BacMap

Definition	Helicobacter hepaticus ATCC 51449 chromosome, complete genome.
Accession	NC_004917
Length	1,799,146

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The map label for this gene is selB

Identifier: 32266240

GI number: 32266240

Start: 725248

End: 727146

Strand: Direct

Name: selB

Synonym: HH0741

Alternate gene names: 32266240

Gene position: 725248-727146 (Clockwise)

Preceding gene: 32266239

Following gene: 32266241

Centisome position: 40.31

GC content: 36.91

Gene sequence:

>1899_bases
ATGAGCGAGGGGCATAATGATATTATCGTTGGCTTAGCTGGGCATATTGACCACGGCAAAACAACCCTTATTAAAGCACT
CAATGGCTTTGATGGCGATAGTTTAGAGGAAGAGAAACAAAGAGGCATTACACTTGATTTGAGTTTTTCTCATCTTCATT
TGCCCTCACGCAATGTCGCATTTATTGATGTGCCCGGACATAATAAGCTTGTAAAAAATATGATTGCAGGGGCATTTGGT
ATTGATGTGTTACTTCTTGTCATTGCTGCAAATGAAGGCATTATGCCTCAAAGTATAGAACATTTACTCATTGCAGATAT
GTTAGGCATTAGCTCTTGTATTTGTGTAATTACCAAAATTGACAAACTTGAAAATCCCTCTTTAGAGCTACCGCGTTTAG
AATCTGATATTGTCGCGCTCTTTAAAACTTGTGATATGAAACTTTATGACACTATTGCTCTTAGTCTGCATTCATCTACA
ATGCCACTCACAAACGCTTATGATAGTTTATCTCAACTCAAAAGGCTAAAAACAAGTTTAGATTCTATCCCTAAACCCCA
AAAGATAGATTTTGGCTTATTTTTATATTATATTGATAGAAGTTTTAGCATTAAGGGTGCAGGCTGTGTAGTTACAGGAA
GCGTTTTAAGCGGTGAATGTTGCGTGGGAGACAAGCTTTATGCCTATGATATAAAGCAAGAAGTCGCTGTGCGAGGAATA
CAAATCCACGATAAAAATGCTACAAAAGCCACTCCCTCTCATCGTGTCGCACTTAATCTCTCTGGAATCAGTCATCACCA
ACTCAAGCGTGGCTTTCTTCTCTCTCAGAAAGGATATTTGCGCGGCTTTGATAGTATTGATGTGGGAATCTTCGGCGCAC
CTCAACATAATACTATCTATCAACTCTATCTAGGAAGCTCAAAACTCAATGCGAAAGTGCATCTTATTAGTGAACCTATC
ACTTCTCACGCCTTTGGTTCAAAGCCTCTTACCTTTGCTACACTTAAATGTGATGGAATTATATTTAGTATATTTTCACA
ACATTTTATTTTACGCGATGATGAAGGTGCTGTGCTTGGTGGCATTATTTTAAATCCTATCATTGACCCTATTAAAAAGC
ATCAACGTGTGCAACTCTTAGAATCCCTTTGTAAAAAGCATTTTGATAGTGCTTTTAGCCTGCTTTGTTCTATTCATAAA
AAAGGTTTTGGGCTTGTAAGCTCTACACAGAGATTCTGTCTTAGCCATACTCAAAGCCTCCAAACCGCTTCTACTCTCAA
AGATATTTTTATTGATGAAAAATCCCTTACACTTTATCCTCTTTCACAAGTAGAATATCTTAAAGCTCATATTTTAGAGA
TTTTCTTGCATAATAAATCTGCTCTGCTCTCGGCTCAAAGTCTCTGTGTAAAAATAAAATGGGCAAGTCTTGGACTTTGC
CAAAAAGCCCTTGATGAACTTCTTAATGAAAAGCAAATTAGATATAAAAATGGATTATATCTCTCACAATGGTGCCAAAT
TAAAGATATTAAAACTTATGTCCAAGAGCGCATACTTGAGATTCTTGCTCAAGGGCATTATGCACCGCCCGCACCTTATA
ATATTTATGAAGAACTTGATATTGACAAAAAAGTAGGTGATGACGCTCTAAAAGCTCTCACTCAAGCTCACAAAGTCGTG
CGTATCACACATAATCTTTTTATCACTTCTTCCGCGCTTAATCATATAGTGAGCCTTATGCGCGAGATTATCTCCACACA
TAGCTATGTTGATGTAAATCTCCTACGAAAACGGACAGATTTAAGTCGCAAATACCTCATTGGTTATTTAGAATATTTAG
ATAAATTTGATGATATTGAATGCAATGAAAACAAACGCTCCTTTAAATACGGCACATAA

Upstream 100 bases:

>100_bases
GGAGAAAAGATTCTTCTTGATGTGCGGACATTACTAGAAGGTGATGAAGAGCGTATTATGGAGATTCTTGGGGAAGTATT
ATCCTCATAAGGAGAAAAAT

Downstream 100 bases:

>100_bases
AGCAAATGAGGAAAATATGAAAAAAACGATACATCTTGATTTTTTAGCAAATGTCCCTCTAAATGCAAATGCAAATGCCT
TATTTGAGGATACTTATCCC

Product: selenocysteine-specific elongation factor SelB

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MSEGHNDIIVGLAGHIDHGKTTLIKALNGFDGDSLEEEKQRGITLDLSFSHLHLPSRNVAFIDVPGHNKLVKNMIAGAFG
IDVLLLVIAANEGIMPQSIEHLLIADMLGISSCICVITKIDKLENPSLELPRLESDIVALFKTCDMKLYDTIALSLHSST
MPLTNAYDSLSQLKRLKTSLDSIPKPQKIDFGLFLYYIDRSFSIKGAGCVVTGSVLSGECCVGDKLYAYDIKQEVAVRGI
QIHDKNATKATPSHRVALNLSGISHHQLKRGFLLSQKGYLRGFDSIDVGIFGAPQHNTIYQLYLGSSKLNAKVHLISEPI
TSHAFGSKPLTFATLKCDGIIFSIFSQHFILRDDEGAVLGGIILNPIIDPIKKHQRVQLLESLCKKHFDSAFSLLCSIHK
KGFGLVSSTQRFCLSHTQSLQTASTLKDIFIDEKSLTLYPLSQVEYLKAHILEIFLHNKSALLSAQSLCVKIKWASLGLC
QKALDELLNEKQIRYKNGLYLSQWCQIKDIKTYVQERILEILAQGHYAPPAPYNIYEELDIDKKVGDDALKALTQAHKVV
RITHNLFITSSALNHIVSLMREIISTHSYVDVNLLRKRTDLSRKYLIGYLEYLDKFDDIECNENKRSFKYGT

Sequences:

>Translated_632_residues
MSEGHNDIIVGLAGHIDHGKTTLIKALNGFDGDSLEEEKQRGITLDLSFSHLHLPSRNVAFIDVPGHNKLVKNMIAGAFG
IDVLLLVIAANEGIMPQSIEHLLIADMLGISSCICVITKIDKLENPSLELPRLESDIVALFKTCDMKLYDTIALSLHSST
MPLTNAYDSLSQLKRLKTSLDSIPKPQKIDFGLFLYYIDRSFSIKGAGCVVTGSVLSGECCVGDKLYAYDIKQEVAVRGI
QIHDKNATKATPSHRVALNLSGISHHQLKRGFLLSQKGYLRGFDSIDVGIFGAPQHNTIYQLYLGSSKLNAKVHLISEPI
TSHAFGSKPLTFATLKCDGIIFSIFSQHFILRDDEGAVLGGIILNPIIDPIKKHQRVQLLESLCKKHFDSAFSLLCSIHK
KGFGLVSSTQRFCLSHTQSLQTASTLKDIFIDEKSLTLYPLSQVEYLKAHILEIFLHNKSALLSAQSLCVKIKWASLGLC
QKALDELLNEKQIRYKNGLYLSQWCQIKDIKTYVQERILEILAQGHYAPPAPYNIYEELDIDKKVGDDALKALTQAHKVV
RITHNLFITSSALNHIVSLMREIISTHSYVDVNLLRKRTDLSRKYLIGYLEYLDKFDDIECNENKRSFKYGT
>Mature_631_residues
SEGHNDIIVGLAGHIDHGKTTLIKALNGFDGDSLEEEKQRGITLDLSFSHLHLPSRNVAFIDVPGHNKLVKNMIAGAFGI
DVLLLVIAANEGIMPQSIEHLLIADMLGISSCICVITKIDKLENPSLELPRLESDIVALFKTCDMKLYDTIALSLHSSTM
PLTNAYDSLSQLKRLKTSLDSIPKPQKIDFGLFLYYIDRSFSIKGAGCVVTGSVLSGECCVGDKLYAYDIKQEVAVRGIQ
IHDKNATKATPSHRVALNLSGISHHQLKRGFLLSQKGYLRGFDSIDVGIFGAPQHNTIYQLYLGSSKLNAKVHLISEPIT
SHAFGSKPLTFATLKCDGIIFSIFSQHFILRDDEGAVLGGIILNPIIDPIKKHQRVQLLESLCKKHFDSAFSLLCSIHKK
GFGLVSSTQRFCLSHTQSLQTASTLKDIFIDEKSLTLYPLSQVEYLKAHILEIFLHNKSALLSAQSLCVKIKWASLGLCQ
KALDELLNEKQIRYKNGLYLSQWCQIKDIKTYVQERILEILAQGHYAPPAPYNIYEELDIDKKVGDDALKALTQAHKVVR
ITHNLFITSSALNHIVSLMREIISTHSYVDVNLLRKRTDLSRKYLIGYLEYLDKFDDIECNENKRSFKYGT

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=384, Percent_Identity=27.0833333333333, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI54607086, Length=311, Percent_Identity=29.903536977492, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI5729864, Length=295, Percent_Identity=25.4237288135593, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI223555963, Length=295, Percent_Identity=25.4237288135593, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI4503471, Length=322, Percent_Identity=27.639751552795, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4503475, Length=321, Percent_Identity=24.9221183800623, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI53729339, Length=230, Percent_Identity=26.5217391304348, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI53729337, Length=230, Percent_Identity=26.5217391304348, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI2367247, Length=391, Percent_Identity=31.2020460358056, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1790412, Length=288, Percent_Identity=33.6805555555556, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789737, Length=288, Percent_Identity=33.6805555555556, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1789108, Length=349, Percent_Identity=22.9226361031519, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1789559, Length=100, Percent_Identity=34, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25141371, Length=301, Percent_Identity=29.2358803986711, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17556456, Length=296, Percent_Identity=30.0675675675676, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17506081, Length=274, Percent_Identity=29.1970802919708, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17552884, Length=324, Percent_Identity=26.5432098765432, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17569207, Length=324, Percent_Identity=26.5432098765432, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71994658, Length=157, Percent_Identity=31.2101910828025, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=251, Percent_Identity=25.8964143426295, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=385, Percent_Identity=27.2727272727273, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325337, Length=321, Percent_Identity=22.7414330218069, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6319594, Length=321, Percent_Identity=22.7414330218069, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324550, Length=131, Percent_Identity=32.0610687022901, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19922690, Length=288, Percent_Identity=32.2916666666667, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19921738, Length=290, Percent_Identity=31.7241379310345, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281363316, Length=304, Percent_Identity=28.2894736842105, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17864358, Length=304, Percent_Identity=28.2894736842105, Blast_Score=122, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45553807, Length=324, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45553816, Length=324, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651721, Length=324, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17864154, Length=324, Percent_Identity=25, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24652838, Length=325, Percent_Identity=25.8461538461538, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137572, Length=325, Percent_Identity=25.8461538461538, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45550900, Length=263, Percent_Identity=23.9543726235741, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28572034, Length=117, Percent_Identity=35.8974358974359, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015189
- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09105 SelB-wing_1; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 70582; Mature: 70450

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEGHNDIIVGLAGHIDHGKTTLIKALNGFDGDSLEEEKQRGITLDLSFSHLHLPSRNVA
CCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHCCEEEEEEEHEEECCCCCEE
FIDVPGHNKLVKNMIAGAFGIDVLLLVIAANEGIMPQSIEHLLIADMLGISSCICVITKI
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DKLENPSLELPRLESDIVALFKTCDMKLYDTIALSLHSSTMPLTNAYDSLSQLKRLKTSL
HHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHH
DSIPKPQKIDFGLFLYYIDRSFSIKGAGCVVTGSVLSGECCVGDKLYAYDIKQEVAVRGI
HCCCCCCCCCCEEEEEEECCCCEECCCCEEEECCEECCCCCCCCCEEEEEHHHHHHHCCE
QIHDKNATKATPSHRVALNLSGISHHQLKRGFLLSQKGYLRGFDSIDVGIFGAPQHNTIY
EEECCCCCCCCCCCEEEEEECCCCHHHHHHCCEECCCCCCCCCCCCCEEEECCCCCCCEE
QLYLGSSKLNAKVHLISEPITSHAFGSKPLTFATLKCDGIIFSIFSQHFILRDDEGAVLG
EEEECCCCCCEEEEEECCCHHHHCCCCCCCEEEEEEECHHHHHHHHCCEEEECCCCCEEH
GIILNPIIDPIKKHQRVQLLESLCKKHFDSAFSLLCSIHKKGFGLVSSTQRFCLSHTQSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
QTASTLKDIFIDEKSLTLYPLSQVEYLKAHILEIFLHNKSALLSAQSLCVKIKWASLGLC
HHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEEEEHHHHHH
QKALDELLNEKQIRYKNGLYLSQWCQIKDIKTYVQERILEILAQGHYAPPAPYNIYEELD
HHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCC
IDKKVGDDALKALTQAHKVVRITHNLFITSSALNHIVSLMREIISTHSYVDVNLLRKRTD
CCHHCCHHHHHHHHHHHHHEEEHHHHEEEHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHH
LSRKYLIGYLEYLDKFDDIECNENKRSFKYGT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SEGHNDIIVGLAGHIDHGKTTLIKALNGFDGDSLEEEKQRGITLDLSFSHLHLPSRNVA
CCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHCCEEEEEEEHEEECCCCCEE
FIDVPGHNKLVKNMIAGAFGIDVLLLVIAANEGIMPQSIEHLLIADMLGISSCICVITKI
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DKLENPSLELPRLESDIVALFKTCDMKLYDTIALSLHSSTMPLTNAYDSLSQLKRLKTSL
HHCCCCCCCCCCCHHHHHHHHHHCCCHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHH
DSIPKPQKIDFGLFLYYIDRSFSIKGAGCVVTGSVLSGECCVGDKLYAYDIKQEVAVRGI
HCCCCCCCCCCEEEEEEECCCCEECCCCEEEECCEECCCCCCCCCEEEEEHHHHHHHCCE
QIHDKNATKATPSHRVALNLSGISHHQLKRGFLLSQKGYLRGFDSIDVGIFGAPQHNTIY
EEECCCCCCCCCCCEEEEEECCCCHHHHHHCCEECCCCCCCCCCCCCEEEECCCCCCCEE
QLYLGSSKLNAKVHLISEPITSHAFGSKPLTFATLKCDGIIFSIFSQHFILRDDEGAVLG
EEEECCCCCCEEEEEECCCHHHHCCCCCCCEEEEEEECHHHHHHHHCCEEEECCCCCEEH
GIILNPIIDPIKKHQRVQLLESLCKKHFDSAFSLLCSIHKKGFGLVSSTQRFCLSHTQSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
QTASTLKDIFIDEKSLTLYPLSQVEYLKAHILEIFLHNKSALLSAQSLCVKIKWASLGLC
HHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHHHEEEEEEEEEHHHHHH
QKALDELLNEKQIRYKNGLYLSQWCQIKDIKTYVQERILEILAQGHYAPPAPYNIYEELD
HHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCC
IDKKVGDDALKALTQAHKVVRITHNLFITSSALNHIVSLMREIISTHSYVDVNLLRKRTD
CCHHCCHHHHHHHHHHHHHEEEHHHHEEEHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHH
LSRKYLIGYLEYLDKFDDIECNENKRSFKYGT
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8893853 [H]