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The map label for this gene is fmt

Identifier: 62184735

GI number: 62184735

Start: 105985

End: 106950

Strand: Direct

Name: fmt

Synonym: CAB091

Alternate gene names: 62184735

Gene position: 105985-106950 (Clockwise)

Preceding gene: 62184734

Following gene: 62184736

Centisome position: 9.26

GC content: 42.65

Gene sequence:

>966_bases
TTGAGTCTTAAGATTGTTTATTTCGGCACGCCACAATTTGCTGCCACAGTTTTAGCAGATTTATTACATCATGAAGTCAA
TGTTGTCGCTGTCGTTACTCGTGTAGATAAACCACAAAAACGTTCGTCACAACTTATTCCTTCTCCTGTTAAAACATTAG
CTTTATCCAAGAATATCCCTCTTTTGCAACCAGAAAAAGTTTCCGATCCACAATTTGTCGAACAATTACGAGATTTTGAG
GCGGATGTTTTTATTGTGGTTGCTTACGGAGCGATTTTAAAGCAAATGGTTTTGGATATTCCAAAATATGGCTGTTATAA
TTTGCACGCAGGCCTATTACCAGCTTACCGTGGGGCAGCTCCTATACAACGTTGTATTATGGACGGGGTCGTACAGTCAG
GAAATACCGTCATTCGTATGGATGCAGGTATGGATACCGGAGATATTGCCAACGTGTCCTTTGTCCCAGTAGGGCCGGAT
ATGACAGCAGGAGAACTTGCCGAAGCTTTGGCTAGCCAAGGCGGAGAAATCTTAATAAAAACTTTACAACAAATCTCTGA
TGGAACCATCACTCATACACCACAAGAGGCATCCAAAGCCTCTATAGCTCCAAAACTATCCAAAGAAGAAGGGTTTATTC
TTTGGGATCATCCTGCAGAGAAGGTGTATGCTCAAATACGGGGGGTCACTCCAGCTCCTGGAGCTTGGACACTCTATTCT
TATCAAGGTAAACCAGCAAGGCGCTTGGTTATTCGTAAAGCCTCTCTCTCTTCTAGTCAGGGGGTTTATGGCCATCCTGG
AGACATTCTCTTGTCAGATCAACAAGAGCTTCTTGTTGCGTGTGCTGAAGGGGCCATTTGCCTAAAAGAAATCCAACCCG
AAGGCAAGGGAGTAATGGATTCAAAAAGTTTTTTGAATGGCCACTCCGGGCATAAATTAAAATTATCGCTTAACTTAATG
TCTTAA

Upstream 100 bases:

>100_bases
TTTATTCATTTTTGTCGGAATCCAAGTAAGCGTGGAATTGAGCGTGGAGCTGCTAAAGAGGCTTTCCAAGAGGAGAGCGT
AGATAAAGAAGGAGCTCTGG

Downstream 100 bases:

>100_bases
TTTCGATTTTAGTCAATATAATTCACTTTATTAATTGGCTTTTGTGTTATAATTGGGGCTTAAAATCTTTATTCTGCTAA
AAAAACCTTTTAATTTTAGG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MSLKIVYFGTPQFAATVLADLLHHEVNVVAVVTRVDKPQKRSSQLIPSPVKTLALSKNIPLLQPEKVSDPQFVEQLRDFE
ADVFIVVAYGAILKQMVLDIPKYGCYNLHAGLLPAYRGAAPIQRCIMDGVVQSGNTVIRMDAGMDTGDIANVSFVPVGPD
MTAGELAEALASQGGEILIKTLQQISDGTITHTPQEASKASIAPKLSKEEGFILWDHPAEKVYAQIRGVTPAPGAWTLYS
YQGKPARRLVIRKASLSSSQGVYGHPGDILLSDQQELLVACAEGAICLKEIQPEGKGVMDSKSFLNGHSGHKLKLSLNLM
S

Sequences:

>Translated_321_residues
MSLKIVYFGTPQFAATVLADLLHHEVNVVAVVTRVDKPQKRSSQLIPSPVKTLALSKNIPLLQPEKVSDPQFVEQLRDFE
ADVFIVVAYGAILKQMVLDIPKYGCYNLHAGLLPAYRGAAPIQRCIMDGVVQSGNTVIRMDAGMDTGDIANVSFVPVGPD
MTAGELAEALASQGGEILIKTLQQISDGTITHTPQEASKASIAPKLSKEEGFILWDHPAEKVYAQIRGVTPAPGAWTLYS
YQGKPARRLVIRKASLSSSQGVYGHPGDILLSDQQELLVACAEGAICLKEIQPEGKGVMDSKSFLNGHSGHKLKLSLNLM
S
>Mature_320_residues
SLKIVYFGTPQFAATVLADLLHHEVNVVAVVTRVDKPQKRSSQLIPSPVKTLALSKNIPLLQPEKVSDPQFVEQLRDFEA
DVFIVVAYGAILKQMVLDIPKYGCYNLHAGLLPAYRGAAPIQRCIMDGVVQSGNTVIRMDAGMDTGDIANVSFVPVGPDM
TAGELAEALASQGGEILIKTLQQISDGTITHTPQEASKASIAPKLSKEEGFILWDHPAEKVYAQIRGVTPAPGAWTLYSY
QGKPARRLVIRKASLSSSQGVYGHPGDILLSDQQELLVACAEGAICLKEIQPEGKGVMDSKSFLNGHSGHKLKLSLNLMS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=316, Percent_Identity=26.5822784810127, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI21614513, Length=336, Percent_Identity=24.702380952381, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI238814322, Length=236, Percent_Identity=27.9661016949153, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1789683, Length=308, Percent_Identity=40.9090909090909, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1788589, Length=290, Percent_Identity=28.2758620689655, Blast_Score=115, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45550868, Length=318, Percent_Identity=28.9308176100629, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28571984, Length=272, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_CHLAB (Q5L722)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219520.1
- ProteinModelPortal:   Q5L722
- SMR:   Q5L722
- GeneID:   3338046
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB091
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- PhylomeDB:   Q5L722
- ProtClustDB:   PRK00005
- BioCyc:   CABO218497:CAB091-MONOMER
- BRENDA:   2.1.2.9
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34595; Mature: 34464

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKIVYFGTPQFAATVLADLLHHEVNVVAVVTRVDKPQKRSSQLIPSPVKTLALSKNIP
CEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCCCHHHHHHHCCCCC
LLQPEKVSDPQFVEQLRDFEADVFIVVAYGAILKQMVLDIPKYGCYNLHAGLLPAYRGAA
CCCCCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCHH
PIQRCIMDGVVQSGNTVIRMDAGMDTGDIANVSFVPVGPDMTAGELAEALASQGGEILIK
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHH
TLQQISDGTITHTPQEASKASIAPKLSKEEGFILWDHPAEKVYAQIRGVTPAPGAWTLYS
HHHHHCCCCEECCCCHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCEEEEE
YQGKPARRLVIRKASLSSSQGVYGHPGDILLSDQQELLVACAEGAICLKEIQPEGKGVMD
ECCCCHHEEEEEECCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEECCCCCCCCCCC
SKSFLNGHSGHKLKLSLNLMS
CHHHHCCCCCCEEEEEEEECC
>Mature Secondary Structure 
SLKIVYFGTPQFAATVLADLLHHEVNVVAVVTRVDKPQKRSSQLIPSPVKTLALSKNIP
EEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCCCHHHHHHHCCCCC
LLQPEKVSDPQFVEQLRDFEADVFIVVAYGAILKQMVLDIPKYGCYNLHAGLLPAYRGAA
CCCCCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCHH
PIQRCIMDGVVQSGNTVIRMDAGMDTGDIANVSFVPVGPDMTAGELAEALASQGGEILIK
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCHHHHH
TLQQISDGTITHTPQEASKASIAPKLSKEEGFILWDHPAEKVYAQIRGVTPAPGAWTLYS
HHHHHCCCCEECCCCHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCEEEEE
YQGKPARRLVIRKASLSSSQGVYGHPGDILLSDQQELLVACAEGAICLKEIQPEGKGVMD
ECCCCHHEEEEEECCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEECCCCCCCCCCC
SKSFLNGHSGHKLKLSLNLMS
CHHHHCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA