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The map label for this gene is glmS

Identifier: 32266353

GI number: 32266353

Start: 832635

End: 834488

Strand: Direct

Name: glmS

Synonym: HH0854

Alternate gene names: 32266353

Gene position: 832635-834488 (Clockwise)

Preceding gene: 32266348

Following gene: 32266356

Centisome position: 46.28

GC content: 39.37

Gene sequence:

>1854_bases
GTGAATAATTTTATAGTAAAATACCCAAAAATTACATTAATTCTAAAAGGAGAGGCAATGTGCGGTATTGTAGGCTATAT
TGGTCGAGATGAAAAAAAAGAGATTCTTTTAAATGGCTTAAAGGAGCTAGAATATCGTGGTTACGATAGTGCAGGAATTG
CGGTATTAAGCGAAAATGAATTGCAAACTTTTCGCTCTGTTGGAAAATTAAGCAATTTAGAATCTAAATGCAAAAATTTT
AGCTCCACAGATTTTGGCGTGAGTATCGGGCATACGCGTTGGGCTACGCACGGCAAACCTACCGAAGCAAATGCCCACCC
TCATATCGCCGCTTTTAGCAATGTTGTGCATAATGGCATTATTGAAAATTATCAAGAAATTAAACACGCTTTGGAACAAA
AAGGACATACTTTTCTCTCGCAAACTGATACCGAAGTGATTGTGCATTTATTTGAGGAATATACACAAACTTTTACAGAT
TCTCTCCAAGCCTTTAAAGCGACTATTGCTGAGCTCAAAGGTGCTTTTGCCATTTTGCTTATTACCAAAAAAGCACCCGA
TTGTATCTTTTATGCCAAAAATGGCTCACCGCTTATCATTGGCAAAAGCGCGACAAAGCAAGATGAAATTTATTTTGCAA
GCTCTGATGCGCCACTCATAGGACTTGTAGAGAGTGTAGTATATTTGCAAGATGGCGATATAGGCGTGATGAAACTTGGC
GCATTTGACACGCTCAAAGGTGCAAAAAAACTAAATAGCACCAAAGGCTACGCACAAAAAGAAGGGTATCGCTACTTTAT
GGAGAAAGAAATCTATGAGCAACACAAAGTTCTCCTTGAAACTATGATGGGACGCGTGAGTGAGGGAGATATTATCCTCA
ATGAAATAGAATCTCACTTTTTTAATGATATACAAAGTATTAGCATTTGTGCGTGTGGGACAAGCTATCACGCGGGATTA
AGCGCAAAATACCTCTTTGAACGTTTGGCAAAAATAAAAACAAATGTGCTCATTGCAAGCGAATTTCGCTATTCTCAACC
TGTGATGAATAAAAATGAGCTTTTTATTGTCATCTCCCAAAGTGGTGAAACTGCCGATACACTTGAAGCCCTCAAGCTTG
CAAAAAAAAATGGCTTAAAAAGCCTCGCTATTTGCAATGTAGATAATAGCTCTATTGTGCGTGAAGCCGATGTCTCGCTC
CTCACTCGTGCAGGAATTGAAAAAGGCGTGGCAAGCACAAAAGCATTTGCAACGCAAATGATGTTGCTGTGGATTCTAAG
CGTGTATATAGGCAAAATACGCGGACATATCGCACAAAAAGAGCTAGAAACTCATATCGCACAAATGGTAGCTTCGGCAA
AAAAAACTTATATAGAATCCGATATGCACGAACACATTAAACGTCTATCAAAGCGATATTTACACGGACACGGATTTTTC
TTTATCGGGCGAGATGTGTTTTATCCTCTCGCACTTGAGGGTGCGCTTAAGCTCAAAGAGATTAGCTATCTTCACGCTGA
AGGCTACCCAAGCGGAGAAATGAAGCACGGACCTATTGCACTAGCAGATTCTGAGCTTTTTACCCTTGCTCTTATGCCTA
CACATTTACTTTTTGATAAAATTAAAAGCAATGTAGAAGAGCTAAGTGCGCGTGATGCAACTATTTGTGCAGTAAGTGCG
CAACCCATTAAAGGCGTTGATGATATGATTCTTATCTCACCTTGCCAAAGCTATATGGAGGAGTTTTTTGCGATGATGGT
AGTGCTTCAACTTTTTGCACTTGAAGTAGCAATCAGATTAGGAAATGATGTAGATATGCCACGTAATCTCGCCAAAAGTG
TTACGGTTGAATAA

Upstream 100 bases:

>100_bases
GCACTGCTTAATCCCACAGATAAATATAGCATACACCATTTATTCATAATTATTTCCCTCCTCTAAATATGGATAGATTC
TCTAAATCGTGTGATAAAGC

Downstream 100 bases:

>100_bases
TTGCCTTATTATCCTTAATCTCTAGCACTTTAACCTTATCTCCCTCTTGCAAGTTATAAGAAGGCTGCTGGCTATTCTCT
TTGCTCTCTTGCTCATACGC

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MNNFIVKYPKITLILKGEAMCGIVGYIGRDEKKEILLNGLKELEYRGYDSAGIAVLSENELQTFRSVGKLSNLESKCKNF
SSTDFGVSIGHTRWATHGKPTEANAHPHIAAFSNVVHNGIIENYQEIKHALEQKGHTFLSQTDTEVIVHLFEEYTQTFTD
SLQAFKATIAELKGAFAILLITKKAPDCIFYAKNGSPLIIGKSATKQDEIYFASSDAPLIGLVESVVYLQDGDIGVMKLG
AFDTLKGAKKLNSTKGYAQKEGYRYFMEKEIYEQHKVLLETMMGRVSEGDIILNEIESHFFNDIQSISICACGTSYHAGL
SAKYLFERLAKIKTNVLIASEFRYSQPVMNKNELFIVISQSGETADTLEALKLAKKNGLKSLAICNVDNSSIVREADVSL
LTRAGIEKGVASTKAFATQMMLLWILSVYIGKIRGHIAQKELETHIAQMVASAKKTYIESDMHEHIKRLSKRYLHGHGFF
FIGRDVFYPLALEGALKLKEISYLHAEGYPSGEMKHGPIALADSELFTLALMPTHLLFDKIKSNVEELSARDATICAVSA
QPIKGVDDMILISPCQSYMEEFFAMMVVLQLFALEVAIRLGNDVDMPRNLAKSVTVE

Sequences:

>Translated_617_residues
MNNFIVKYPKITLILKGEAMCGIVGYIGRDEKKEILLNGLKELEYRGYDSAGIAVLSENELQTFRSVGKLSNLESKCKNF
SSTDFGVSIGHTRWATHGKPTEANAHPHIAAFSNVVHNGIIENYQEIKHALEQKGHTFLSQTDTEVIVHLFEEYTQTFTD
SLQAFKATIAELKGAFAILLITKKAPDCIFYAKNGSPLIIGKSATKQDEIYFASSDAPLIGLVESVVYLQDGDIGVMKLG
AFDTLKGAKKLNSTKGYAQKEGYRYFMEKEIYEQHKVLLETMMGRVSEGDIILNEIESHFFNDIQSISICACGTSYHAGL
SAKYLFERLAKIKTNVLIASEFRYSQPVMNKNELFIVISQSGETADTLEALKLAKKNGLKSLAICNVDNSSIVREADVSL
LTRAGIEKGVASTKAFATQMMLLWILSVYIGKIRGHIAQKELETHIAQMVASAKKTYIESDMHEHIKRLSKRYLHGHGFF
FIGRDVFYPLALEGALKLKEISYLHAEGYPSGEMKHGPIALADSELFTLALMPTHLLFDKIKSNVEELSARDATICAVSA
QPIKGVDDMILISPCQSYMEEFFAMMVVLQLFALEVAIRLGNDVDMPRNLAKSVTVE
>Mature_617_residues
MNNFIVKYPKITLILKGEAMCGIVGYIGRDEKKEILLNGLKELEYRGYDSAGIAVLSENELQTFRSVGKLSNLESKCKNF
SSTDFGVSIGHTRWATHGKPTEANAHPHIAAFSNVVHNGIIENYQEIKHALEQKGHTFLSQTDTEVIVHLFEEYTQTFTD
SLQAFKATIAELKGAFAILLITKKAPDCIFYAKNGSPLIIGKSATKQDEIYFASSDAPLIGLVESVVYLQDGDIGVMKLG
AFDTLKGAKKLNSTKGYAQKEGYRYFMEKEIYEQHKVLLETMMGRVSEGDIILNEIESHFFNDIQSISICACGTSYHAGL
SAKYLFERLAKIKTNVLIASEFRYSQPVMNKNELFIVISQSGETADTLEALKLAKKNGLKSLAICNVDNSSIVREADVSL
LTRAGIEKGVASTKAFATQMMLLWILSVYIGKIRGHIAQKELETHIAQMVASAKKTYIESDMHEHIKRLSKRYLHGHGFF
FIGRDVFYPLALEGALKLKEISYLHAEGYPSGEMKHGPIALADSELFTLALMPTHLLFDKIKSNVEELSARDATICAVSA
QPIKGVDDMILISPCQSYMEEFFAMMVVLQLFALEVAIRLGNDVDMPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=31.3868613138686, Blast_Score=313, Evalue=3e-85,
Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=31.5328467153285, Blast_Score=304, Evalue=2e-82,
Organism=Escherichia coli, GI1790167, Length=617, Percent_Identity=42.6256077795786, Blast_Score=466, Evalue=1e-132,
Organism=Escherichia coli, GI1788651, Length=211, Percent_Identity=25.1184834123223, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=504, Percent_Identity=29.9603174603175, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=30.5555555555556, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17532897, Length=434, Percent_Identity=29.7235023041475, Blast_Score=197, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6322745, Length=452, Percent_Identity=31.6371681415929, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6323731, Length=433, Percent_Identity=29.7921478060046, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323730, Length=213, Percent_Identity=36.6197183098592, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21357745, Length=692, Percent_Identity=32.514450867052, Blast_Score=320, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 68570; Mature: 68570

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNFIVKYPKITLILKGEAMCGIVGYIGRDEKKEILLNGLKELEYRGYDSAGIAVLSENE
CCCCEEECCEEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECHH
LQTFRSVGKLSNLESKCKNFSSTDFGVSIGHTRWATHGKPTEANAHPHIAAFSNVVHNGI
HHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IENYQEIKHALEQKGHTFLSQTDTEVIVHLFEEYTQTFTDSLQAFKATIAELKGAFAILL
HHHHHHHHHHHHHCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ITKKAPDCIFYAKNGSPLIIGKSATKQDEIYFASSDAPLIGLVESVVYLQDGDIGVMKLG
EECCCCCEEEEECCCCEEEEECCCCCCCCEEEECCCCCHHHHHHHHHEEECCCCCEEEEC
AFDTLKGAKKLNSTKGYAQKEGYRYFMEKEIYEQHKVLLETMMGRVSEGDIILNEIESHF
CHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
FNDIQSISICACGTSYHAGLSAKYLFERLAKIKTNVLIASEFRYSQPVMNKNELFIVISQ
HHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEEEEC
SGETADTLEALKLAKKNGLKSLAICNVDNSSIVREADVSLLTRAGIEKGVASTKAFATQM
CCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLWILSVYIGKIRGHIAQKELETHIAQMVASAKKTYIESDMHEHIKRLSKRYLHGHGFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
FIGRDVFYPLALEGALKLKEISYLHAEGYPSGEMKHGPIALADSELFTLALMPTHLLFDK
EECCHHHHHHHHHCCHHHHHHHEEECCCCCCCCCCCCCEEEECCCEEEEEHHHHHHHHHH
IKSNVEELSARDATICAVSAQPIKGVDDMILISPCQSYMEEFFAMMVVLQLFALEVAIRL
HHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNDVDMPRNLAKSVTVE
CCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MNNFIVKYPKITLILKGEAMCGIVGYIGRDEKKEILLNGLKELEYRGYDSAGIAVLSENE
CCCCEEECCEEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECHH
LQTFRSVGKLSNLESKCKNFSSTDFGVSIGHTRWATHGKPTEANAHPHIAAFSNVVHNGI
HHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IENYQEIKHALEQKGHTFLSQTDTEVIVHLFEEYTQTFTDSLQAFKATIAELKGAFAILL
HHHHHHHHHHHHHCCCEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
ITKKAPDCIFYAKNGSPLIIGKSATKQDEIYFASSDAPLIGLVESVVYLQDGDIGVMKLG
EECCCCCEEEEECCCCEEEEECCCCCCCCEEEECCCCCHHHHHHHHHEEECCCCCEEEEC
AFDTLKGAKKLNSTKGYAQKEGYRYFMEKEIYEQHKVLLETMMGRVSEGDIILNEIESHF
CHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
FNDIQSISICACGTSYHAGLSAKYLFERLAKIKTNVLIASEFRYSQPVMNKNELFIVISQ
HHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEEEEC
SGETADTLEALKLAKKNGLKSLAICNVDNSSIVREADVSLLTRAGIEKGVASTKAFATQM
CCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLWILSVYIGKIRGHIAQKELETHIAQMVASAKKTYIESDMHEHIKRLSKRYLHGHGFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
FIGRDVFYPLALEGALKLKEISYLHAEGYPSGEMKHGPIALADSELFTLALMPTHLLFDK
EECCHHHHHHHHHCCHHHHHHHEEECCCCCCCCCCCCCEEEECCCEEEEEHHHHHHHHHH
IKSNVEELSARDATICAVSAQPIKGVDDMILISPCQSYMEEFFAMMVVLQLFALEVAIRL
HHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GNDVDMPRNLAKSVTVE
CCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]