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The map label for this gene is mutT1 [H]

Identifier: 28572824

GI number: 28572824

Start: 771236

End: 772135

Strand: Direct

Name: mutT1 [H]

Synonym: TW683

Alternate gene names: 28572824

Gene position: 771236-772135 (Clockwise)

Preceding gene: 28572823

Following gene: 28572825

Centisome position: 83.29

GC content: 45.67

Gene sequence:

>900_bases
ATGAGCGAGGCGCAAAATGGATCAATCCCAAACGACAAGTGGGTGATACAAATTGCTGCTGGCACCATATGTTGGCGACA
GCGAGATGATGCAGAAGTGGAAATTCTGACCATAAGTCGTCGCGGATACGGCGGCGTATCCTTTCCAAAAGGAAAGAGAG
AGCCAGGCGAAAGTCTCCATTTGACAGCGTTTCGGGAAACTCTGGAAGAGACGAATGTAACAGTTAGGTTGGGGCAGTTT
ATTGGGGAAAGCTCCTACTCATTTTTAGGTTCTGCAGACTATCCAAATAGAAGTGGTCACGCCATGAGGAATGCAAATAC
CAGGCAGGGCAGAAAACAGCTAATCAAGAAACAGGTTCATTACTGGGCCGCAAAGCCAAGGGTTATAGAGAAATTTTTAT
CAAATGACGAAGTTCAGAAAATACACTGGATAAAAGCTTCGGATATTAAAAGGGCTCAGCTACACAAGAGCGATATGGAA
ATCGCAAATAAATTTCTTGATCTATACAAAAGAAGAGCAGAGCTGTTTCATGGAAAAACTGTTATTCTTCTGAGGCATGC
ACACACACACGGAGAGGATGCTCTGTCACCGTTAGGCATGCAGCGTTCACAAACACTTCCCGTTGAACTATCGCCCTGGG
CGCCGGAAAAAATATACTGCTCACCAAAACAGAGATGCATACAGACCGTCCATCCGCTATCCAAAACAGGAATAGATGTA
CTCAACGATCCAGCACTTGGCGGTGAGAGCGGTGACAATATCTTGGAGAATATAAGGGAATATCCAGGGGAATGTATCTT
GATCTGTACCCATGCGCCGCTTATAGCATCAACACTCAGCGCCTTAGGTGTTGAGCAAACAAATATCGCACCGGGAGAAT
ACAGGGTTGTAACCCTGTAG

Upstream 100 bases:

>100_bases
ATTTCGCAGAAGTTGAAAGAGACATTTTGTTCAATGTACGGGGAGGAAGATGAAGCAGAAGGTCTGTGAAGAATTCTCAC
AAATAGTTAGGGTTGTGTAG

Downstream 100 bases:

>100_bases
GGTCAGAGTGGGCCCGGTGGGGCTCGAACCCACGACCAGCGGATTAAAAGTCCGATGCTCTTCCAGCTGAGCTACAGGCC
CCACGGAGAACCGAGATTTT

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSEAQNGSIPNDKWVIQIAAGTICWRQRDDAEVEILTISRRGYGGVSFPKGKREPGESLHLTAFRETLEETNVTVRLGQF
IGESSYSFLGSADYPNRSGHAMRNANTRQGRKQLIKKQVHYWAAKPRVIEKFLSNDEVQKIHWIKASDIKRAQLHKSDME
IANKFLDLYKRRAELFHGKTVILLRHAHTHGEDALSPLGMQRSQTLPVELSPWAPEKIYCSPKQRCIQTVHPLSKTGIDV
LNDPALGGESGDNILENIREYPGECILICTHAPLIASTLSALGVEQTNIAPGEYRVVTL

Sequences:

>Translated_299_residues
MSEAQNGSIPNDKWVIQIAAGTICWRQRDDAEVEILTISRRGYGGVSFPKGKREPGESLHLTAFRETLEETNVTVRLGQF
IGESSYSFLGSADYPNRSGHAMRNANTRQGRKQLIKKQVHYWAAKPRVIEKFLSNDEVQKIHWIKASDIKRAQLHKSDME
IANKFLDLYKRRAELFHGKTVILLRHAHTHGEDALSPLGMQRSQTLPVELSPWAPEKIYCSPKQRCIQTVHPLSKTGIDV
LNDPALGGESGDNILENIREYPGECILICTHAPLIASTLSALGVEQTNIAPGEYRVVTL
>Mature_298_residues
SEAQNGSIPNDKWVIQIAAGTICWRQRDDAEVEILTISRRGYGGVSFPKGKREPGESLHLTAFRETLEETNVTVRLGQFI
GESSYSFLGSADYPNRSGHAMRNANTRQGRKQLIKKQVHYWAAKPRVIEKFLSNDEVQKIHWIKASDIKRAQLHKSDMEI
ANKFLDLYKRRAELFHGKTVILLRHAHTHGEDALSPLGMQRSQTLPVELSPWAPEKIYCSPKQRCIQTVHPLSKTGIDVL
NDPALGGESGDNILENIREYPGECILICTHAPLIASTLSALGVEQTNIAPGEYRVVTL

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX; PF00300 PGAM [H]

EC number: NA

Molecular weight: Translated: 33517; Mature: 33385

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAQNGSIPNDKWVIQIAAGTICWRQRDDAEVEILTISRRGYGGVSFPKGKREPGESLH
CCCCCCCCCCCCCEEEEEECCEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEE
LTAFRETLEETNVTVRLGQFIGESSYSFLGSADYPNRSGHAMRNANTRQGRKQLIKKQVH
HHHHHHHHHHCCEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YWAAKPRVIEKFLSNDEVQKIHWIKASDIKRAQLHKSDMEIANKFLDLYKRRAELFHGKT
HHCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VILLRHAHTHGEDALSPLGMQRSQTLPVELSPWAPEKIYCSPKQRCIQTVHPLSKTGIDV
EEEEEECCCCCCHHHCCCCCCCCCCCCEEECCCCCCCEEECHHHHHHHHHCCHHHCCCCC
LNDPALGGESGDNILENIREYPGECILICTHAPLIASTLSALGVEQTNIAPGEYRVVTL
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SEAQNGSIPNDKWVIQIAAGTICWRQRDDAEVEILTISRRGYGGVSFPKGKREPGESLH
CCCCCCCCCCCCEEEEEECCEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEE
LTAFRETLEETNVTVRLGQFIGESSYSFLGSADYPNRSGHAMRNANTRQGRKQLIKKQVH
HHHHHHHHHHCCEEEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YWAAKPRVIEKFLSNDEVQKIHWIKASDIKRAQLHKSDMEIANKFLDLYKRRAELFHGKT
HHCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VILLRHAHTHGEDALSPLGMQRSQTLPVELSPWAPEKIYCSPKQRCIQTVHPLSKTGIDV
EEEEEECCCCCCHHHCCCCCCCCCCCCEEECCCCCCCEEECHHHHHHHHHCCHHHCCCCC
LNDPALGGESGDNILENIREYPGECILICTHAPLIASTLSALGVEQTNIAPGEYRVVTL
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]