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The map label for this gene is dapA2 [H]

Identifier: 28379189

GI number: 28379189

Start: 2384769

End: 2385638

Strand: Direct

Name: dapA2 [H]

Synonym: lp_2685

Alternate gene names: 28379189

Gene position: 2384769-2385638 (Clockwise)

Preceding gene: 28379188

Following gene: 28379191

Centisome position: 72.08

GC content: 50.0

Gene sequence:

>870_bases
ATGAATTTAGCATCCGCACACCTGATTACCGCCATGGTCACCCCATTTGATGACCAACAACACATTGATTTCCACCGCTT
AGAGCAACTGATCGAACACTTACTTGCAACTGGCACGGACGGCTTATTAGTCGGGGGCACGACTGGCGAAGGCCCCACGT
TGAGCATCGCTGAGAAACGAGATTTATACACGCAGACAGCTAGGATCGTTGCTGGGCGAGTTCCAATCATCGCTAATACG
GGGACCAATGACACTGCCGCCACAATTCATTTCACTCACATTGTCAGTCAAATCGAGGGCATCGACGCCGCCCTCGTCGT
TGTCCCGCCTTATAACAAACCCAACCAAACCGGGATGATGGCGCATTTTACAGCCATTGCCGAAAAATCAGACTTGCCCA
TTATAATTTATAATATTCCCGGTCGCGTAGGCGTTAAGATGACGGTCACGACGATTCTCACGTTGGCCCACAACCCCAAC
ATTATTGGGATCAAACAATGTGGTTCCGATGAAGAACTGGCCGCAATTGTTGAAAAGGCGCCTAAAGATTTTCTCGTTTA
CACGGGCGAAGATGCTCAGAGCTTGACCACCCTCGTCTTGGGTGGTCAGGGAACGATTTCAGTGGCGAGTCATTTATTTG
GAAATGAAATGGCGACGATGCGCCGCGCCTTGAACCACGGCGATATCACCCAAGCAGGGCAAATTCAACGACGTTTAATG
CCGAAGATGGCAGCACTATTCACACAACCCTCACCGGCACCCGTCAAAGCGGCGCTGAACGCCCAACACTGGTTAGTCGG
AAGCACGCGCCTACCAATTTTACCGTTAACCACCAATGAACAAAGTCAACTACTCAACAGCTTAAAATAA

Upstream 100 bases:

>100_bases
TTCCGGATAAGTTATGCAGCCAGTCAATCGGCACTACGCGAAGGGCTAAATCGTTTAGCCTTATGGCGCGCCCAAACTAC
CACACAGGAGGATTAGCCAC

Downstream 100 bases:

>100_bases
TGCAGAACGGTTGGTAGTACCTGGCAAAAGCGCGTATACTGAACCTAAAATAATTAGGAAAGTGGTGACCATGATGTGCG
GTTGGGCTTTTACTGGCGGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNLASAHLITAMVTPFDDQQHIDFHRLEQLIEHLLATGTDGLLVGGTTGEGPTLSIAEKRDLYTQTARIVAGRVPIIANT
GTNDTAATIHFTHIVSQIEGIDAALVVVPPYNKPNQTGMMAHFTAIAEKSDLPIIIYNIPGRVGVKMTVTTILTLAHNPN
IIGIKQCGSDEELAAIVEKAPKDFLVYTGEDAQSLTTLVLGGQGTISVASHLFGNEMATMRRALNHGDITQAGQIQRRLM
PKMAALFTQPSPAPVKAALNAQHWLVGSTRLPILPLTTNEQSQLLNSLK

Sequences:

>Translated_289_residues
MNLASAHLITAMVTPFDDQQHIDFHRLEQLIEHLLATGTDGLLVGGTTGEGPTLSIAEKRDLYTQTARIVAGRVPIIANT
GTNDTAATIHFTHIVSQIEGIDAALVVVPPYNKPNQTGMMAHFTAIAEKSDLPIIIYNIPGRVGVKMTVTTILTLAHNPN
IIGIKQCGSDEELAAIVEKAPKDFLVYTGEDAQSLTTLVLGGQGTISVASHLFGNEMATMRRALNHGDITQAGQIQRRLM
PKMAALFTQPSPAPVKAALNAQHWLVGSTRLPILPLTTNEQSQLLNSLK
>Mature_289_residues
MNLASAHLITAMVTPFDDQQHIDFHRLEQLIEHLLATGTDGLLVGGTTGEGPTLSIAEKRDLYTQTARIVAGRVPIIANT
GTNDTAATIHFTHIVSQIEGIDAALVVVPPYNKPNQTGMMAHFTAIAEKSDLPIIIYNIPGRVGVKMTVTTILTLAHNPN
IIGIKQCGSDEELAAIVEKAPKDFLVYTGEDAQSLTTLVLGGQGTISVASHLFGNEMATMRRALNHGDITQAGQIQRRLM
PKMAALFTQPSPAPVKAALNAQHWLVGSTRLPILPLTTNEQSQLLNSLK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=283, Percent_Identity=26.8551236749117, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI13540533, Length=233, Percent_Identity=25.3218884120172, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788823, Length=283, Percent_Identity=38.86925795053, Blast_Score=189, Evalue=1e-49,
Organism=Escherichia coli, GI1789620, Length=230, Percent_Identity=31.304347826087, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082415, Length=251, Percent_Identity=28.6852589641434, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1786463, Length=252, Percent_Identity=28.968253968254, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31029; Mature: 31029

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLASAHLITAMVTPFDDQQHIDFHRLEQLIEHLLATGTDGLLVGGTTGEGPTLSIAEKR
CCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEHHHH
DLYTQTARIVAGRVPIIANTGTNDTAATIHFTHIVSQIEGIDAALVVVPPYNKPNQTGMM
HHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCHH
AHFTAIAEKSDLPIIIYNIPGRVGVKMTVTTILTLAHNPNIIGIKQCGSDEELAAIVEKA
HHHHHHHCCCCCCEEEEECCCCCCEEEEEHEEEEECCCCCEEEEECCCCCHHHHHHHHHC
PKDFLVYTGEDAQSLTTLVLGGQGTISVASHLFGNEMATMRRALNHGDITQAGQIQRRLM
CCCEEEEECCCHHHEEEEEECCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHH
PKMAALFTQPSPAPVKAALNAQHWLVGSTRLPILPLTTNEQSQLLNSLK
HHHHHHHCCCCCCCHHHHCCCCEEEEECCCCCEEEECCCHHHHHHHHCC
>Mature Secondary Structure
MNLASAHLITAMVTPFDDQQHIDFHRLEQLIEHLLATGTDGLLVGGTTGEGPTLSIAEKR
CCCCHHEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEHHHH
DLYTQTARIVAGRVPIIANTGTNDTAATIHFTHIVSQIEGIDAALVVVPPYNKPNQTGMM
HHHHHHHHHHHCCCCEEEECCCCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCHH
AHFTAIAEKSDLPIIIYNIPGRVGVKMTVTTILTLAHNPNIIGIKQCGSDEELAAIVEKA
HHHHHHHCCCCCCEEEEECCCCCCEEEEEHEEEEECCCCCEEEEECCCCCHHHHHHHHHC
PKDFLVYTGEDAQSLTTLVLGGQGTISVASHLFGNEMATMRRALNHGDITQAGQIQRRLM
CCCEEEEECCCHHHEEEEEECCCCHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHH
PKMAALFTQPSPAPVKAALNAQHWLVGSTRLPILPLTTNEQSQLLNSLK
HHHHHHHCCCCCCCHHHHCCCCEEEEECCCCCEEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA