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The map label for this gene is mutS [H]

Identifier: 33863813

GI number: 33863813

Start: 1636739

End: 1639225

Strand: Reverse

Name: mutS [H]

Synonym: PMT1546

Alternate gene names: 33863813

Gene position: 1639225-1636739 (Counterclockwise)

Preceding gene: 33863814

Following gene: 33863811

Centisome position: 67.99

GC content: 58.14

Gene sequence:

>2487_bases
ATGCAGCCGCTTGGTTACGGCAGGGATGATTGGCTGCTTTCAAGTTCAGTGGGGCGCAACAGCGTTGAAATGAGCGCTGT
AGTCATGAGCTCTGAGGTCTCGACTGCTTCCCTTGCCTTTCAGGACACACTCAAGCAGCTTGAATGGCCACGCTTATGTG
AACACCTCGCTGGATTTGCCAGCACCTTGCAGGGCCGGCGTCATTGCCAGACTTTGTCGCTTCCTGCCGATTTGTCTGCT
AGCCGTTTGCGCTTGGCAGAAACTCTTGAGATCGGTGCTTTGGATGGTCTGATTGATGGAGGCCTCAGCTTTCAGGGTGT
CCATGACCTTGGCCATATCCTGGCTCGCTGTTCAAAAGGTGGTGTGGCTTCTGGGGAAGAGCTTTTAGCTGTTGCCGACA
CCCTTGCAGCAGCGCGCCGCTTGCGCCGCCAGATTAATGATCCAGAGCTTCGTCCCACGATCTCGTCACTGTTGCTGGAT
GTCGCAACGATGCCCGAGCTGGAACGGCGACTCAAATTTGCATTGGAAGAGGGTGGTCGGGTGGCTGATCGCGTCAGCTC
CAAGCTCGCTGGCTTGCGACGACAGTGGCAAGGTTTGCGTCAGGAACGTCGTGATTGCCTACAGGAGGTGGTCAGGCGTC
ATGCGGCCATGCTGCAGGACACTGTGATCGCAGATCGCCATGGCCGGCCAGTGCTAGCGGTGAAAGCCGCCGCAGTGTCT
CAACTCCCCGGCCTGGTCCACGACAGCTCAGCATCTGGCAGCACAGTCTTTGTTGAGCCTCAGGTTGTGATCACCCTGAG
TAATCGTCTTGCTGAATTGGATGGTCGTATCCGAGAGCAGCAGCAGCTCGTCTTGGCGGAGTTGAGTGCGGCGGTGGCTG
AGGCCGGCGTATCGATCGGGCGCCTGGCAGAGGTTCTGCTTCAACTCGACTTGGCTCTGGCTCGTGGCCGTTATGGTCAA
TGGCTTGGTGGGGTCCCCCCTACGTTGCATGCCGAGGCTGCAGCTCCTTTTAGCCTTCAGGAGCTGCGACATCCCTTGCT
GGTTTGGCAGCATCGCCGTGACCATGGGGAAGCTGTGGTGCCGATCAGCGTTGAGGTCTCCTCCACCCTGAAAGTGGTCG
CGATTACAGGACCCAACACCGGTGGAAAGACTGTCACGCTTAAGAGTGTTGGCCTGGCCTTGCTGATGGCTCGGGCGGGT
CTCTTGTTGCCTTGCACAGGGAGTCCATCAATGCCTTGGTGTGCTCAGGTGCTTGCTGATATCGGTGATGAACAGTCACT
ACAACAGAATCTCTCCACCTTTAGTGGCCATGTGAAGCGCATTGGCTGCATTCTTGAAGCCTTGAACGAGGGGCCTGGTC
CAGCTTTGGTGCTTCTTGATGAGGTCGGGGCGGGTACTGATCCCAGTGAAGGGACGGCCCTGGCCACAGCCCTGCTGCGC
ACGCTTGCCGACCGGGCTCGCCTGACCATCGCGACAACTCATTTCGGCAAACTCAAGGCACTCAAATATGGCGATTCTCG
CTTTGAAAACGCTTCTGTGGCCTTTGATGGCGAGACGATGTTGCCCACCTATCGACTGCAATGGGGAATCCCTGGTCGCA
GTAATGCCCTCAGTATCGCGATGCGGCTTGGCCTAGACGGCGCAGTGATTGCTCATGCCCAAGAGCTGCTGGGACCTTGT
GGTGATGGAGAGGTGAATGAAGTGATCCGTGGTCTTGAAGAGCAACGCAGCCTTCAACAGGCAGCTGCTGAAGATGCCGC
GGCTCTGCTGGCACGCACGGAATTGCTGCATGAGGAACTTCTCAGTCGCTGGCAGAAGCAGCGCAAGCAGTCTGCAGCTT
TGCAGGAACAAGGTCGCCAGAAGCTGGAGAGCTCCATTCGAGAGGGGCAGAAGGAAGTCCGTCAGTTGATTCGCCGGTTG
CGCGAGGGTCGTGCCGATGGTGAGTCCGCACGACGTGCAGGTCAGCGCTTGCGTCGCATTCAGGCTGACCATCGGATTCA
GCCTCAACGCAAACAGCACATGGGCTGGCGTCCTGAGGTGGGAGAGCGCATTCGGCTGTTGGCCCTTGGCAAGGCGGCAG
AAGTGATTGCTATCTCTGAAGATGGCAAACAACTCACGGTGCGTTGTGGAGTCATGCGCAGCACTGTGGAGCTGTCAGGG
GTGGAAAGCCTTGATGGCCTGAAGCCAAGTCCTCCAGAGTTGGTGGTGAAGGTGAAGGTCCGTTCAGGTCTGGGCCGTGG
CGCGGAGGTACGCACGACCCGCAACACCGTGGATGTTCGCGGACTGCGTGTGCATGAAGCCGAGGTTGCCGTTGAGGAGC
ACTTGCGCAGTAGCACTGGTCCGATATGGGTCATTCATGGCATCGGCAGCGGCAAACTCAAGCGGGGGCTACGCCAGTGG
CTTGAGACCGTTCCTTATGTGGAACGCGTCCACGATGCGGATCAGGGTGATGGTGGAGCCGGTTGCAGTGTGATTTGGCT
GCATTAG

Upstream 100 bases:

>100_bases
GCGGAAAGGGGTTGGCTTGATGAGCGGGCGGTGGTTCTAGAAACCTTGTTGAGTTTCAAGCGAGCTGGTGCCGATTTGAT
CCTCACCTACCACGCTTGTG

Downstream 100 bases:

>100_bases
CCCAGAATGGGCAAGTGGAGTTTGCGGTCGTTTGGGTCTTGTTCAGTGTTGTCTTGAACTGTCATTGCGATGGCTTCCCC
GTCGGCACCAAACAGTCGCC

Product: DNA mismatch repair protein MutS family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 828; Mature: 828

Protein sequence:

>828_residues
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFASTLQGRRHCQTLSLPADLSA
SRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCSKGGVASGEELLAVADTLAAARRLRRQINDPELRPTISSLLLD
VATMPELERRLKFALEEGGRVADRVSSKLAGLRRQWQGLRQERRDCLQEVVRRHAAMLQDTVIADRHGRPVLAVKAAAVS
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGRIREQQQLVLAELSAAVAEAGVSIGRLAEVLLQLDLALARGRYGQ
WLGGVPPTLHAEAAAPFSLQELRHPLLVWQHRRDHGEAVVPISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAG
LLLPCTGSPSMPWCAQVLADIGDEQSLQQNLSTFSGHVKRIGCILEALNEGPGPALVLLDEVGAGTDPSEGTALATALLR
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDGETMLPTYRLQWGIPGRSNALSIAMRLGLDGAVIAHAQELLGPC
GDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEELLSRWQKQRKQSAALQEQGRQKLESSIREGQKEVRQLIRRL
REGRADGESARRAGQRLRRIQADHRIQPQRKQHMGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
VESLDGLKPSPPELVVKVKVRSGLGRGAEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTGPIWVIHGIGSGKLKRGLRQW
LETVPYVERVHDADQGDGGAGCSVIWLH

Sequences:

>Translated_828_residues
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFASTLQGRRHCQTLSLPADLSA
SRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCSKGGVASGEELLAVADTLAAARRLRRQINDPELRPTISSLLLD
VATMPELERRLKFALEEGGRVADRVSSKLAGLRRQWQGLRQERRDCLQEVVRRHAAMLQDTVIADRHGRPVLAVKAAAVS
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGRIREQQQLVLAELSAAVAEAGVSIGRLAEVLLQLDLALARGRYGQ
WLGGVPPTLHAEAAAPFSLQELRHPLLVWQHRRDHGEAVVPISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAG
LLLPCTGSPSMPWCAQVLADIGDEQSLQQNLSTFSGHVKRIGCILEALNEGPGPALVLLDEVGAGTDPSEGTALATALLR
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDGETMLPTYRLQWGIPGRSNALSIAMRLGLDGAVIAHAQELLGPC
GDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEELLSRWQKQRKQSAALQEQGRQKLESSIREGQKEVRQLIRRL
REGRADGESARRAGQRLRRIQADHRIQPQRKQHMGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
VESLDGLKPSPPELVVKVKVRSGLGRGAEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTGPIWVIHGIGSGKLKRGLRQW
LETVPYVERVHDADQGDGGAGCSVIWLH
>Mature_828_residues
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFASTLQGRRHCQTLSLPADLSA
SRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCSKGGVASGEELLAVADTLAAARRLRRQINDPELRPTISSLLLD
VATMPELERRLKFALEEGGRVADRVSSKLAGLRRQWQGLRQERRDCLQEVVRRHAAMLQDTVIADRHGRPVLAVKAAAVS
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGRIREQQQLVLAELSAAVAEAGVSIGRLAEVLLQLDLALARGRYGQ
WLGGVPPTLHAEAAAPFSLQELRHPLLVWQHRRDHGEAVVPISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAG
LLLPCTGSPSMPWCAQVLADIGDEQSLQQNLSTFSGHVKRIGCILEALNEGPGPALVLLDEVGAGTDPSEGTALATALLR
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDGETMLPTYRLQWGIPGRSNALSIAMRLGLDGAVIAHAQELLGPC
GDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEELLSRWQKQRKQSAALQEQGRQKLESSIREGQKEVRQLIRRL
REGRADGESARRAGQRLRRIQADHRIQPQRKQHMGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
VESLDGLKPSPPELVVKVKVRSGLGRGAEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTGPIWVIHGIGSGKLKRGLRQW
LETVPYVERVHDADQGDGGAGCSVIWLH

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=405, Percent_Identity=24.9382716049383, Blast_Score=90, Evalue=9e-18,
Organism=Homo sapiens, GI26638666, Length=337, Percent_Identity=26.7062314540059, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI4505253, Length=337, Percent_Identity=26.7062314540059, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI26638664, Length=337, Percent_Identity=26.7062314540059, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI262231786, Length=212, Percent_Identity=30.188679245283, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4557761, Length=205, Percent_Identity=29.2682926829268, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4504191, Length=211, Percent_Identity=27.9620853080569, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1789089, Length=261, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508445, Length=304, Percent_Identity=25.3289473684211, Blast_Score=87, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17534743, Length=292, Percent_Identity=22.6027397260274, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539736, Length=379, Percent_Identity=23.7467018469657, Blast_Score=70, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17508447, Length=242, Percent_Identity=25.6198347107438, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321912, Length=196, Percent_Identity=26.530612244898, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319935, Length=205, Percent_Identity=29.2682926829268, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=425, Percent_Identity=22.3529411764706, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584320, Length=306, Percent_Identity=26.1437908496732, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24664545, Length=267, Percent_Identity=27.3408239700375, Blast_Score=79, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 89776; Mature: 89776

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFA
CCCCCCCCCCCEEECCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
STLQGRRHCQTLSLPADLSASRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCSKG
HHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHCCC
GVASGEELLAVADTLAAARRLRRQINDPELRPTISSLLLDVATMPELERRLKFALEEGGR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
VADRVSSKLAGLRRQWQGLRQERRDCLQEVVRRHAAMLQDTVIADRHGRPVLAVKAAAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHH
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGRIREQQQLVLAELSAAVAEAGVSIG
HCCCCEECCCCCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RLAEVLLQLDLALARGRYGQWLGGVPPTLHAEAAAPFSLQELRHPLLVWQHRRDHGEAVV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHCCCCCCEEE
PISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAGLLLPCTGSPSMPWCAQVLAD
EEEEEECCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHH
IGDEQSLQQNLSTFSGHVKRIGCILEALNEGPGPALVLLDEVGAGTDPSEGTALATALLR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDGETMLPTYRLQWGIPGRSNALSIA
HHHHHCEEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCHHHHH
MRLGLDGAVIAHAQELLGPCGDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEEL
HHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRWQKQRKQSAALQEQGRQKLESSIREGQKEVRQLIRRLREGRADGESARRAGQRLRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QADHRIQPQRKQHMGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
HHHCCCCCHHHHCCCCCCCHHHHEEEEEECCCCEEEEECCCCCEEEEEEHHHHHHHHHCC
VESLDGLKPSPPELVVKVKVRSGLGRGAEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTG
CHHHCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCEEECCEEEHHHHHHHHHHHHCCCC
PIWVIHGIGSGKLKRGLRQWLETVPYVERVHDADQGDGGAGCSVIWLH
CEEEEECCCCHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MQPLGYGRDDWLLSSSVGRNSVEMSAVVMSSEVSTASLAFQDTLKQLEWPRLCEHLAGFA
CCCCCCCCCCCEEECCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHH
STLQGRRHCQTLSLPADLSASRLRLAETLEIGALDGLIDGGLSFQGVHDLGHILARCSKG
HHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHCCC
GVASGEELLAVADTLAAARRLRRQINDPELRPTISSLLLDVATMPELERRLKFALEEGGR
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
VADRVSSKLAGLRRQWQGLRQERRDCLQEVVRRHAAMLQDTVIADRHGRPVLAVKAAAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHH
QLPGLVHDSSASGSTVFVEPQVVITLSNRLAELDGRIREQQQLVLAELSAAVAEAGVSIG
HCCCCEECCCCCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RLAEVLLQLDLALARGRYGQWLGGVPPTLHAEAAAPFSLQELRHPLLVWQHRRDHGEAVV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHCCCCCCEEE
PISVEVSSTLKVVAITGPNTGGKTVTLKSVGLALLMARAGLLLPCTGSPSMPWCAQVLAD
EEEEEECCCEEEEEEECCCCCCCEEEHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHH
IGDEQSLQQNLSTFSGHVKRIGCILEALNEGPGPALVLLDEVGAGTDPSEGTALATALLR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHH
TLADRARLTIATTHFGKLKALKYGDSRFENASVAFDGETMLPTYRLQWGIPGRSNALSIA
HHHHHCEEEEEEECCCCEEEEECCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCHHHHH
MRLGLDGAVIAHAQELLGPCGDGEVNEVIRGLEEQRSLQQAAAEDAAALLARTELLHEEL
HHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSRWQKQRKQSAALQEQGRQKLESSIREGQKEVRQLIRRLREGRADGESARRAGQRLRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QADHRIQPQRKQHMGWRPEVGERIRLLALGKAAEVIAISEDGKQLTVRCGVMRSTVELSG
HHHCCCCCHHHHCCCCCCCHHHHEEEEEECCCCEEEEECCCCCEEEEEEHHHHHHHHHCC
VESLDGLKPSPPELVVKVKVRSGLGRGAEVRTTRNTVDVRGLRVHEAEVAVEEHLRSSTG
CHHHCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCEEECCEEEHHHHHHHHHHHHCCCC
PIWVIHGIGSGKLKRGLRQWLETVPYVERVHDADQGDGGAGCSVIWLH
CEEEEECCCCHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]