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The map label for this gene is lpxA

Identifier: 62184734

GI number: 62184734

Start: 105156

End: 105995

Strand: Direct

Name: lpxA

Synonym: CAB090

Alternate gene names: 62184734

Gene position: 105156-105995 (Clockwise)

Preceding gene: 62184733

Following gene: 62184735

Centisome position: 9.19

GC content: 42.02

Gene sequence:

>840_bases
ATGACGAACATTCACCCAACAGCAATTATCGAACCCGGGGCTAAAATCGGAAGGAATGTTGTTATTGAGCCGTATGTTGT
TATTAAATCTACGGTGACCCTTTGTGATGATGTAGTTGTTAAATCCTATGCGTATATTGATGGATACACAACGATAGGCA
GAGGTACAACGATTTGGCCGTCCGCTATGATCGGTAACAAACCTCAGGATTTAAAATATCAGGGTGAAAAGACCTATGTT
ACTATAGGGGAAAATTGTGAGATTCGCGAATTCGCTATTATTACCTCTTCTACATTTGAAGGAACCACAGTTTCTATAGG
AAATAATTGTCTTATCATGCCCTGGGCTCATGTAGCTCATAACTGTACAATTGGCAATCATGTGGTCTTAAGTAATCATG
CACAGTTGGCGGGCCACGTTGTAGTAGAAGATTATGCCATTATTGGCGGTATGGTCGGTGTCCATCAGTTTGTTCGTATT
GGTGCACACGCTATGGTCGGAGCTTTAAGTGGCGTGCGAAGAGATGTTCCTCCATATACTATAGGCACAGGGAACCCCTA
CCAGTTAGGCGGAATCAATAAAGTTGGTTTACAGAGACGACAGGTAGGCTTTGAAATACGTTTGGCTTTGATCAAGGTGT
TTAAGAAAGTCTATCGTTCTGAAGACGGCTTCTTTGAAGCTTTATTAGAAGCTCAAGAAGAATACGGCCATATTCCTGAA
GTCCAAAATTTTATTCATTTTTGTCGGAATCCAAGTAAGCGTGGAATTGAGCGTGGAGCTGCTAAAGAGGCTTTCCAAGA
GGAGAGCGTAGATAAAGAAGGAGCTCTGGTTGAGTCTTAA

Upstream 100 bases:

>100_bases
GAAAGCTTCGGCTCGGGCTTGTGTGGGTTCCCAGGTTGCGGCTGAGGGAGAACTAAGCTTTGCTCTTGTAGACAAGAAAT
CTTTAGATTAACGGAGACGT

Downstream 100 bases:

>100_bases
GATTGTTTATTTCGGCACGCCACAATTTGCTGCCACAGTTTTAGCAGATTTATTACATCATGAAGTCAATGTTGTCGCTG
TCGTTACTCGTGTAGATAAA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTNIHPTAIIEPGAKIGRNVVIEPYVVIKSTVTLCDDVVVKSYAYIDGYTTIGRGTTIWPSAMIGNKPQDLKYQGEKTYV
TIGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAHNCTIGNHVVLSNHAQLAGHVVVEDYAIIGGMVGVHQFVRI
GAHAMVGALSGVRRDVPPYTIGTGNPYQLGGINKVGLQRRQVGFEIRLALIKVFKKVYRSEDGFFEALLEAQEEYGHIPE
VQNFIHFCRNPSKRGIERGAAKEAFQEESVDKEGALVES

Sequences:

>Translated_279_residues
MTNIHPTAIIEPGAKIGRNVVIEPYVVIKSTVTLCDDVVVKSYAYIDGYTTIGRGTTIWPSAMIGNKPQDLKYQGEKTYV
TIGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAHNCTIGNHVVLSNHAQLAGHVVVEDYAIIGGMVGVHQFVRI
GAHAMVGALSGVRRDVPPYTIGTGNPYQLGGINKVGLQRRQVGFEIRLALIKVFKKVYRSEDGFFEALLEAQEEYGHIPE
VQNFIHFCRNPSKRGIERGAAKEAFQEESVDKEGALVES
>Mature_278_residues
TNIHPTAIIEPGAKIGRNVVIEPYVVIKSTVTLCDDVVVKSYAYIDGYTTIGRGTTIWPSAMIGNKPQDLKYQGEKTYVT
IGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAHNCTIGNHVVLSNHAQLAGHVVVEDYAIIGGMVGVHQFVRIG
AHAMVGALSGVRRDVPPYTIGTGNPYQLGGINKVGLQRRQVGFEIRLALIKVFKKVYRSEDGFFEALLEAQEEYGHIPEV
QNFIHFCRNPSKRGIERGAAKEAFQEESVDKEGALVES

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=256, Percent_Identity=45.3125, Blast_Score=204, Evalue=5e-54,
Organism=Escherichia coli, GI1786376, Length=187, Percent_Identity=28.3422459893048, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_CHLAB (Q5L723)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219519.1
- HSSP:   P0A722
- ProteinModelPortal:   Q5L723
- SMR:   Q5L723
- GeneID:   3337454
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB090
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- PhylomeDB:   Q5L723
- ProtClustDB:   PRK05289
- BioCyc:   CABO218497:CAB090-MONOMER
- BRENDA:   2.3.1.129
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 30603; Mature: 30472

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIHPTAIIEPGAKIGRNVVIEPYVVIKSTVTLCDDVVVKSYAYIDGYTTIGRGTTIWP
CCCCCCCEEECCCHHHCCCEEECCEEEEHHHHHHHHHHHHHHHHEECCEEECCCCCEECC
SAMIGNKPQDLKYQGEKTYVTIGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAH
HHHHCCCCCCCEECCCEEEEEECCCCCEEEEEEEECCCCCCEEEEECCCEEEEEHHHHHC
NCTIGNHVVLSNHAQLAGHVVVEDYAIIGGMVGVHQFVRIGAHAMVGALSGVRRDVPPYT
CCCCCCEEEEECCHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IGTGNPYQLGGINKVGLQRRQVGFEIRLALIKVFKKVYRSEDGFFEALLEAQEEYGHIPE
ECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHH
VQNFIHFCRNPSKRGIERGAAKEAFQEESVDKEGALVES
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TNIHPTAIIEPGAKIGRNVVIEPYVVIKSTVTLCDDVVVKSYAYIDGYTTIGRGTTIWP
CCCCCCEEECCCHHHCCCEEECCEEEEHHHHHHHHHHHHHHHHEECCEEECCCCCEECC
SAMIGNKPQDLKYQGEKTYVTIGENCEIREFAIITSSTFEGTTVSIGNNCLIMPWAHVAH
HHHHCCCCCCCEECCCEEEEEECCCCCEEEEEEEECCCCCCEEEEECCCEEEEEHHHHHC
NCTIGNHVVLSNHAQLAGHVVVEDYAIIGGMVGVHQFVRIGAHAMVGALSGVRRDVPPYT
CCCCCCEEEEECCHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IGTGNPYQLGGINKVGLQRRQVGFEIRLALIKVFKKVYRSEDGFFEALLEAQEEYGHIPE
ECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHH
VQNFIHFCRNPSKRGIERGAAKEAFQEESVDKEGALVES
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA