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The map label for this gene is flhA [H]

Identifier: 62185043

GI number: 62185043

Start: 475882

End: 477639

Strand: Direct

Name: flhA [H]

Synonym: CAB414

Alternate gene names: 62185043

Gene position: 475882-477639 (Clockwise)

Preceding gene: 62185036

Following gene: 62185044

Centisome position: 41.58

GC content: 40.27

Gene sequence:

>1758_bases
TTGGTGACAAGCAAACAAGAGAAATTATGGAGAATGGCTCTCATTCCCTTAGGTATTCTTCTTTCTTTTTTGATTCCTTT
ACCTCAGCTGCTTTTAGATACGGGTTTATGTATCAACTTTATTTTATCGCTCACCGTTGTATTTTGGGTATTTTCTTTAA
AATCTAGCCTGGAAGCTAGGCTCTTTCCTGCGTTATTTGTGTACCTTTGCTTATTTCGTTTGGGATTGAATCTTGCTTCA
ACTCGATTGATTTTATCCTCGGGTTGGGCATCACCTATGATTTTCTCTTTGGGGAATTTTTTTTCCTTAGGGAGTTTAGG
AGCAGGAATCGCTGCCTGCTGTCTGTTTTTTTTAGTAAATTTTCTTGTCATTGCCAAGGGATCAGAAAGAGTCGCGGAAG
TACGTGCAAGATTTATTTTAGAAGCTCTGCCTGGTAAGCAAATGTCACTAGATGCCGATCTTGTGTCTGGACGAGCCTCG
GCGATGGATGTTGAAAAACAAAAACAAGATCTTTTTGAAGAAAGCGATTTTTTTTCTTCGATGGAGGGAGTGTTTCGCTT
TGTAAAAGGGGATGCTGTTGTCAGTTGTATTTTGCTCATTGTCAATACGATAGCAGCTGCCTATTTTGCTTGTTCTGTGG
ATAGAGAATCAGCAAGTTTATGGCTCACCGTGGTAGGAGATGCTTTAGTCAGCCAAGTGCCTGCACTCATGACATCATGT
GCTGCAGCGACCTTGATATCCAAGGTGGGCCAAAAAGCATCTCTCCTTGAGTATATGATAGACTATTACGAGCAAGCGCG
AGTGCATTTTCGAACGATTGCTCTTTTATTCTCCTCACTACTGTTCATCCCAGGGACTCCTAAAGCTCCTGTGATTGTTT
TTGCTATTGCCTTGCTCATCGCCTATAAACCACCCAAAGATGTACAGGGGCCTGAAATTCTATCTGAAATATTCCAACAA
ATACACCTCTCTCTTTCTACAGATTACACAGGAGTGAACCCGCACGAGCTCTATGCACAAGCACGGGAAGAGATCTTCAA
TGAAACAGGCGTATTCTTGCATCAAGAGATGAAGATTTTTTATCGTGACAAACCCGCATCTTTGAGTTGCTGTGGGAAAC
ATTTTCATCTCGAAGAAATTTCTTTATCTCGTCTTTTACCCATACTAAGAAATCTACTCCCAGAGGCTATTCACGGAAAT
TATGTCAAAATGCTTGTACGACAAGCGCAAAATGTTTTGGGTATCTCGATCGATGAGATTATTCCAAAAAAAATATCTGA
AAATTCCTTGCTCTTTCTCATAAAAGGTCTGGTCAAAGAACGCGTATCTTTGAGGTTATTCCCTAAGGTATTGGAAGCGA
TAGCGTTATATGGATCTCCAGAAGAAAACCCTGAAATACTTGCCGAGAAAATTAGAAAATACCTAGGGAAACATATAGGA
AGAGCCCTTTGGGATCAGCAAAATACACTAGAGATCATCACGGTAGATTCGCATGTAGAACGTATGATAGGTGATTTATA
TTCAAAATCTAATCCATTGATGTGTGATAAGGTAATTTGCCAAGTACAGACTCTCTTAAATCAATCCGCGGGGGGAGATT
TTCGTGCGATCATTACGGGATGTGAGTCGCGTTTTGAACTAAGGAAAATGATAGAACCTTACTTTCCAGATTTGCTTGTT
TTATCACATAATGAACTTCCAGAAGAAATCCCTATTTCTTTGCTAGGATCCGTGTCTGACGAGGTTTTGACACTTTAA

Upstream 100 bases:

>100_bases
TAACCTAAAATTCATGAATCTCTGTCATAAGAGTTTTTCTTGAAGATATATGTTTTTTATCGTTATTGAGGAAAATAAGA
GAGTCTCATAGGGGAGGCGC

Downstream 100 bases:

>100_bases
TTGTGAAATTCATCTAATTAAAACAAATAAAATATTTTAATTGAGGTGTTGTTTAAAATATTTTTTTTATTTAATCTTAA
AATAATTACTGAAAGAAAAA

Product: type III secretion system protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MVTSKQEKLWRMALIPLGILLSFLIPLPQLLLDTGLCINFILSLTVVFWVFSLKSSLEARLFPALFVYLCLFRLGLNLAS
TRLILSSGWASPMIFSLGNFFSLGSLGAGIAACCLFFLVNFLVIAKGSERVAEVRARFILEALPGKQMSLDADLVSGRAS
AMDVEKQKQDLFEESDFFSSMEGVFRFVKGDAVVSCILLIVNTIAAAYFACSVDRESASLWLTVVGDALVSQVPALMTSC
AAATLISKVGQKASLLEYMIDYYEQARVHFRTIALLFSSLLFIPGTPKAPVIVFAIALLIAYKPPKDVQGPEILSEIFQQ
IHLSLSTDYTGVNPHELYAQAREEIFNETGVFLHQEMKIFYRDKPASLSCCGKHFHLEEISLSRLLPILRNLLPEAIHGN
YVKMLVRQAQNVLGISIDEIIPKKISENSLLFLIKGLVKERVSLRLFPKVLEAIALYGSPEENPEILAEKIRKYLGKHIG
RALWDQQNTLEIITVDSHVERMIGDLYSKSNPLMCDKVICQVQTLLNQSAGGDFRAIITGCESRFELRKMIEPYFPDLLV
LSHNELPEEIPISLLGSVSDEVLTL

Sequences:

>Translated_585_residues
MVTSKQEKLWRMALIPLGILLSFLIPLPQLLLDTGLCINFILSLTVVFWVFSLKSSLEARLFPALFVYLCLFRLGLNLAS
TRLILSSGWASPMIFSLGNFFSLGSLGAGIAACCLFFLVNFLVIAKGSERVAEVRARFILEALPGKQMSLDADLVSGRAS
AMDVEKQKQDLFEESDFFSSMEGVFRFVKGDAVVSCILLIVNTIAAAYFACSVDRESASLWLTVVGDALVSQVPALMTSC
AAATLISKVGQKASLLEYMIDYYEQARVHFRTIALLFSSLLFIPGTPKAPVIVFAIALLIAYKPPKDVQGPEILSEIFQQ
IHLSLSTDYTGVNPHELYAQAREEIFNETGVFLHQEMKIFYRDKPASLSCCGKHFHLEEISLSRLLPILRNLLPEAIHGN
YVKMLVRQAQNVLGISIDEIIPKKISENSLLFLIKGLVKERVSLRLFPKVLEAIALYGSPEENPEILAEKIRKYLGKHIG
RALWDQQNTLEIITVDSHVERMIGDLYSKSNPLMCDKVICQVQTLLNQSAGGDFRAIITGCESRFELRKMIEPYFPDLLV
LSHNELPEEIPISLLGSVSDEVLTL
>Mature_585_residues
MVTSKQEKLWRMALIPLGILLSFLIPLPQLLLDTGLCINFILSLTVVFWVFSLKSSLEARLFPALFVYLCLFRLGLNLAS
TRLILSSGWASPMIFSLGNFFSLGSLGAGIAACCLFFLVNFLVIAKGSERVAEVRARFILEALPGKQMSLDADLVSGRAS
AMDVEKQKQDLFEESDFFSSMEGVFRFVKGDAVVSCILLIVNTIAAAYFACSVDRESASLWLTVVGDALVSQVPALMTSC
AAATLISKVGQKASLLEYMIDYYEQARVHFRTIALLFSSLLFIPGTPKAPVIVFAIALLIAYKPPKDVQGPEILSEIFQQ
IHLSLSTDYTGVNPHELYAQAREEIFNETGVFLHQEMKIFYRDKPASLSCCGKHFHLEEISLSRLLPILRNLLPEAIHGN
YVKMLVRQAQNVLGISIDEIIPKKISENSLLFLIKGLVKERVSLRLFPKVLEAIALYGSPEENPEILAEKIRKYLGKHIG
RALWDQQNTLEIITVDSHVERMIGDLYSKSNPLMCDKVICQVQTLLNQSAGGDFRAIITGCESRFELRKMIEPYFPDLLV
LSHNELPEEIPISLLGSVSDEVLTL

Specific function: Could be involved in the secretion of the yop virulence proteins [H]

COG id: COG1298

COG function: function code NU; Flagellar biosynthesis pathway, component FlhA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=304, Percent_Identity=32.8947368421053, Blast_Score=171, Evalue=1e-43,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001712
- InterPro:   IPR006302 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 65136; Mature: 65136

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTSKQEKLWRMALIPLGILLSFLIPLPQLLLDTGLCINFILSLTVVFWVFSLKSSLEAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
LFPALFVYLCLFRLGLNLASTRLILSSGWASPMIFSLGNFFSLGSLGAGIAACCLFFLVN
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
FLVIAKGSERVAEVRARFILEALPGKQMSLDADLVSGRASAMDVEKQKQDLFEESDFFSS
HHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MEGVFRFVKGDAVVSCILLIVNTIAAAYFACSVDRESASLWLTVVGDALVSQVPALMTSC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AAATLISKVGQKASLLEYMIDYYEQARVHFRTIALLFSSLLFIPGTPKAPVIVFAIALLI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AYKPPKDVQGPEILSEIFQQIHLSLSTDYTGVNPHELYAQAREEIFNETGVFLHQEMKIF
HCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
YRDKPASLSCCGKHFHLEEISLSRLLPILRNLLPEAIHGNYVKMLVRQAQNVLGISIDEI
CCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHH
IPKKISENSLLFLIKGLVKERVSLRLFPKVLEAIALYGSPEENPEILAEKIRKYLGKHIG
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
RALWDQQNTLEIITVDSHVERMIGDLYSKSNPLMCDKVICQVQTLLNQSAGGDFRAIITG
HHHHCCCCCEEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
CESRFELRKMIEPYFPDLLVLSHNELPEEIPISLLGSVSDEVLTL
HHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11402007 [H]