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The map label for this gene is pdhB [H]

Identifier: 28572939

GI number: 28572939

Start: 904954

End: 905958

Strand: Reverse

Name: pdhB [H]

Synonym: TW798

Alternate gene names: 28572939

Gene position: 905958-904954 (Counterclockwise)

Preceding gene: 28572940

Following gene: 28572938

Centisome position: 97.84

GC content: 48.06

Gene sequence:

>1005_bases
ATGAGTACGCCATCTTGGAATCGCGATGTGGATTCCCGTCGTGAGGCTGATCTGACACTGGTCTCGGCTCTTAATCTAGC
TCTCGATGACGAGTTAGCTCTTGATCCAAAATTGCTGCTTATGGGAGAGGACCTTGGTGCACTTGGTGGGGTTTTTCGCG
TTACAGACAGATTGTGTAAGAAGTATGGTAAGAATCGTGTGATTGACACCCCGCTTGCTGAGTCTGGAATTGTCGGTACT
GCAATTGGATTGGCTGCCAAGGGGTTTAGGCTTGTACTTGAGATCCAATTTAATGGGTTTATTTTTCCTGCATTTAACCA
GATAACAACCCAGCTTGCTCGGCAAAACTTTCGAAACAAAATTCCCATGCCGGTAGTCATAAGAGTTCCACATGGGGGTC
ATATCGGGGCCGTTGAACACCATATGGAAGCCCCAGAAGCTTACTTTGCACATACTCCTGGTCTGCGAGTTGTGAATTGT
TCGACACCGTCGGACGCGTATTGGATGTTACGTCAGGCAATCCGTTGCCCGGACCCCGTCATTTTCTTTGAACCCTTGTC
CCTGTATTGGAATAAGGGAACAGTGAGTTTTTCTTCTCCTGATTTGGATTTGCACGCGGCCTCCATTGTACGTAAAGGGA
ATGATGTGACCCTATTGGGTCATGGTGGCATCACGCGCACTCTTATTGCCGCTGCCGAGCATACCCGAGATGTAAGTGTT
GAGATAATTGACCTTCGTTCTCTTTCTCCCGTAGACTACGAAACAATTCTTGCCTCGGTCAAGAAAACCGGAAGATTGGT
TATAGCGCAAGAGTCGCCGGGCTTTGTTAGTTTGGGTAGCGAGATTGCCGCTACAGTTTCAGAAAAGGCCTTTTACCATC
TGGAGGCACCTGTTGCGCGTGTTAGCGGGTACGACACCCCCTTTCCTCCGGCAAAACTTGAGAAGGTCTATTTACCGGAT
GTTGATAGAGTCTTAACAGCAATTAAGGGTGTTATGTCCCATTAG

Upstream 100 bases:

>100_bases
CCCAGCCTGATACGAAAAAGATATTTGATAACGTTTATTCCGCTTATCACCCATTGGTTTCTTCACAGAGCGCCCACCTC
CTTGGCCTCACGGAATCGCG

Downstream 100 bases:

>100_bases
GATGAGAAGAACCTAATATGCCAGAAGTTACTTTCCTTTTAACCGATCCGGGCGAAGGCTTGGTCGAGGCCGAAATTGTC
TCCTTGAGGGTTACCGAGGG

Product: pyruvate dehydrogenase E1 component, beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSTPSWNRDVDSRREADLTLVSALNLALDDELALDPKLLLMGEDLGALGGVFRVTDRLCKKYGKNRVIDTPLAESGIVGT
AIGLAAKGFRLVLEIQFNGFIFPAFNQITTQLARQNFRNKIPMPVVIRVPHGGHIGAVEHHMEAPEAYFAHTPGLRVVNC
STPSDAYWMLRQAIRCPDPVIFFEPLSLYWNKGTVSFSSPDLDLHAASIVRKGNDVTLLGHGGITRTLIAAAEHTRDVSV
EIIDLRSLSPVDYETILASVKKTGRLVIAQESPGFVSLGSEIAATVSEKAFYHLEAPVARVSGYDTPFPPAKLEKVYLPD
VDRVLTAIKGVMSH

Sequences:

>Translated_334_residues
MSTPSWNRDVDSRREADLTLVSALNLALDDELALDPKLLLMGEDLGALGGVFRVTDRLCKKYGKNRVIDTPLAESGIVGT
AIGLAAKGFRLVLEIQFNGFIFPAFNQITTQLARQNFRNKIPMPVVIRVPHGGHIGAVEHHMEAPEAYFAHTPGLRVVNC
STPSDAYWMLRQAIRCPDPVIFFEPLSLYWNKGTVSFSSPDLDLHAASIVRKGNDVTLLGHGGITRTLIAAAEHTRDVSV
EIIDLRSLSPVDYETILASVKKTGRLVIAQESPGFVSLGSEIAATVSEKAFYHLEAPVARVSGYDTPFPPAKLEKVYLPD
VDRVLTAIKGVMSH
>Mature_333_residues
STPSWNRDVDSRREADLTLVSALNLALDDELALDPKLLLMGEDLGALGGVFRVTDRLCKKYGKNRVIDTPLAESGIVGTA
IGLAAKGFRLVLEIQFNGFIFPAFNQITTQLARQNFRNKIPMPVVIRVPHGGHIGAVEHHMEAPEAYFAHTPGLRVVNCS
TPSDAYWMLRQAIRCPDPVIFFEPLSLYWNKGTVSFSSPDLDLHAASIVRKGNDVTLLGHGGITRTLIAAAEHTRDVSVE
IIDLRSLSPVDYETILASVKKTGRLVIAQESPGFVSLGSEIAATVSEKAFYHLEAPVARVSGYDTPFPPAKLEKVYLPDV
DRVLTAIKGVMSH

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=326, Percent_Identity=42.3312883435583, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI34101272, Length=326, Percent_Identity=42.3312883435583, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI156564403, Length=331, Percent_Identity=34.441087613293, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI291084858, Length=329, Percent_Identity=32.8267477203647, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17506935, Length=334, Percent_Identity=39.2215568862275, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17538422, Length=328, Percent_Identity=36.890243902439, Blast_Score=197, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6319698, Length=328, Percent_Identity=34.1463414634146, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI160714828, Length=325, Percent_Identity=43.3846153846154, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=43.3846153846154, Blast_Score=240, Evalue=8e-64,
Organism=Drosophila melanogaster, GI21358145, Length=325, Percent_Identity=37.8461538461538, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24650940, Length=325, Percent_Identity=37.8461538461538, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24650943, Length=89, Percent_Identity=43.8202247191011, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650945, Length=89, Percent_Identity=43.8202247191011, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36495; Mature: 36364

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPSWNRDVDSRREADLTLVSALNLALDDELALDPKLLLMGEDLGALGGVFRVTDRLCK
CCCCCCCCCCCCHHHCCCCEEHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
KYGKNRVIDTPLAESGIVGTAIGLAAKGFRLVLEIQFNGFIFPAFNQITTQLARQNFRNK
HHCCCCEECCCCCCCCCHHHHHHHHCCCEEEEEEEEECCEEEECHHHHHHHHHHHHHHCC
IPMPVVIRVPHGGHIGAVEHHMEAPEAYFAHTPGLRVVNCSTPSDAYWMLRQAIRCPDPV
CCCCEEEECCCCCCCCHHHHHHCCCHHHEECCCCCEEEEECCCCHHHHHHHHHHCCCCCE
IFFEPLSLYWNKGTVSFSSPDLDLHAASIVRKGNDVTLLGHGGITRTLIAAAEHTRDVSV
EEEECEEEEECCCEEEECCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCEE
EIIDLRSLSPVDYETILASVKKTGRLVIAQESPGFVSLGSEIAATVSEKAFYHLEAPVAR
EEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCEECCHHHHHHHHHHHEEEECCCHHH
VSGYDTPFPPAKLEKVYLPDVDRVLTAIKGVMSH
HCCCCCCCCHHHCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STPSWNRDVDSRREADLTLVSALNLALDDELALDPKLLLMGEDLGALGGVFRVTDRLCK
CCCCCCCCCCCHHHCCCCEEHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
KYGKNRVIDTPLAESGIVGTAIGLAAKGFRLVLEIQFNGFIFPAFNQITTQLARQNFRNK
HHCCCCEECCCCCCCCCHHHHHHHHCCCEEEEEEEEECCEEEECHHHHHHHHHHHHHHCC
IPMPVVIRVPHGGHIGAVEHHMEAPEAYFAHTPGLRVVNCSTPSDAYWMLRQAIRCPDPV
CCCCEEEECCCCCCCCHHHHHHCCCHHHEECCCCCEEEEECCCCHHHHHHHHHHCCCCCE
IFFEPLSLYWNKGTVSFSSPDLDLHAASIVRKGNDVTLLGHGGITRTLIAAAEHTRDVSV
EEEECEEEEECCCEEEECCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCEE
EIIDLRSLSPVDYETILASVKKTGRLVIAQESPGFVSLGSEIAATVSEKAFYHLEAPVAR
EEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCEECCHHHHHHHHHHHEEEECCCHHH
VSGYDTPFPPAKLEKVYLPDVDRVLTAIKGVMSH
HCCCCCCCCHHHCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA