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The map label for this gene is pyrH

Identifier: 28210949

GI number: 28210949

Start: 1353050

End: 1353763

Strand: Direct

Name: pyrH

Synonym: CTC01263

Alternate gene names: 28210949

Gene position: 1353050-1353763 (Clockwise)

Preceding gene: 28210948

Following gene: 28210950

Centisome position: 48.34

GC content: 34.31

Gene sequence:

>714_bases
ATGAATGATATAAAGTATAAAAGAATTATGTTAAAATTATCTGGCGAAGCTTTGGCAGGAGAAAATGGATATGGTTTAGA
CTTTAAAGTAGTTAAAAGAATATCCAAAGAAATAAAAGAATTAGTAGATATGGGAGTAGAAATTGGAGCAGTAGTAGGCG
GAGGCAACATTTGGAGAGGCAGAAATGGTGAGGATATGGACAGAACTACCGCAGACTATATGGGAATGCTTGCTACATGT
ATAAATGCTATGGCTTTACAAGACTCTTTAGAGCAATTAGGAGTTGATACAAGAGTTCAAACAGCTATTGAAATGAAAGA
AGTTGCTGAGCCTTTTATAAGAAGAAGAGCTATGAGACACTTAGAAAAAGGTAGAGTTGTTATATTTGCAGCTGGTACAG
GCAATCCATATTTCTCAACAGACACAACAGCAGCCCTAAGAGCGGCTGAAATAGAGGCAGATATAATACTATTAGCCAAA
AAAGTAGATGGAGTATATGATAAAGATCCTCACAAACACGAAAAAGCACAAAAATTTGAAACTTTGACATACATAGATGT
TTTGGATCAAGGTCTTCAAGTTATGGATTCTACAGCTACATCTTTATGTATGGATAATAATATACCTATACTAGTTTTTG
CCTTAGATGCTCCAGGTAATATAAGAAAAGCTATTTCTGGAGAAAAAATAGGAACTATAGTATGTAAGGAATAA

Upstream 100 bases:

>100_bases
CATCAATTGATACATCTATAACCAAAAATGCTTTTTGAAATAAAAGTTCTAAATTAAAAATTACATTGTAATTTTTAACA
ATTTGGAGGTATAATATAAT

Downstream 100 bases:

>100_bases
AGGGAGGAGTTTTTATGTTAAAAGAAATAATGAATACAGCTGAAGACAAAATGAGTAAGGCTTTATTAGCTTTAAAGAAA
GACTTAGCCTCATTAAAGGC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNDIKYKRIMLKLSGEALAGENGYGLDFKVVKRISKEIKELVDMGVEIGAVVGGGNIWRGRNGEDMDRTTADYMGMLATC
INAMALQDSLEQLGVDTRVQTAIEMKEVAEPFIRRRAMRHLEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEADIILLAK
KVDGVYDKDPHKHEKAQKFETLTYIDVLDQGLQVMDSTATSLCMDNNIPILVFALDAPGNIRKAISGEKIGTIVCKE

Sequences:

>Translated_237_residues
MNDIKYKRIMLKLSGEALAGENGYGLDFKVVKRISKEIKELVDMGVEIGAVVGGGNIWRGRNGEDMDRTTADYMGMLATC
INAMALQDSLEQLGVDTRVQTAIEMKEVAEPFIRRRAMRHLEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEADIILLAK
KVDGVYDKDPHKHEKAQKFETLTYIDVLDQGLQVMDSTATSLCMDNNIPILVFALDAPGNIRKAISGEKIGTIVCKE
>Mature_237_residues
MNDIKYKRIMLKLSGEALAGENGYGLDFKVVKRISKEIKELVDMGVEIGAVVGGGNIWRGRNGEDMDRTTADYMGMLATC
INAMALQDSLEQLGVDTRVQTAIEMKEVAEPFIRRRAMRHLEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEADIILLAK
KVDGVYDKDPHKHEKAQKFETLTYIDVLDQGLQVMDSTATSLCMDNNIPILVFALDAPGNIRKAISGEKIGTIVCKE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=46.7811158798283, Blast_Score=228, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CLOTE (Q895L0)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781893.1
- HSSP:   P0A7E9
- ProteinModelPortal:   Q895L0
- SMR:   Q895L0
- GeneID:   1059345
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC01263
- NMPDR:   fig|212717.1.peg.1115
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q895L0
- ProtClustDB:   PRK00358
- BioCyc:   CTET212717:CTC_01263-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR001057
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- PRINTS:   PR00474
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26073; Mature: 26073

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 72-72 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDIKYKRIMLKLSGEALAGENGYGLDFKVVKRISKEIKELVDMGVEIGAVVGGGNIWRG
CCCCCEEEEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECC
RNGEDMDRTTADYMGMLATCINAMALQDSLEQLGVDTRVQTAIEMKEVAEPFIRRRAMRH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEADIILLAKKVDGVYDKDPHKHEKAQKFE
HHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCHHEEEEEEHHCCCCCCCCCHHHHHHHHH
TLTYIDVLDQGLQVMDSTATSLCMDNNIPILVFALDAPGNIRKAISGEKIGTIVCKE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MNDIKYKRIMLKLSGEALAGENGYGLDFKVVKRISKEIKELVDMGVEIGAVVGGGNIWRG
CCCCCEEEEEEEECCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECC
RNGEDMDRTTADYMGMLATCINAMALQDSLEQLGVDTRVQTAIEMKEVAEPFIRRRAMRH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEADIILLAKKVDGVYDKDPHKHEKAQKFE
HHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCHHEEEEEEHHCCCCCCCCCHHHHHHHHH
TLTYIDVLDQGLQVMDSTATSLCMDNNIPILVFALDAPGNIRKAISGEKIGTIVCKE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129