Click here to switch to the map view.

The map label for this gene is mraY

Identifier: 28572694

GI number: 28572694

Start: 582278

End: 583387

Strand: Reverse

Name: mraY

Synonym: TW546

Alternate gene names: 28572694

Gene position: 583387-582278 (Counterclockwise)

Preceding gene: 28572695

Following gene: 28572693

Centisome position: 63.0

GC content: 42.7

Gene sequence:

>1110_bases
ATGATTGCAATTTTGCTTGCCGTTGCATTCGGTATTACATTCACACTGTTTACTACCCCATTTTTTATAAGACTGTTTAG
GAAAATTGGTTGGGGTCAGTTTATCCGACTTGATGGCCCAAGGCAACACGCAATTAAACGGGGCACACCAACCATGGGTG
GTCTTGTAATAGTTGTTGCATCGATTATTTCTTATTTTCTGGCAAATTTTTTCTTAGGGCTCAGTGTAGAGCCTTCGGGA
CTGCTTGTTATTTTTATGTTTGTTGGAATGAGTCTTGTTGGTTTTCTGGATGACATCCTAAAGGTAAGAAAGCAGCACAG
TGGAGGGCTGGGTCCTTTCTATAAAGTTGTTTTACAAAGTTTTATTGCGGTGCCATTCGCCCTCCTTACCTTTCTTGTCA
AGGACGCAAGAGGCATCCCTCATTCGAGTATGTCCATTTCATTCGCGCGTGATACGGGGATTAATTTTTCCGCACTGTTT
AGCTTAGGGATAATTGGCGTGTTTTCTGCATGGGTTTTATATCTTCTCTGGATAAATCTTATTGCGGTTTCGTCTGTGAA
TGCAGTAAATATTACAGACGGTCTGGATGGGCTCGCTGCCGGCGCTATGATTTTCACAATGCTTGCATACGTAGTTATTG
GATTTTGGCAGTCTGGTCAAAACTGCGCAAGAAAAAGCCTTCCACTGGAAAATATATCAAAATGTTATTCGGTAAATGGG
CCGCTTGATATGTCGATTCTTGCCGCAGCAATACTGGGATCATTGCTCGGATTTTTATGGTGGAATACAAATCCGAGCAA
GATAATGATGGGTGACACCGGTGCACTTGCGCTTGGTGGGGCAGCTGCTGCTTTGAGTATTCTTACCCACACCCAGTTAT
TGTTTCTTGTGCTGGGCGGCTTGTTCGTTATAGAGGCAGGCTCTGTTATTTTGCAGATTGCTTTCTACAAGAAGTATCGA
CGCAGGATTTTTCTTATGAGTCCCTTACATCACCATTTTGAGCTAAAAGGTTGGGCTGAAATCACTGTTGTTGTGCGTTT
TTGGATAATTGCAGGTTTATTCACTGCCCTTGGCATTGGTTTATTTTATGCGGATTGGCTATATTCGTGA

Upstream 100 bases:

>100_bases
TATTTTCTCCAGGAGATATAGTTCTTTTCAAAGCCTCAAATGCGGAGAATTTTTCTAGCCTCGTGGAGAGTGTAAAGCAC
AAAGCAGGCAAGTTTGCGGG

Downstream 100 bases:

>100_bases
CTTTGCAGGGTAAACCATACAGATTATCTGATCTAATAAAACAAACAGGTGTGCGCCTTACCGATTGTTCGAATCAGTTC
TCAGATAGGTTTGTATCCGG

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MIAILLAVAFGITFTLFTTPFFIRLFRKIGWGQFIRLDGPRQHAIKRGTPTMGGLVIVVASIISYFLANFFLGLSVEPSG
LLVIFMFVGMSLVGFLDDILKVRKQHSGGLGPFYKVVLQSFIAVPFALLTFLVKDARGIPHSSMSISFARDTGINFSALF
SLGIIGVFSAWVLYLLWINLIAVSSVNAVNITDGLDGLAAGAMIFTMLAYVVIGFWQSGQNCARKSLPLENISKCYSVNG
PLDMSILAAAILGSLLGFLWWNTNPSKIMMGDTGALALGGAAAALSILTHTQLLFLVLGGLFVIEAGSVILQIAFYKKYR
RRIFLMSPLHHHFELKGWAEITVVVRFWIIAGLFTALGIGLFYADWLYS

Sequences:

>Translated_369_residues
MIAILLAVAFGITFTLFTTPFFIRLFRKIGWGQFIRLDGPRQHAIKRGTPTMGGLVIVVASIISYFLANFFLGLSVEPSG
LLVIFMFVGMSLVGFLDDILKVRKQHSGGLGPFYKVVLQSFIAVPFALLTFLVKDARGIPHSSMSISFARDTGINFSALF
SLGIIGVFSAWVLYLLWINLIAVSSVNAVNITDGLDGLAAGAMIFTMLAYVVIGFWQSGQNCARKSLPLENISKCYSVNG
PLDMSILAAAILGSLLGFLWWNTNPSKIMMGDTGALALGGAAAALSILTHTQLLFLVLGGLFVIEAGSVILQIAFYKKYR
RRIFLMSPLHHHFELKGWAEITVVVRFWIIAGLFTALGIGLFYADWLYS
>Mature_369_residues
MIAILLAVAFGITFTLFTTPFFIRLFRKIGWGQFIRLDGPRQHAIKRGTPTMGGLVIVVASIISYFLANFFLGLSVEPSG
LLVIFMFVGMSLVGFLDDILKVRKQHSGGLGPFYKVVLQSFIAVPFALLTFLVKDARGIPHSSMSISFARDTGINFSALF
SLGIIGVFSAWVLYLLWINLIAVSSVNAVNITDGLDGLAAGAMIFTMLAYVVIGFWQSGQNCARKSLPLENISKCYSVNG
PLDMSILAAAILGSLLGFLWWNTNPSKIMMGDTGALALGGAAAALSILTHTQLLFLVLGGLFVIEAGSVILQIAFYKKYR
RRIFLMSPLHHHFELKGWAEITVVVRFWIIAGLFTALGIGLFYADWLYS

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=345, Percent_Identity=35.9420289855072, Blast_Score=197, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_TROW8 (Q83HJ8)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789474.1
- STRING:   Q83HJ8
- GeneID:   1064749
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW546
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   AAGSMAM
- ProtClustDB:   PRK00108
- BioCyc:   TWHI218496:TW0519-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 40326; Mature: 40326

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb9a4b08)-; HASH(0xb77f364)-; HASH(0xc08a354)-; HASH(0xc97f290)-; HASH(0xc2834e4)-; HASH(0xc1b8db8)-; HASH(0xcf368c4)-; HASH(0xb103e38)-; HASH(0xc976ef8)-; HASH(0x96d9e34)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAILLAVAFGITFTLFTTPFFIRLFRKIGWGQFIRLDGPRQHAIKRGTPTMGGLVIVVA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHH
SIISYFLANFFLGLSVEPSGLLVIFMFVGMSLVGFLDDILKVRKQHSGGLGPFYKVVLQS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FIAVPFALLTFLVKDARGIPHSSMSISFARDTGINFSALFSLGIIGVFSAWVLYLLWINL
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAVSSVNAVNITDGLDGLAAGAMIFTMLAYVVIGFWQSGQNCARKSLPLENISKCYSVNG
HHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHCCCC
PLDMSILAAAILGSLLGFLWWNTNPSKIMMGDTGALALGGAAAALSILTHTQLLFLVLGG
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LFVIEAGSVILQIAFYKKYRRRIFLMSPLHHHFELKGWAEITVVVRFWIIAGLFTALGIG
HHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LFYADWLYS
HHHHHHHCH
>Mature Secondary Structure
MIAILLAVAFGITFTLFTTPFFIRLFRKIGWGQFIRLDGPRQHAIKRGTPTMGGLVIVVA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHH
SIISYFLANFFLGLSVEPSGLLVIFMFVGMSLVGFLDDILKVRKQHSGGLGPFYKVVLQS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FIAVPFALLTFLVKDARGIPHSSMSISFARDTGINFSALFSLGIIGVFSAWVLYLLWINL
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAVSSVNAVNITDGLDGLAAGAMIFTMLAYVVIGFWQSGQNCARKSLPLENISKCYSVNG
HHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHCCCC
PLDMSILAAAILGSLLGFLWWNTNPSKIMMGDTGALALGGAAAALSILTHTQLLFLVLGG
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LFVIEAGSVILQIAFYKKYRRRIFLMSPLHHHFELKGWAEITVVVRFWIIAGLFTALGIG
HHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LFYADWLYS
HHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12606174