Definition Helicobacter hepaticus ATCC 51449 chromosome, complete genome.
Accession NC_004917
Length 1,799,146

Click here to switch to the map view.

The map label for this gene is selA

Identifier: 32266239

GI number: 32266239

Start: 723867

End: 725237

Strand: Direct

Name: selA

Synonym: HH0740

Alternate gene names: 32266239

Gene position: 723867-725237 (Clockwise)

Preceding gene: 32266237

Following gene: 32266240

Centisome position: 40.23

GC content: 37.64

Gene sequence:

>1371_bases
GTGCAACATTTACTCAAATCCCTCCCCAAAGTTGATACACTACTTGCTCATAATGAACTTAAAATGTTTCAAAAATCTAC
ACTTTTGCCACTTATTCAATCACATTTATCGCTATTGCGTGAAAATATATGCTCAAATACTCTTTCACCTAAAGAATTAG
AATCTGCCCTAAACGAAATTATCCCTGTGATTAAAAAAAAAGCTATTGAGGCAACTAAACCCACGCTTACACGAGTAATT
AATGCTACCGGTGTGGTGATTCACACAAATCTTGGGCGAAGTGTTCTTTCACCTCAAATCCTTGATGAAATCACACCTTT
TTTGAGAAGCTATCACACGCTTGAATATGATTTAGCTAAAGGTAAAAGAAGTGAGCGATATACCCATACTAAGCAGATTC
TGTGCGAAATGTTTGGTTGTGAAGATGCACTTTTGGTCAATAATAATGCTGCAGCCGTGCTTTTAATCCTCAACACCTTT
GCAGCCCATAAGGAAGTGATTATTTCTCGTGGAGAGCTTGTGGAAATCGGAGGAAGTTTTAGAATCCCAGAAGTGATGAA
AAGTGCTTCAAGTATCCTCTGCGAAGTAGGTGCAACAAATAAAACACATTTAAAAGATTATGAAAATGCTATTAATGAAC
AAAGTGCAATGATTATGAAAGTTCATCAAAGCAATTTTAAACAAATTGGCTTTGTAAAGCAATGCCATATCAAAGAAATC
ATACATCTTGCACAAAAACATCATCTTATTGATTATTTTGATTTAGGTAGCGGACACATAGGCGCATTGCCCCTCGCAGA
TGAACCAAGTGTTCGCGAAATCTGCAAATATAAACCCTCACTCCTTAGCTTTAGTGGCGATAAATTGCTCGGTGGTCCTC
AAGTAGGCATTATCATCGGCAAATCACAGCTTATTGCGCAATTAAAGCATAATCAGCTTTTACGCGCTTTAAGGGTAGAT
AAGTTTAGTATTCTCGCCTTACAAGCAACGCTCAAAGCATATCAAAACAAAGAATATCACAAAATCCCAACTCTTGCTAT
GCTTGCTTTCACCCCCAAAGAGTTAGAATCTAAGGCTAAAAATCTCAAAAAACGCATACTTGCCTCATCTATTGCTTCAG
AACTTGAAGTTGAAGTGATACCTTTACACTCACTCGCAGGTGGTGGGAGTGTGCCACATTTATCTTTTGATTCTTTTGGT
ATCTCACTTCAAGCAAAACATTTACAAGTGCAGGATTTTGAATTTGCTTTGCGAGCCTTAGGACTAATTAGCTGCATACA
AGGAGAAAAGATTCTTCTTGATGTGCGGACATTACTAGAAGGTGATGAAGAGCGTATTATGGAGATTCTTGGGGAAGTAT
TATCCTCATAA

Upstream 100 bases:

>100_bases
GATAAATTACTGCCATATATTACCTCCAAAATTTATAAGTGTAAAAAAAGTTATTCTACGATATAATTGTGTCCTTGCTG
TTTATACAAAGGAGAAACAG

Downstream 100 bases:

>100_bases
GGAGAAAAATATGAGCGAGGGGCATAATGATATTATCGTTGGCTTAGCTGGGCATATTGACCACGGCAAAACAACCCTTA
TTAAAGCACTCAATGGCTTT

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MQHLLKSLPKVDTLLAHNELKMFQKSTLLPLIQSHLSLLRENICSNTLSPKELESALNEIIPVIKKKAIEATKPTLTRVI
NATGVVIHTNLGRSVLSPQILDEITPFLRSYHTLEYDLAKGKRSERYTHTKQILCEMFGCEDALLVNNNAAAVLLILNTF
AAHKEVIISRGELVEIGGSFRIPEVMKSASSILCEVGATNKTHLKDYENAINEQSAMIMKVHQSNFKQIGFVKQCHIKEI
IHLAQKHHLIDYFDLGSGHIGALPLADEPSVREICKYKPSLLSFSGDKLLGGPQVGIIIGKSQLIAQLKHNQLLRALRVD
KFSILALQATLKAYQNKEYHKIPTLAMLAFTPKELESKAKNLKKRILASSIASELEVEVIPLHSLAGGGSVPHLSFDSFG
ISLQAKHLQVQDFEFALRALGLISCIQGEKILLDVRTLLEGDEERIMEILGEVLSS

Sequences:

>Translated_456_residues
MQHLLKSLPKVDTLLAHNELKMFQKSTLLPLIQSHLSLLRENICSNTLSPKELESALNEIIPVIKKKAIEATKPTLTRVI
NATGVVIHTNLGRSVLSPQILDEITPFLRSYHTLEYDLAKGKRSERYTHTKQILCEMFGCEDALLVNNNAAAVLLILNTF
AAHKEVIISRGELVEIGGSFRIPEVMKSASSILCEVGATNKTHLKDYENAINEQSAMIMKVHQSNFKQIGFVKQCHIKEI
IHLAQKHHLIDYFDLGSGHIGALPLADEPSVREICKYKPSLLSFSGDKLLGGPQVGIIIGKSQLIAQLKHNQLLRALRVD
KFSILALQATLKAYQNKEYHKIPTLAMLAFTPKELESKAKNLKKRILASSIASELEVEVIPLHSLAGGGSVPHLSFDSFG
ISLQAKHLQVQDFEFALRALGLISCIQGEKILLDVRTLLEGDEERIMEILGEVLSS
>Mature_456_residues
MQHLLKSLPKVDTLLAHNELKMFQKSTLLPLIQSHLSLLRENICSNTLSPKELESALNEIIPVIKKKAIEATKPTLTRVI
NATGVVIHTNLGRSVLSPQILDEITPFLRSYHTLEYDLAKGKRSERYTHTKQILCEMFGCEDALLVNNNAAAVLLILNTF
AAHKEVIISRGELVEIGGSFRIPEVMKSASSILCEVGATNKTHLKDYENAINEQSAMIMKVHQSNFKQIGFVKQCHIKEI
IHLAQKHHLIDYFDLGSGHIGALPLADEPSVREICKYKPSLLSFSGDKLLGGPQVGIIIGKSQLIAQLKHNQLLRALRVD
KFSILALQATLKAYQNKEYHKIPTLAMLAFTPKELESKAKNLKKRILASSIASELEVEVIPLHSLAGGGSVPHLSFDSFG
ISLQAKHLQVQDFEFALRALGLISCIQGEKILLDVRTLLEGDEERIMEILGEVLSS

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family

Homologues:

Organism=Escherichia coli, GI2367248, Length=463, Percent_Identity=39.3088552915767, Blast_Score=278, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELA_HELHP (Q7VI68)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860271.1
- ProteinModelPortal:   Q7VI68
- GeneID:   1492429
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0740
- NMPDR:   fig|235279.1.peg.740
- HOGENOM:   HBG564950
- OMA:   VFLILNT
- ProtClustDB:   PRK04311
- BioCyc:   HHEP235279:HH_0740-MONOMER
- BRENDA:   2.9.1.1
- GO:   GO:0005737
- HAMAP:   MF_00423
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534
- Gene3D:   G3DSA:3.40.640.10
- TIGRFAMs:   TIGR00474

Pfam domain/function: PF03841 SelA; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.9.1.1

Molecular weight: Translated: 50581; Mature: 50581

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MQHLLKSLPKVDTLLAHNELKMFQKSTLLPLIQSHLSLLRENICSNTLSPKELESALNEI
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IPVIKKKAIEATKPTLTRVINATGVVIHTNLGRSVLSPQILDEITPFLRSYHTLEYDLAK
HHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHC
GKRSERYTHTKQILCEMFGCEDALLVNNNAAAVLLILNTFAAHKEVIISRGELVEIGGSF
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCEEEECCCC
RIPEVMKSASSILCEVGATNKTHLKDYENAINEQSAMIMKVHQSNFKQIGFVKQCHIKEI
CCHHHHHHHHHHEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCHHHHCHHHHHHHHHH
IHLAQKHHLIDYFDLGSGHIGALPLADEPSVREICKYKPSLLSFSGDKLLGGPQVGIIIG
HHHHHHCCCEEEEECCCCCEECCCCCCCCCHHHHHCCCCCHHCCCCCCCCCCCCEEEEEC
KSQLIAQLKHNQLLRALRVDKFSILALQATLKAYQNKEYHKIPTLAMLAFTPKELESKAK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHEECCHHHHHHHHH
NLKKRILASSIASELEVEVIPLHSLAGGGSVPHLSFDSFGISLQAKHLQVQDFEFALRAL
HHHHHHHHHHHHHHCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
GLISCIQGEKILLDVRTLLEGDEERIMEILGEVLSS
HHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHLLKSLPKVDTLLAHNELKMFQKSTLLPLIQSHLSLLRENICSNTLSPKELESALNEI
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
IPVIKKKAIEATKPTLTRVINATGVVIHTNLGRSVLSPQILDEITPFLRSYHTLEYDLAK
HHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHC
GKRSERYTHTKQILCEMFGCEDALLVNNNAAAVLLILNTFAAHKEVIISRGELVEIGGSF
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCEEEECCCC
RIPEVMKSASSILCEVGATNKTHLKDYENAINEQSAMIMKVHQSNFKQIGFVKQCHIKEI
CCHHHHHHHHHHEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHCHHHHCHHHHHHHHHH
IHLAQKHHLIDYFDLGSGHIGALPLADEPSVREICKYKPSLLSFSGDKLLGGPQVGIIIG
HHHHHHCCCEEEEECCCCCEECCCCCCCCCHHHHHCCCCCHHCCCCCCCCCCCCEEEEEC
KSQLIAQLKHNQLLRALRVDKFSILALQATLKAYQNKEYHKIPTLAMLAFTPKELESKAK
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHEECCHHHHHHHHH
NLKKRILASSIASELEVEVIPLHSLAGGGSVPHLSFDSFGISLQAKHLQVQDFEFALRAL
HHHHHHHHHHHHHHCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
GLISCIQGEKILLDVRTLLEGDEERIMEILGEVLSS
HHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12810954