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The map label for this gene is fadE [H]

Identifier: 29142923

GI number: 29142923

Start: 2616726

End: 2619170

Strand: Direct

Name: fadE [H]

Synonym: t2541

Alternate gene names: 29142923

Gene position: 2616726-2619170 (Clockwise)

Preceding gene: 29142920

Following gene: 29142924

Centisome position: 54.61

GC content: 56.07

Gene sequence:

>2445_bases
ATGATGATTTTGAGTATTATCGCTACGGTTGTTCTGCTCGGCGCATTGTTCTATCACCGCGTGAGTTTATTTCTCAGCAG
CCTGATTCTGCTCGCCTGGACCGCCGCACTTGGCGTCGCTGGCCTGTGGTCCATCTGGCTGTTGGTTCCTCTGGCCATTA
TCCTCGTGCCGTTTAACCTCACACCGATGCGAAAATCAATGATTTCCGCACCGGTGTTCCGCGGCTTCCGTAAGGTCATG
CCGCCGATGTCGCGCACTGAGAAAGAAGCGATTGATGCCGGTACAACCTGGTGGGAAGGCGATCTGTTCCAGGGCAAGCC
TGACTGGAAAAAACTGCACAACTATCCGCAACCGCAACTCACTGCCGAAGAGCAAGCGTTTCTCGACGGCCCGGTAGAAG
AAGCGTGCCGGATGGCGAACGATTTCCAGATTACCCATGAACTGGCGGATCTGCCGCCGGAACTGTGGGCTTACCTGAAA
GAGCATCGTTTTTTTGCGATGATCATTAAAAAAGAGTACGGCGGGCTGGAGTTCTCCGCTTATGTGCAGTCCCGTGTACT
GCAAAAACTGTCCGGCGTCTCCGGGATTCTGGCTATCACCGTCGGCGTTCCAAACTCACTCGGCCCTGGCGAGCTGTTGC
AGCACTATGGTACGGAAGAGCAGAAGAATCACTATCTGCCGCGACTGGCGCGCGGCCAAGAAATCCCCTGCTTTGCGCTG
ACCAGCCCGGAAGCAGGTTCTGATGCAGGCGCTATTCCGGATACCGGCGTGGTTTGCATGGGCGAATGGCAGGGCCAGCA
GGTGCTGGGTATGCGTCTGACCTGGAACAAGCGTTACATTACGCTGGCGCCGATAGCTACCGTGTTGGGCTTGGCGTTTA
AGCTTTCCGATCCGGATAGATTGTTAGGCGGAGAAGAAGAGCTGGGTATTACCTGCGCCCTGATCCCCACCTCAACGCCG
GGTGTGGAAATTGGTCGTCGTCACTTCCCGCTTAACGTTCCGTTCCAGAATGGCCCAACCCGCGGTAACGATATTTTCGT
GCCTATTGATTATATTATCGGCGGCCCCAAAATGGCCGGACAGGGCTGGCGTATGCTGGTGGAATGTTTGTCGGTAGGAC
GCGGTATTACCCTGCCGTCCAACTCCACTGGCGGGGTGAAATCCGTCGCGCTGGCAACCGGCGCCTATGCTCACATTCGT
CGTCAGTTCAAAATTTCTATCGGCAAGATGGAAGGTATTGAAGAACCGCTGGCGCGTATTGCAGGTAACGCTTATGTGAT
GGATGCCGCCGCATCGTTAATCACCTACGGCATTATGCTAGGCGAAAAACCGGCGGTACTGTCGGCTATCGTGAAGTACC
ACTGCACCCACCGCGGCCAGCAGTCCATTATCGACGCGATGGATATCACTGGGGGTAAAGGCATTATGCTGGGCGAGAGC
AACTTCCTGGCGCGTGCTTACCAGGGCGCGCCTATCGCGATCACCGTGGAAGGCGCGAATATCCTGACCCGTAGCATGAT
GATCTTTGGTCAGGGCGCCATTCGCTGCCATCCTTATGTACTGGAAGAGATGGCCGCAGCGCAGAATAATGATGTGAATG
CCTTTGATAAACTGTTGTTTAAACATATTGGCCATGTCGGCAGCAATACCGTCCGCAGTTTCTGGCTTGGCCTGACCCGC
GGATTAACGAGCCATACGCCAACCGGCGACGCCACGAAGCGTTATTACCAGCATCTGAACCGACTGAGCGCAAACCTGGC
CCTGCTGTCCGACGTGTCAATGGCGGTACTGGGCGGCAGCCTGAAACGCCGCGAGCGTATCTCCACGCGTCTGGGCGATG
TGTTGAGTCAGCTTTATCTGGCCTCAGCCGTACTGAAGCGTTACGACGACGAAGGCCGCCACGAAGCCGACCTGCCGCTG
GTGCACTGGGGCGTACAGGATGCGCTGTATCGTGCTGAACAAGCGATGGACGATCTGCTGCAGAACTTCCCGAACCGCGT
CGTGGCCGGATTGCTCACCGCGATGATCTTCCCGACTGGCCGTCATTATCTGGCGCCGTCTGATAAGCTGGATCACGCCG
TGGCGAAGATCCTACAGGTGCCGAACGCCACACGTTCACGTATTGGGCGCGGTCAGTATCTGACGCCCGCCGAACATAAT
CCGGTCGGTTTACTGGAAGAAGCGCTGCGTGATGTCATCGCTGCCGACCCTATCCACCAGCGCATCTGCAAAGAACTGGG
TAAAAATCTGCCGTTTACTCGTCTGGATGAACTGGCGCGCAATGCGCTGGCGAAAGGGCTTATAGATAAAGATGAAGCCG
CCATCCTGGCGAAAGCGGAAGAGAGCCGCCTGCGCAGTATCAACGTTGATGATTTTGAACCTGAAGCGCTGGCGACCAAA
CCGGTAAAGCTGCCGGAGAAAGTGCGTAAAGTCGAAGCCGCATAA

Upstream 100 bases:

>100_bases
TGTAATTATTTTGTAAACACATTGCTAAAAGATTTTACATCCACTACAACCTAATCATCACAAGTGGTCAGACCTCCTAC
AAGCAAGGGAGCTTTTCGTT

Downstream 100 bases:

>100_bases
TCAGTCTCGTGTCTTTCCTGCCCCGCTTTCGCGGGGCTTTTTCTTGCCGCTTTTTTATTATTGCTCATGCTACAGTGTAA
AGACGCTGTTCAATGAGGAG

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 814; Mature: 814

Protein sequence:

>814_residues
MMILSIIATVVLLGALFYHRVSLFLSSLILLAWTAALGVAGLWSIWLLVPLAIILVPFNLTPMRKSMISAPVFRGFRKVM
PPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPQLTAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLK
EHRFFAMIIKKEYGGLEFSAYVQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGQEIPCFAL
TSPEAGSDAGAIPDTGVVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPDRLLGGEEELGITCALIPTSTP
GVEIGRRHFPLNVPFQNGPTRGNDIFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIR
RQFKISIGKMEGIEEPLARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGES
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMAAAQNNDVNAFDKLLFKHIGHVGSNTVRSFWLGLTR
GLTSHTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGSLKRRERISTRLGDVLSQLYLASAVLKRYDDEGRHEADLPL
VHWGVQDALYRAEQAMDDLLQNFPNRVVAGLLTAMIFPTGRHYLAPSDKLDHAVAKILQVPNATRSRIGRGQYLTPAEHN
PVGLLEEALRDVIAADPIHQRICKELGKNLPFTRLDELARNALAKGLIDKDEAAILAKAEESRLRSINVDDFEPEALATK
PVKLPEKVRKVEAA

Sequences:

>Translated_814_residues
MMILSIIATVVLLGALFYHRVSLFLSSLILLAWTAALGVAGLWSIWLLVPLAIILVPFNLTPMRKSMISAPVFRGFRKVM
PPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPQLTAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLK
EHRFFAMIIKKEYGGLEFSAYVQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGQEIPCFAL
TSPEAGSDAGAIPDTGVVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPDRLLGGEEELGITCALIPTSTP
GVEIGRRHFPLNVPFQNGPTRGNDIFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIR
RQFKISIGKMEGIEEPLARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGES
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMAAAQNNDVNAFDKLLFKHIGHVGSNTVRSFWLGLTR
GLTSHTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGSLKRRERISTRLGDVLSQLYLASAVLKRYDDEGRHEADLPL
VHWGVQDALYRAEQAMDDLLQNFPNRVVAGLLTAMIFPTGRHYLAPSDKLDHAVAKILQVPNATRSRIGRGQYLTPAEHN
PVGLLEEALRDVIAADPIHQRICKELGKNLPFTRLDELARNALAKGLIDKDEAAILAKAEESRLRSINVDDFEPEALATK
PVKLPEKVRKVEAA
>Mature_814_residues
MMILSIIATVVLLGALFYHRVSLFLSSLILLAWTAALGVAGLWSIWLLVPLAIILVPFNLTPMRKSMISAPVFRGFRKVM
PPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPQLTAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLK
EHRFFAMIIKKEYGGLEFSAYVQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGQEIPCFAL
TSPEAGSDAGAIPDTGVVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPDRLLGGEEELGITCALIPTSTP
GVEIGRRHFPLNVPFQNGPTRGNDIFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIR
RQFKISIGKMEGIEEPLARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGES
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMAAAQNNDVNAFDKLLFKHIGHVGSNTVRSFWLGLTR
GLTSHTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGSLKRRERISTRLGDVLSQLYLASAVLKRYDDEGRHEADLPL
VHWGVQDALYRAEQAMDDLLQNFPNRVVAGLLTAMIFPTGRHYLAPSDKLDHAVAKILQVPNATRSRIGRGQYLTPAEHN
PVGLLEEALRDVIAADPIHQRICKELGKNLPFTRLDELARNALAKGLIDKDEAAILAKAEESRLRSINVDDFEPEALATK
PVKLPEKVRKVEAA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=546, Percent_Identity=27.1062271062271, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI4557233, Length=419, Percent_Identity=27.6849642004773, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI4557235, Length=403, Percent_Identity=25.0620347394541, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI76496475, Length=382, Percent_Identity=25.3926701570681, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4501859, Length=337, Percent_Identity=26.1127596439169, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI226958412, Length=369, Percent_Identity=25.2032520325203, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI7656849, Length=310, Percent_Identity=23.5483870967742, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI226958414, Length=332, Percent_Identity=25.3012048192771, Blast_Score=68, Evalue=4e-11,
Organism=Escherichia coli, GI87081702, Length=814, Percent_Identity=95.3316953316953, Blast_Score=1610, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=410, Percent_Identity=24.1463414634146, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985192, Length=356, Percent_Identity=23.314606741573, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=329, Percent_Identity=25.2279635258359, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=283, Percent_Identity=26.1484098939929, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=27.5423728813559, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508101, Length=277, Percent_Identity=26.7148014440433, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363737, Length=461, Percent_Identity=27.3318872017354, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24646207, Length=280, Percent_Identity=26.4285714285714, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24666513, Length=331, Percent_Identity=25.3776435045317, Blast_Score=72, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355753, Length=355, Percent_Identity=22.8169014084507, Blast_Score=67, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 89276; Mature: 89276

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMILSIIATVVLLGALFYHRVSLFLSSLILLAWTAALGVAGLWSIWLLVPLAIILVPFNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPMRKSMISAPVFRGFRKVMPPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPQL
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCCCCCCCCHHHHCCCCCCCC
TAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLKEHRFFAMIIKKEYGGLEFSA
CCHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHCCCCCHHH
YVQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGQEIPCFAL
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHCCCCCHHHCCCCCCEEEE
TSPEAGSDAGAIPDTGVVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPDR
CCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHCCCCCHH
LLGGEEELGITCALIPTSTPGVEIGRRHFPLNVPFQNGPTRGNDIFVPIDYIIGGPKMAG
HCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEEHHHEECCCCCCC
QGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIRRQFKISIGKMEGIEEPLARI
HHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHH
AGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGES
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCC
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMAAAQNNDVNAFDKLLF
CHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCEECHHHHHHHHHHCCCCCHHHHHHHH
KHIGHVGSNTVRSFWLGLTRGLTSHTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGS
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LKRRERISTRLGDVLSQLYLASAVLKRYDDEGRHEADLPLVHWGVQDALYRAEQAMDDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHH
QNFPNRVVAGLLTAMIFPTGRHYLAPSDKLDHAVAKILQVPNATRSRIGRGQYLTPAEHN
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC
PVGLLEEALRDVIAADPIHQRICKELGKNLPFTRLDELARNALAKGLIDKDEAAILAKAE
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ESRLRSINVDDFEPEALATKPVKLPEKVRKVEAA
HHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MMILSIIATVVLLGALFYHRVSLFLSSLILLAWTAALGVAGLWSIWLLVPLAIILVPFNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPMRKSMISAPVFRGFRKVMPPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPQL
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCCCCCCCCHHHHCCCCCCCC
TAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLKEHRFFAMIIKKEYGGLEFSA
CCHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHCCCCCHHH
YVQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTEEQKNHYLPRLARGQEIPCFAL
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHCCCCCHHHCCCCCCEEEE
TSPEAGSDAGAIPDTGVVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPDR
CCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHCCCCCHH
LLGGEEELGITCALIPTSTPGVEIGRRHFPLNVPFQNGPTRGNDIFVPIDYIIGGPKMAG
HCCCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEEHHHEECCCCCCC
QGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIRRQFKISIGKMEGIEEPLARI
HHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHH
AGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGES
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCC
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMAAAQNNDVNAFDKLLF
CHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCEECHHHHHHHHHHCCCCCHHHHHHHH
KHIGHVGSNTVRSFWLGLTRGLTSHTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGS
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LKRRERISTRLGDVLSQLYLASAVLKRYDDEGRHEADLPLVHWGVQDALYRAEQAMDDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHH
QNFPNRVVAGLLTAMIFPTGRHYLAPSDKLDHAVAKILQVPNATRSRIGRGQYLTPAEHN
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC
PVGLLEEALRDVIAADPIHQRICKELGKNLPFTRLDELARNALAKGLIDKDEAAILAKAE
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ESRLRSINVDDFEPEALATKPVKLPEKVRKVEAA
HHHHHCCCCCCCCCHHHCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]