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The map label for this gene is T6C23.6 [H]

Identifier: 33863814

GI number: 33863814

Start: 1639197

End: 1640261

Strand: Reverse

Name: T6C23.6 [H]

Synonym: PMT1547

Alternate gene names: 33863814

Gene position: 1640261-1639197 (Counterclockwise)

Preceding gene: 33863815

Following gene: 33863813

Centisome position: 68.04

GC content: 55.02

Gene sequence:

>1065_bases
GTGGCTTCAGATGGCTCCACTCTGAGGCGAGACTTACGCTCACGAGATTGTTATGCGGTTTTGATGGATCTCACTTATCG
CCCTCGTCGGCTGCGTCGTACTCCTGCCCTGCGTTCCATGGTGCGGGAGCACAGCCTCACTGCTGCTGACTTTATCTATC
CCTTGTTTGTCCATGAGGGAGCTGGTGTTGAGCCGATCGGTGCCATGCCAGGAACCAATCGCTGGAGCCTCGATCGCTTA
ATGGCAGAAGTTCAACGGGCCTGGGGGCTGGGCATTCGTTGTGTGGTGCTTTTCCCGAAAGTTGCTGAGGGCCTCAAAAC
TGAAGATGGGGCGGAATGTTTCAATGAGCATGGGTTGATTCCGCGGGCCATCACGCAGCTCAAGCATGAGCTGCCGGAAA
TGACAGTGATGACCGATGTGGCTTTGGATCCCTATTCCTGTGATGGTCATGACGGCATCGTTAGCACCGAGGGTGTGGTG
CTTAACGACGAGACGATTGAACAACTCTGTCGTCAGGCGGTGGTTCAGGCTCGTGCTGGTGCTGACATGATTGGACCCAG
CGACATGATGGATGGCCGCGTCGGCGCCATCCGTGAAGCTCTTGACGACGAGGGTTTTGAGCATGTGGGGATCATCAGCT
ATACAGCGAAATACTCTTCGGCGTACTACGGCCCGTTTCGCGAGGCGCTTGATTCAGCCCCGCGCGTGGCTGGTGGCAAG
CCAATCCCTAAAGACAAGAGTACTTATCAAATGGATCCAGCCAATGCTCGTGAGGCCATTACTGAGGCTCAACTCGATGA
GCAGGAAGGTGCAGACATTCTCATGGTGAAGCCTGGCCTGGCCTATCTCGACATCATTCATCGTTTAAGCGAAGAATCGG
AGTTACCCATCGCTGCTTACAACGTGAGTGGCGAGTATTCGATGGTGAAGGCTGCTGCGGAAAGGGGTTGGCTTGATGAG
CGGGCGGTGGTTCTAGAAACCTTGTTGAGTTTCAAGCGAGCTGGTGCCGATTTGATCCTCACCTACCACGCTTGTGATGC
AGCCGCTTGGTTACGGCAGGGATGA

Upstream 100 bases:

>100_bases
TCTTGACCCTCAACCTGAAGTTACCGTCTGAATGGTCTGCCGATGAGCTGGAGTTGTTGAAACGGTTGCAGCAGTCTCGC
AGTACTGACCCCCGCCAGGC

Downstream 100 bases:

>100_bases
TTGGCTGCTTTCAAGTTCAGTGGGGCGCAACAGCGTTGAAATGAGCGCTGTAGTCATGAGCTCTGAGGTCTCGACTGCTT
CCCTTGCCTTTCAGGACACA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MASDGSTLRRDLRSRDCYAVLMDLTYRPRRLRRTPALRSMVREHSLTAADFIYPLFVHEGAGVEPIGAMPGTNRWSLDRL
MAEVQRAWGLGIRCVVLFPKVAEGLKTEDGAECFNEHGLIPRAITQLKHELPEMTVMTDVALDPYSCDGHDGIVSTEGVV
LNDETIEQLCRQAVVQARAGADMIGPSDMMDGRVGAIREALDDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRVAGGK
PIPKDKSTYQMDPANAREAITEAQLDEQEGADILMVKPGLAYLDIIHRLSEESELPIAAYNVSGEYSMVKAAAERGWLDE
RAVVLETLLSFKRAGADLILTYHACDAAAWLRQG

Sequences:

>Translated_354_residues
MASDGSTLRRDLRSRDCYAVLMDLTYRPRRLRRTPALRSMVREHSLTAADFIYPLFVHEGAGVEPIGAMPGTNRWSLDRL
MAEVQRAWGLGIRCVVLFPKVAEGLKTEDGAECFNEHGLIPRAITQLKHELPEMTVMTDVALDPYSCDGHDGIVSTEGVV
LNDETIEQLCRQAVVQARAGADMIGPSDMMDGRVGAIREALDDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRVAGGK
PIPKDKSTYQMDPANAREAITEAQLDEQEGADILMVKPGLAYLDIIHRLSEESELPIAAYNVSGEYSMVKAAAERGWLDE
RAVVLETLLSFKRAGADLILTYHACDAAAWLRQG
>Mature_353_residues
ASDGSTLRRDLRSRDCYAVLMDLTYRPRRLRRTPALRSMVREHSLTAADFIYPLFVHEGAGVEPIGAMPGTNRWSLDRLM
AEVQRAWGLGIRCVVLFPKVAEGLKTEDGAECFNEHGLIPRAITQLKHELPEMTVMTDVALDPYSCDGHDGIVSTEGVVL
NDETIEQLCRQAVVQARAGADMIGPSDMMDGRVGAIREALDDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRVAGGKP
IPKDKSTYQMDPANAREAITEAQLDEQEGADILMVKPGLAYLDIIHRLSEESELPIAAYNVSGEYSMVKAAAERGWLDER
AVVLETLLSFKRAGADLILTYHACDAAAWLRQG

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=312, Percent_Identity=38.4615384615385, Blast_Score=221, Evalue=7e-58,
Organism=Escherichia coli, GI87081728, Length=332, Percent_Identity=48.1927710843374, Blast_Score=275, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321398, Length=323, Percent_Identity=36.2229102167183, Blast_Score=190, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21358291, Length=298, Percent_Identity=37.9194630872483, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 38993; Mature: 38862

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDGSTLRRDLRSRDCYAVLMDLTYRPRRLRRTPALRSMVREHSLTAADFIYPLFVHEG
CCCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHEECC
AGVEPIGAMPGTNRWSLDRLMAEVQRAWGLGIRCVVLFPKVAEGLKTEDGAECFNEHGLI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCHHHHHHHCCCC
PRAITQLKHELPEMTVMTDVALDPYSCDGHDGIVSTEGVVLNDETIEQLCRQAVVQARAG
HHHHHHHHHHCCCCEEHHHCCCCCCCCCCCCCEEECCCEEECHHHHHHHHHHHHHHHHCC
ADMIGPSDMMDGRVGAIREALDDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRVAGGK
CCCCCCHHHCCCHHHHHHHHHCCCCCCEEEEEEEHHHHCCCCCCHHHHHHHCCCCCCCCC
PIPKDKSTYQMDPANAREAITEAQLDEQEGADILMVKPGLAYLDIIHRLSEESELPIAAY
CCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEEEE
NVSGEYSMVKAAAERGWLDERAVVLETLLSFKRAGADLILTYHACDAAAWLRQG
ECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCC
>Mature Secondary Structure 
ASDGSTLRRDLRSRDCYAVLMDLTYRPRRLRRTPALRSMVREHSLTAADFIYPLFVHEG
CCCHHHHHHHHHCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCHHHHHHHHHHEECC
AGVEPIGAMPGTNRWSLDRLMAEVQRAWGLGIRCVVLFPKVAEGLKTEDGAECFNEHGLI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCHHHHHHHCCCC
PRAITQLKHELPEMTVMTDVALDPYSCDGHDGIVSTEGVVLNDETIEQLCRQAVVQARAG
HHHHHHHHHHCCCCEEHHHCCCCCCCCCCCCCEEECCCEEECHHHHHHHHHHHHHHHHCC
ADMIGPSDMMDGRVGAIREALDDEGFEHVGIISYTAKYSSAYYGPFREALDSAPRVAGGK
CCCCCCHHHCCCHHHHHHHHHCCCCCCEEEEEEEHHHHCCCCCCHHHHHHHCCCCCCCCC
PIPKDKSTYQMDPANAREAITEAQLDEQEGADILMVKPGLAYLDIIHRLSEESELPIAAY
CCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCEEEE
NVSGEYSMVKAAAERGWLDERAVVLETLLSFKRAGADLILTYHACDAAAWLRQG
ECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]