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The map label for this gene is ilvC [H]

Identifier: 29347484

GI number: 29347484

Start: 2599081

End: 2600160

Strand: Reverse

Name: ilvC [H]

Synonym: BT_2074

Alternate gene names: 29347484

Gene position: 2600160-2599081 (Counterclockwise)

Preceding gene: 29347485

Following gene: 29347482

Centisome position: 41.53

GC content: 45.0

Gene sequence:

>1080_bases
ATGGCGCAAGTCATCAAAACAAAAAAACAAAAAAAAATGGCACAGTTGAATTTTGGCGGAACTGTAGAAAATGTAGTTAT
CCGTGATGAATTTCCATTGGAAAAAGCTCGTGAAGTATTGAAAAATGAAACAATCGCTGTAATCGGTTATGGCGTACAAG
GTCCTGGACAGGCTCTGAACCTTCGTGATAACGGTTTCAATGTAATCGTTGGTCAACGCCAGGGAAAGACATATGACAAA
GCGGTAGCTGACGGATGGGTTCCGGGTGAAACTTTGTTCGGTATTGAAGAAGCTTGCGAAAAAGGTACGATCATTATGTG
CCTGTTGTCTGATGCAGCGGTAATGTCTGTATGGCCTACTATCAAGCCTTACCTGACTGCAGGAAAAGCTCTTTATTTCT
CTCATGGTTTTGCTATTACATGGAGTGATCGCACAGGTGTAGTTCCTCCTGCAGATATCGACGTAATCATGGTTGCTCCT
AAAGGTTCGGGTACATCCTTGCGTACTATGTTCCTTGAAGGTCGCGGCTTGAACTCTTCTTACGCTATCTATCAGGATGC
AACAGGCAACGCTATGGACAGAACAATCGCATTGGGTATCGGTATCGGTTCAGGTTATTTGTTCGAAACAACTTTCATCC
GCGAAGCTACTTCCGACCTGACAGGCGAACGTGGTTCATTGATGGGAGCTATCCAGGGTCTGTTGCTGGCACAATACGAA
GTGTTACGTGAAAACGGTCACACTCCTTCCGAAGCATTCAACGAAACTGTAGAAGAGCTGACTCAGTCATTGATGCCGTT
GTTTGCAAAGAACGGTATGGACTGGATGTATGCTAACTGCTCTACTACAGCTCAACGTGGTGCTCTCGACTGGATGGGCC
CCTTCCACGATGCTATCAAACCGGTAGTTGAAAAGTTGTATCACAGTGTGAAGACTGGTAACGAAGCACAGATTTCAATC
GACTCTAACTCCAAACCGGATTATCGTGAGAAACTGGAAGAAGAACTGAAAGCATTGCGCGAAAGCGAAATGTGGCAGAC
TGCCGTGACAGTTCGTAAACTTCGTCCGGAAAATAATTAA

Upstream 100 bases:

>100_bases
AACGAGTTTCATGTAGAGGTGAAGAAAAACGGCAGCGAGGTAGTATGCCGTTCCAAAGTGATATTTGAATAATATAGAGT
ATAAAATCAATTAATAACAG

Downstream 100 bases:

>100_bases
TCAGACTTATACTATATAAGTTTTTCAAAAGGCGGGAAAAGCGTATTTTCCCGCTTTTTCTATGTAGATACCGGTCTTTT
GAGTAATAGAAAAAGGATGA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAQVIKTKKQKKMAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQALNLRDNGFNVIVGQRQGKTYDK
AVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMSVWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAP
KGSGTSLRTMFLEGRGLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGLLLAQYE
VLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMGPFHDAIKPVVEKLYHSVKTGNEAQISI
DSNSKPDYREKLEEELKALRESEMWQTAVTVRKLRPENN

Sequences:

>Translated_359_residues
MAQVIKTKKQKKMAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQALNLRDNGFNVIVGQRQGKTYDK
AVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMSVWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAP
KGSGTSLRTMFLEGRGLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGLLLAQYE
VLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMGPFHDAIKPVVEKLYHSVKTGNEAQISI
DSNSKPDYREKLEEELKALRESEMWQTAVTVRKLRPENN
>Mature_358_residues
AQVIKTKKQKKMAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQALNLRDNGFNVIVGQRQGKTYDKA
VADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMSVWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPK
GSGTSLRTMFLEGRGLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGLLLAQYEV
LRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMGPFHDAIKPVVEKLYHSVKTGNEAQISID
SNSKPDYREKLEEELKALRESEMWQTAVTVRKLRPENN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=300, Percent_Identity=27.6666666666667, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323387, Length=347, Percent_Identity=59.9423631123919, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 39463; Mature: 39332

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQVIKTKKQKKMAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQALN
CCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCEEE
LRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMSVWPT
EECCCEEEEEECCCCCCHHHHHHCCCCCCHHHHCHHHHHCCCCEEEEEECCCHHHHHCCC
IKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGRGLNSS
HHHHHHCCCEEEEECCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCC
YAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGLLLAQYE
EEEEECCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMGPFHDAIK
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCCHHHHHHH
PVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVRKLRPENN
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AQVIKTKKQKKMAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQALN
CCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCEEE
LRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMSVWPT
EECCCEEEEEECCCCCCHHHHHHCCCCCCHHHHCHHHHHCCCCEEEEEECCCHHHHHCCC
IKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGRGLNSS
HHHHHHCCCEEEEECCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCC
YAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGLLLAQYE
EEEEECCCCCCCCCEEEEEEECCCCCEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMGPFHDAIK
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCCHHHHHHH
PVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVRKLRPENN
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]