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The map label for this gene is pleC [H]

Identifier: 28210209

GI number: 28210209

Start: 454492

End: 455826

Strand: Direct

Name: pleC [H]

Synonym: CTC00456

Alternate gene names: 28210209

Gene position: 454492-455826 (Clockwise)

Preceding gene: 28210208

Following gene: 28210210

Centisome position: 16.24

GC content: 27.19

Gene sequence:

>1335_bases
TTGTATAGAAAAAAGAAAGTAAGCAGGGTTTTAAGTATTAAGGAGGAAAAAATGTATAAACGTATGTTGAAGGAGCTTAT
TGAGATAGAGGAGATACAAAATCTTATGGAAAAGCTGTATTCTATTGTAGGAATATCTCATAGCATATTAGACTTGGATG
GCAATTTAATAGTTGGCATAGGTGAAAAAGGTATTTATAAAAGCAAAAATACTAAGGAATACTTTAGTTATAATCAAAAG
TATGATAAAAAAGAGGAATATTTTTTACTAACTTGTAAAGAAGGCACAAAAAAAATTGTATCACCTATAAAAGTAAAAGA
AGAAAGAATAGGATATATAGTTACTGAAGATTTTTTTATAAAAGGGGAAGATAAAGAGCATTGTAAAACTTGCATAAGAG
AAGACTTAGAATACATAAATTATGTAGAAAAAATACCTGTTATAAATGAAGAACAGGTTAAAAATACAATAATATATCAA
AGAGATTTAATAGAGCTTATAATAAATAAGAAGATAACTGATTTATCTTATGAAGAAAATGCATATGCAAAAATGAGACA
TAAATTTTTTGCCAATTTATCTCATGAATTTAGAACACCTATTACAGTAATATTAAGCTCCCTATATATGTGTGAAATTT
TTTTGAAAAAAACTCAGGAAGATATATTAGATATAAAAGTTACTACATATTTAAAAAACATAAAGAAAAATGCATATAGA
TTGTTAAGACTGATTAATAACTTAATAGATATGACTAAAATAAATTGTGGAGAGCTTATTTTATTTAAAGAAAACAATGA
TATTGTAAATATAGTGGAGGAGACTACCTTAAGAGTAGCAAAGTATGTATATAGTAAAAATATAGATATAGTTTTTGATA
CAGATGTAGAGGAAAAAATAATAGCTTGTGATAAGGAAAAAATCGAAAGAATAATATTAAATCTTCTATCAAATGCAGTA
AAATTTACTCCCCGGGGAGGCCGTATATTGGTTCAAGTAGAAAATACTAATGATTTCGTAAGAATTTCTGTAGAAGATAC
AGGAATAGGAATTCCAGAAGAAGAAAAGGACTTGATTTTTGAGCCCTTTACCCAAGTAGATAAGGGATTTTCAAGAATAG
CAGAAGGAAGTGGCATAGGATTACCCATAATAAAATCTTTAGTGGAAATGCACAAAGGAATAATATGGGTAGAGAGTATT
TGTGGAGAAGGAAGTAAATTTTTTATAGAGCTTCCCAACGTAACTTTAGAAGATTGTAATAATGCTAATGGAAAGGTTCA
ATTTTCTGGTGGAGAAGAAAATACTCACATAGAATTTTCAGATATATATTTTTAG

Upstream 100 bases:

>100_bases
AAAAAGCATTAATAGATTTCTGTAAAGGAATATGTCAAAAACAATTTAATGTGATAAAACTGCAATTCGTCAATCAAATA
AATAATCCACCAATGATGAT

Downstream 100 bases:

>100_bases
CAACTAATAATTAATGTATATATATAATTTATCTTGTATTATAATATAAATAGAATAAAACTAGGAGTGTGAGTAAAATC
ATGAAAAGAATACCCTATGG

Product: sensory transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MYRKKKVSRVLSIKEEKMYKRMLKELIEIEEIQNLMEKLYSIVGISHSILDLDGNLIVGIGEKGIYKSKNTKEYFSYNQK
YDKKEEYFLLTCKEGTKKIVSPIKVKEERIGYIVTEDFFIKGEDKEHCKTCIREDLEYINYVEKIPVINEEQVKNTIIYQ
RDLIELIINKKITDLSYEENAYAKMRHKFFANLSHEFRTPITVILSSLYMCEIFLKKTQEDILDIKVTTYLKNIKKNAYR
LLRLINNLIDMTKINCGELILFKENNDIVNIVEETTLRVAKYVYSKNIDIVFDTDVEEKIIACDKEKIERIILNLLSNAV
KFTPRGGRILVQVENTNDFVRISVEDTGIGIPEEEKDLIFEPFTQVDKGFSRIAEGSGIGLPIIKSLVEMHKGIIWVESI
CGEGSKFFIELPNVTLEDCNNANGKVQFSGGEENTHIEFSDIYF

Sequences:

>Translated_444_residues
MYRKKKVSRVLSIKEEKMYKRMLKELIEIEEIQNLMEKLYSIVGISHSILDLDGNLIVGIGEKGIYKSKNTKEYFSYNQK
YDKKEEYFLLTCKEGTKKIVSPIKVKEERIGYIVTEDFFIKGEDKEHCKTCIREDLEYINYVEKIPVINEEQVKNTIIYQ
RDLIELIINKKITDLSYEENAYAKMRHKFFANLSHEFRTPITVILSSLYMCEIFLKKTQEDILDIKVTTYLKNIKKNAYR
LLRLINNLIDMTKINCGELILFKENNDIVNIVEETTLRVAKYVYSKNIDIVFDTDVEEKIIACDKEKIERIILNLLSNAV
KFTPRGGRILVQVENTNDFVRISVEDTGIGIPEEEKDLIFEPFTQVDKGFSRIAEGSGIGLPIIKSLVEMHKGIIWVESI
CGEGSKFFIELPNVTLEDCNNANGKVQFSGGEENTHIEFSDIYF
>Mature_444_residues
MYRKKKVSRVLSIKEEKMYKRMLKELIEIEEIQNLMEKLYSIVGISHSILDLDGNLIVGIGEKGIYKSKNTKEYFSYNQK
YDKKEEYFLLTCKEGTKKIVSPIKVKEERIGYIVTEDFFIKGEDKEHCKTCIREDLEYINYVEKIPVINEEQVKNTIIYQ
RDLIELIINKKITDLSYEENAYAKMRHKFFANLSHEFRTPITVILSSLYMCEIFLKKTQEDILDIKVTTYLKNIKKNAYR
LLRLINNLIDMTKINCGELILFKENNDIVNIVEETTLRVAKYVYSKNIDIVFDTDVEEKIIACDKEKIERIILNLLSNAV
KFTPRGGRILVQVENTNDFVRISVEDTGIGIPEEEKDLIFEPFTQVDKGFSRIAEGSGIGLPIIKSLVEMHKGIIWVESI
CGEGSKFFIELPNVTLEDCNNANGKVQFSGGEENTHIEFSDIYF

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=32.7935222672065, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786600, Length=251, Percent_Identity=31.4741035856574, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=29.5546558704453, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786783, Length=226, Percent_Identity=30.0884955752212, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=29.4871794871795, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=32.0833333333333, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=28.0172413793103, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=27.1966527196653, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=25.5411255411255, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=28.3185840707965, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=28.4, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=28.2945736434109, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790300, Length=263, Percent_Identity=25.8555133079848, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790346, Length=239, Percent_Identity=24.2677824267782, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788279, Length=227, Percent_Identity=28.6343612334802, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790861, Length=205, Percent_Identity=26.3414634146341, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=88, Percent_Identity=42.0454545454545, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51621; Mature: 51621

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRKKKVSRVLSIKEEKMYKRMLKELIEIEEIQNLMEKLYSIVGISHSILDLDGNLIVGI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCEEEEE
GEKGIYKSKNTKEYFSYNQKYDKKEEYFLLTCKEGTKKIVSPIKVKEERIGYIVTEDFFI
CCCCCCCCCCCHHHHCCCCCCCCCCCEEEEEECCCCHHHHCCHHCCHHHCCEEEEECEEE
KGEDKEHCKTCIREDLEYINYVEKIPVINEEQVKNTIIYQRDLIELIINKKITDLSYEEN
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
AYAKMRHKFFANLSHEFRTPITVILSSLYMCEIFLKKTQEDILDIKVTTYLKNIKKNAYR
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLRLINNLIDMTKINCGELILFKENNDIVNIVEETTLRVAKYVYSKNIDIVFDTDVEEKI
HHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCEEECCCCHHHH
IACDKEKIERIILNLLSNAVKFTPRGGRILVQVENTNDFVRISVEDTGIGIPEEEKDLIF
HHCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHH
EPFTQVDKGFSRIAEGSGIGLPIIKSLVEMHKGIIWVESICGEGSKFFIELPNVTLEDCN
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEEHHHCCCCEEEEECCCCCCCCCC
NANGKVQFSGGEENTHIEFSDIYF
CCCCEEEECCCCCCCEEEEEECCC
>Mature Secondary Structure
MYRKKKVSRVLSIKEEKMYKRMLKELIEIEEIQNLMEKLYSIVGISHSILDLDGNLIVGI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCEEEEE
GEKGIYKSKNTKEYFSYNQKYDKKEEYFLLTCKEGTKKIVSPIKVKEERIGYIVTEDFFI
CCCCCCCCCCCHHHHCCCCCCCCCCCEEEEEECCCCHHHHCCHHCCHHHCCEEEEECEEE
KGEDKEHCKTCIREDLEYINYVEKIPVINEEQVKNTIIYQRDLIELIINKKITDLSYEEN
ECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
AYAKMRHKFFANLSHEFRTPITVILSSLYMCEIFLKKTQEDILDIKVTTYLKNIKKNAYR
HHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLRLINNLIDMTKINCGELILFKENNDIVNIVEETTLRVAKYVYSKNIDIVFDTDVEEKI
HHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCEEECCCCHHHH
IACDKEKIERIILNLLSNAVKFTPRGGRILVQVENTNDFVRISVEDTGIGIPEEEKDLIF
HHCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHH
EPFTQVDKGFSRIAEGSGIGLPIIKSLVEMHKGIIWVESICGEGSKFFIELPNVTLEDCN
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEEHHHCCCCEEEEECCCCCCCCCC
NANGKVQFSGGEENTHIEFSDIYF
CCCCEEEECCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]