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The map label for this gene is uppS

Identifier: 29349134

GI number: 29349134

Start: 4836468

End: 4837202

Strand: Reverse

Name: uppS

Synonym: BT_3726

Alternate gene names: 29349134

Gene position: 4837202-4836468 (Counterclockwise)

Preceding gene: 29349135

Following gene: 29349133

Centisome position: 77.27

GC content: 43.27

Gene sequence:

>735_bases
ATGTCCTATATAGAGAAAATAGACAAAAATCGGATTCCCCAGCACATAGCCATCATTATGGATGGGAATGGGAGATGGGC
TAAACAGCGGGGAAAAGAACGAACTTACGGTCACCAGGCAGGCGCAGAAACGGTACATAAAATTATCGAGGATGCTGCAC
GTCTGGGGGTTAAATATCTGACTTTATATACTTTCTCCACCGAGAATTGGAATCGTCCGCAGGAAGAAGTAGCAGCTTTA
ATGAATCTATTGGTGGATTCTATCGAAGAAGAAACGTTGATGAAGAACAATATTCGTTTCCGCATTATTGGTGATATTAA
GAAATTACCTGCAGAAGTGCAGGAAGGTCTGTCAAGATGTATAGAACACACAGCTAATAATACAGGAACCTGCCTGGTAC
TGGCACTCAGCTACTCTTCCCGCTGGGAAATGACTGAAGCAGTCCGACAGATTGCAACGCTTGCAAAAACGGGAGAAATA
TCTCCCGAACAAATAACAGATGAATACATAACTGCTCATCTGACCACAAACTTTATGCCCGATCCGGATTTACTGATCCG
CACGGGAGGAGAAATCCGACTAAGCAACTACCTGCTATGGCAATGTGCTTATTCGGAGCTTTATTTTTGTGATACATTCT
GGCCGGACTTCGATAAAGAAGAATTCTGTAAAGCCATTTATGAGTATCAGCAAAGAGAGCGCCGGTTCGGCAAAACGAGT
GAACAAATCAGCTAA

Upstream 100 bases:

>100_bases
TGGTCAAGGTATTGACAAAATCTGGCGTGGTAGAGTTAATAAACTCGGATTTCTAATACAGTAATAAGAAGTAGTTAAAT
ACGAACCTTATAATCAAAAC

Downstream 100 bases:

>100_bases
CATAATTCGAAACTTCAAATTATAACATAAATGCATTATCGTATTTCCTTTATATTCGTAACGTTTATCTGCCTGTTCTG
CTTTGCAGCCACGGGCTTTA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSYIEKIDKNRIPQHIAIIMDGNGRWAKQRGKERTYGHQAGAETVHKIIEDAARLGVKYLTLYTFSTENWNRPQEEVAAL
MNLLVDSIEEETLMKNNIRFRIIGDIKKLPAEVQEGLSRCIEHTANNTGTCLVLALSYSSRWEMTEAVRQIATLAKTGEI
SPEQITDEYITAHLTTNFMPDPDLLIRTGGEIRLSNYLLWQCAYSELYFCDTFWPDFDKEEFCKAIYEYQQRERRFGKTS
EQIS

Sequences:

>Translated_244_residues
MSYIEKIDKNRIPQHIAIIMDGNGRWAKQRGKERTYGHQAGAETVHKIIEDAARLGVKYLTLYTFSTENWNRPQEEVAAL
MNLLVDSIEEETLMKNNIRFRIIGDIKKLPAEVQEGLSRCIEHTANNTGTCLVLALSYSSRWEMTEAVRQIATLAKTGEI
SPEQITDEYITAHLTTNFMPDPDLLIRTGGEIRLSNYLLWQCAYSELYFCDTFWPDFDKEEFCKAIYEYQQRERRFGKTS
EQIS
>Mature_243_residues
SYIEKIDKNRIPQHIAIIMDGNGRWAKQRGKERTYGHQAGAETVHKIIEDAARLGVKYLTLYTFSTENWNRPQEEVAALM
NLLVDSIEEETLMKNNIRFRIIGDIKKLPAEVQEGLSRCIEHTANNTGTCLVLALSYSSRWEMTEAVRQIATLAKTGEIS
PEQITDEYITAHLTTNFMPDPDLLIRTGGEIRLSNYLLWQCAYSELYFCDTFWPDFDKEEFCKAIYEYQQRERRFGKTSE
QIS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=229, Percent_Identity=36.6812227074236, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI45580742, Length=229, Percent_Identity=36.6812227074236, Blast_Score=161, Evalue=4e-40,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=48.6842105263158, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=35.8407079646018, Blast_Score=144, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=33.4883720930233, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=215, Percent_Identity=34.4186046511628, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=35.5555555555556, Blast_Score=143, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_BACTN (Q8A1E0)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_812637.1
- ProteinModelPortal:   Q8A1E0
- SMR:   Q8A1E0
- GeneID:   1074317
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_3726
- NMPDR:   fig|226186.1.peg.3724
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   Q8A1E0
- ProtClustDB:   PRK14838
- BioCyc:   BTHE226186:BT_3726-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28276; Mature: 28145

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 21-21

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYIEKIDKNRIPQHIAIIMDGNGRWAKQRGKERTYGHQAGAETVHKIIEDAARLGVKYL
CCHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCCCCCHHCCHHHHHHHHHHHHHCCEEEE
TLYTFSTENWNRPQEEVAALMNLLVDSIEEETLMKNNIRFRIIGDIKKLPAEVQEGLSRC
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCHHHHHHHHHHH
IEHTANNTGTCLVLALSYSSRWEMTEAVRQIATLAKTGEISPEQITDEYITAHLTTNFMP
HHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCC
DPDLLIRTGGEIRLSNYLLWQCAYSELYFCDTFWPDFDKEEFCKAIYEYQQRERRFGKTS
CCCEEEECCCCEEECCEEEEEEHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCH
EQIS
HCCC
>Mature Secondary Structure 
SYIEKIDKNRIPQHIAIIMDGNGRWAKQRGKERTYGHQAGAETVHKIIEDAARLGVKYL
CHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCCCCCHHCCHHHHHHHHHHHHHCCEEEE
TLYTFSTENWNRPQEEVAALMNLLVDSIEEETLMKNNIRFRIIGDIKKLPAEVQEGLSRC
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCHHHHHHHHHHH
IEHTANNTGTCLVLALSYSSRWEMTEAVRQIATLAKTGEISPEQITDEYITAHLTTNFMP
HHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEECCCC
DPDLLIRTGGEIRLSNYLLWQCAYSELYFCDTFWPDFDKEEFCKAIYEYQQRERRFGKTS
CCCEEEECCCCEEECCEEEEEEHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCH
EQIS
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928