGTSSFLTVLKRFGPSNPGHLSFPMQGWTLAVDLPAAVPGLFEVLDHLD
EHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCHHCHHHHHHHHHHH
EHIAAENGRLYLAKDSRQSATILRRTYPRLEEWQQAREKLDPSKVFSSDMAIRTGL
HHHHCCCCEEEEEECCCCHHHHHHHHCHHHHHHHHHHHCCCHHHHHHCCCHHCCCC
>Mature Secondary Structure
MVGTDHVVHSLVACALCFKAVTLPLSSQTQILSGWGRTMPVQAKVVQPASVQQVQELVRQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHC
ASPASLIARGLGRSYGDAAQLDGASAVEMGAFDQINLDLVKGSVTAGAGVSLNQLLRVIV
CCCHHHHHHHHCCCCCCHHHCCCCCCEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
PAGFFLPVTPGTRNVTIGGAIAADVHGKNHHVDGSFGNHLQRLLLVDGRGELRELTPSGK
CCCCEEECCCCCCEEEECCEEEEECCCCCCCCCCCHHHHHHHHEEECCCCHHHHCCCCCC
SSVDEIEQFWATVGGMGLTGIIVEATFSLIPISSSLISVNTARYHNLDELMAAMVASDSN
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCEEECHHHHCCHHHHHHHHHHCCCC
YRYSVAWIDSLNAKGRGVLSCGDHAMAEQLPTSQQADPLVYDPKPLASAPTFLPVGLLNK
CEEEEEEEECCCCCCCEEEECCCHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHHHHH
LTVRAFNEAWFRKAPKQRLGELQTIGAYFHPLDGVQDWNRIYGPAGFLQYQFVVPDNASH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEEECCCCCE
LVLYTLEALRKIGTSSFLTVLKRFGPSNPGHLSFPMQGWTLAVDLPAAVPGLFEVLDHLD
EHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCHHCHHHHHHHHHHH
EHIAAENGRLYLAKDSRQSATILRRTYPRLEEWQQAREKLDPSKVFSSDMAIRTGL
HHHHCCCCEEEEEECCCCHHHHHHHHCHHHHHHHHHHHCCCHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]