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The map label for this gene is serS

Identifier: 28572881

GI number: 28572881

Start: 835755

End: 837008

Strand: Direct

Name: serS

Synonym: TW740

Alternate gene names: 28572881

Gene position: 835755-837008 (Clockwise)

Preceding gene: 28572880

Following gene: 28572882

Centisome position: 90.26

GC content: 46.57

Gene sequence:

>1254_bases
GTGATTGACCCAGAAATATTGGTAAATACCCCAGATATCGTCAGGCTTTCGCAGAAAAAGCGTGGGGAAAGCCAGTCTAT
TGTTGAAGATGCACTTATAGCAAGGCGTAATCTACGCATAGCAATAAATAACTTCGAGACCTTGCGGGCAGAGCAAAACG
TTCTTAGCAAAAAAATCGCTGGCTCAGAAGATAGCGATAGGCCTGAACTTATGAGAGTGGCAAATCTGTTGGCCGAGCGT
GTTAAAAACGCTCGCGAAGAGCAGGAAAAGGCAAATAGTGAGTGGAAAAAATTATTATTTGAGATACCAAATATAGTCTC
ATCAGAAGCCCCGTACGGTGTGGAAGATAAATGCGCAGTTATGAAAACTGTTGGTGATATTCCAGAGTTTGACTTTGAAC
CGGCAGACCATCTACAGCTCGGAGAGCAGCTGGATGCAATCGACGTGTCAAGAGGGGTAAAGGTTTCGGGTACTCGCTTC
TATTTTCTGAAAGGATGGGGCGCCCGGCTTGAGCTTGCGGTTATGAATTTGGCGCTCGATCTGGCGCTTAAGTCTGGACT
TACATTGCTTATAACACCAACGCTTGTAAAACCAGAAATAATGCTGGGAACCGGGTTTCTAGGTCGACATGAGGGTGAGG
TGTATCGACTGCCAAGCGGGTATTATCTGACCGGAACCAGCGAAGTTGCCATTGCGGGATATCATAGCGATGAGATATTG
GATATCTCCTCTGGGCCAATACGATATGCTGGATGGTCCTCTTGTTACAGGAGAGAGGCGGGGTCTCACGGGCGGGACAC
ACGTGGAATTATGCGTGTGCATCAATTTTCCAAACTGGAGATGTTTAGCTATGTTCATCCGCAGCAATCAACCAGAGAAC
TCGAGCACATTGTCTCAATGCAAGAAAAGATGCTAAATCTACTCGAAATTCCGTACCGTGTTTCTGATATTGCTGCAGAG
GAATTGGGGACAAGCGCTTCTAGAAAGTATGATCTAGAGGCATGGATACCCAGTCAAAATACATGGCGAGAGGTAACCAG
TGCGAGTGACTGTACAACCTTTCAGGCGCGCAGACTGAATGTGAGATATCGAGACGAGTCAGGAAGGACAGGGTATGTTG
CAACTCTTAATGGGACTCTTGCAACTACAAGATTCCTAGTTGCCATTCTGGAAAATCATCAGACTTCCAATGGGAGTATC
AGGGTGCCAGAAGCCCTTAGACCTCTCCTGGGTCAGGATGTAATAGAGAGATAG

Upstream 100 bases:

>100_bases
ATCATTGGTTTGCCATCTTTGATGTAAAGGACTTTGGTAAGTGTCTTTGGTTGTTGCGCCCTGAAGGGTATCAGAGATAT
GGACAGGGTAAACTTGTCCC

Downstream 100 bases:

>100_bases
TATCGGAAATTCTTGGAATAGTATGAATAAGCTTCTTATAGCTCTTGATATTGATGGAACTGTTCTGAACCACGACGGAC
ACACTCCGAGTGAGGGTATC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIDPEILVNTPDIVRLSQKKRGESQSIVEDALIARRNLRIAINNFETLRAEQNVLSKKIAGSEDSDRPELMRVANLLAER
VKNAREEQEKANSEWKKLLFEIPNIVSSEAPYGVEDKCAVMKTVGDIPEFDFEPADHLQLGEQLDAIDVSRGVKVSGTRF
YFLKGWGARLELAVMNLALDLALKSGLTLLITPTLVKPEIMLGTGFLGRHEGEVYRLPSGYYLTGTSEVAIAGYHSDEIL
DISSGPIRYAGWSSCYRREAGSHGRDTRGIMRVHQFSKLEMFSYVHPQQSTRELEHIVSMQEKMLNLLEIPYRVSDIAAE
ELGTSASRKYDLEAWIPSQNTWREVTSASDCTTFQARRLNVRYRDESGRTGYVATLNGTLATTRFLVAILENHQTSNGSI
RVPEALRPLLGQDVIER

Sequences:

>Translated_417_residues
MIDPEILVNTPDIVRLSQKKRGESQSIVEDALIARRNLRIAINNFETLRAEQNVLSKKIAGSEDSDRPELMRVANLLAER
VKNAREEQEKANSEWKKLLFEIPNIVSSEAPYGVEDKCAVMKTVGDIPEFDFEPADHLQLGEQLDAIDVSRGVKVSGTRF
YFLKGWGARLELAVMNLALDLALKSGLTLLITPTLVKPEIMLGTGFLGRHEGEVYRLPSGYYLTGTSEVAIAGYHSDEIL
DISSGPIRYAGWSSCYRREAGSHGRDTRGIMRVHQFSKLEMFSYVHPQQSTRELEHIVSMQEKMLNLLEIPYRVSDIAAE
ELGTSASRKYDLEAWIPSQNTWREVTSASDCTTFQARRLNVRYRDESGRTGYVATLNGTLATTRFLVAILENHQTSNGSI
RVPEALRPLLGQDVIER
>Mature_417_residues
MIDPEILVNTPDIVRLSQKKRGESQSIVEDALIARRNLRIAINNFETLRAEQNVLSKKIAGSEDSDRPELMRVANLLAER
VKNAREEQEKANSEWKKLLFEIPNIVSSEAPYGVEDKCAVMKTVGDIPEFDFEPADHLQLGEQLDAIDVSRGVKVSGTRF
YFLKGWGARLELAVMNLALDLALKSGLTLLITPTLVKPEIMLGTGFLGRHEGEVYRLPSGYYLTGTSEVAIAGYHSDEIL
DISSGPIRYAGWSSCYRREAGSHGRDTRGIMRVHQFSKLEMFSYVHPQQSTRELEHIVSMQEKMLNLLEIPYRVSDIAAE
ELGTSASRKYDLEAWIPSQNTWREVTSASDCTTFQARRLNVRYRDESGRTGYVATLNGTLATTRFLVAILENHQTSNGSI
RVPEALRPLLGQDVIER

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=324, Percent_Identity=38.5802469135802, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI225579074, Length=324, Percent_Identity=38.5802469135802, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI16306548, Length=451, Percent_Identity=34.1463414634146, Blast_Score=211, Evalue=7e-55,
Organism=Escherichia coli, GI1787120, Length=424, Percent_Identity=37.5, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17539260, Length=453, Percent_Identity=33.112582781457, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=385, Percent_Identity=31.6883116883117, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320226, Length=423, Percent_Identity=34.51536643026, Blast_Score=237, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321799, Length=391, Percent_Identity=33.7595907928389, Blast_Score=212, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24581334, Length=458, Percent_Identity=35.3711790393013, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI17737985, Length=268, Percent_Identity=38.8059701492537, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_TROW8 (Q83HA1)

Other databases:

- EMBL:   BX251412
- RefSeq:   NP_789661.1
- ProteinModelPortal:   Q83HA1
- SMR:   Q83HA1
- STRING:   Q83HA1
- GeneID:   1064940
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW740
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   NLRYRDP
- PhylomeDB:   Q83HA1
- ProtClustDB:   PRK05431
- BioCyc:   TWHI218496:TW0706-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46859; Mature: 46859

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 273-273 BINDING 280-280 BINDING 379-379

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPEILVNTPDIVRLSQKKRGESQSIVEDALIARRNLRIAINNFETLRAEQNVLSKKIA
CCCCCEEECCCHHHEEHHHHCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHC
GSEDSDRPELMRVANLLAERVKNAREEQEKANSEWKKLLFEIPNIVSSEAPYGVEDKCAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
MKTVGDIPEFDFEPADHLQLGEQLDAIDVSRGVKVSGTRFYFLKGWGARLELAVMNLALD
HHHHCCCCCCCCCCCHHHHHHHHCCCEECCCCCEECCCEEEEEECCCCEEEHHHHHHHHH
LALKSGLTLLITPTLVKPEIMLGTGFLGRHEGEVYRLPSGYYLTGTSEVAIAGYHSDEIL
HHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCEEECCCCEEEECCCCEEEEECCCCCEE
DISSGPIRYAGWSSCYRREAGSHGRDTRGIMRVHQFSKLEMFSYVHPQQSTRELEHIVSM
ECCCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QEKMLNLLEIPYRVSDIAAEELGTSASRKYDLEAWIPSQNTWREVTSASDCTTFQARRLN
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCCCEEHHHEEE
VRYRDESGRTGYVATLNGTLATTRFLVAILENHQTSNGSIRVPEALRPLLGQDVIER
EEEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDPEILVNTPDIVRLSQKKRGESQSIVEDALIARRNLRIAINNFETLRAEQNVLSKKIA
CCCCCEEECCCHHHEEHHHHCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHC
GSEDSDRPELMRVANLLAERVKNAREEQEKANSEWKKLLFEIPNIVSSEAPYGVEDKCAV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
MKTVGDIPEFDFEPADHLQLGEQLDAIDVSRGVKVSGTRFYFLKGWGARLELAVMNLALD
HHHHCCCCCCCCCCCHHHHHHHHCCCEECCCCCEECCCEEEEEECCCCEEEHHHHHHHHH
LALKSGLTLLITPTLVKPEIMLGTGFLGRHEGEVYRLPSGYYLTGTSEVAIAGYHSDEIL
HHHHCCCEEEEECCCCCCEEEEECCCCCCCCCCEEECCCCEEEECCCCEEEEECCCCCEE
DISSGPIRYAGWSSCYRREAGSHGRDTRGIMRVHQFSKLEMFSYVHPQQSTRELEHIVSM
ECCCCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QEKMLNLLEIPYRVSDIAAEELGTSASRKYDLEAWIPSQNTWREVTSASDCTTFQARRLN
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCCCEEHHHEEE
VRYRDESGRTGYVATLNGTLATTRFLVAILENHQTSNGSIRVPEALRPLLGQDVIER
EEEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12606174