Click here to switch to the map view.

The map label for this gene is hisB [H]

Identifier: 33864146

GI number: 33864146

Start: 1985751

End: 1986380

Strand: Reverse

Name: hisB [H]

Synonym: PMT1880

Alternate gene names: 33864146

Gene position: 1986380-1985751 (Counterclockwise)

Preceding gene: 33864147

Following gene: 33864145

Centisome position: 82.39

GC content: 55.87

Gene sequence:

>630_bases
ATGGGCATCATGACGTCGCTAAGACAGGGGGATGTTCATCGCGTCACCGCTGAAACCGACGTGCTTGTTCGTGTTGGGCT
TGATGGCTGTGGTCAGTGCAACGTTTCTACGGGGGTCGCCTTCCTCGATCACATGCTTCACCAGCTTTCCAGCCATGGCC
TGCTGGATTTAGAGATCACCGCGACTGGTGACACCCACATCGATGACCATCACACCAATGAGGATGTGGGTATTGCTGTT
GGTCAGGCCCTATCTCAGGCACTTGGAGATCGACGTGGCATCCACCGCTTCGGTCATTTTGTGGCACCACTTGATGAGGC
GTTGGTTCAGGTCGTTCTGGATTGCTCCGGTAGGCCTCATCTCAGTTATGGCCTGCAAATTCCCGCTGAGCGCATTGGTA
GCTACGACAGCGAGTTGGTGAAGGAGTTCTTCGTGGCAGTTGTGAACAACAGCGGCCTGACCCTGCATATTCGCCAGTTG
GCAGGCACCAATTCCCACCACATCGTTGAAGCCTGTTTCAAGGCCTTTGCCAGAGCTTTGCGCATGGCAATTGAAATCGA
CCCGCGAAGGGCCGGTGCAGTACCTAGCAGCAAGGGTGTGCTGGAGCAGGCTGGCGGGCAGAAGAGCTGA

Upstream 100 bases:

>100_bases
GAGCGATCTTTCCAGTGGTATCTCCGGTCAGACGCTTTATGTGGATGCTGGTTACTGCATTAACGGAATGTGATTTGACT
GGCAGCATGACTTCATTTGG

Downstream 100 bases:

>100_bases
ATGCTTGGGGAGTGGGGATTTCCTCGCTCGCGGCTGTAAGCCCTTTTGCGTAAGGATTAGTCAATCTTGATCAGCCTTGC
AGTGAGCACAGTGAGCGATA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEITATGDTHIDDHHTNEDVGIAV
GQALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPHLSYGLQIPAERIGSYDSELVKEFFVAVVNNSGLTLHIRQL
AGTNSHHIVEACFKAFARALRMAIEIDPRRAGAVPSSKGVLEQAGGQKS

Sequences:

>Translated_209_residues
MGIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEITATGDTHIDDHHTNEDVGIAV
GQALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPHLSYGLQIPAERIGSYDSELVKEFFVAVVNNSGLTLHIRQL
AGTNSHHIVEACFKAFARALRMAIEIDPRRAGAVPSSKGVLEQAGGQKS
>Mature_208_residues
GIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEITATGDTHIDDHHTNEDVGIAVG
QALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPHLSYGLQIPAERIGSYDSELVKEFFVAVVNNSGLTLHIRQLA
GTNSHHIVEACFKAFARALRMAIEIDPRRAGAVPSSKGVLEQAGGQKS

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=48.9690721649485, Blast_Score=184, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=168, Percent_Identity=47.6190476190476, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22431; Mature: 22300

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEIT
CCCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
ATGDTHIDDHHTNEDVGIAVGQALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPH
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
LSYGLQIPAERIGSYDSELVKEFFVAVVNNSGLTLHIRQLAGTNSHHIVEACFKAFARAL
CEECCCCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHH
RMAIEIDPRRAGAVPSSKGVLEQAGGQKS
HHHHEECCHHCCCCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
GIMTSLRQGDVHRVTAETDVLVRVGLDGCGQCNVSTGVAFLDHMLHQLSSHGLLDLEIT
CCCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
ATGDTHIDDHHTNEDVGIAVGQALSQALGDRRGIHRFGHFVAPLDEALVQVVLDCSGRPH
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
LSYGLQIPAERIGSYDSELVKEFFVAVVNNSGLTLHIRQLAGTNSHHIVEACFKAFARAL
CEECCCCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHH
RMAIEIDPRRAGAVPSSKGVLEQAGGQKS
HHHHEECCHHCCCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA