Click here to switch to the map view.

The map label for this gene is mscL [H]

Identifier: 28572825

GI number: 28572825

Start: 772508

End: 773119

Strand: Direct

Name: mscL [H]

Synonym: TW684

Alternate gene names: 28572825

Gene position: 772508-773119 (Clockwise)

Preceding gene: 28572824

Following gene: 28572826

Centisome position: 83.43

GC content: 46.73

Gene sequence:

>612_bases
ATGTTTGCTGGATTCCGTGATTTTATAGCACGCAGGAACGTTGTCGATCTCTCGGCTGCGGTTGTAATCGGTGCAGCTTC
AACCGCTGTTATAAACGCAATTGTGGATGACATCTTCAGTCCCCTTATAAGCGCAGCACTAAGCTCTAGCAAAATCGAAA
ACAGTCTCGTGCTGACAATACCAACCCTATCCCACGGACATGTACAACTGAAGTTCGGCACTGTTCTTCTAGCGCTAATA
AAATTTGTTCTTGTTTCAGCGGTTGTGTACTTTGTGATAATCCTGCCTCTGAACCACCTCAAAGACATCAGGCGGACCCT
CGGAAACAGTTTGCCAGGGCCTTTGGGGGCATTATCGGCGATTATATCTGGGGGTAAAAACACAAAAGATGAGGATCCTG
ATAAAGACGAACTAGCTGATGGTCAATCGTCCGCAGAAACTAAGGTTGGTAATGATGGCACGGGCTCGGAAGAGTTGAGT
GATACGCGACCCTCGGGTTCCCTCGAGGGTGATACGGTAACAAAACTGTTGATGGAGATTCGTGATCTGTTACTCCTGAT
GGGCGAAATGGATAATAAGAAGAGTAAAGACCATTCCGAAAGAGGACTCTAA

Upstream 100 bases:

>100_bases
ATTGTTGGTTCTGGATTGTACAGTTGTGTGTATCCTTTTGTATTTACCTGTACCTGTCACCGGGTTGCACCGGTGCAGAC
AGTAATGTTTGGGCGCTTGT

Downstream 100 bases:

>100_bases
GCGCGTTATTCCAAGGCGCGTTATTCCAAGAAATGTACCCTAAATAAGACGCTCTTGACAAGGCGATTTGCGTATGGTAT
ACCTAGGAGCGTCACGGCGA

Product: large-conductance mechanosensitive channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MFAGFRDFIARRNVVDLSAAVVIGAASTAVINAIVDDIFSPLISAALSSSKIENSLVLTIPTLSHGHVQLKFGTVLLALI
KFVLVSAVVYFVIILPLNHLKDIRRTLGNSLPGPLGALSAIISGGKNTKDEDPDKDELADGQSSAETKVGNDGTGSEELS
DTRPSGSLEGDTVTKLLMEIRDLLLLMGEMDNKKSKDHSERGL

Sequences:

>Translated_203_residues
MFAGFRDFIARRNVVDLSAAVVIGAASTAVINAIVDDIFSPLISAALSSSKIENSLVLTIPTLSHGHVQLKFGTVLLALI
KFVLVSAVVYFVIILPLNHLKDIRRTLGNSLPGPLGALSAIISGGKNTKDEDPDKDELADGQSSAETKVGNDGTGSEELS
DTRPSGSLEGDTVTKLLMEIRDLLLLMGEMDNKKSKDHSERGL
>Mature_203_residues
MFAGFRDFIARRNVVDLSAAVVIGAASTAVINAIVDDIFSPLISAALSSSKIENSLVLTIPTLSHGHVQLKFGTVLLALI
KFVLVSAVVYFVIILPLNHLKDIRRTLGNSLPGPLGALSAIISGGKNTKDEDPDKDELADGQSSAETKVGNDGTGSEELS
DTRPSGSLEGDTVTKLLMEIRDLLLLMGEMDNKKSKDHSERGL

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185
- InterPro:   IPR015089 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 21554; Mature: 21554

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAGFRDFIARRNVVDLSAAVVIGAASTAVINAIVDDIFSPLISAALSSSKIENSLVLTI
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
PTLSHGHVQLKFGTVLLALIKFVLVSAVVYFVIILPLNHLKDIRRTLGNSLPGPLGALSA
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IISGGKNTKDEDPDKDELADGQSSAETKVGNDGTGSEELSDTRPSGSLEGDTVTKLLMEI
HHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHH
RDLLLLMGEMDNKKSKDHSERGL
HHHHHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure
MFAGFRDFIARRNVVDLSAAVVIGAASTAVINAIVDDIFSPLISAALSSSKIENSLVLTI
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
PTLSHGHVQLKFGTVLLALIKFVLVSAVVYFVIILPLNHLKDIRRTLGNSLPGPLGALSA
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IISGGKNTKDEDPDKDELADGQSSAETKVGNDGTGSEELSDTRPSGSLEGDTVTKLLMEI
HHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHH
RDLLLLMGEMDNKKSKDHSERGL
HHHHHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA