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The map label for this gene is glcD [H]

Identifier: 28210683

GI number: 28210683

Start: 1042424

End: 1043833

Strand: Direct

Name: glcD [H]

Synonym: CTC00976

Alternate gene names: 28210683

Gene position: 1042424-1043833 (Clockwise)

Preceding gene: 28210682

Following gene: 28210686

Centisome position: 37.24

GC content: 31.06

Gene sequence:

>1410_bases
ATGAAAGTAAATGAAGCTTATAAGACAATAGATAAAAAGGATATAGAATATTTCATTTCAATTCTAGGGAAAAATAGGGT
TTTAGTAGGAGATGAAATCAGTGAAGACTTTAGCCATGACGAATTAGGTGGAATAGAAAAAATGCCAGATGTATTAGTAG
AAGCTAATACAACAGAGGAAATATCAAAAATAATGAAATATGCCTATGAAAATAATATACCAGTAGTACCAAGAGGATCA
GGTACAGGACTAGTAGGGGCATCTGTTCCAATCTACGGTGGAATAATGATAAATTTAACTAAAATGAATAAAATATTAGA
ATTAGACGAAGAAAATTTAACTTTAACTGTGGAACCAGGCGTATTATTAATGGAAATAGCTGATTATGTAGAAGATAAAG
ATTTCTTCTATCCACCAGACCCAGGTGAAAAGTCTGCTACTATAGGGGGGAACATTAATACTAATGCAGGAGGAATGAGA
GCTGTAAAATATGGTGTAACAAGAGACTATGTAAGGGGATTAGAAGTAGTTTTAGCAGATGGAACTATTATGGAACTTGG
GGGTAAAGTTGTAAAAAATAGTTCAGGATACAGTTTGAAAGATTTTGTATGTGGTTCAGAAGGAACTTTAGCTATAGTTA
CAAAAGCTATATTAAAATTACTTCCACTTCCTAAACAATCCATAAGTCTTTTAATACCTTTTAAAGATTTGGACAAAGCT
ATAGAAACAGTACCTAGAATTATAAAATCAAAATCCATACCAACTTCTATAGAATTTATGGAAAGAGATGTTATATTAGC
TTCAGAAGAGTTTTTAGGTAAAAAGTTTCCGGACAATTCATCAGATGCATACTTAATATTAACTTTTGATGGAAATAGCA
AAGAAGAAATAGAAAAGTATTATGATAATGTAGCAAAAATAGCTATAGAAAACGGAGCATTGGATGTTTTAATTGCAGAT
ACTGATGAAAGAAAAGAATCTATATGGAATGCAAGAGGAGCATTTTTGGAAGCTATAAAAGCATCCACTACTGAAATGGA
TGAATGTGACGTATGTGTACCACGAAATAAAGTTGCAGAATTTATAAAGTACACTTATGAATTACAAAATAAATTTGGCA
TCAAAATTAAAAACTTTGGACATGCGGGAGATGGAAATCTTCATGTATATGTATTGAGAGATGATTTAAATGAAGAACAG
TGGAAAAAGAAATTAAATGATGTATTTAAGTGTATGTATGATAAAGCTCACGAATTAGAGGGTACTGTATCAGGTGAACA
TGGTATAGGATATGCTAAAAAAGAATACTTATTTGAATCAATAGGAGATGAACAAAAAGAACTTATGAAGAGAATTAAAT
TGGCCTTTGATCCTAAGAATATTTTGAATCCAGGTAAACTCTGCCAATAG

Upstream 100 bases:

>100_bases
TCACTACGCCATAGTAGGGGATATATATCAAGTAATACCTCAAATAATTAGCGATATAAAAAATCATAAGAAAATAGTAT
AAATTTAGGAGGTTTATTTT

Downstream 100 bases:

>100_bases
ATAAAATAAAGTCTGCCACAATTGTGGCAGACTTTATTTTATCTATTGATTTATTTCATTTTTTAATTTTTCTATACCTA
TTTTAACTCTTTTTAAAGTT

Product: (S)-2-hydroxy-acid oxidase chain D

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKVNEAYKTIDKKDIEYFISILGKNRVLVGDEISEDFSHDELGGIEKMPDVLVEANTTEEISKIMKYAYENNIPVVPRGS
GTGLVGASVPIYGGIMINLTKMNKILELDEENLTLTVEPGVLLMEIADYVEDKDFFYPPDPGEKSATIGGNINTNAGGMR
AVKYGVTRDYVRGLEVVLADGTIMELGGKVVKNSSGYSLKDFVCGSEGTLAIVTKAILKLLPLPKQSISLLIPFKDLDKA
IETVPRIIKSKSIPTSIEFMERDVILASEEFLGKKFPDNSSDAYLILTFDGNSKEEIEKYYDNVAKIAIENGALDVLIAD
TDERKESIWNARGAFLEAIKASTTEMDECDVCVPRNKVAEFIKYTYELQNKFGIKIKNFGHAGDGNLHVYVLRDDLNEEQ
WKKKLNDVFKCMYDKAHELEGTVSGEHGIGYAKKEYLFESIGDEQKELMKRIKLAFDPKNILNPGKLCQ

Sequences:

>Translated_469_residues
MKVNEAYKTIDKKDIEYFISILGKNRVLVGDEISEDFSHDELGGIEKMPDVLVEANTTEEISKIMKYAYENNIPVVPRGS
GTGLVGASVPIYGGIMINLTKMNKILELDEENLTLTVEPGVLLMEIADYVEDKDFFYPPDPGEKSATIGGNINTNAGGMR
AVKYGVTRDYVRGLEVVLADGTIMELGGKVVKNSSGYSLKDFVCGSEGTLAIVTKAILKLLPLPKQSISLLIPFKDLDKA
IETVPRIIKSKSIPTSIEFMERDVILASEEFLGKKFPDNSSDAYLILTFDGNSKEEIEKYYDNVAKIAIENGALDVLIAD
TDERKESIWNARGAFLEAIKASTTEMDECDVCVPRNKVAEFIKYTYELQNKFGIKIKNFGHAGDGNLHVYVLRDDLNEEQ
WKKKLNDVFKCMYDKAHELEGTVSGEHGIGYAKKEYLFESIGDEQKELMKRIKLAFDPKNILNPGKLCQ
>Mature_469_residues
MKVNEAYKTIDKKDIEYFISILGKNRVLVGDEISEDFSHDELGGIEKMPDVLVEANTTEEISKIMKYAYENNIPVVPRGS
GTGLVGASVPIYGGIMINLTKMNKILELDEENLTLTVEPGVLLMEIADYVEDKDFFYPPDPGEKSATIGGNINTNAGGMR
AVKYGVTRDYVRGLEVVLADGTIMELGGKVVKNSSGYSLKDFVCGSEGTLAIVTKAILKLLPLPKQSISLLIPFKDLDKA
IETVPRIIKSKSIPTSIEFMERDVILASEEFLGKKFPDNSSDAYLILTFDGNSKEEIEKYYDNVAKIAIENGALDVLIAD
TDERKESIWNARGAFLEAIKASTTEMDECDVCVPRNKVAEFIKYTYELQNKFGIKIKNFGHAGDGNLHVYVLRDDLNEEQ
WKKKLNDVFKCMYDKAHELEGTVSGEHGIGYAKKEYLFESIGDEQKELMKRIKLAFDPKNILNPGKLCQ

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=458, Percent_Identity=31.4410480349345, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI37595754, Length=484, Percent_Identity=29.9586776859504, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI119964728, Length=468, Percent_Identity=30.7692307692308, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4501993, Length=470, Percent_Identity=26.1702127659574, Blast_Score=119, Evalue=8e-27,
Organism=Escherichia coli, GI1789351, Length=441, Percent_Identity=29.9319727891156, Blast_Score=218, Evalue=8e-58,
Organism=Escherichia coli, GI1787977, Length=509, Percent_Identity=26.1296660117878, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI48994907, Length=475, Percent_Identity=22.3157894736842, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI48994914, Length=184, Percent_Identity=29.3478260869565, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71992373, Length=471, Percent_Identity=31.8471337579618, Blast_Score=241, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI71992381, Length=471, Percent_Identity=30.3609341825902, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI71992392, Length=382, Percent_Identity=31.6753926701571, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17534361, Length=473, Percent_Identity=29.1754756871036, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17556096, Length=473, Percent_Identity=24.1014799154334, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320027, Length=449, Percent_Identity=31.6258351893096, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320023, Length=482, Percent_Identity=31.1203319502075, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320764, Length=491, Percent_Identity=30.142566191446, Blast_Score=203, Evalue=6e-53,
Organism=Drosophila melanogaster, GI18921117, Length=471, Percent_Identity=31.8471337579618, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24639277, Length=471, Percent_Identity=31.8471337579618, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24639275, Length=471, Percent_Identity=31.8471337579618, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24653753, Length=228, Percent_Identity=27.6315789473684, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 52285; Mature: 52285

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNEAYKTIDKKDIEYFISILGKNRVLVGDEISEDFSHDELGGIEKMPDVLVEANTTEE
CCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCCCCCCHHHCCHHEEECCCHHH
ISKIMKYAYENNIPVVPRGSGTGLVGASVPIYGGIMINLTKMNKILELDEENLTLTVEPG
HHHHHHHHHCCCCCEEECCCCCEEEECCCCEECCEEEEEEHHHHHHEECCCCEEEEECCC
VLLMEIADYVEDKDFFYPPDPGEKSATIGGNINTNAGGMRAVKYGVTRDYVRGLEVVLAD
CHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEECCCCHHHHCCEEEEEEC
GTIMELGGKVVKNSSGYSLKDFVCGSEGTLAIVTKAILKLLPLPKQSISLLIPFKDLDKA
CCHHHHCCEEEECCCCCCHHHEECCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHHHHH
IETVPRIIKSKSIPTSIEFMERDVILASEEFLGKKFPDNSSDAYLILTFDGNSKEEIEKY
HHHHHHHHHCCCCCCHHHHHHHCEEEECHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHH
YDNVAKIAIENGALDVLIADTDERKESIWNARGAFLEAIKASTTEMDECDVCVPRNKVAE
HHHHHEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
FIKYTYELQNKFGIKIKNFGHAGDGNLHVYVLRDDLNEEQWKKKLNDVFKCMYDKAHELE
HHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
GTVSGEHGIGYAKKEYLFESIGDEQKELMKRIKLAFDPKNILNPGKLCQ
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCCCC
>Mature Secondary Structure
MKVNEAYKTIDKKDIEYFISILGKNRVLVGDEISEDFSHDELGGIEKMPDVLVEANTTEE
CCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHCCCCCCCCCHHHCCHHEEECCCHHH
ISKIMKYAYENNIPVVPRGSGTGLVGASVPIYGGIMINLTKMNKILELDEENLTLTVEPG
HHHHHHHHHCCCCCEEECCCCCEEEECCCCEECCEEEEEEHHHHHHEECCCCEEEEECCC
VLLMEIADYVEDKDFFYPPDPGEKSATIGGNINTNAGGMRAVKYGVTRDYVRGLEVVLAD
CHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEECCCCHHHHCCEEEEEEC
GTIMELGGKVVKNSSGYSLKDFVCGSEGTLAIVTKAILKLLPLPKQSISLLIPFKDLDKA
CCHHHHCCEEEECCCCCCHHHEECCCCCCHHHHHHHHHHHCCCCCCCCEEEECHHHHHHH
IETVPRIIKSKSIPTSIEFMERDVILASEEFLGKKFPDNSSDAYLILTFDGNSKEEIEKY
HHHHHHHHHCCCCCCHHHHHHHCEEEECHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHH
YDNVAKIAIENGALDVLIADTDERKESIWNARGAFLEAIKASTTEMDECDVCVPRNKVAE
HHHHHEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
FIKYTYELQNKFGIKIKNFGHAGDGNLHVYVLRDDLNEEQWKKKLNDVFKCMYDKAHELE
HHHHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
GTVSGEHGIGYAKKEYLFESIGDEQKELMKRIKLAFDPKNILNPGKLCQ
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]