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The map label for this gene is pdhA [H]

Identifier: 28572940

GI number: 28572940

Start: 905955

End: 907067

Strand: Reverse

Name: pdhA [H]

Synonym: TW799

Alternate gene names: 28572940

Gene position: 907067-905955 (Counterclockwise)

Preceding gene: 28572944

Following gene: 28572939

Centisome position: 97.96

GC content: 49.24

Gene sequence:

>1113_bases
TTGAAGGACAAAGGATATCCTGTCGTGCAATTTTTGCGCCCTGATGGATCATTTTGCCCTTCTGAAACTGCCGAGCCCTT
TTTGAGCCATGCACAGTCATTGGATGTCGAGGATATTCAGCGGTTTTATCGAGACATTATCCTGGTTCGGCAAATTGACC
ATGAGGCTGCCCTCCTGCAGCGCCGCGGCGAGCTGGCGCTTTGGCCGCCGGTTTATGGACAAGAGGCCTCACAAATAGGT
GCAACCTATGCGTGCAGCGAAAACGATATGATCTTCCCTTCTTACCGCGATCATGCCGTGATGCATGCCAGGGGGATTGA
TCTTGTGCATATTGCCAAATTATTCAGGGGAGCGAGCAATAACGATTGGGATGTTAGACAACATAAGGTGTGGGGGTACA
CCCTTTGTATCGGTGCACAGGTACTACATTCCACCGGTTATGCAATTGGGATCGTATTAGAACGCCAAATGTCATGCACT
GATGATAACTCGGGGTATCCCGAAGCGGTTATGGTGTGGTTTGGTGATGGAGCGAGCAGTCAGGGGGATGTTAGTGAATC
AATGGTATTTGCCGCGCGATATCAAACACCCCAGGTATTTATGCTGCAGAATAACCAATACGCTATTTCCGTACCTGCAT
CCGTTCCCTCTGCCGCATGTCCCCTTTATAAACGCGGTTATGGTTTTGGCATTCCGGGTATTAGGATTGACGGCAATGAT
GTTATCGCAGCCTATGCTGTGGTTCGCGAATACATGGACCGTGCGCGATCCGGAAAAGGACCCCATCTGATTGAGGCTTT
TACATATCGCCTTGGCGCTCATACAACAAGTGATGATCCAACGAGGTACAGGAGCGAGGATGAACATAGGGAATGGTTGG
CCCTTGACCCGATTATCAGGCTCGAGCGGTATCTATTTAGTCTTGGGGTAGAAAAGACCTGGTTTGACCGCATCCGCGCA
GATATTCAACTCTCTGTTATAGGTTTTAGGAATGCCGTCTTATCAATCCCCCAGCCTGATACGAAAAAGATATTTGATAA
CGTTTATTCCGCTTATCACCCATTGGTTTCTTCACAGAGCGCCCACCTCCTTGGCCTCACGGAATCGCGATGA

Upstream 100 bases:

>100_bases
GAGGTGTTACGCGTGGGCTGCGCTTGGCGATTTTTATGCGGGTGGTTTTCCGCTTTTGTAGAGACAGACCCGCTGCCCGG
GTGGGTTTCCTGGAGGCGAG

Downstream 100 bases:

>100_bases
GTACGCCATCTTGGAATCGCGATGTGGATTCCCGTCGTGAGGCTGATCTGACACTGGTCTCGGCTCTTAATCTAGCTCTC
GATGACGAGTTAGCTCTTGA

Product: pyruvate dehydrogenase E1 component, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKDKGYPVVQFLRPDGSFCPSETAEPFLSHAQSLDVEDIQRFYRDIILVRQIDHEAALLQRRGELALWPPVYGQEASQIG
ATYACSENDMIFPSYRDHAVMHARGIDLVHIAKLFRGASNNDWDVRQHKVWGYTLCIGAQVLHSTGYAIGIVLERQMSCT
DDNSGYPEAVMVWFGDGASSQGDVSESMVFAARYQTPQVFMLQNNQYAISVPASVPSAACPLYKRGYGFGIPGIRIDGND
VIAAYAVVREYMDRARSGKGPHLIEAFTYRLGAHTTSDDPTRYRSEDEHREWLALDPIIRLERYLFSLGVEKTWFDRIRA
DIQLSVIGFRNAVLSIPQPDTKKIFDNVYSAYHPLVSSQSAHLLGLTESR

Sequences:

>Translated_370_residues
MKDKGYPVVQFLRPDGSFCPSETAEPFLSHAQSLDVEDIQRFYRDIILVRQIDHEAALLQRRGELALWPPVYGQEASQIG
ATYACSENDMIFPSYRDHAVMHARGIDLVHIAKLFRGASNNDWDVRQHKVWGYTLCIGAQVLHSTGYAIGIVLERQMSCT
DDNSGYPEAVMVWFGDGASSQGDVSESMVFAARYQTPQVFMLQNNQYAISVPASVPSAACPLYKRGYGFGIPGIRIDGND
VIAAYAVVREYMDRARSGKGPHLIEAFTYRLGAHTTSDDPTRYRSEDEHREWLALDPIIRLERYLFSLGVEKTWFDRIRA
DIQLSVIGFRNAVLSIPQPDTKKIFDNVYSAYHPLVSSQSAHLLGLTESR
>Mature_370_residues
MKDKGYPVVQFLRPDGSFCPSETAEPFLSHAQSLDVEDIQRFYRDIILVRQIDHEAALLQRRGELALWPPVYGQEASQIG
ATYACSENDMIFPSYRDHAVMHARGIDLVHIAKLFRGASNNDWDVRQHKVWGYTLCIGAQVLHSTGYAIGIVLERQMSCT
DDNSGYPEAVMVWFGDGASSQGDVSESMVFAARYQTPQVFMLQNNQYAISVPASVPSAACPLYKRGYGFGIPGIRIDGND
VIAAYAVVREYMDRARSGKGPHLIEAFTYRLGAHTTSDDPTRYRSEDEHREWLALDPIIRLERYLFSLGVEKTWFDRIRA
DIQLSVIGFRNAVLSIPQPDTKKIFDNVYSAYHPLVSSQSAHLLGLTESR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=327, Percent_Identity=32.4159021406728, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI258645172, Length=341, Percent_Identity=31.6715542521994, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4885543, Length=324, Percent_Identity=28.0864197530864, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI291084742, Length=335, Percent_Identity=27.1641791044776, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4505685, Length=335, Percent_Identity=27.1641791044776, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI291084744, Length=339, Percent_Identity=26.5486725663717, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI291084757, Length=329, Percent_Identity=25.2279635258359, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI86563355, Length=290, Percent_Identity=30.6896551724138, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI86563357, Length=290, Percent_Identity=30.6896551724138, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32564172, Length=268, Percent_Identity=27.2388059701493, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17536047, Length=276, Percent_Identity=27.536231884058, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321026, Length=316, Percent_Identity=30.0632911392405, Blast_Score=129, Evalue=8e-31,
Organism=Drosophila melanogaster, GI21355903, Length=356, Percent_Identity=28.3707865168539, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24639748, Length=297, Percent_Identity=29.96632996633, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24639740, Length=295, Percent_Identity=26.7796610169492, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24639744, Length=295, Percent_Identity=26.4406779661017, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28571106, Length=295, Percent_Identity=26.4406779661017, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24639746, Length=287, Percent_Identity=27.1777003484321, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41650; Mature: 41650

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKGYPVVQFLRPDGSFCPSETAEPFLSHAQSLDVEDIQRFYRDIILVRQIDHEAALLQ
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHH
RRGELALWPPVYGQEASQIGATYACSENDMIFPSYRDHAVMHARGIDLVHIAKLFRGASN
HCCCEEECCCCCCCCHHHCCCEEEECCCCEECCCCCCCEEEEECCCCHHHHHHHHCCCCC
NDWDVRQHKVWGYTLCIGAQVLHSTGYAIGIVLERQMSCTDDNSGYPEAVMVWFGDGASS
CCCCCEEEEEEEEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCC
QGDVSESMVFAARYQTPQVFMLQNNQYAISVPASVPSAACPLYKRGYGFGIPGIRIDGND
CCCCHHHEEEEEECCCCEEEEEECCEEEEECCCCCCCHHCCHHHCCCCCCCCCEEECCCC
VIAAYAVVREYMDRARSGKGPHLIEAFTYRLGAHTTSDDPTRYRSEDEHREWLALDPIIR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHCCCCCHHCCEEEHHHHHH
LERYLFSLGVEKTWFDRIRADIQLSVIGFRNAVLSIPQPDTKKIFDNVYSAYHPLVSSQS
HHHHHHHHCCCHHHHHHHHCCEEEEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHCCCC
AHLLGLTESR
CEEEEECCCC
>Mature Secondary Structure
MKDKGYPVVQFLRPDGSFCPSETAEPFLSHAQSLDVEDIQRFYRDIILVRQIDHEAALLQ
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHH
RRGELALWPPVYGQEASQIGATYACSENDMIFPSYRDHAVMHARGIDLVHIAKLFRGASN
HCCCEEECCCCCCCCHHHCCCEEEECCCCEECCCCCCCEEEEECCCCHHHHHHHHCCCCC
NDWDVRQHKVWGYTLCIGAQVLHSTGYAIGIVLERQMSCTDDNSGYPEAVMVWFGDGASS
CCCCCEEEEEEEEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCC
QGDVSESMVFAARYQTPQVFMLQNNQYAISVPASVPSAACPLYKRGYGFGIPGIRIDGND
CCCCHHHEEEEEECCCCEEEEEECCEEEEECCCCCCCHHCCHHHCCCCCCCCCEEECCCC
VIAAYAVVREYMDRARSGKGPHLIEAFTYRLGAHTTSDDPTRYRSEDEHREWLALDPIIR
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHCCCCCHHCCEEEHHHHHH
LERYLFSLGVEKTWFDRIRADIQLSVIGFRNAVLSIPQPDTKKIFDNVYSAYHPLVSSQS
HHHHHHHHCCCHHHHHHHHCCEEEEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHCCCC
AHLLGLTESR
CEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA